Biomedica最新文献_第9页

Pulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor 肺和中枢神经系统诺卡病:酒精中毒作为免疫损害因素

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-30 DOI: 10.7705/biomedica.6606

Adriana Isabel Márquez, Eduardo Mora, Andrés Felipe Bernal, Andrés Felipe Salazar, Diana Patricia Mora, Ledmar Jovanny Vargas

{"title":"Pulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor","authors":"Adriana Isabel Márquez, Eduardo Mora, Andrés Felipe Bernal, Andrés Felipe Salazar, Diana Patricia Mora, Ledmar Jovanny Vargas","doi":"10.7705/biomedica.6606","DOIUrl":"https://doi.org/10.7705/biomedica.6606","url":null,"abstract":"<p><p>Nocardiosis is a disease with worldwide distribution. It is usually found in tropical areas and mainly affects immunocompromised patients, however, there are also cases where its infection has been reported in immunocompetent patients. This pathology is caused by bacteria known as Nocardia spp., which are gram-positive microorganisms and environmental saprophytes, and although exposure to Nocardia spp. is almost universal, only a small fraction of exposed people develops the disease.\u0000We present the case of a 47-year-old man, with no evidence of immunosuppression, from a rural area of Boyacá, who was admitted due to intense and intermittent headache accompanied by paresthesia and, finally, a decrease in consciousness. A brain magnetic resonance was performed and evidenced a fronto-temporo- occipital space-occupying lesion in the cortico-subcortical region with a compressive effect and displacement of the ventricular system cavities. It was suspected at first a neoplastic lesion or a brain abscess.\u0000The lesion was surgically resected, and its culture showed Nocardia africana/nova. In later studies a possible primary pulmonary focus was evidenced. Alcoholism was the only risk factor documented. The patient completed 6 weeks of hospital antibiotic treatment with favorable clinical and radiological evolution and was discharged with a 1-year plan of outpatient antibiotic therapy. Although Nocardia spp. mainly affects immunocompromised patients, evidence shows that this microorganism can also be a threat to individuals without traditional immunosuppression risk factors.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participation of Healthy Volunteers in Clinical Trials – Motives, Barriers and Ethical Issues 健康志愿者参与临床试验的动机、障碍和伦理问题

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-869

Rajabzadeh Asghar, J. Saleem, Muhammad Ishaq

{"title":"Participation of Healthy Volunteers in Clinical Trials – Motives, Barriers and Ethical Issues","authors":"Rajabzadeh Asghar, J. Saleem, Muhammad Ishaq","doi":"10.24911/biomedica/5-869","DOIUrl":"https://doi.org/10.24911/biomedica/5-869","url":null,"abstract":"Recruitment of adequate number of healthy volunteers is vital for success of clinical trials but there is limited research on factors motivating the healthy volunteers to participate in clinical trials especially in developing countries. Pakistani researchers also faced the problems in enrollment of enough healthy volunteers during COVID-19 pandemic when a number of clinical trials began in Pakistan. Around 117 research proposals were processed by the National Bioethics Committee (NBC) of Pakistan in last two years. A major proportion of these clinical research studies target healthy populations as primary research subjects or as controls. \u0000Numerous studies have investigated factors such as motives, barriers, risks. benefits and ethical values affecting recruitment and participation of healthy volunteers in clinical trials. We have reviewed the literature to learn about factors that motivate or prevent the healthy persons to volunteer along with the pertaining ethical issues. \u0000Financial incentive is the principal motive for healthy volunteers to participate in clinical trials along with altruism, contribution to sciences, research and other people’s health, desire to take part in something important, learning more about science and medicine, access to healthcare & free medical checkup and prospects of one’s social network expansion whereas time inconvenience, confidentiality, possible side effects & route of administration of drug and fear of contacting the disease were identified as important barriers. \u0000Application of knowledge of these motives and barriers will help Pakistani researchers to enroll adequate number of healthy volunteer for their clinical trials.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79931927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De Quervain’s tenosynovitis and thumb pain in physiotherapists practicing manual therapy: prevalence and associated factors De Quervain的腱鞘炎和拇指疼痛的物理治疗师进行手工治疗:患病率和相关因素

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-846

T. Mazhar, Saba Riaz, Sumbal Riaz, A. Batool, Awishbah Khan, Sadia Khan

{"title":"De Quervain’s tenosynovitis and thumb pain in physiotherapists practicing manual therapy: prevalence and associated factors","authors":"T. Mazhar, Saba Riaz, Sumbal Riaz, A. Batool, Awishbah Khan, Sadia Khan","doi":"10.24911/biomedica/5-846","DOIUrl":"https://doi.org/10.24911/biomedica/5-846","url":null,"abstract":"Background and Objective: Manual therapy is a treatment approach by physical therapists where different techniques are applied to patients with hands for rehabilitation purposes. The objective of the study was to find the frequency of De’Quervain tenosynovitis and thumb and wrist pain in physical therapists working in different rehabilitation centers in relation to age, body mass index (BMI), and working hours. \u0000Methods: A cross-sectional study was conducted on 135 physical therapists working in different settings in Lahore, Pakistan. Physiotherapists were enrolled by convenience sampling. Data were recorded on a questionnaire form. Finkelstein test was performed to check De Quervain’s tenosynovitis. A numeric pain rating scale was sued to measure pain. The data were tested for significance using statistical tests. \u0000Results: On the dominant hand, 99 (73.3%) physical therapists had no wrist pain, 104 (77%) had no thumb pain, 28 (20.7%) had mild wrist pain and 20 (14.8%) had mild thumb pain. Only 21 (15.6%) physiotherapists were tested positive for Finkelstein (De Quervain’s tenosynovitis). Finkelstein test reported 100% negative result on the non-dominant side. There is a negative correlation between thumb pain with the age (r = -0.005), BMI (r = -0.110) and working hours (r = -0.033) of the physical therapists. \u0000Conclusion: The study concluded that the prevalence of De Quervain’s tenosynovitis, thumb, and wrist pain was more on the dominant hand than on the non-dominant side. The majority of the physical therapists reported mild to no pain in the wrist and thumb. There is a negative correlation of thumb pain with age, BMI and working hours. \u0000 ","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79778274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pretreatment with Ajwa dates (Phoenix dactylifera Linn) prevents development of alloxan-induced diabetes in rats 用Ajwa枣(Phoenix dactylifera Linn)预处理可以防止大鼠四氧嘧啶诱导的糖尿病的发展

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-841

A. H. Siddiqui, S. Chiragh, M. Malik

{"title":"Pretreatment with Ajwa dates (Phoenix dactylifera Linn) prevents development of alloxan-induced diabetes in rats","authors":"A. H. Siddiqui, S. Chiragh, M. Malik","doi":"10.24911/biomedica/5-841","DOIUrl":"https://doi.org/10.24911/biomedica/5-841","url":null,"abstract":"ABSTRACT \u0000Background and Objective: A global increase in the prevalence of diabetes mellitus (DM) is associated with increased morbidity and mortality. Oxidative stress is a fundamental component in the pathogenesis of DM Ajwa dates are known to have a high antioxidant content, especially in their seeds. Hence this study was designed to determine the preventive effects of Ajwa date fruit on alloxan-induced diabetes in an experimental rat model. \u0000Methods: This experimental study was conducted at the Post Graduate Medical Institute, Lahore, Pakistan. A total of forty Sprague-Dawley rats were divided into five groups with eight animals in each. Rats in group A were normal control, whereas rats in group B were induced with intraperitoneal alloxan (160 mg/kg body weight) to develop diabetes. Groups C, D, and E rats were fed on a diet supplemented with Ajwa flesh, seed, and whole Ajwa respectively for 1 week. Blood and urine glucose levels were measured on days 0, 7 (pre-alloxan) and 11, 14, 19 (post-alloxan). Serum insulin, homeostatic model assessment (HOMA) for β-cell function (HOMA-β), and insulin resistance (HOMA[1]IR) were estimated terminally. \u0000Results: Diabetes was induced successfully in animals of all experimental groups except the normal control group. Rats of the Ajwa-seed group (D) showed relative resistance to diabetes induction with three non-diabetic rats on day 19. In group E, rats had lower blood sugar levels than rats in group C (p = 0.010). Serum insulin, HOMA-β and HOMA-IR, revealed partial beta cells restoration in the experimental animals of groups D and C. Insulin resistance was significantly higher, despite the highest insulin level (3.77 µIU/ml; p value <0.001) in group C. \u0000Conclusion: Ajwa date seed powder appears to provide relative protection against the development of diabetes in rats induced by alloxan.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87023161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of single-stage reverse sural artery flap versus two-staged interpolated flap in distal lower limb injuries 单期腓肠动脉逆行皮瓣与两期内插皮瓣治疗下肢远端损伤的比较

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-802

Tauqeer Nazim, Sarfraz Ahmad, K. Hamid, Z. Bhatti, Muhammad Maaz Arif, S. Khalid, D. Mohsin

{"title":"Comparison of single-stage reverse sural artery flap versus two-staged interpolated flap in distal lower limb injuries","authors":"Tauqeer Nazim, Sarfraz Ahmad, K. Hamid, Z. Bhatti, Muhammad Maaz Arif, S. Khalid, D. Mohsin","doi":"10.24911/biomedica/5-802","DOIUrl":"https://doi.org/10.24911/biomedica/5-802","url":null,"abstract":"Background and Objective: Plastic surgeons face challenging conditions when dealing with soft tissue injuries or defects involving the lower part of the leg and the proximal part of the foot. The objective of the current study is to compare single-staged reverse sural artery flaps with two-staged interpolated flaps in distal lower limb injuries. \u0000Methods: It was a prospective study carried out at the Department of Plastic Surgery, Allama Iqbal Memorial Teaching Hospital, Sialkot, Pakistan, over 5 years from 2015 to 2020. Sixty-eight (n = 68) patients with distal lower limb soft-tissue defects were enrolled and randomly allotted a two-stage interpolated flap design (group A) or single-stage reverse sural artery flap design (group B). The measured outcomes included the frequency of flap-tip necrosis, epidermolysis, partial or total flap loss, and additional procedures needed for managing these complications. \u0000Results: Out of all the patients, 72% were of male gender and 28% were females with a mean age of 38.38 ± 10.76 years. In group A, there were 6% of the cases where tip necrosis was the only impediment as compared to 17% in group B. In patients of group A, epidermolysis was seen in 12% as compared to 35% in group B whereas only 6% of patients in group A required secondary procedures for flap tip necrosis as compared to group B (47%). Paired t-test was used to calculate the statistical significance of the outcome between the two groups (p-value of 0.0491). \u0000Conclusion: The two-staged interpolated flap procedure results in fewer complications as compared to a single-staged reverse sural artery flap procedure. However, the shorter hospital stay in single-staged flap design is satisfying for the patients who did not report any complications with this procedure.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82167077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D levels have a potential role in predicting the disease severity in COVID-19 positive pediatric patients 维生素D水平在预测COVID-19阳性儿科患者疾病严重程度方面具有潜在作用

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-880

Margaret Hassan, Iffat Batool, Hasan Mujtaba, M. Javaid, Uzma Abid

{"title":"Vitamin D levels have a potential role in predicting the disease severity in COVID-19 positive pediatric patients","authors":"Margaret Hassan, Iffat Batool, Hasan Mujtaba, M. Javaid, Uzma Abid","doi":"10.24911/biomedica/5-880","DOIUrl":"https://doi.org/10.24911/biomedica/5-880","url":null,"abstract":"Background and Objective: The contagious and invasive nature has made coronavirus disease-19 (COVID-19) a critical health issue for the community. The lower respiratory tract is the major site of inflammation seen in COVID-19-positive individuals. Vitamin D (Vit D) has been proposed to have a positive role in immunomodulation, hence, this study aimed to determine the association between Vit D levels and the severity of COVID-19 in infected pediatric patients presenting at a secondary healthcare hospital in Pakistan. \u0000Methods: This cross-sectional analytical study was conducted on 100 pediatric patients of the age range 1-18 years from March to December 2021. These patients were hospitalized and diagnosed with coronavirus disease with confirmed results on a real‐time reverse transcription-polymerase chain reaction. Blood samples of the patients were taken to monitor the baseline levels of markers of acute infection and Vit D levels. Patients with serum Vit D levels ≤ 20ng/ml were labeled with deficiency, those with levels 21-29ng/ml were presumed to have Vit D insufficiency whereas levels ≥30 ng/ml were considered normal. \u0000Results: There were 57 (57%) males and 43 (43%) female pediatric patients. The mean age of the patients was 10.46 ± 4.25 years (1-18 years). The deficient Vit D level group had a greater frequency of pyrexia, weakness, cough, anosmia, headache, myalgia, and diarrhea. The levels of Vit D and severity of the disease were significantly associated (p-value = 0.027). \u0000Conclusion: Pediatric patients with COVID-19 having optimum levels of Vit D were less likely to develop complications associated with the severity of the disease.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73343000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of TNF-α and DC-SIGN promoter polymorphisms in patients with dengue fever in Lahore city of Pakistan 巴基斯坦拉合尔市登革热患者TNF-α和DC-SIGN启动子多态性调查

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-835

Syed Rizvan Ali, Sumra Batool, S. Khaliq

{"title":"Investigation of TNF-α and DC-SIGN promoter polymorphisms in patients with dengue fever in Lahore city of Pakistan","authors":"Syed Rizvan Ali, Sumra Batool, S. Khaliq","doi":"10.24911/biomedica/5-835","DOIUrl":"https://doi.org/10.24911/biomedica/5-835","url":null,"abstract":"Background and Objective: Dengue fever (DF) has been a major health concern globally. Pakistan is also combating this infection for the last decade. Cytokine genes play an important role in DF pathogenesis. This study aimed to analyze dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and tumor necrosis factor α (TNF-α) genes promoter polymorphisms in DF patients. \u0000Methods: A total of 140 (n = 140) dDF patients were recruited for study at the Department of Human Genetics and Molecular Biology of University of Health Sciences, Lahore, Pakistan over a period of 3 years. Simple DF was noted in 105 patients (75%) while 35 (25%) showed bleeding complications. All patients were found positive for dengue non-structural protein or dengue IgM. All patients were tested for two polymorphisms in TNF-α (-238G/A, and -308G/A) and one polymorphism in DC-SIGN (-336G/A) using restriction fragment length polymorphism technique. A single nucleotide polymorphism stats program was used for statistical analysis. \u0000Results: Susceptibility to develop dengue infection in the presence of -336G allele odds ratio (OR = 27.95, p = <0.0001) and GG genotype (OR = 183.77, p = <0.0001) was found to be significantly associated in this study. Presence of a combination of alleles -336G/-238A/-308A was noted in 59.4% of DF cases and 7.6% healthy controls, a difference with statistical significance (OR = 31.46, p = <0.0001). Moreover, prevalence of DF symptoms showed a trend higher in G-carriers versus non-G-carriers of DC-SIGN -336 polymorphism. \u0000Conclusion: This work suggests a potential association of DC-SIGN -336 polymorphism with susceptibility to develop symptomatic dengue illness. However, no potential association was found between TNF-α promoter polymorphisms and dengue infection in this study.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88180115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of parental knowledge and attitude towards poliomyelitis and its immunization in Sialkot city: a mix method study 锡亚尔科特市父母对脊髓灰质炎及其免疫的知识和态度的决定因素:一项混合方法研究

IF 0.9 4区医学

Biomedica Pub Date : 2023-03-26 DOI: 10.24911/biomedica/5-683

Taskeen Zahra, Ayesha Parvez, Hamzah Ahmad, Hassiba Ifftikhar, F. Mushtaq, S. Ayub

{"title":"Determinants of parental knowledge and attitude towards poliomyelitis and its immunization in Sialkot city: a mix method study","authors":"Taskeen Zahra, Ayesha Parvez, Hamzah Ahmad, Hassiba Ifftikhar, F. Mushtaq, S. Ayub","doi":"10.24911/biomedica/5-683","DOIUrl":"https://doi.org/10.24911/biomedica/5-683","url":null,"abstract":"Background and Objectives: Poliomyelitis still remains a significant public health concern in developing countries though it has been eradicated from most of the world. Illiteracy, cultural constraints, and skepticism of the general public regarding vaccination are considered major impediments to its successful eradication from developing countries. In this study, the authors aimed to evaluate parental knowledge and attitudes about poliomyelitis and its immunization in a local population as well as to elucidate the determinants and barriers relating to the immunization process. \u0000Methods: This mixed-method study was conducted on 350 consenting parents who accompanied their children under 5 years of age at the pediatric outdoors of a tertiary care hospital in Sialkot, Pakistan. Parents of only those children were included for the study who had failed to receive a polio dose during the last two supplementary immunization activities The parents were interviewed on a pre-tested, semi structured questionnaire. Statistical Package for the Social Sciences was used for statistical analysis considering p-value <0.05 as significant. \u0000Results: Among 350 parents, 91.7% lacked knowledge about polio vaccination and 82% reported a negative attitude towards the disease and its immunization. A total of 11.4% of subjects completely refused to get their child vaccinated. The socioeconomic status, religious myths, level of literacy, and occupation of the parents significantly influenced their level of knowledge and attitude toward the disease and its vaccination (p < 0.05). \u0000Conclusion: Poor knowledge and negative attitudes of parents towards poliomyelitis vaccination were observed. Fear of side effects and religious beliefs were identified as the most common barriers to immunization toward achieving polio eradication.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85236264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aplicaciones actuales de la ultrasonografía en anestesia 超声在麻醉中的应用

IF 0.9 4区医学

Biomedica Pub Date : 2023-01-30 DOI: 10.5377/alerta.v6i1.15610

Luis Arévalo Gutiérrez

{"title":"Aplicaciones actuales de la ultrasonografía en anestesia","authors":"Luis Arévalo Gutiérrez","doi":"10.5377/alerta.v6i1.15610","DOIUrl":"https://doi.org/10.5377/alerta.v6i1.15610","url":null,"abstract":"La ecografía es una herramienta segura, portátil, económica y de fácil acceso. Los médicos anestesiólogos pueden beneficiarse con esta herramienta diagnóstica rápida y precisa en su práctica habitual. Existen múltiples áreas potenciales donde la ecografía desempeña un papel importante, para la orientación de intervenciones a ciegas e invasivas, el diagnóstico de condiciones críticas y la evaluación de posibles variaciones anatómicas que pueden conducir a la modificación del plan anestésico. Esta revisión narrativa describe las principales aplicaciones de la ecografía en anestesia, las técnicas ecoguiadas y las tendencias actuales del manejo anestésico perioperatorio del paciente quirúrgico. Se realizó una búsqueda en las bases de datos PubMed y Cochrane, se incluyeron artículos originales, estudios aleatorizados y de revisión, en español y en inglés, publicados entre 2017-2021. El uso de ecografía ha entrado en el campo de la medicina del dolor, anestesia regional y del intervencionismo analgésico durante la última década, e incluso es el estándar de la práctica, por tanto, la capacitación y un adecuado aprendizaje en la ecografía deben ser parte del plan de estudios de cualquier programa de anestesiología.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81016196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallazgos histopatológicos pulmonares asociados a COVID-19. Una revisión sistemática y metaanálisis 与COVID-19相关的肺组织病理学发现。系统回顾和荟萃分析

IF 0.9 4区医学

Biomedica Pub Date : 2023-01-30 DOI: 10.5377/alerta.v6i1.14324

M. V. Rodríguez-Funes, Héctor Herrera Huezo, A. Ortiz, Cecilia Belem Osorio, Dennys Molina, Verónica Reina Meléndez, Juan José Vindell, Luis E. Ortiz-Muñoz, G. Rada

{"title":"Hallazgos histopatológicos pulmonares asociados a COVID-19. Una revisión sistemática y metaanálisis","authors":"M. V. Rodríguez-Funes, Héctor Herrera Huezo, A. Ortiz, Cecilia Belem Osorio, Dennys Molina, Verónica Reina Meléndez, Juan José Vindell, Luis E. Ortiz-Muñoz, G. Rada","doi":"10.5377/alerta.v6i1.14324","DOIUrl":"https://doi.org/10.5377/alerta.v6i1.14324","url":null,"abstract":"Introducción. La COVID-19 es una nueva enfermedad que requería resultados prontos provenientes de la investigación. Un abordaje para la comprensión de su fisiopatología es conocer el daño a nivel histopatológico que genera en los pulmones de los afectados. Objetivo. Proveer un resumen riguroso de la evidencia disponible sobre los hallazgos histopatológicos pulmonares en pacientes con COVID-19. Metodología. Se desarrolló una revisión sistemática con metaanálisis de proporciones. Se incluyeron estudios primarios de cualquier diseño que tuvieran datos primarios de hallazgos histopatológicos de pulmones en pacientes COVID-19. Se excluyeron revisiones y guías. Las fuentes de información fueron el repositorio centralizado Living OVerview of Evidence, PubMed/Medline, LitCovid, la base de datos COVID-19 de la Organización Mundial de la Salud, y medRxiv hasta el 3 de abril 2021. La evaluación del riesgo de sesgos se realizó utilizando las herramientas del Instituto Joanna Briggs para series de casos y reportes de casos. Se extrajo cada dato de hallazgo pulmonar histopatológico. Se calcularon las frecuencias encontradas y los datos de los hallazgos más frecuentes fueron resumidas en metaanálisis usando el método de efectos aleatorios de Der Simmonian-Liard. Se midió la heterogeneidad. Resultados. Los criterios de inclusión fueron cumplidos por 69 artículos sumando 594 sujetos. Presentaron bajo riesgo de sesgos 35 artículos. El metaanálisis de proporciones mostro daño alveolar difuso en 0,62 (IC 95 % 0,51-0,72), I2 59 % (p < 0,01), en su fase temprana (85,14 %). Conclusión. El daño alveolar difuso temprano fue el hallazgo histopatológico más frecuente en muestras pulmonares de pacientes con COVID-19.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88257763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0