Biomedica最新文献

{"title":"Serum nitric oxide concentration in generalized chronic and aggressive periodontitis in the Mexican population is not related to the severity of the disease","authors":"Martha Graciela Fuentes-Lerma,&nbsp;Ana Lourdes Zamora-Pérez,&nbsp;Cecilia Robles-Gómez,&nbsp;Celia Guerrero-Velázquez,&nbsp;Jorge Peregrina-Sandoval,&nbsp;Melva Gutiérrez-Angulo,&nbsp;Rocío Patricia Mariaud-Schmidt","doi":"10.7705/biomedica.6690","DOIUrl":"https://doi.org/10.7705/biomedica.6690","url":null,"abstract":"<p><p>Introduction: Periodontitis is an inflammatory disease that affects the supporting tissues of teeth, the effects of excess of nitric oxide, may contribute to the symptoms of periodontitis.\u0000Objective: To determine the serum nitric oxide concentration in generalized chronic and aggressive periodontitis patients and to compare it with a healthy subject group from the Mexican population.\u0000Materials and methods: A case and control study was performed. Sixty-nine individuals were recruited from the Clínica de Posgrado de Periodoncia of the Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, México. Patients with clinical features of generalized chronic periodontitis (GCP group, n=19), generalized aggressive periodontitis (GAP group, n=11), and a group of healthy subjects (HS group, n=39) were included in the study. Informed consent was obtained from each subject, and serum nitric oxide concentration was measured by an enzyme-linked immunosorbent assay.\u0000Results: Nitric oxide concentration in the study groups was greater in the GCP group (462.57 ± 16.57 μmol/L) than in the GAP group (433.84 ± 18.61 μmol/L) and the HS group (422.46 ± 12.07 μmol/L). A comparison using Student’s t-test (one-tailed) between healthy subjects and generalized chronic periodontitis showed borderline significance (p<0.04), whereas no significant differences were observed in HS and GAP groups, with a p-value of 0.64, and the GAP vs. GCP p-value was 0.33.\u0000Conclusion: The serum nitric oxide concentration observed in the present study suggests that nitric oxide plays a major role in the inflammatory process, which cannot necessarily be linked to the severity of the disease and periodontal tissue destruction.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomics of psychiatric disorders: Regional challenges and opportunities","authors":"Diego A Forero","doi":"10.7705/biomedica.6996","DOIUrl":"https://doi.org/10.7705/biomedica.6996","url":null,"abstract":"A recent article, based on the Global Burden of Disease Study 2019, estimated that about 970 million people were affected around the world by common psychiatric disorders and that anxiety and depressive disorders led to the largest numbers of disability-adjusted life-years (DALY) (2). A previous work analyzed the prevalence of psychiatric disorders in fourteen countries and found that México and Colombia had higher rates than several European countries (3). In terms of the global economic impact associated with psychiatric disorders, a recent paper estimated that it is around USD $5 trillion; for the global burden of disease region in which Colombia is located it is equivalent to 5.7 percent of the gross domestic product (GDP) (4). These major impacts on burden of disease, particularly on morbidity, is associated with the fact that common psychiatric disorders affect patients for many decades of life (2).","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the care of Ewing’s sarcoma in a Jehovah’s Witness patient","authors":"Carlos Julio Vargas-Potes,&nbsp;Diana Marcela Mendoza-Urbano,&nbsp;Luis Gabriel Parra-Lara,&nbsp;Ángela R Zambrano","doi":"10.7705/biomedica.6720","DOIUrl":"https://doi.org/10.7705/biomedica.6720","url":null,"abstract":"<p><p>Ewing’s sarcoma is a bone and soft tissue neoplasm, whose management is related to hematological toxicity. This aspect represents a medical and ethical challenge in Jehovah’s Witnesses patients, who, due to their religious beliefs, reject the blood component transfusion, with the risk of discontinuing chemotherapy or using suboptimal doses.\u0000We present the case of a 34-year-old Colombian woman, Jehovah’s Witness, diagnosed with Ewing’s sarcoma with clinical stage IIB (T1N0M0) in the left maxillary and mandibular regions, treated with chemotherapy, who presented a hemoglobin nadir of up to 4.5 g/dL, and surgical indication as part of the treatment. In these patients, the transfusion decision has ethical implications that require therapeutic alternatives and a multidisciplinary approach.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor. Clinical validation of the isothermal RT-LAMP test for rapid diagnosis of SARS-CoV-2. Biomédica. 2022;42(Supl.2):59-72","authors":"César Antonio Bonilla-Asalde,&nbsp;David Alberto Díaz-Robles,&nbsp;Edwin César Cieza-Macedo,&nbsp;Oriana Rivera-Lozada,&nbsp;Lisandro A Pacheco,&nbsp;Leidy Hurtado,&nbsp;Diana Díaz,&nbsp;Katherine Escorcia,&nbsp;Laura Flórez,&nbsp;Yesit Bello,&nbsp;Yirys Díaz,&nbsp;Elkin Navarro,&nbsp;Leonardo C Pacheco,&nbsp;Nataly Galán,&nbsp;Ronald Maestre,&nbsp;Antonio Acosta","doi":"10.7705/biomedica.6997","DOIUrl":"10.7705/biomedica.6997","url":null,"abstract":"Hemos leído con sumo interés la reciente publicación de su prestigiosa revista, donde encontramos el excelente artículo original de Hurtado, et al. (1), quienes “validaron la técnica RT-LAMP colorimétrica en muestras de hisopado nasofaríngeo previamente confirmadas por RT-qPCR como prueba de referencia”. En cuanto a ello, nos permitimos resaltar el aporte de los autores, mediante experiencia en un país sudamericano que mostró la precisión diagnóstica de pruebas basadas en amplificación isotérmica mediada en lazo de transcriptasa inversa (RT-LAMP, por sus siglas en inglés), para detectar ARN de coronavirus en muestras respiratorias de pacientes.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and clinical features of venomous snake bites in the Northern Amazon of Ecuador (2017-2021)","authors":"Manuel Calvopiña,&nbsp;Elías Guamán-Charco,&nbsp;Karen Ramírez,&nbsp;Felipe Dávalos,&nbsp;Paola Chiliquinga,&nbsp;Sergio Villa-Soxo,&nbsp;René Oña-Vistin,&nbsp;Daniel Romero-Álvarez","doi":"10.7705/biomedica.6587","DOIUrl":"https://doi.org/10.7705/biomedica.6587","url":null,"abstract":"<p><p>Introduction: In Ecuador, poisonous snakebites are a public health problem. However, there is no recent hospital information from the Amazon.\u0000Objective: To retrospectively analyse the clinical-epidemiological characteristics of snakebites in patients admitted to a hospital in the Ecuadorian Amazon.\u0000Materials and methods: This is a cross-sectional study conducted at the Nueva Loja-Sucumbíos Provincial Hospital, bordering Colombia (2017-2021). Demographic,\u0000epidemiological and clinical variables, and condition at hospital discharge, were obtained from the epidemiological file of the Ministerio de Salud Pública.\u0000Results: In 5 years, 147 patients (29.4 per year) were hospitalized with no mortality. They corresponded to 26, 34, 32, 29 and 26 cases, in 2017, 2018, 2019, 2020 and 2021, respectively. Men with 99 (67.3%), aged 21-30 years with 28, mixed race with 94 cases, students, and farmers, were the most affected. The most affected (99; 67.3%) were men, people 21 to 30 years-old (28; 19.0%), mestizos (94; 63.9%), students, and farmers. The median age was 28 (range: 4-81) years. Prevalence was higher in April, June, and September. All accidents were caused by Viperidae snakes. Twenty (13.6%) cases were mild, (61.2%) were moderate and 37 (25.2%) were severe. The feet with 45 were the most bitten. Pre-hospitalization anti-venom serum was received by 53.1% and tourniquet by 19.8% patients. Median hospital arrival time was 5 (range 1-192) hours, mostly between 2-3 hours with 41 cases. No statistically significant differences were found considering the severity.\u0000Conclusions: A high prevalence of snakebites was evidenced in the north of the Amazon in Ecuador, with a higher incidence in the rainy season and all by Viperidae species. It is important to highlight the null mortality. Information campaigns on prevention and first aid, such as discouraging the use of tourniquets, especially among vulnerable groups.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathology of COVID-19: An illustration of the findings from fatal cases.","authors":"Jorge Rivera,&nbsp;Sheryll Corchuelo,&nbsp;Julián Naizaque,&nbsp;Édgar Parra,&nbsp;Eugenio Aladino Meek,&nbsp;Diego Álvarez-Díaz,&nbsp;María Mercado,&nbsp;Orlando Torres-Fernández","doi":"10.7705/biomedica.6737","DOIUrl":"https://doi.org/10.7705/biomedica.6737","url":null,"abstract":"COVID-19 represents the greatest global public health crisis since the influenza pandemic of 1918 (1). Since its first report in December, 2019, the SARS-CoV-2 coronavirus responsible for coronavirus disease 2019 (COVID-19) has efficiently transmitted from person to person, and two years after the declaration of the pandemic by the World Health Organization (WHO), it has caused approximately 481,756,671 infections and 6,127,981 deaths worldwide (2).","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium regulation by SERC-A before and during Alzheimer disease","authors":"Alamira Farah Alwiraikat-Flores,&nbsp;Pablo Octavio-Aguilar","doi":"10.7705/biomedica.6704","DOIUrl":"10.7705/biomedica.6704","url":null,"abstract":"<p><p>There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease.\u0000This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative public health research published in Colombian biomedical journals between 2011 and 2021","authors":"Rodolfo Rodríguez-Gómez","doi":"10.7705/biomedica.6476","DOIUrl":"https://doi.org/10.7705/biomedica.6476","url":null,"abstract":"<p><p>Introduction: Qualitative research seeks to understand the meaning and perspective of individuals and investigates considering the context. This paradigm allows the interpretation and study of phenomena from their own complexity. In public health, qualitative research has gained ground, as it allows the study of subjective aspects of the health-disease process.\u0000Objective: To describe and analyze qualitative research on health issues published in Colombian journals between 2011 and 2021.\u0000Materials and methods: A descriptive study on qualitative health research published in Colombian journals between 2011 and 2021 was carried out.\u0000Results: Eighty-one articles were included. The journal with the highest number of publications was the Revista de Salud Pública (44.4%). The year with the highest\u0000production corresponded to 2019 and the main design was the fundamental theory (17.3%). In 79% of the articles, women were the main author and nursing was the most frequent profession of undergraduate training. The most frequent topic was HIV/AIDS (12.3%), followed by cancer (11.1%). In 24.6% of the studies, a software was used for the analysis.\u0000Conclusions: Qualitative research in public health has had a variable dynamic in scientific production between 2011 and 2021. Despite its benefits, the adoption of computer programs for qualitative analysis is rare. Nursing stands out as the area that concentrates the largest number of qualitative studies in public health with contributions on topics such as COVID-19 and HIV/AIDS.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and healthcare resource utilization in atopic dermatitis in Colombia: A retrospective analysis of data from the National Health Registry from 2015 to 2020","authors":"Angela María Londoño,&nbsp;Juan Raúl Castro-Ayarza,&nbsp;Amira Kronfly,&nbsp;Diana Camila Buitrago,&nbsp;Daniel Felipe Samacá","doi":"10.7705/biomedica.6666","DOIUrl":"https://doi.org/10.7705/biomedica.6666","url":null,"abstract":"<p><p>Introduction: Atopic dermatitis, also known as eczema or atopic eczema, is a chronic inflammatory skin disorder characterized by the presence of pruritus accompanied by itching. In Colombia, epidemiological and healthcare resource utilization information regarding this pathology is limited.\u0000Objective: To describe atopic dermatitis epidemiological characteristics and healthcare resource utilization patterns in Colombia.\u0000Material and methods: A retrospective database study using real-world data obtained from the national claims database SISPRO (Sistema de Información para la Protección Social) for the 2015-2020 period was carried out. Sociodemographic (age, and health services delivery), epidemiological (incidence, prevalence, and comorbidities), and healthcare resource utilization data were extracted from the SISPRO database.\u0000Results: The epidemiological results showed increased incidence and prevalence of atopic dermatitis in Colombia in the 2018-2019 period compared to 2015-2017. Accordingly, the number of medical consultations (particularly with specialists), the number of procedures, and the number of hospitalizations of patients with atopic dermatitis increased. Topic and systemic corticoids were the most frequently prescribed drugs.\u0000Conclusions: Diagnoses of atopic dermatitis in Colombia increased with a concomitant increase in healthcare resource utilization during 2015-2020, which was possibly slowed down by the arrival of the Covid-19. This study may help physicians gaining a better understanding of the disease, improving atopic dermatitis patient management.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver abscess due to Granulicatella adiacens in an immunocompetent patient: Case report.","authors":"Julio García-Casallas,&nbsp;Katherine Patiño-Salazar,&nbsp;Eduardo Tuta-Quintero,&nbsp;Miguel Molina-Ardila","doi":"10.7705/biomedica.6504","DOIUrl":"https://doi.org/10.7705/biomedica.6504","url":null,"abstract":"<p><p>Pyogenic liver abscesses due to Granulicatella adiacens are infections associated with high mortality, mainly in immunocompromised patients. The main microorganisms associated with liver abscesses are Klebsiella pneumoniae, and Escherichia coli, though it may also be polymicrobial. However, case reports describing liver infection by Granulicatella adiacens are scarce. We present the case of an immunocompetent adult patient who presented 15 days of evolution consisting of quantified fever peaks associated with asthenia, adynamia, chills, jaundice and coluria. The initial clinical examination revealed a generalized icteric tint without abdominal pain, and blood pressure with a tendency to hypotension. Biliopancreatic confluent neoplasia, secondary cholangitis and sepsis of biliary origin were suspected, initiating fluid resuscitation and antibiotic therapy; blood cultures and complementary diagnostic studies were taken. Hepatobiliary ultrasound with evidence of an abscess of 73 x 62 mm in segment IV; the bile duct and pancreas were within normal limits. To better characterize the lesion evidenced in the liver, a contrast-enhanced computed tomography of the abdomen was performed. The patient completed antibiotic management with ciprofloxacin, vancomycin, and metronidazole in good condition and was successfully discharged. This is the first pyogenic liver abscess reported caused by Granulicatella adiacens in an immunocompetent patient, in whom early microbiological diagnosis in conjunction with targeted antibiotic treatment and percutaneous drainage of the lesion was decisive in the clinical outcome.</p>","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}