Biomedica最新文献_第5页

Insuficiencia respiratoria en una paciente con síndrome de Sézary sezary综合征患者的呼吸衰竭

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.16211

Neftalí Alexander Granados Flores, Gerson Jonathan Castillo Hernández, Rafael Antonio Trejo Ayala

{"title":"Insuficiencia respiratoria en una paciente con síndrome de Sézary","authors":"Neftalí Alexander Granados Flores, Gerson Jonathan Castillo Hernández, Rafael Antonio Trejo Ayala","doi":"10.5377/alerta.v6i2.16211","DOIUrl":"https://doi.org/10.5377/alerta.v6i2.16211","url":null,"abstract":"Presentación del caso. Paciente de 44 años de sexo femenino, sin ninguna enfermedad de base preexistente, con una historia de aproximadamente diez meses de presentar lesiones eritemato-descamativas pruriginosas inicialmente localizadas en extremidades inferiores y que luego se generalizaron en todo el cuerpo, asociándose a la pérdida de peso de aproximadamente 15 kg. Intervención terapéutica. El manejo inicial consistió en corticoides tópicos y antihistamínicos orales con poca respuesta clínica. Se inició el estudio por dermatología y se confirmó el diagnóstico inicial de neoplasia cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» que confirmaron el diagnóstico de síndrome de Sézary. La paciente recibió esquema de quimioterapia ciclofosfamida, doxorrubicina, vincristina, etopósido y prednisona. Evolución clínica. La respuesta inicial fue favorable, con alta hospitalaria y seguimiento en la consulta externa. Transcurridos tres meses de tratamiento, la paciente consultó por episodio febril, tos productiva más distrés respiratorio asociado a estertores basales bilaterales, presentó insuficiencia respiratoria y durante la inducción a la ventilación mecánica sufrió un paro cardiorrespiratorio y falleció.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"61 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77368258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probióticos y prebióticos en pacientes con enfermedad celíaca y sensibilidad al gluten no celíaca 乳糜泻和非乳糜泻麸质敏感性患者的益生菌和益生元

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.16208

Kevin André Valiente Vásquez, Nathalia Melissa Méndez Díaz, Sofia Alejandra Pleitez Molina

{"title":"Probióticos y prebióticos en pacientes con enfermedad celíaca y sensibilidad al gluten no celíaca","authors":"Kevin André Valiente Vásquez, Nathalia Melissa Méndez Díaz, Sofia Alejandra Pleitez Molina","doi":"10.5377/alerta.v6i2.16208","DOIUrl":"https://doi.org/10.5377/alerta.v6i2.16208","url":null,"abstract":"La enfermedad celíaca y la sensibilidad al gluten no celíaca han tenido un aumento en su incidencia, esto las ha convertido en tema de interés en la búsqueda de enfoques terapéuticos innovadores que ayuden a mejorar los síntomas intestinales y extraintestinales. Esta revisión pretende determinar los efectos del uso de probióticos y prebióticos en la enfermedad celíaca y sensibilidad al gluten no celíaca. Se realizó una búsqueda en bases de datos HINARI, PubMed y Scopus en idioma español e inglés, se incluyeron artículos originales y de revisión con un máximo de cinco años desde su publicación. El uso de probióticos y prebióticos para la enfermedad celíaca ha mostrado beneficios restaurando la composición de la microbiota intestinal, en especial con el uso de Lactobacilli y Bifidobacterium spp.; en la sensibilidad al gluten no celíaca, el uso se ve limitado al no conocer con exactitud su fisiopatología; no obstante, se propone como mejor pauta terapéutica una dieta libre de gluten. El uso de probióticos y prebióticos podría aliviar los síntomas gastrointestinales y mejorar la disbiosis en pacientes con enfermedad celíaca y sensibilidad al gluten no celíaca. Sin embargo, se necesitan más estudios que evidencien los beneficios de su uso como alternativa terapéutica.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"101 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81280691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rol de trampas extracelulares de neutrófilos en el pronóstico de las infecciones del sistema respiratorio 中性粒细胞细胞外陷阱在呼吸系统感染预后中的作用

IF 0.9 4区医学

Biomedica Pub Date : 2023-07-19 DOI: 10.5377/alerta.v6i2.15448

Francisco David Flores Guzmán, Anna Gabriela Hernández Rivera, Karla Gabriela Iraheta Tobar

{"title":"Rol de trampas extracelulares de neutrófilos en el pronóstico de las infecciones del sistema respiratorio","authors":"Francisco David Flores Guzmán, Anna Gabriela Hernández Rivera, Karla Gabriela Iraheta Tobar","doi":"10.5377/alerta.v6i2.15448","DOIUrl":"https://doi.org/10.5377/alerta.v6i2.15448","url":null,"abstract":"Las trampas extracelulares de neutrófilos (NET, por sus siglas en inglés) han surgido recientemente como un vínculo potencial entre la inmunidad y la inflamación, que podría cumplir un papel clave en la patogénesis de las infecciones de vías respiratorias. El objetivo de esta revisión es determinar su rol como marcador pronóstico en enfermedades infecciosas de vías respiratorias. Para la elaboración de este artículo de revisión narrativa se consultaron las publicaciones disponibles a través de una búsqueda automatizada en las bases de datos de PubMed, Scopus y Embase. Las concentraciones elevadas de trampas extracelulares de neutrófilos (cfADN, complejos de mieloperoxidasas-ADN) en pacientes con cuadro clínico grave por infecciones de vías respiratorias, se relacionan con una estancia hospitalaria más larga, periodo prolongado de administración de antibióticos, aumento del riesgo de ingreso a la UCI, necesidad de ventilación mecánica, disfunción orgánica e incluso la muerte (p ≤ 0,05). A pesar de no contar con un parámetro de medición estandarizado, el exceso de trampas extracelulares de neutrófilos se corresponde con la gravedad del daño tisular observado en pacientes con infecciones de vías respiratorias, esto revela el importante rol pronóstico de la respuesta de los neutrófilos y del proceso de la NETosis en las enfermedades infecciosas pulmonares.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"23 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82141765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrahepatic cholestasis due to Treponema pallidum in an immunocompetent patient 一名免疫功能正常患者因梅毒螺旋体引起的肝内胆汁淤积

IF 0.8 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6630

Beatriz E Orozco-Sebá, Diego Viasus, Esperanza Meléndez, Jairo Fuentes, José Tovar, Elkin A Amado, Daniela Loaiza

引用次数: 0

Characteristics of cerebral venous thrombosis in patients from two university hospitals in Colombia between 2018-2020 2018-2020年哥伦比亚两家大学医院患者脑静脉血栓形成特征

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6877

Adriana Marcela Ruiz, Gabriel Esteban Acelas, Hernán Mauricio Patiño, Jean Paul Vergara, Miguel Arturo Silva, María Daniela Camargo

{"title":"Characteristics of cerebral venous thrombosis in patients from two university hospitals in Colombia between 2018-2020","authors":"Adriana Marcela Ruiz, Gabriel Esteban Acelas, Hernán Mauricio Patiño, Jean Paul Vergara, Miguel Arturo Silva, María Daniela Camargo","doi":"10.7705/biomedica.6877","DOIUrl":"10.7705/biomedica.6877","url":null,"abstract":"Introduction: Cerebral venous thrombosis is an uncommon cause of cerebrovascular disease, which has been increasing worldwide. In Colombia, there are not enough recent studies that allow us to determine epidemiological characteristics of the disease in our population to identify more frequent risk factors and complications according to our living conditions.Objetive: To describe clinical, demographic, and radiographic characteristics, and risk factors in a cohort of patients with cerebral venous thrombosis attended at two hospitals in Colombia.Materials and methods: Retrospective descriptive study with patients treated in the hospitalization neurology service of two hospitals in Bogotá, Colombia from December 2018 to December 2020.Results: Thirty-three patients were included. There was a higher incidence of cerebral venous thrombosis in women of childbearing age in the puerperium (n=7; 33.3%) and associated with autoimmune diseases (n=10; 30.3%). The most common initial symptom was headache (n=31; 93.9 %), followed by neurological focal signs (n=9; 27.2%) and seizures (n=8; 24.2%). Fifty-one percent (n=17) of the patients had a normal physical examination. Cerebral venous infarction occurred in 21.1 % (n=7), subarachnoid hemorrhage in 12.1 % (n=4), and intraparenchymal hematoma in 9 % (n=3) of all the patients. Sixty-point six percent (n=20) of the patients had a total independent Barthel functional scale. None of those died.Conclusions: We found similar sociodemographic, clinical, and radiography characteristics to those reported in the world literature. Regarding the differences, deep cerebral venous circulation was higher than that described in previous studies but without complications increase or mortality.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 2","pages":"213-221"},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of changes in clinical outcomes following the implementation of an antibiotic stewardship program in a level IV hospital 四级医院实施抗生素管理计划后临床结果变化的描述

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6748

Raúl Eduardo Reyes, María José López, Jairo Enrique Pérez, Gustavo Martínez

{"title":"Description of changes in clinical outcomes following the implementation of an antibiotic stewardship program in a level IV hospital","authors":"Raúl Eduardo Reyes, María José López, Jairo Enrique Pérez, Gustavo Martínez","doi":"10.7705/biomedica.6748","DOIUrl":"10.7705/biomedica.6748","url":null,"abstract":"Introduction: Inadequate prescription of antibiotics has been recognized as a public health problem by the World Health Organization. In this context, antibiotic stewardship programs have been implemented as a tool to mitigate its impact.Objetive: To describe the changes in clinical outcomes after the implementation of an antibiotic stewardship program in a level IV hospital.Materials and methods: We conducted a unique cohort study of patients hospitalized for infectious pathologies that were treated with antibiotics in an advanced medical facility. We collected the clinical history before the implementation of the antibiotic stewardship program (2013 to 2015) and then we compared it to the records from 2018 to 2019 collected after the implementation of the program. We evaluated changes in clinical outcomes such as overall mortality, and hospital stay, among others.Results: We analyzed 1,066 patients: 266 from the preimplementation group and 800 from the post-implementation group. The average age was 59.2 years and 62% of the population was male. Statistically significant differences were found in overall mortality (29% vs 15%; p<0.001), mortality due to infectious causes (25% vs 9%; p<0.001), and average hospital stay (45 days vs 21 days; p<0.001); we also observed a tendency to decrease hospital readmission at 30 days for infectious causes (14% vs 10%; p=0.085).Conclusions: The antibiotic stewardship program implemented was associated with a decrease in overall mortality and mortality due to infectious causes, as well as in average hospital stay. Our results evidenced the importance of interventions aimed at mitigating the impact of inadequate prescription of antibiotics.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 2","pages":"244-251"},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive open online courses: learning opportunities about global health for Latin American countries 大规模开放在线课程：拉丁美洲国家学习全球健康的机会

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6582

Guido Bendezu-Quispe, Brenda Caira-Chuquineyra, Daniel Fernandez-Guzman, Reggie Casanova-Pérez, Andrés Guido Bendezú-Martínez

{"title":"Massive open online courses: learning opportunities about global health for Latin American countries","authors":"Guido Bendezu-Quispe, Brenda Caira-Chuquineyra, Daniel Fernandez-Guzman, Reggie Casanova-Pérez, Andrés Guido Bendezú-Martínez","doi":"10.7705/biomedica.6582","DOIUrl":"10.7705/biomedica.6582","url":null,"abstract":"Introduction: Massive open online courses provide the opportunity to train health professionals and researchers from Latin America in global health.Objetives: To determine the global offer of massive open online courses in global health and the characteristics of their content.Material and methods: We examined massive open online course platforms to compile the global health offerings. The search had no time restriction and was last conducted in November, 2021. The search strategy only included the descriptor “global health”. We obtained the characteristics of the courses, their content, and the global health domain covered. These data were analyzed using descriptive statistics, reporting absolute and relative frequencies.Results: Our search strategy identified 4,724 massive open online courses. Of these, only 92 were related to global health. Most of these courses (n=44; 47.8%) were offered through Coursera. More than half (n=50; 54.4%) of the MOOCs were conducted by U.S.A. institutions and in English language (n=90; 97.8%). Most courses focused on “globalization of health and healthcare” (n=24; 26.1%), followed by the domains “capacity building” (n=16; 17.4%), “global burden of disease” and “social and environmental determinants of health” (n=15; 16.3%).Conclusions: We found a high offer of massive open online courses on global health. These courses covered the global health competencies required for health professionals.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 2","pages":"261-269"},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water consumption in 0-6-month-old healthy infants and effective factors: A systematic review 0-6个月健康婴儿饮水量及其影响因素的系统评价

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6745

Özge Karakaya Suzan, Ozge Kaya, Tugce Kolukısa, Oguz Koyuncu, Seda Tecik, Nursan Cinar

{"title":"Water consumption in 0-6-month-old healthy infants and effective factors: A systematic review","authors":"Özge Karakaya Suzan, Ozge Kaya, Tugce Kolukısa, Oguz Koyuncu, Seda Tecik, Nursan Cinar","doi":"10.7705/biomedica.6745","DOIUrl":"10.7705/biomedica.6745","url":null,"abstract":"Introduction: Early introduction of fluids and water affects the duration of breastfeeding, the infant immune system, and possibly causes infants to consume less breast milk, which may, in turn, affect their nutritional and immune status.Objective: This study was carried out to determine water consumption in 0-6-month-old infants and the factors affecting this consumption.Materials and methods: A literature review was conducted in seven electronic databases (Medline, Web of Science, PubMed, ScienceDirect, Scopus, Cochrane Library, and TÜBITAK) for studies published until April 25, 2022, using the keywords: drinking water, infant, and breastfeeding.Results: The systematic review included 13 studies. Five studies were crosssectional, three were descriptive and quasi-experimental, and the others were case-control and cohort studies. It was reported in the examined studies that 86.2% of the infants were around 6 weeks old, 44 % of the infants were 1 month old, 77% were 3 months old, 2.5% were 4 months old, and 2.5 to 85% of the infants were around 6 months old when they first consumed water. The prominent reasons for making the infants drink water are the thought that they need it and cultural reasons.Conclusions: The exclusive breastfeeding of 0-6-month-old infants is the recommendation of reliable health authorities. Nurses play a key role in implementing this practice. In this systematic review, it was seen that families gave their infants water at varying rates in the 0-6-month period, and the factors affecting this situation were revealed. If nurses determine which factors affect families in terms of the early introduction of fluids, they could be able to plan the necessary education and interventions.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 2","pages":"181-199"},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the biological efficacy and susceptibility in Aedes aegypti to the pyrethroid insecticides deltamethrin and cyfluthrin during the Zika virus outbreak in Kuna Yala, Panama 巴拿马库纳亚拉寨卡病毒爆发期间埃及伊蚊对拟除虫菊酯类杀虫剂溴氰菊酯和氯氟氰菊酯的生物效力和易感性评估

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.6746

Lorenzo Cáceres, Cipriano Ayarza, Damaris Bernal

{"title":"Evaluation of the biological efficacy and susceptibility in Aedes aegypti to the pyrethroid insecticides deltamethrin and cyfluthrin during the Zika virus outbreak in Kuna Yala, Panama","authors":"Lorenzo Cáceres, Cipriano Ayarza, Damaris Bernal","doi":"10.7705/biomedica.6746","DOIUrl":"10.7705/biomedica.6746","url":null,"abstract":"Introduction. The development of resistance to insecticides in Aedes aegypti represents a major threat to public health. Surveillance and monitoring of the behavior of bioefficacy and susceptibility of insecticides is of fundamental importance to prolong the useful life of insecticide molecules.\u0000Objective. To evaluate the bioefficacy and susceptibility of the insecticides deltamethrin and cyfluthrin in Aedes aegypti during the zika epidemic outbreak in Kuna Yala, Panama.\u0000Methods and materials. The bioefficacy and susceptibility of deltamethrin and cyfluthrin in Aedes aegypti Ustupo using WHO standardized bioassays during the Zika epidemic outbreak in Kuna Yala, Panama.\u0000Results. In the bioassays with Aedes aegypti Ustupo, possible resistance to deltamethrin and cyfluthrin was observed, with a mortality rate of 95,3% and 94%, respectively. The bioefficacy results with Aedes aegypti Ustupo registered low bioefficacy of deltamethrin and cyfluthrin with average percentages of mortality in the intradomicile of 75% and 31,1%, respectively, while in the peridomicile it was 63,7% and 26,1%, respectively.\u0000Conclusion. The results of this study represent a challenge that the National Aedes Control Program must face in order to care for and maintain the toxic effect of insecticides applied against Aedes populations. It is necessary for the National Aedes Control Program to establish a resistance management program to evaluate resistance and its distribution in order to guarantee the sustainability of anti-vector interventions against Aedes populations.","PeriodicalId":9186,"journal":{"name":"Biomedica","volume":"43 2","pages":"222-243"},"PeriodicalIF":0.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Credibility gain challenges to province innovations 诚信为省级创新带来挑战

IF 0.9 4区医学

Biomedica Pub Date : 2023-06-30 DOI: 10.7705/biomedica.7111

Iván Darío Vélez

引用次数: 0