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Passenger mutations in cancer evolution 癌症进化中的乘客突变
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000188
Aparisi F, Amado-Labrador H, Calabuig-Fariñas S, Torres S, Herreros-Pomares A, Jantus-Lewintre E, Blasco A, I. V, Camps C
{"title":"Passenger mutations in cancer evolution","authors":"Aparisi F, Amado-Labrador H, Calabuig-Fariñas S, Torres S, Herreros-Pomares A, Jantus-Lewintre E, Blasco A, I. V, Camps C","doi":"10.15761/crr.1000188","DOIUrl":"https://doi.org/10.15761/crr.1000188","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of pancreatic ductal adenocarcinoma (PDAC): Progress in the past decade and challenges for the future 胰腺导管腺癌(PDAC)的治疗:过去十年的进展和未来的挑战
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000184
Roger Clementine, M. Leo, Granier Sandra, C. Elise, Neuzillet C, Hammel Pascal
{"title":"Management of pancreatic ductal adenocarcinoma (PDAC): Progress in the past decade and challenges for the future","authors":"Roger Clementine, M. Leo, Granier Sandra, C. Elise, Neuzillet C, Hammel Pascal","doi":"10.15761/crr.1000184","DOIUrl":"https://doi.org/10.15761/crr.1000184","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with 41,615 deaths in 2015 as well as in Europe where 128,000 persons are expected to die from this tumor in 2018 [1,2]. Although the worldwide incidence is low with 4.2 per 100 000, and there are important geographic differences (from 7.4 per 100 000 in North America to fewer than 1.5 in Central Africa), the incidence is rising in developed countries such as France, where it nearly doubled between 1982 and 2012 and ranges from 10.2 per 100 000 in men to 6.9 per 100 000 in women [3]. Because the mortality rate will either remain unchanged or moderately increase in upcoming years, PDAC is expected to become the third leading cause of cancer death in the EU by 2025 and the second leading cause of cancer-related death in the United States by 2030 [4,5].","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Zoledronic acid effects the cell cycle signalling AURKA gene in MDA MB231 breast cancer cells 唑来膦酸对MDA MB231乳腺癌细胞周期信号通路AURKA基因的影响
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000189
N. Abraham, Mario G. Hollomon, A. Player
{"title":"Zoledronic acid effects the cell cycle signalling AURKA gene in MDA MB231 breast cancer cells","authors":"N. Abraham, Mario G. Hollomon, A. Player","doi":"10.15761/crr.1000189","DOIUrl":"https://doi.org/10.15761/crr.1000189","url":null,"abstract":"Purpose: The drug Zoledronic acid (ZOL) has been extensively studied as a therapeutic strategy to treat breast cancers. Previous data show the triple negative breast (TNBC) samples are particularly sensitive to killing following exposure to the drug. The goal of this current study was to examine the effect of ZOL on TNBC and identify genes that might contribute to this sensitivity. Methods: A cell line model was used to perform experiments to determine the dose effect of ZOL on TNBC and the genes differentially expressed following drug exposure. Following treatment, the mode of death was established and the transcriptomes of the cells were examined via microarray and differentially expressed genes were identified and validated via transcript and protein expression analyses. Results: Data show that TNBC cells are sensitive to killing following ZOL, with cell death occurring via the autophagy mechanism. Data also show an enrichment in dysregulation in signalling events related to cell cycle regulation. Previous studies have shown involvement of the cell cycle regulator CDKN1A/p21. We observed similar involvement of CDKN1A/p21, but in addition we found down-regulation of the mitotic serine/threonine kinase AURKA gene. Conclusion: In autophagy associated cell death in TNBC, ZOL functions via cell cycle-mediated signalling events related to regulation of CDKN1A proteinase inhibitor and down-regulation of AURKA kinase. *Correspondence to: Audrey Player, Department of Biology, NSB 203P, Texas Southern University, 3100 Cleburne Street, Houston Texas 77004, USA, E-mail: audrey.player@tsu.edu","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term survivors of metastatic gastric cancer for >5 years after chemotherapy initiation 化疗开始后50年的转移性胃癌长期存活者
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000183
Ina K, Furuta R, Hirade K, K. T., Kabeya M
{"title":"Long-term survivors of metastatic gastric cancer for >5 years after chemotherapy initiation","authors":"Ina K, Furuta R, Hirade K, K. T., Kabeya M","doi":"10.15761/crr.1000183","DOIUrl":"https://doi.org/10.15761/crr.1000183","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporary remission of advanced hepatocellular carcinoma in a patient treated with sorafenib therapy alone - A case report and literature review 单用索拉非尼治疗晚期肝细胞癌患者的暂时缓解- 1例报告和文献复习
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000180
S. Elder, Yixing Jiang
{"title":"Temporary remission of advanced hepatocellular carcinoma in a patient treated with sorafenib therapy alone - A case report and literature review","authors":"S. Elder, Yixing Jiang","doi":"10.15761/crr.1000180","DOIUrl":"https://doi.org/10.15761/crr.1000180","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a primary liver tumor which has been increasing in incidence over the past several years [1], and is the second leading cause of cancer death in the world [2]. Advanced HCC usually carries a poor prognosis. Over the past decade, systemic therapy for HCC has been evolving rapidly offering more therapeutic options and longer survival for those with incurable HCC. Here, we report a case of advanced HCC treated with single agent sorafenib and achieved complete radiographic response. In this article, we also provide a summary of current status of systemic therapy for HCC. *Correspondence to: Yixing Jiang, Marlene and Stewart Greenebaum Cancer Center, University of Maryland Medical Center, Baltimore, USA, E-mail: yjiang@umm.edu","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial DNA mutations and dysfunctions in oral carcinogenesis 口腔癌发生中的线粒体DNA突变和功能障碍
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000191
Pandey R, M. D., C. C., S. R., Parmar D, M. S., Chandra S
{"title":"Mitochondrial DNA mutations and dysfunctions in oral carcinogenesis","authors":"Pandey R, M. D., C. C., S. R., Parmar D, M. S., Chandra S","doi":"10.15761/crr.1000191","DOIUrl":"https://doi.org/10.15761/crr.1000191","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Embarrassment and behavioural changes among patients living with scars from cancer surgery: the appearance-related side effects and psychological distress 癌症手术疤痕患者的尴尬和行为变化:与外观相关的副作用和心理困扰
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000186
M. E., Sebastiani C, M. P
{"title":"Embarrassment and behavioural changes among patients living with scars from cancer surgery: the appearance-related side effects and psychological distress","authors":"M. E., Sebastiani C, M. P","doi":"10.15761/crr.1000186","DOIUrl":"https://doi.org/10.15761/crr.1000186","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of neoadjuvant chemoradiotherapy vs chemotherapy in cancer of oesophagus 新辅助放化疗与化疗在食管癌中的作用
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000195
G. Saini, R. Shukla, VPareek Vv, Goswami
{"title":"The role of neoadjuvant chemoradiotherapy vs chemotherapy in cancer of oesophagus","authors":"G. Saini, R. Shukla, VPareek Vv, Goswami","doi":"10.15761/crr.1000195","DOIUrl":"https://doi.org/10.15761/crr.1000195","url":null,"abstract":"Oesophageal malignancies are accounted as the eighth most common malignancy across the globe and the sixth leading cause of cancer-related deaths. The mortality to incidence ratio noted to be 0.88 The momentum towards neoadjuvant and adjuvant treatments is therefore understandable. Neoadjuvant radiochemotherapy (nRCT) has emerged as a standard of care in most parts of the world and we review the strength of evidence in favour of the same viz a viz neoadjuvant chemotherapy. *Correspondence to: Gagan Saini, Department of Radiation Oncology, Max Institute of Cancer Care, Vaishali and Patparganj, Delhi NCR, India, E-mail: drgagansaini@gmail.com","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A systematic and holistic approach leads to surgery followed with chemotherapy and palliative radiation in a locally advanced case of squamous cell carcinoma of gluteal region 一个系统和整体的方法导致手术后化疗和姑息性放疗局部晚期病例的臀区鳞状细胞癌
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000185
S. Chaudhary, Rashmi Gupta, Rajendra Kumar
{"title":"A systematic and holistic approach leads to surgery followed with chemotherapy and palliative radiation in a locally advanced case of squamous cell carcinoma of gluteal region","authors":"S. Chaudhary, Rashmi Gupta, Rajendra Kumar","doi":"10.15761/crr.1000185","DOIUrl":"https://doi.org/10.15761/crr.1000185","url":null,"abstract":"Introduction: Squamous Cell Carcinoma of gluteal region is not more oftenly seen, requires a conventional treatment to remove the magnitude of the disease with combined modalities of treatment. Presentation of the case: Here a case of 58-year-old male from Bihar state (India) presented with history of large ulcer proliferative lesion in the gluteal region from last 8 months, which was progressively increasing in size due to inadequate treatment. Discussion: Biopsy has been retrieved. Due to large volume of disease, treatment started with chemotherapy followed by palliative radiation then considered for surgery. We observed regression of magnitude of disease on subsequent follow up and improvement in the quality of life. Conclusion: Clinicians must know the possibility of tumor of the gluteal region especially in the remote areas and they must be treated conventionally with combined modalities to improve the overall survival. *Correspondence to: Shwetima Chaudhary, Department of Radiotherapy, King George’s Medical University, Lucknow UP, India, E-mail: swm222@gmail.com","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-aneurysmal subarachnoid hemorrhage in a case of moyamoya disease 烟雾病非动脉瘤性蛛网膜下腔出血1例
Cancer reports and reviews Pub Date : 2019-01-01 DOI: 10.15761/crr.1000190
Mai A. Mostafa
{"title":"Non-aneurysmal subarachnoid hemorrhage in a case of moyamoya disease","authors":"Mai A. Mostafa","doi":"10.15761/crr.1000190","DOIUrl":"https://doi.org/10.15761/crr.1000190","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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