Pediatric dimensions最新文献

{"title":"Safety and efficacy of the point-of-care BreathID®Hp and BreathID®Hp Lab System 13C-Urea breath test for the detection of H. pylori in children","authors":"S. Hussain, T. Shalem, D. Leung, P. Raj, David M. Troendle, A. Shannon, S. Acra, Annette Vannilam, H. Shirin, E. Broide","doi":"10.15761/pd.1000188","DOIUrl":"https://doi.org/10.15761/pd.1000188","url":null,"abstract":"Despite the fact that urea breath test (UBT) for the diagnosis of Helicobacter pylori (H. pylori) has high sensitivity and specificity, the accuracy of UBT in pediatrics is less than that of adults. The aim of the current study was to prospectively determine the safety and the diagnostic accuracy of the 13C-UBT for the detection of H. pylori using the point-of-care continuous BreathID®Hp and the breath sampling bag test, BreathID®Hp Lab System, in a pediatric population. Fifty-three children performed the 13C-UBT via both the BreathID®Hp and the BreathID® Hp Lab System and were asked to provide a stool sample for conventional H. pylori antigen testing. BreathID®Hp sensitivity was 93.3% [95% CI (68.05%; 99.83%)] and specificity was 100% [95% CI (86.77%; 100.00%)] compared to stool antigen. The overall agreement in detection of H. pylori using the BreathID®Hp breath test versus the stool antigen test was 97.56% [95% CI (87.14%; 99.94%)]. BreathID®Hp Lab System sensitivity was 93.3% [95% CI (68.05%; 99.83%)] and specificity was 100% [95% CI (87.23%; 100.00%)] compared to stool antigen. The overall agreement in detection of H. pylori using the BreathID®Hp Lab System breath test versus the stool antigen test was 97.62% [95% CI (87.43%; 99.94%)]. One minor possibly related adverse event was recorded. Conclusions: Both the BreathID®Hp and the BreathID®Hp Lab System breath sample collection devices were safe and accurate in diagnosis of H. pylori infection in children. *Correspondence to: Sunny Z Hussain, Willis-Knighton Pediatric GI Specialist/ Willis-Knighton Health System, Shreveport, LA, USA, Tel: 318-212-5858; Fax 318212-5877; E-mail: Shussain@wkhs.com Tzippora Shalem, The Kamila Gonczarowski Institute of Gastroenterology, Shamir (Assaf Harofeh) Medical Center and the Sackler School of Medicine, Tel Aviv University, Israel, E-mail: tzippi.shalem@gmail.com","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyscalculia: Early predictors and practical recommendations","authors":"A. Desoete","doi":"10.15761/pd.1000184","DOIUrl":"https://doi.org/10.15761/pd.1000184","url":null,"abstract":"Dyscalculia or the specific learning disorder with impairments in mathematics is a neurodevelopmental disorder causing interference with academic and occupational performance despite the provision of interventions that target those difficulties. A biological origin is the basis for behavioural signs. Studies on early predictors related to this disorder have been receiving growing attention. In this review some study outcomes on the relative importance of predictors of at-risk development in young children will be summarized.","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new therapeutic regimen on prevention of Bronchopulmonary Dysplasia (BPD) in preterm infant","authors":"Hsin-Chun Huang, I. Chen, T. Yeh","doi":"10.15761/pd.1000196","DOIUrl":"https://doi.org/10.15761/pd.1000196","url":null,"abstract":"Received: September 09, 2019; Accepted: September 26, 2019; Published: September 30, 2019 Although the advance of prematurity care and gentle ventilation have significantly improved the survival rate of very low birth weight infants, bronchopulmonary dysplasia (BPD) continuously to be the most common chronic lung disease [1,2] in infancy. Several antenatal, perinatal and postnatal factors may contribute to the development of BPD [3,4]. It is postulated that early lung injury, inflammation, immaturity and arrestment of lung development play an important role in the pathogenesis of BPD [5,6]. Various strategies, including vitamin A and caffeine has been shown beneficial for prevention or treatment for BPD [7,8]. However, none of these therapies can eliminate this complication. Postnatal corticosteroids therapies, in particular, dexamethasone has been used in infant with evolving BPD and in infant with difficult extubation. However, systemic dexamethasone therapy in premature infants is not generally recommended because of the long-term adverse neurodevelopmental outcomes [9,10]. Inhaled steroids refer to less complication than systemic steroids, but technically difficult and the effects are limited [11]. Our research showed that, by using surfactant as vehicle, intratracheal administration of surfactant/ budesonide compared with surfactant alone significantly decreased the incidence of BPD or death without apparent immediate and long-term side effect [12]. This new therapeutic regimen is based on a physical phenomenon “Marangoni effect”’ that surfactant can be used as an effective vehicle to facilitate the delivery of a topical steroid, budesonide, to the lung periphery. Budesonide will remain in the lung [13] for some time and inhibit the lung inflammation. Pharmacokinetic study showed that more than 80% of budesonide remained in the lungs for up to 8 hours after intra-tracheal instillation of surfactant/budesonide [13]. With a proper concentration ratio between budesonide and surfactant (survanta/ budesonide ≥50, or curosurf/budesonide ≥160), addition of budesonide to surfactant would not affect the biophysical and chemical stability of surfactant. Preliminary follow up study showed insignificant side effect.","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of cumulative risk scoring with ASQ-3 outcomes in a rural impoverished region of Guatemala","authors":"Lauren Mehner, G. Domek, Madiha F Abdel-maksoud, Andrea Jimenez-Zambrano, E. Asturias, M. Lamb, S. Berman","doi":"10.15761/pd.1000198","DOIUrl":"https://doi.org/10.15761/pd.1000198","url":null,"abstract":"Background: Child development is a global health priority. Cumulative risk scoring may be a useful tool to design more effective interventions to help high-risk young children reach their developmental potential in impoverished rural regions. Objective: To develop a risk score comprised of easily obtainable factors to design interventions and identify high-risk children who would most benefit from the interventions. Methods: Mother-child behavior interaction surveys and Ages and Stages Questionnaire, Third Edition (ASQ-3) developmental screens were completed in a convenience sample of 148 mothers with children aged 12-52 months in rural Guatemala. Associations between abnormal scores in the ASQ-3 developmental domains and demographic variables and mother-child interactions were examined. Scores were calculated by assigning 1 point for each of the included factors: 1) Maternal Demographic Risk score (DR): having no formal education, cannot read and write, having 3 or more children, and having 4 or more pregnancies; 2) Mother-Child Interaction score (MCI): sings songs, tells stories, plays with child with toys, converses with child while feeding, points to and names objects for child, and reads books to child; and 3) Combined Risk score (CR): combined two significant demographic elements and two significant negative mother-child interactions. Results: At baseline, 58% of children had abnormal scores in ≥1 ASQ-3 domain, and 35% in ≥2 domains. The probability of having ≥2 domains with abnormal scores increased significantly with an increasing DR score (OR, 1.46 [95% CI, 1.15-1.86] p<0.05) and an increasing CR score (OR, 2.08 [95% CI, 1.41-3.07], p<0.05). Conclusion: Rural Guatemalan children have high rates of ASQ-3 defined abnormal scores. A combined demographic and mother-child interaction cumulative risk index appears to be a useful tool to predict which children have abnormal scores across multiple domains. This CRI should be validated with more structured developmental testing that is not based on parent report. *Correspondence to: Stephen Berman, Director, Center for Global Health, Colorado School of Public Health, Mail Stop A090, 13199 E Montview Blvd, Suite 310, Aurora, CO 80045, USA, E-mail: stephen.berman@childrenscolorado.org Received: December 15, 2019; Accepted: December 27, 2019; Published: December 30, 2019 Introduction Child development is a global health priority. Approximately 4 in 10 children living in the developing world have developmental delays early in life. This risk of developmental delay is probably considerably higher for children born into rural impoverished communities [1]. Multiple studies document that children exposed to adverse environmental factors are at increased risk for atypical brain development, developmental delay, increased psychological stress, poor school readiness and poor academic achievement [2-13]. Recognizing the importance of these factors, the American Academy of Pediatrics Committee on Children wit","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of relationship among the functional classification systems in cerebral palsy and the different types according to the Surveillance of Cerebral Palsy in Europe","authors":"S. Montero-Mendoza, I. Calvo-Muñoz","doi":"10.15761/pd.1000181","DOIUrl":"https://doi.org/10.15761/pd.1000181","url":null,"abstract":"This study aimed to analyse the relationship between Gross Motor Functional Classification (GMFCS), Manual Ability Classification System (MACS), Communication Function Classification System (CFCS) and Eating and Drinking Ability Classification System (EDACS) in children with Cerebral Palsy (CP) and development of a global profile of the child’s role in activities of daily living. It is further intended to determine if the functional classifications present a predictive factor for one or several types of CP established by the Surveillance of Cerebral Palsy in Europe (SCPE). An observational study was developed in schools in the Region of Murcia during the months of March to June 2018. Participants included children and adolescents from 3 to 18 years of age evaluated individually under the same conditions by a physiotherapist with more than 10 years of experience and following the available manuals. A high correlation between the scales was found. Spastic unilateral CP presented a greater prognosis in the development of the functional abilities described by the functional scales. The study shows how the classification systems complement each other to provide a better description of the functional profile of children with CP, and the four scales involve a predictive factor for some types of CP. *Correspondence to: Sergio Montero-Mendoza, Ministry of Education, Youth and Sports of the Region of Murcia (Spain), Physiotherapy Department, Catholic University of San Antonio (UCAM), Murcia, Spain, E-mail: smontero@ucam.edu","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroblastoma in Vietnam: A retrospective analysis of MYCN status and clinical features to inform prognosis and improve outcome","authors":"C. Bui, U. Nguyen, Diem Truong, Niem VT Vo, D. Vu, Uyen DP Nguyen, Ban T Ho, Van D Nguyen, Dinh Q Truong, Khai D Truong","doi":"10.15761/pd.1000195","DOIUrl":"https://doi.org/10.15761/pd.1000195","url":null,"abstract":"Background: Neuroblastoma is the most common childhood cancer worldwide. While recent advances in diagnosis and treatment have resulted in dramatic improvements in patient survival, neuroblastoma recurrence and mortality rates in Vietnam are unknown. This study evaluated the survival rates of Vietnamese patients with NB and investigated the impact of clinical factors and MYCN status on prognosis. Methods: This study analysed survival rates, clinical factors and MYCN status of NB patients across three hospitals in Ho Chi Minh City. Kaplan-Meier and multivariable Cox proportional hazards models were used to describe Survival rates and determine hazard ratios. Patient samples were analysed retrospectively for MYCN amplification by fluorescence in-situ hybridization (FISH) and quantitative polymerase chain reaction (qPCR). Results: 5-year overall survival (OS) was 39.78% ± 4.31% and event-free survival (EFS) was 56.63% ± 5.47% in our cohort, and significantly lower than OS and EFS rates in Europe, USA, Japan, China and Thailand. MYCN- amplified or Stage III and IV NB patients showed significantly decreased survival time in comparison to those without MYCN amplification (log rank P =0.000) or diagnosed at stage I, II and IVs (log rank P =0.000). Furthermore, patients older than 18 months or at stage III and IV had a significantly higher probability of recurrence ( P =0.038 and P =0.000, respectively). Conclusions: This study demonstrates poor outcome for NB patients in Vietnam. Furthermore, prognosis is significantly worsened by their MYCN status; NB stage and age at diagnosis.","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study on application of continuous renal replacement therapy for severe hand foot and mouth disease","authors":"H. M. Tuan, D. C. Viet","doi":"10.15761/pd.1000199","DOIUrl":"https://doi.org/10.15761/pd.1000199","url":null,"abstract":"Background: The patients with severe hand foot and mouth disease (HFMD) grade 4 will be indicated continuous renal replacement therapy (CRRT), but the mortality rate is still high. The study was conducted to show the application of CRRT for severe HFMD patients in earlier stage improving the mortality. Method: A retrospective case series study was conducted about severe HFMD cases diagnosed clinically according to guidelines of the Ministry of Health and confirmed by Polymerase Chain Reaction (PCR) assay and having CRRT done. Variables would be recorded at admission, at starting CRRT and 16 hours later. The data were processed and analysed by software Stata version 14.0. Results: There were 38 eligible cases included in the study. The mean age was 25.3 months; the male: female ratio was 1.5. Most cases admitted within the first 3 day of illness (94.7%). The rate of HFMD grade 4 and grade 4 indicated CRRT was about 26.3% and 73.7% respectively. Vital signs, haematology parameters, biochemical parameters were improved significantly after 16 hours of CRRT. Average duration of CRRT was 2.4 ± 0.7 days. The survival rate of cases with HFMD grade 3 was 82.1% higher than that of cases with HFMD grade 4 at 40% significantly. Overall survival rate of HFMD patients indicated CRRT was about 71%. Conclusion: The CRRT could be considered as one of the measures that contributed to the improvement of mortality in patients with severe HFMD, and if the CRRT is indicated early it can produce much better results.","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do mental health disorders matter in pre- adolescents with cerebral palsy?","authors":"Bjorgaas Hm, Hysing M, Elgen I","doi":"10.15761/pd.1000183","DOIUrl":"https://doi.org/10.15761/pd.1000183","url":null,"abstract":"Objective: To assess the rate of mental health disorders according to diagnostic criteria, in pre-adolescents with Cerebral Palsy (CP). Design: Participants in this cohort study were 47 children with a diagnosis of CP, assessed at 11 years of age. They were born 2001-2003 and living in the Western Health Region of Norway. The Kiddie-SADS, a child psychiatric, diagnostic instrument, was used for assessment of mental health disorders. Results: Almost four in five children met diagnostic criteria for one or more mental health disorders. Of these children, two in three met criteria for behavioural disorder, one in three met criteria for anxiety disorder, and there was a considerable co-occurrence of disorders. No significant association was found between medical parameters and mental health disorders. Conclusions: Mental health disorders are highly prevalent in pre-adolescents with CP in the present study, and we suggest that mental health assessment should be included as part of the regular follow-up of children with CP. Correspondence to: Hanne Marit Bjorgaas, Department of Child Habilitation and Neurology, Stavanger University Hospital, Stavanger HF, Post box 8100, 4068 Stavanger, Norway, Tel: 47-98895956; E-mail: bjhm@sus.no","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric cardiomyopathies: A review of literature on clinical status and meta-analysis of diagnosis and clinical management methods","authors":"Aref Albakri","doi":"10.15761/PD.1000169","DOIUrl":"https://doi.org/10.15761/PD.1000169","url":null,"abstract":"Cardiomyopathies define a heterogeneous group of heart muscle disorders. They are an important cause of heart failure and a leading indication for heart transplantation in pediatric patients. Research on cardiomyopathy has however focused on the adult populations with fewer dedicated clinical trials investigating pediatric cardiomyopathy. Diagnosis and clinical management of pediatric cardiomyopathy are also challenging because of the lack of specific methods for diagnosis and treatment. Assessment of ventricular structure using absolute values in adults are not useful in children because of their constantly changing body surface area. Therapies developed for adults applied to pediatric patients also have had varied clinical outcomes. This paper therefore reviews existing research evidence on pediatric cardiomyopathy, with the objective of broadening its clinical understanding and management. *Correspondence to: Aref Albakri, Department of Internal Medicine, St-Marien Hospital Bonn Venusberg, Germany, E-mail: arefalbakri@yahoo.com","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Youth receiving orthodontic care are not immune to poor diet and overweight: a call for dental providers to participate in prevention efforts.","authors":"Katharine E Schmitz, Sandy Liles, Ashley N Hyman, C Richard Hofstetter, Saori Obayashi, Melanie Parker, Santiago A Surillo, David Noel, Melbourne F Hovell","doi":"10.15761/PD.1000113","DOIUrl":"10.15761/PD.1000113","url":null,"abstract":"<p><strong>Objectives: </strong>While obesity is common in the US, disparities exist. Orthodontic samples are assumed to be more affluent than the general population and not in need of assistance in developing or maintaining healthy lifestyles. This paper evaluates the need of the orthodontic population for intervention by examining diet and weight status of an orthodontic patient sample and describes a role for dental clinicians in obesity prevention efforts.</p><p><strong>Methods: </strong>552 patients age 8-14 years, 54% female, 51% non-Hispanic white, 26% Hispanic were recruited from orthodontic practices in Southern California to participate in a randomized controlled trial of clinician-delivered health promotion. Height, weight, demographics, and diet were recorded. Chi-Square analyses were used to test for differences at baseline by gender, age, ethnicity, and income.</p><p><strong>Results: </strong>13% of the sample was overweight and 9% was obese. Males had a higher rate of obesity than females. Lower income youth had a higher rate than higher income youth. Hispanic youth had a higher rate than non-Hispanic white youth. Failure to meet national dietary guidelines was common, differing significantly by demographic group.</p><p><strong>Conclusions: </strong>Within a sample not typically thought of as needing assistance, nearly 25% were overweight or obese and the majority failed to meet dietary recommendations. While most patients could benefit from intervention, male, Hispanic, and lower income groups were in greatest need of assistance. Dental providers, who see youth frequently and already discuss nutrition in the context of oral health, have the opportunity to contribute to obesity prevention.</p>","PeriodicalId":91786,"journal":{"name":"Pediatric dimensions","volume":"1 3 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67503404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}