Bioinorganic chemistry最新文献_第4页

Binding of Iodomercurates to Sulfhydryl-blocked β-Lactoglobulin-A,-B, and -C 巯基阻断β-乳球蛋白a、-B和-C与碘酸盐的结合

Bioinorganic chemistry Pub Date : 1978-06-01 DOI: 10.1016/0006-3061(78)80005-2

William L. Stone*, Arnold Wishnia

{"title":"Binding of Iodomercurates to Sulfhydryl-blocked β-Lactoglobulin-A,-B, and -C","authors":"William L. Stone*, Arnold Wishnia","doi":"10.1016/0006-3061(78)80005-2","DOIUrl":"10.1016/0006-3061(78)80005-2","url":null,"abstract":"<div>Sulfhydryl-blocked β-lactoglobulins (β-LG-S-SCH2CH2OH)-A, -B, and -C bind only one iodomercurate species, HgI3−, at only one site, with a dissociation constant of 4.0 x 10−5M at 25°, pH 5.0, 0.10 ionic strength. (Binding to native β-LG-SH-A, -B, and -C is more complex, involving the sulfhydryl and two other sites and several iodomercurates). Ther red shift of the HgI3− spectrum on binding would ordinarily suggest a hydrophobic site, but the HgI3− site is distinct from, and independent of, the alkane-binding site of native and blocked β-LG:HgI3− may bind a group that shifts its trigonal planar structure toward the tetrahedron of HgI42−. Binding of HgI3− to blocked β-LG interferes with the well-known association of β-LG-A to octamers at pH 4.6 and low temperature. The relation of the HgI3− site to the crystallographic iodomercurate-binding sites of β-LG-SH is examined.To facilitate these and future studies if iodomercurate binding, the 200-400 nm spectra of HgI2. HgI3−, and HgI42− in aqueous solutions and the thermodynamic formation constants at 25° for the equilibria HgI2 + I−=HgI3− (4.9 x 103 M−1 and HgI3− + I−=HgI42− (0.118 x 103 M−1) were obtained.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 6","pages":"Pages 517-529"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0006-3061(78)80005-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11784327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Circular dichroism investigation of the (L Lysine)n-Cu(II) (I:I) System with n = 4 and n = 25 n = 4和n = 25时(L赖氨酸)n- cu (II) (I:I)体系的圆二色性研究

Bioinorganic chemistry Pub Date : 1978-06-01 DOI: 10.1016/0006-3061(78)80003-9

Arlette Garnier, Lucia Tosi

引用次数: 11

N-Methyly Isatin β-thiosemicarbazone-Copper Complex Inhibits RNA-Dependent DNA Polymerase but not Ribunuclease rous Sarcoma Virus n -甲基Isatin β-硫代氨基脲-铜复合物抑制rna依赖性DNA聚合酶，但不抑制核糖核酸酶rous肉瘤病毒

Bioinorganic chemistry Pub Date : 1978-06-01 DOI: 10.1016/0006-3061(78)80007-6

Lu-Hai Wang, Warren Levinson

引用次数: 5

Reductive dechlorination and degradation of mirex and kepone with vitamin B12s 维生素B12s对乳糜和酮的还原脱氯和降解

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80285-9

G.N. Schrauzer, R.Nathan Katz

{"title":"Reductive dechlorination and degradation of mirex and kepone with vitamin B12s","authors":"G.N. Schrauzer, R.Nathan Katz","doi":"10.1016/S0006-3061(00)80285-9","DOIUrl":"10.1016/S0006-3061(00)80285-9","url":null,"abstract":"<div>Vitamin B12s effects the reductive dechlorination of mirex (dechlorane) in protic solvent systems, under both catalytic and stoichiometric conditions, mainly to yield compounds of composition C10Cl12-nHn, with n = 1–8, in which the basic dihomocubane cage structure is retained; the formation of cage-opened, reductively dehalogenated derivatives of 4,7-methanoindene occurs only to a very minor extent.The corresponding reactions of kepone (chlordecone), in contrast, occur with predominant formation of indene derivatives C9Cl8-nH (with n = 3–5), presumably via 4,7-methanoinden-8-one derivatives. Under certain mild conditions, vitamin B12s induces a fragmentation of kepone leading to the destruction of the dihomocubane moiety and the formation of an isolable organocobalamin having a C3Cl3H2 residue attached to the cobalt atom. In strongly alkaline media, the reaction of kepone with vitamin B12s may in addition yield high-molecular-weight condensation products of unknown constitution. Reactions of this type are of interest as prototypes of soil-decontamination processes.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"9 2","pages":"Pages 123-142"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80285-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11302578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Coordination chemistry of molybdenum and tungsten—VIII. Oxomolybdenum(V) complexes of 8-hydroxyquinoline and relevance of EPR spectra to binding sites in flavoenzymes 钼和钨的配位化学。8-羟基喹啉氧钼(V)配合物及EPR光谱与黄酶结合位点的相关性

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80166-0

Charles A. McAuliffe, Barry J. Sayle

引用次数: 2

Lanthanide octaethylprophyrins: Preparation, association, and interaction with axial ligands 八乙基镧系卟啉:制备、缔合及与轴向配体的相互作用

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80005-8

Tapeshwari S. Srivastava

{"title":"Lanthanide octaethylprophyrins: Preparation, association, and interaction with axial ligands","authors":"Tapeshwari S. Srivastava","doi":"10.1016/S0006-3061(00)80005-8","DOIUrl":"10.1016/S0006-3061(00)80005-8","url":null,"abstract":"<div>The synthesis of virtually all the lanthanide octaethylporphyrin complexes have been achieved by heating appropriate anhydrous lanthanide halide and octaethylporphyrin in imidazole melt at 210°C for two hours. The lighter lanthanide porphyrin complexes are very susceptible to hydrolysis, the middle lanthanide porphyrin complexes are moderately stable, and the heavier lanthanide porphyrin complexes are relatively more stable to hydrolysis. Two out of four lanthanide porphyrin complexes studied in detail, namely ytterbium and lutetium octaethylporphyrins, aggregate in benzene and the Soret bands in their absorption spectra are about 6 nm shifted to higher energies upon a hundred-fold increase in their concentrations. The aggregations of these lanthanide porphyrin complexes in non-coordinating solvents have been further verified by 1H NMR spectral studies. This spectral behavior can be interpreted qualitatively in terms of the model of the molecular exciton interactions with stacking of at least two prophyrins. A dimeric structure of these lanthanide porphyrin complexes has been proposed on the basis of geometrical considerations. On the contrary, the europium and gadolinium octaethylporphyrins associate very weakly in benzen in the concentration range studied. All four lanthanide porphyrin complexes interact with pyridine and piperidine, and the Soret bands in their absorption spectra are about 8 nm shifted to low energies as compared with their values in pure benzene.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 1","pages":"Pages 61-76"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11826394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Postinductive actinomycin D effects on the concentrations of cadmium thionein, and copper chelatin in rat liver 放线菌素D诱导后对大鼠肝脏中镉硫蛋白和铜螯合蛋白浓度的影响

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80236-7

Frances A. Day, Barbara J. Coles, Frank O. Brady

{"title":"Postinductive actinomycin D effects on the concentrations of cadmium thionein, and copper chelatin in rat liver","authors":"Frances A. Day, Barbara J. Coles, Frank O. Brady","doi":"10.1016/S0006-3061(00)80236-7","DOIUrl":"10.1016/S0006-3061(00)80236-7","url":null,"abstract":"<div>The time courses of induction in rat liver of copper chelatin by copper, cadmium thionein by cadmium, and zinc thionein by copper, cadmium, and zinc were monitored following single intraperitoneal injections of metal salts. Low dosages of inducing metal were used in order to avoid toxic effects, being 5 mg zinc, 0.5 mg copper, and 0.25 mg cadmium per kg body weight. Peak times of induction and half times of decay observed were: copper chelatin (9 h, 8.6 h), cadmium thionein (18 h, 6.80 days), and zinc thionein (zinc rats, 18 h, 10.1 h; copper rats, 9 h, 18.2 h; cadmium rats, 24 h, 4.53 days). Administration of actinomycin D (1 mg per kg body weight) at the peak times of induction of the various proteins had no effect on the concentrations of chelatin or cadmium thionein observed up to 24 hours later, but in the case of zinc thionein, induced by zinc, copper, or cadmium, elevated concentrations were observed up to 23 h after administration of the drug. Such behavior is reminiscent of superinduction previously seen with other proteins and enzymes. We postulate that the intracellular concentration of free zinc in liver is of fundamental importance in the induction of zinc thionein, and this can be disturbed by exogenous copper or cadmium resulting in the induction of synthesis of zinc thionein.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 2","pages":"Pages 93-105"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80236-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11841964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

A proposed mechanism relating the antitumor behavior of cis-platinum amine complexes to their inhibition of a model enzyme 顺铂胺配合物的抗肿瘤行为与其抑制模型酶的机制

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80168-4

Michael E. Friedman , Paul Melius , Charles A. McAuliffe

引用次数: 4

Measurement of binding of terbium to DNA 测量铽与DNA的结合

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80274-4

Gene Yonuschot, Gerry Robey, George W. Mushrush , Donald Helman , George Vande Woude

引用次数: 12

Ionization and divalent cation dissociation constants of nalidixic and oxolinic acids 钠二酸和草啉酸的电离和二价阳离子解离常数

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80286-0

Kim Timmers , Rolf Sternglanz

引用次数: 89