Journal of pigmentary disorders最新文献

{"title":"Skin lightening effect of tetrahydrocurcumin","authors":"pDheeraj Nagore, Prachi Pawarp","doi":"10.4172/2376-0427-C1-009","DOIUrl":"https://doi.org/10.4172/2376-0427-C1-009","url":null,"abstract":"","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44345769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Infantile Hemangiomas: Demographic and Clinical Characteristics at Hera General Hospital, Makkah, Saudi Arabia","authors":"M. Fatani, H. Otaibi, Mm Alshareef, M. Khalifa, Ss Mohammed","doi":"10.4172/2376-0427.1000270","DOIUrl":"https://doi.org/10.4172/2376-0427.1000270","url":null,"abstract":"Objective: The objective of this study is to provide the clinical features of infantile hemangiomas and their associated risk factors. Method: The study included patients who have been diagnosed with infantile hemangiomas, who were identified from a logbook in the Dermatology Department of Hera General Hospital, Makkah, Saudi Arabia. Demographic, prenatal, perinatal, and clinical data, along with complications and treatment modalities, were included on the data sheet. Result: The medical records of 61 patients were examined. Most of our patients were female (69.9%) and the maternal age of their mothers ranged from 22 to 43 years, with a mean maternal age of 28.8 years and a median age of 28 years. A positive family history of vascular anomalies in first-degree relatives was reported in 11.5% of patients. In 58 patients (95.1%), the age of onset for lesions was before two weeks (86.2%) and over two weeks (13.8%). Complications were noted in eight patients (13.3%). Most of our patients were treated by topical betablockers (39.7%), followed by pulsed-dye laser (10.3%) and systemic propranolol (10.3%). Observation of the hemangioma progression was seen in 57.6% of our patients. Conclusion: Hemangiomas more commonly occur in premature, female infants, who are more likely to be born as a product of single gestation. Further studies are needed to define other risk factors and to understand the relationship between potentially confounding factors.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70306619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Estradiol and Estriol Serum Levels to Melasma Severity in Pregnant Women","authors":"A. Rofiq, Shw Tantari, A. Widiatmoko, Dyah Ayu Savitri","doi":"10.4172/2376-0427.1000268","DOIUrl":"https://doi.org/10.4172/2376-0427.1000268","url":null,"abstract":"Combination of hormonal change, ultraviolet radiation and genetics are the most responsible factors in melasma. One of pigmentation change caused by pregnancy is melasma. The critical key to describe hyperpigmentation process is increased levels of estradiol and estriol. This study is aimed to determined correlation of serum levels of estradiol and estriol to melasma severity in pregnant women. This cross-sectional study was conducted with consecutive sampling in pregnant women with melasma. This study was conducted from June to July 2017 at Dr. Saiful Anwar Regional Hospital, Malang, East Java, Indonesia. Pregnant woman with melasma (15-49 years) was included and pregnant women with the history of melasma not caused by pregnancy, which used hormonal contraception or oral hormone therapy containing estrogen and took oral phototoxic drugs, were excluded. Anamnesis, physical examination, Wood Lamp, MASI (Melasma Area and Severity Index) Score and blood was drawn to measure serum levels of estradiol and estriol by using ELISA to 25 pregnant women with melasma. Data analysis was done with Pearson correlation test and multiple linear regressions. The result showed serum levels of estradiol was significantly positive correlated with MASI Score (r=0.462; p 0.05). Multiple linear regression revealed R2=0.244 (p<0.05), which means that serum levels of estradiol and estriol had 24.4% effects to MASI Score, while the rest 75.6% was influenced by others variables that were not included in this study. The conclusion is that there is a positive correlation between serum levels of estradiol with melasma severity in pregnant women, but serum levels of estriol are not correlated with melasma severity. Another factor besides serum levels estradiol and estriol might influence melasma severity.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70306542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Case Report of Angiolymphoid Hyperplasia with Eosinophilia","authors":"R. Belkharoeva, A. Hubail, N. P. Tepljuk, O. Olisova, V. Pinegin, V. Koroleva","doi":"10.4172/2376-0427.1000269","DOIUrl":"https://doi.org/10.4172/2376-0427.1000269","url":null,"abstract":"Aims and objective: The aim of this study was to assess the clinical and demographic features of a rare cutaneous condition, angiolymphoid hyperplasia with eosinophilia (ALHE), and compare them with those previously reported. ALHE is a benign vascular proliferation of unknown etiology and its treatment is unclear. Methods: A 29 year old woman visited the Hospital of Skin and Venereal diseases for pruritic lesion in the ear. She presented with a reddish papulonodular rash. Laboratory tests showed no abnormalities. She was diagnosed with ALHE based on clinical, histological, and immunological features. Treatment with injectable prolonged systemic glucocorticoid and topical prednisolone was initiated. The rash and pruritic sensation improved within one week in the hospital, and the reddish infiltration and nodules had dramatically decreased at the 6 month follow-up. Continuous topical application resulted in no recurrence at the 6 month follow-up. Results and conclusion: Management of ALHE is still poorly standardized and poorly understood due to uncertainties concerning its pathophysiology and development and the small number of available studies. Establishing the final clinical diagnosis is difficult owing to the absence of subjective sensations. ALHE can persist for years but serious complications like cancer transformation do not occur.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70306554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of breakfast intake on body mass index of females at one year after delivery in Egypt","authors":"pNermeen El Beltagyp","doi":"10.4172/2376-0427-C1-007","DOIUrl":"https://doi.org/10.4172/2376-0427-C1-007","url":null,"abstract":"Methods: One hundred (100) postpartum cases with BMI>25 at one year after delivery were matched with one hundred (100) normal weight control mothers for age between January and December, 2014. All study participants were interviewed and dietary behavior was assessed using the Snack and Beverage Food Frequency Questionnaire (SBFFQ). Seven days recall of breakfast and snack intake was done. Mothers’ intake of certain sweet and salty items during the prior seven days was assessed by asking how many days, how many times per day, and how much of the item the mother consumes. Finally, the intake was converted into the total calories consumed for each individual item and was summed to obtain the total daily caloric intake.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70307278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Supplement with Phenolic Compounds for Treatment of Melasma: Double Blind Placebo Controlled Trial Safety and Efficacy Evaluation","authors":"J. Downie, N. A. Abdullah","doi":"10.4172/2376-0427.1000271","DOIUrl":"https://doi.org/10.4172/2376-0427.1000271","url":null,"abstract":"Background: Melasma is a chronic skin problem that causes dark, discolored patches on the skin and therefore can have adverse effects on quality of life. Recently, a novel complex was shown to decrease melasma. Specifically, the goal of the study was to prove that the formula can reduce melasma, overall hyperpigmentation and nontransient erythema. Objectives: The primary efficacy outcome measure was a minimum of 50% improvement of the modified melasma area and severity index (mMASI) score from the baseline at the 90 day follow-up visit. Secondary outcomes were overall hyperpigmentation score collection and analyses, patient’s self-assessment regarding their non-transient erythema score when evaluated across the whole patient population at the baseline and at 90 days and the analyses of adverse events. Methods: Forty subjects with Fitzpatrick skin types III-V were enrolled in the double-blinded, randomized, placebo controlled trial: 20 were treated over 90 days with the oral supplement and 20 received a placebo over 90 days. Subjects were assessed at onset and re-assessed at 60 and 90 days by the Modified Melasma Area and Severity Index (mMASI), photographic documentation, hyperpigmentation tool, erythema index and client satisfaction. Subjects used the product or a placebo (in tablet form) orally once a day. Results: At 90 days, the modified melasma area and severity index score (mMASI) improved by more than 50% in 75% of cases (p<0.001), thus indicating treatment efficacy. There was a greater decrease in mMASI for the supplement group vs placebo (-3.28 for the active arm vs. -0.73 for the placebo arm, p<0.001). Furthermore, at the 90-day follow-up visit, the overall hyperpigmentation and non-transient erythema scores (p<0.001) improved significantly: by 55% and 38%, respectively. Results obtained from patients showed overall satisfaction with the therapy course and results. The product was well tolerated, with no reports of adverse events or side effects. Conclusion: Consistent, statistically significant reductions in melasma, as measured by mMASI scores, overall hyperpigmentation and non-transient erythema scores were achieved while meeting patient expectations at the 90 day follow-up evaluation point when compared to placebo. Results from this clinical trial suggest that this oral supplement is an effective treatment for melasma and may provide an alternative treatment for overall hyperpigmentation and non-transient erythema, while meeting expectations of patients. The product was well tolerated, with no reports of adverse events or side effects.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70306687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthomatoses in a child with hyperlipidemia","authors":"F. Salim","doi":"10.4172/2376-0427-C1-006","DOIUrl":"https://doi.org/10.4172/2376-0427-C1-006","url":null,"abstract":"","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"04 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45110491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Overfilled Syndrome","authors":"Tingsong Lim","doi":"10.4172/2376-0427-C1-004","DOIUrl":"https://doi.org/10.4172/2376-0427-C1-004","url":null,"abstract":"","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70307216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse of Multibacillary Leprosy Treated with Rifampicin and Ofloxacin: A Case Report","authors":"S. Basuki, M. Rahmi","doi":"10.4172/2376-0427.1000267","DOIUrl":"https://doi.org/10.4172/2376-0427.1000267","url":null,"abstract":"Introduction: Despite the dramatic success of the MDT by WHO regimens, a newer generation such as Ofloxacin displayed very promising bactericidal activity and in combination with Rifampicin by far is the highly bactericidal drug against M. leprae.Case summary: A 38 year old Javanese man presented with relapsed leprosy after a 14 month course of WHO MDT. He complained persisted lesions all over his body lasting 1 year and several well demarcated erythematous and hyperpigmented plaques were observed. There were sensory impairment on some lesions and thickening of nerve on extremities. Leprosy was diagnosed in 2014 and after he completed WHO-MDT for 1 year, his BI was found to be 3+ and MI of 10%. A skin biopsy revealed borderline lepromatous and upgrading reaction. He was started on re-treatment MBMDT for two months but lesions persist and skin smear increased, showed a BI 5+ with MI of 60%. He was commenced on daily 600 mg rifampicin, 400 mg ofloxacin and 500 mg aspirin three times daily for six months. The patient completed the treatment and his lesions regressed. Conclusion: This case highlights therapeutic efficacy of Rifampicin and Ofloxacin in producing clinical improvement and bacterial killing. Additionally it resurrects the use of aspirin to treat type 1 reaction.Introduction: Despite the dramatic success of the MDT by WHO regimens, a newer generation such as Ofloxacin displayed very promising bactericidal activity and in combination with Rifampicin by far is the highly bactericidal drug against M. leprae. Case summary: A 38 year old Javanese man presented with relapsed leprosy after a 14 month course of WHO MDT. He complained persisted lesions all over his body lasting 1 year and several well demarcated erythematous and hyperpigmented plaques were observed. There were sensory impairment on some lesions and thickening of nerve on extremities. Leprosy was diagnosed in 2014 and after he completed WHO-MDT for 1 year, his BI was found to be 3+ and MI of 10%. A skin biopsy revealed borderline lepromatous and upgrading reaction. He was started on re-treatment MBMDT for two months but lesions persist and skin smear increased, showed a BI 5+ with MI of 60%. He was commenced on daily 600 mg rifampicin, 400 mg ofloxacin and 500 mg aspirin three times daily for six months. The patient completed the treatment and his lesions regressed.Conclusion: This case highlights therapeutic efficacy of Rifampicin and Ofloxacin in producing clinical improvement and bacterial killing. Additionally it resurrects the use of aspirin to treat type 1 reaction.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42947404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral blood mononuclear cells may contain a small amount of mesenchymal stem cells which express type VII collagen","authors":"E. Nakano, D. Sawamura","doi":"10.4172/2376-0427-C1-001","DOIUrl":"https://doi.org/10.4172/2376-0427-C1-001","url":null,"abstract":"","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70307207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}