Journal of pigmentary disorders最新文献_第10页

Evaluation of Acitretin in the Treatment of Multiple Recalcitrant Common Warts: a Pilot Study 评价阿维a治疗多发性顽固性常见疣:一项初步研究

Journal of pigmentary disorders Pub Date : 2015-05-25 DOI: 10.4172/2376-0427.1000183

Ibrahim El Gharib, D. Aly, Hanaa Emam, Omnia Hani Khater

{"title":"Evaluation of Acitretin in the Treatment of Multiple Recalcitrant Common Warts: a Pilot Study","authors":"Ibrahim El Gharib, D. Aly, Hanaa Emam, Omnia Hani Khater","doi":"10.4172/2376-0427.1000183","DOIUrl":"https://doi.org/10.4172/2376-0427.1000183","url":null,"abstract":"Background: Oral acitretin, a synthetic compound of retinoids, seems to be a promising modality in treating warts. To the best of our knowledge, no studies regarding its use have been performed on Egyptian patients. Objectives: Evaluating the role of acitretin in the treatment of multiple recalcitrant common warts. Patients and Methods: Forty adult patients with multiple recalcitrant warts were treated with oral acitretin [20 with 1 mg/kg/day for 3 month (group A), 20 with 0.5 mg/kg/day for 3 months (group B), and 20 served as controls and were given placebo (group C)]. Results: Oral acitretin was found to be a statistically significant therapy compared to placebo in treating warts. Total clearance of lesions was noted in 70% of group A compared to 80% in group B and none in group C. A non significant difference between group A and B was noted. However, there was a significant relation between the clinical response and the duration of disease, as the longer the duration of the disease, the higher was the percentage of patients showing complete response to therapy. Conclusions: Acitretin can be used as an effective non-invasive alternative form of therapy for multiple recalcitrant common warts.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"2 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70305112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Halo Nevus - the Vascular Connection 晕痣-血管连接

Journal of pigmentary disorders Pub Date : 2015-05-25 DOI: 10.4172/2376-0427.1000188

B. Iyengar

{"title":"Halo Nevus - the Vascular Connection","authors":"B. Iyengar","doi":"10.4172/2376-0427.1000188","DOIUrl":"https://doi.org/10.4172/2376-0427.1000188","url":null,"abstract":"Abstract Background: Halo Nevi (HN), are defined as benign melanocytic nevi that are surrounded by a rim of depigmentation, resembling a halo. The halo phenomenon indicates the involution and subsequent regression of the melanocytic nevus. Material and Methods: A random series of 137 nevi, including 75 HN were examined. Serial paraffin and frozen sections were subjected to: routine histochemistry; (HE, Reticulin, Auro, PAS), enzyme histochemistry: dopa oxidase, counterstained with Nuclear Fast Red (NFR) to highlight the endothelium and dopamine oxidase; immunohistochemistry to assess presence of lymphocytic infiltrates; electron microscopy: after enbloc dopa stain. Results and Discussion: Junctional nevi show proliferation of highly dendritic melanocytes within the epidermis. Intradermal nevi are composed of dermal nevus cells separated from the epidermis by a clear Grenz zone. Compound nevi show a combination of junctional activity and sheets of dermal nevus cells. Some nevi show a depigmented halo and can regress completely to be replaced by a depigmented patch, the halo nevus. The nevus cells and marginal melanocytes are replaced by endothelial cells, lining vascular spaces, with involution of the nevus. Intriguingly there is a complete absence of inflammatory and immune related lympho-histiocytic cells in the cases studied. These observations, suggest that nevus cells are replaced by vascular endothelial cell types which results in dissolution of the lesion.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70305287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pigmentation Disorders: A Short Review 色素沉着障碍:简要回顾

Journal of pigmentary disorders Pub Date : 2015-05-25 DOI: 10.4172/2376-0427.1000189

R. I. Engin, Y. Çayır

引用次数: 3

Nodular Melanoma-Like Superficial Spreading Melanoma Arising fromIntradermal Unna Nevus-Can Incomplete Oncogenic-senescence beResponsible for Non-hierarchical Melanomagenesis? 表皮Unna痣引起的结节性黑色素瘤样浅表性黑色素瘤-不完全致癌-衰老是否会导致非分级黑色素瘤形成?

Journal of pigmentary disorders Pub Date : 2015-04-25 DOI: 10.4172/2376-0427.1000179

B. Tas, O. Pilanci, Y. Koy, U. Tetikkurt

引用次数: 3

Genetics of Vitiligo: An Insight 白癜风的遗传学:一种见解

Journal of pigmentary disorders Pub Date : 2015-04-25 DOI: 10.4172/2376-0427.1000178

S. Poojary

{"title":"Genetics of Vitiligo: An Insight","authors":"S. Poojary","doi":"10.4172/2376-0427.1000178","DOIUrl":"https://doi.org/10.4172/2376-0427.1000178","url":null,"abstract":"Vitiligo is the most common depigmenting disorder having a major impact on the quality of life of patients. Despite continued progress toward an elucidation of the biochemical, genetic and immunopathological pathways in vitiligo, a definitive cure remains elusive. During the past few decades, advances in the field of molecular genetics have enriched us in understanding the etiopathogenesis of vitiligo. Several candidate genes have been associated with susceptibility to vitiligo. They include genes important for melanin biosynthesis, response to oxidative stress and/or regulation of autoimmunity. A recent genome-wide scan performed on families with numerous members presenting with vitiligo has clearly revealed linkage of susceptibility loci especially autoimmune susceptibility loci. Genetic studies have helped us identify not only the natural course and clinical aspects of vitiligo but also the shed profound light on the inverse relationship between genetic susceptibility to GV and malignant melanoma. In the future, dissection of the complex genetic architecture of vitiligo will provide new approaches for treatment and prevention. In this article, we review the genes involved in vitiligo and also focus on the pathogenic mechanisms of the same.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0427.1000178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70305474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Vogt-Koyanagi-Harada Syndrome: Case Report Vogt-Koyanagi-Harada综合征1例报告

Journal of pigmentary disorders Pub Date : 2015-04-25 DOI: 10.4172/2376-0427.1000181

C. Jordão, C. Sodré, M. Ramos‐e‐Silva

引用次数: 0

Melasma: A Commentary 黄褐斑:评论

Journal of pigmentary disorders Pub Date : 2015-04-25 DOI: 10.4172/2376-0427.1000177

K. Khatri

{"title":"Melasma: A Commentary","authors":"K. Khatri","doi":"10.4172/2376-0427.1000177","DOIUrl":"https://doi.org/10.4172/2376-0427.1000177","url":null,"abstract":"Copyright: © 2015 Khatri KA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. One of my patients, a about 50 year old Hispanic female, with skin type IV, came to discuss treatment options of Melasma. After her skin evaluation, I recommended a TCA peel. She understood the risks and benefits and agreed to proceed with the peel. A 35% TCA peel was performed. She was also using bleaching creams and sunblock. When I saw her for a one month follow up, I was surprised to see that her Melasma was gone and she was very pleased. She came back three years later with Melasma again. She insisted that she wants the “same” treatment as three years ago. I performed another 35% TCA peel. This time when she came back for one month follow up, her melasma was worse than before the peel. I advised her to use TriLuma cream. Her one month follow up showed no improvement. I advised her to continue TriLuma for few more weeks. When she came back for her follow up this time, her Melasma has cleared 90%. I was very pleased but she told me that TriLuma didn’t work and she has been using a Chinese bleaching cream that she found at a Flea market. She showed be the box of the cream but everything was written in Chinese and I could not figure out the ingredients. Few months later while I was on a flight, I asked a fellow passenger sitting next to me who was reading a Chinese newspaper, to read the writings on the box. She told me that there are no ingredients listed but it only shows where this cream was produced. I did some more research to find out the ingredients but failed. I assume it had Mercury.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70305413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short Review of Pigmentation Disorders in Systemic Diseases 全身性疾病中色素沉着障碍的综述

Journal of pigmentary disorders Pub Date : 2015-04-20 DOI: 10.4172/2376-0427.1000174

M. Rojekar, S. Sawant

引用次数: 4

Physical Examination in Medicine 医学体格检查

Journal of pigmentary disorders Pub Date : 2015-04-15 DOI: 10.4172/2376-0427.1000E106

A. Lagi

引用次数: 2

Analysis of Neurofibromatosis Type 1 (NF1) Children and AdolescentsÃ¢ÂÂWeight, Length and Head Circumference - A Cross-Sectional Study 1型神经纤维瘤病(NF1)儿童与AdolescentsÃⅱÂÂWeight、长度和头围的横断面分析

Journal of pigmentary disorders Pub Date : 2015-04-15 DOI: 10.4172/2376-0427.1000182

M. Ribeiro, M. Coutinho

{"title":"Analysis of Neurofibromatosis Type 1 (NF1) Children and AdolescentsÃ¢ÂÂWeight, Length and Head Circumference - A Cross-Sectional Study","authors":"M. Ribeiro, M. Coutinho","doi":"10.4172/2376-0427.1000182","DOIUrl":"https://doi.org/10.4172/2376-0427.1000182","url":null,"abstract":"Objective: The main purpose of this study was to carry out a clinical evaluation about anthropometric measurements (weight, length and head circumference) of a group of Brazilian Neurofibromatosis type 1 (NF1) children and adolescent individuals. Patients and Methods: This was an observational and cross-sectional study. The patient sample included 146 children and adolescents of both sexes; aged zero to 19 years and each individual was measured just once. The dispersion of the anthropometric measurements was evaluated and their position in relation to the percentiles of standard WHO growth charts were used as a reference in pediatric practice. Results: Short stature was present in 17.1% of the subjects; the higher frequency was observed in males aged 5-19 years (20.4%). The heritability of NF1 in patients with short stature was not statistically significant (p value >0.05) when we compared the individuals that presented short stature or not and positive or negative familial history of NF1 using a 2×2 Table (χ2 analysis). In males, the percentage of low birth weight was 5.5% while in females it was 1.4%. The percentage of underweight individuals was 3.7%. Macrocephaly was observed in 25.0% of boys and girls aged 0-5 years. Conclusions: In a group of Brazilian NF1 patients, we found cases of short stature even in the first five years of life. Weight below percentile 50 was predominant in girls aged 0-5 years (72.2%) and head circumference above percentile 50 with macrocephaly was also present. Birth’s mean weight and length below average apparently are not general characteristics of NF1 individuals from Brazil.","PeriodicalId":91761,"journal":{"name":"Journal of pigmentary disorders","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70305053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3