{"title":"Effect of β-cryptoxanthin–rich Satsuma mandarin juice supplementation on pulse wave velocity: A randomized controlled trial","authors":"M. Nakamura , M. Sugiura , Y. Shibata , T. Ojima","doi":"10.1016/j.jnim.2017.03.001","DOIUrl":"10.1016/j.jnim.2017.03.001","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Cohort studies in Japan indicate that citrus fruit and β-cryptoxanthin–rich Satsuma mandarin are candidate foods for lowering cardiovascular risk; however, there have been few intervention studies of β-cryptoxanthin and Satsuma mandarin supplementation.</p></div><div><h3>Methods and Results</h3><p>A randomized, placebo-controlled, double-blind parallel trial was performed. Apparently healthy men and women were randomly assigned to two groups: one receiving concentrated β-cryptoxanthin–rich Satsuma mandarin juice (β-cryptoxanthin 4 mg per 125 mL/day: active group) and one receiving β-cryptoxanthin–deprived Satsuma mandarin juice (β-cryptoxanthin 0 mg per 125 mL/day: control group) for 12 weeks. The primary outcome was brachial-ankle pulse wave velocity (baPWV), which assesses arterial stiffness. An oxidative stress biomarker and clinical outcomes were also evaluated. Effect of the intervention on the outcome variables was analyzed using generalized linear mixed models. After the trial, a prespecified 8-month follow-up examination was conducted. One hundred eighteen subjects were randomly assigned, and 117 completed the intervention. Serum β-cryptoxanthin concentration was increased among the active group after β-cryptoxanthin–rich Satsuma mandarin juice supplementation. Both supplementations lowered baPWV and oxidative stress biomarker levels; however, there was no additional effect in the active group compared with the control group. At the 8-month examination, the increase in baPWV among the active group was smaller than that among the control group.</p></div><div><h3>Conclusion</h3><p>Satsuma mandarin juice supplementation is potentially beneficial for reducing cardiovascular risk; however, additional β-cryptoxanthin supplementation did not enhance this effect. Further study is needed to evaluate the long-term effect of β-cryptoxanthin supplementation.</p></div><div><h3>Registration</h3><p>UMIN-CTR, UMIN000013579.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 8-13"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116019886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The nexus between animal and human nutrition","authors":"F.R. Dunshea","doi":"10.1016/j.jnim.2017.04.011","DOIUrl":"10.1016/j.jnim.2017.04.011","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 64"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116357553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of sodium on inflammation related to multiple sclerosis","authors":"E. Mowbray, Y.C. Probst, K. Walton","doi":"10.1016/j.jnim.2017.04.092","DOIUrl":"10.1016/j.jnim.2017.04.092","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 85"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134072153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Don't trust your taste buds - an evidence-based social media campaign to raise awareness of high salt consumption","authors":"R. Beauchamp , C. Yam , S. Shiell","doi":"10.1016/j.jnim.2017.04.032","DOIUrl":"10.1016/j.jnim.2017.04.032","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 69-70"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133354281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Chu , M. Foster , D. Hancock , P. Petocz , S. Samman
{"title":"Gene expression and coordination of cellular zinc transporters and metallothioneins are altered in Type 2 diabetes mellitus","authors":"A. Chu , M. Foster , D. Hancock , P. Petocz , S. Samman","doi":"10.1016/j.jnim.2017.04.085","DOIUrl":"10.1016/j.jnim.2017.04.085","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 83"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45536540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of nutrition in tolerance development","authors":"M. Tang","doi":"10.1016/j.jnim.2017.04.015","DOIUrl":"10.1016/j.jnim.2017.04.015","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 65"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115833536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emma Louise Beckett , Charlotte Martin , Lyndell Boyd , Teagan Porter , Katrina King , Suzanne Niblett , Zoe Yates , Martin Veysey , Mark Lucock
{"title":"Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts","authors":"Emma Louise Beckett , Charlotte Martin , Lyndell Boyd , Teagan Porter , Katrina King , Suzanne Niblett , Zoe Yates , Martin Veysey , Mark Lucock","doi":"10.1016/j.jnim.2017.04.001","DOIUrl":"10.1016/j.jnim.2017.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>In 2009, Australia implemented mandatory folic acid fortification in wheat flour for bread-making. The primary aim was to improve folate status in reproductive-aged women to reduce neural tube defect incidence. However, folic acid consumption has consequently increased in all demographics. Blood folate is inversely associated with homocysteine levels, a risk factor for multiple diseases. Therefore, we assessed the impact of mandatory folic acid fortification on homocysteine levels in elderly Australians.</p></div><div><h3>Methods</h3><p>Homocysteine and blood folate levels were compared between two elderly cross-sectional cohorts (pre-versus post-mandatory folic acid fortification). Importantly, dietary habits were assessed to evaluate the confounding influence of altered dietary patterns not related to fortification.</p></div><div><h3>Results</h3><p>Post-fortification, plasma homocysteine levels (10.6 vs. 14.5 μmol/L) and hyperhomocysteinemia incidence (27.2% vs 56.3%) were significantly reduced, relative to the pre-fortification subjects. This was associated with increased blood folate (red cell: 1243 vs 1066 nmol/L, serum 28.0 vs 23.9 nmol/L), and increased intake of synthetic folic acid (366.8 vs 231.0 DFE/day) but not natural folate (332.7 vs 323.6 DFE/day). Limited other differences were detected in dietary intake patterns between groups. The positive relationship between homocysteine levels and age was abrogated post-fortification <em>(p</em> = <em>0.3 vs p</em> = <em>0.0003)</em>.</p></div><div><h3>Conclusions</h3><p>A potential off-target benefit of mandatory folic acid fortification in Australia was demonstrated. With many countries still considering the merits and consequences of mandatory fortification policies, it is important to unravel the off-target effects including dietary context.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 14-20"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116836631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C.R. Davis , K.J. Murphy , J.M. Hodgson , J. Bryan , R.J. Woodman , C. Wilson
{"title":"A Mediterranean diet improves endothelial function in men and women over 65 years: Results from the MedLey study","authors":"C.R. Davis , K.J. Murphy , J.M. Hodgson , J. Bryan , R.J. Woodman , C. Wilson","doi":"10.1016/j.jnim.2017.04.069","DOIUrl":"10.1016/j.jnim.2017.04.069","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 79"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117157041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}