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Journal of nutrition & intermediary metabolism最新文献

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Disruption of redox homeostasis in liver function and activation of apoptosis on consumption of aspartame in folate deficient rat model 叶酸缺乏大鼠模型中阿斯巴甜摄入对肝功能氧化还原稳态的破坏和细胞凋亡的激活
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.06.002
Ashok Iyaswamy , Dapkupar Wankhar , Sundareswaran Loganathan , Sambantham Shanmugam , Ravindran Rajan , Sheeladevi Rathinasamy
{"title":"Disruption of redox homeostasis in liver function and activation of apoptosis on consumption of aspartame in folate deficient rat model","authors":"Ashok Iyaswamy ,&nbsp;Dapkupar Wankhar ,&nbsp;Sundareswaran Loganathan ,&nbsp;Sambantham Shanmugam ,&nbsp;Ravindran Rajan ,&nbsp;Sheeladevi Rathinasamy","doi":"10.1016/j.jnim.2017.06.002","DOIUrl":"10.1016/j.jnim.2017.06.002","url":null,"abstract":"<div><p>This study assesses the effect of long-term intake of aspartame on liver function and apoptosis signaling pathway in the Wistar albino rats. Several reports have suggested that methanol is one of the major metabolites of Aspartame. Non-primate animals are usually resistant to methanol-induced metabolic acidosis due to high levels of hepatic folate content; hence a folate deficiency model was induced by treating animals with methotrexate (MTX) prior to aspartame exposure. The aspartame treated MTX animals exhibited a marked significant increase in hepatic alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and lactic acid dehydrogenase (LDH) activity compared to controls. Aspartame treated MTX animals additionally exhibited down-regulation of genes namely B-cell lymphoma 2 (Bcl2) expression and up-regulation of Bcl-2-associated X protein (Bax), Fas-associated protein with death domain (FADD) and Caspase 3, 9 genes and apoptotic protein expression, indicating the augmentation of hepatic apoptosis. Nuclear condensation, micro vacuole formation in the cytoplasm and necrosis were observed in the liver of the aspartame treated animals on histopathology evaluation. Additionally, Immunohistochemical analysis revealed a significant increase in positive cells expressing Fas, FADD, Bax and Caspase 9 protein, indicating an increase in apoptotic protein expression in the liver. Thus, Aspartame may act as a chemical stressor which alters the functional status of liver, leading to hepatotoxicity.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 41-50"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121784990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The impact of storage conditions and growing season on the anthocyanin content of sweet cherry varieties 贮藏条件和生长季节对甜樱桃花色苷含量的影响
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.082
M.L. Blackhall, R. Berry, J.T. Walls
{"title":"The impact of storage conditions and growing season on the anthocyanin content of sweet cherry varieties","authors":"M.L. Blackhall,&nbsp;R. Berry,&nbsp;J.T. Walls","doi":"10.1016/j.jnim.2017.04.082","DOIUrl":"10.1016/j.jnim.2017.04.082","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 82-83"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130150199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of red and processed meat and refined grains on insulin sensitivity in insulin resistant subjects 红肉和加工肉类及精制谷物对胰岛素抵抗受试者胰岛素敏感性的影响
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.037
Y.A. Kim, J.B. Keogh, P.M. Clifton
{"title":"Effect of red and processed meat and refined grains on insulin sensitivity in insulin resistant subjects","authors":"Y.A. Kim,&nbsp;J.B. Keogh,&nbsp;P.M. Clifton","doi":"10.1016/j.jnim.2017.04.037","DOIUrl":"10.1016/j.jnim.2017.04.037","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 71"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125811475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salt preference of commercially available products among school children aged 8–10 years 8-10岁学龄儿童对市售产品的盐偏好
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.019
M.L. West, D.G. Liem, K.J. Campbell, A.O. Booth, C. Nowson, C. Grimes
{"title":"Salt preference of commercially available products among school children aged 8–10 years","authors":"M.L. West,&nbsp;D.G. Liem,&nbsp;K.J. Campbell,&nbsp;A.O. Booth,&nbsp;C. Nowson,&nbsp;C. Grimes","doi":"10.1016/j.jnim.2017.04.019","DOIUrl":"10.1016/j.jnim.2017.04.019","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 66"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132881367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of dietary prebiotic supplementation on metabolic biomarkers in adults with prediabetes – A crossover RCT 膳食益生元补充对成人糖尿病前期代谢生物标志物的影响-一项交叉随机对照试验
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.036
N.J. Kellow , K.C. Sourris , C.M. Reid , M.T. Coughlan
{"title":"Effect of dietary prebiotic supplementation on metabolic biomarkers in adults with prediabetes – A crossover RCT","authors":"N.J. Kellow ,&nbsp;K.C. Sourris ,&nbsp;C.M. Reid ,&nbsp;M.T. Coughlan","doi":"10.1016/j.jnim.2017.04.036","DOIUrl":"10.1016/j.jnim.2017.04.036","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 70-71"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126425512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantity, type and variety of vegetable intake and atherosclerotic vascular disease mortality: A prospective cohort study 蔬菜摄入量、类型和种类与动脉粥样硬化性血管疾病死亡率:一项前瞻性队列研究
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.068
L.C. Blekkenhorst , R.L. Prince , J.R. Lewis , A. Devine , R.J. Woodman , C.P. Bondonno , J.M. Hodgson
{"title":"Quantity, type and variety of vegetable intake and atherosclerotic vascular disease mortality: A prospective cohort study","authors":"L.C. Blekkenhorst ,&nbsp;R.L. Prince ,&nbsp;J.R. Lewis ,&nbsp;A. Devine ,&nbsp;R.J. Woodman ,&nbsp;C.P. Bondonno ,&nbsp;J.M. Hodgson","doi":"10.1016/j.jnim.2017.04.068","DOIUrl":"10.1016/j.jnim.2017.04.068","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 79"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122647154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low dose dietary nitrate improves endothelial dysfunction & plaque stability in the ApoE-/- mouse fed a high fat diet 低剂量膳食硝酸盐改善高脂饮食ApoE-/-小鼠内皮功能障碍和斑块稳定性
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.075
J.R. Bakker , N.P. Bondonno , T.A. Gaspari , B.K. Kemp-Harper , A.J. McCashney , J.M. Hodgson , K.D. Croft , N.C. Ward
{"title":"Low dose dietary nitrate improves endothelial dysfunction & plaque stability in the ApoE-/- mouse fed a high fat diet","authors":"J.R. Bakker ,&nbsp;N.P. Bondonno ,&nbsp;T.A. Gaspari ,&nbsp;B.K. Kemp-Harper ,&nbsp;A.J. McCashney ,&nbsp;J.M. Hodgson ,&nbsp;K.D. Croft ,&nbsp;N.C. Ward","doi":"10.1016/j.jnim.2017.04.075","DOIUrl":"10.1016/j.jnim.2017.04.075","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 80-81"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123035580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skipping breakfast in youth: Prevalence & correlates from the 2011-12 national nutrition & physical activity survey 青少年不吃早餐:2011-12年全国营养与身体活动调查的流行程度及其相关因素
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.020
K.J. Smith , M.C. Breslin , S.A. McNaughton , S.L. Gall , L. Blizzard , A.J. Venn
{"title":"Skipping breakfast in youth: Prevalence & correlates from the 2011-12 national nutrition & physical activity survey","authors":"K.J. Smith ,&nbsp;M.C. Breslin ,&nbsp;S.A. McNaughton ,&nbsp;S.L. Gall ,&nbsp;L. Blizzard ,&nbsp;A.J. Venn","doi":"10.1016/j.jnim.2017.04.020","DOIUrl":"10.1016/j.jnim.2017.04.020","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 66-67"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134182776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary pectin's effect on digestive pancreatic enzymes and residual macronutrients in grower pigs 日粮果胶对生长猪消化胰酶和剩余宏量营养素的影响
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.072
A. Pluschke, B. Williams, D. Zhang, M.J. Gidley
{"title":"Dietary pectin's effect on digestive pancreatic enzymes and residual macronutrients in grower pigs","authors":"A. Pluschke,&nbsp;B. Williams,&nbsp;D. Zhang,&nbsp;M.J. Gidley","doi":"10.1016/j.jnim.2017.04.072","DOIUrl":"10.1016/j.jnim.2017.04.072","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Page 80"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115825567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipidomic profiles after a 30-day krill oil supplementation compared with fish oil in healthy women 健康女性补充磷虾油与鱼油30天后的脂质组学特征
Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.086
H.H. Sung , A.J. Sinclair , P.J. Meikle , N. Mellett , P.A. Lewandowski , X.Q. Su
{"title":"Lipidomic profiles after a 30-day krill oil supplementation compared with fish oil in healthy women","authors":"H.H. Sung ,&nbsp;A.J. Sinclair ,&nbsp;P.J. Meikle ,&nbsp;N. Mellett ,&nbsp;P.A. Lewandowski ,&nbsp;X.Q. Su","doi":"10.1016/j.jnim.2017.04.086","DOIUrl":"10.1016/j.jnim.2017.04.086","url":null,"abstract":"","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"8 ","pages":"Pages 83-84"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.04.086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121418802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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