Journal of nutrition & intermediary metabolism最新文献_第7页

The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial 藏红花(Crocus sativus L.)水酒精提取物对2型糖尿病患者肝肾功能的影响:一项双盲随机对照试验

Journal of nutrition & intermediary metabolism Pub Date : 2017-09-01 DOI: 10.1016/j.jnim.2017.07.002

Alireza Milajerdi , Shima Jazayeri , Vida Bitarafan , Najmeh Hashemzadeh , Elham Shirzadi , Zhaleh Derakhshan , Mahmood Mahmoodi , Alireza Rayati , Abolghassem Djazayeri , Shahin Akhondzadeh

{"title":"The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial","authors":"Alireza Milajerdi , Shima Jazayeri , Vida Bitarafan , Najmeh Hashemzadeh , Elham Shirzadi , Zhaleh Derakhshan , Mahmood Mahmoodi , Alireza Rayati , Abolghassem Djazayeri , Shahin Akhondzadeh","doi":"10.1016/j.jnim.2017.07.002","DOIUrl":"10.1016/j.jnim.2017.07.002","url":null,"abstract":"<div><h3>Background and aim</h3><p>Uncontrolled diabetes causes liver and renal dysfunctions. Since, saffron may improve diabetes control and indicate renal and liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients.</p></div><div><h3>Materials and methods</h3><p>In this double-blind clinical trial, 54 type 2 diabetic patients were randomly recruited to consume either 15 mg saffron extract (n = 27) or placebo capsules (n = 27) twice a day for 8 weeks. Alkaline phosphatase, aspartate and alanine amino transferase, uric acid, blood urea nitrogen, and creatinine of the patients as well as their physical activity, dietary intakes, anthropometric measures and blood pressure were measured. Data were analyzed by SPSS.18 software.</p></div><div><h3>Results</h3><p>Uric acid and blood urea nitrogen were significantly decreased in the saffron group (P < 0.05), however, there were no significant differences between the two groups at the end of the study (p = 0.29 and 0.14, respectively). Moreover, changes in other profiles, including liver enzymes, were not statistically significant in the two groups. Also, no significant changes in blood pressure, dietary intakes, and physical activity were seen among the two groups.</p></div><div><h3>Conclusion</h3><p>Saffron hydro-alcoholic extract did not considerably improve renal and liver functions in T2DM patients in an 8-week randomized clinical trials. The results deserved further investigations with more accurate methods to confirm.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"9 ","pages":"Pages 6-11"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125075878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Assessment of lipid lowering effect of Nepeta hindostana herb extract in experimentally induced dyslipidemia 荆芥提取物对实验性血脂异常的降脂作用评价

Journal of nutrition & intermediary metabolism Pub Date : 2017-09-01 DOI: 10.1016/j.jnim.2017.08.002

Sushma Devi, Randhir Singh

{"title":"Assessment of lipid lowering effect of Nepeta hindostana herb extract in experimentally induced dyslipidemia","authors":"Sushma Devi, Randhir Singh","doi":"10.1016/j.jnim.2017.08.002","DOIUrl":"10.1016/j.jnim.2017.08.002","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><p><em>Nepeta hindostana</em> traditional Indo-Pak medicine with cardioprotective properties. The aim of the study is to assess the lipid lowering effect of <em>Nepeta hindostana</em> extracts in experimentally induced dyslipidemia in rats.</p></div><div><h3>Material and methods</h3><p>The dyslipidemia was induced by administration of intraperitoneal (<em>i.p</em>.) injection of triton WR 1339 (400 mg/kg) (acute study) and fed high cholesterol diet for 21 days (sub-acute study).</p></div><div><h3>Results</h3><p>Methanolic extract (400 mg/kg) have lowest atherogenic index and maximum % protection in triton and cholesterol diet induced dyslipidemia. Lipid levels were significantly attenuated by different doses of extracts. The histology of blood vessels also proved the effectiveness of both extracts (at dose 400 mg/kg) in case of dyslipidemia induced by cholesterol diet. Methanolic extract was found more effective than aqueous extract.</p></div><div><h3>Conclusion</h3><p>The results indicate that antidyslipidemic effect of the plant extracts was meditated through the inhibition of biosynthesis, absorption and secretion of lipids. This may be possibly due partly to the presence of antioxidant constituents in this plant. Therefore, the present study rationalizes the medicinal use of <em>Nepeta hindostana</em> in dyslipidemia.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"9 ","pages":"Pages 17-23"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132677464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Fibre utilisation is not defective but colonic epithelial function may be abnormal in quiescent ulcerative colitis 纤维利用没有缺陷，但结肠上皮功能可能在静止性溃疡性结肠炎中异常

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.090

C.K. Yao, R.E. Burgell, K.M. Taylor, J.S. Barrett, A. Asthana, M.G. Ward, P.R. Gibson, J.G. Muir

引用次数: 0

Interaction between diet and evolution of digestive mechanisms 饮食与消化机制进化的相互作用

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.013

J.B. Furness

引用次数: 0

The accuracy of lifestyle management information on websites for the management of PCOS 网站生活方式管理信息对多囊卵巢综合征管理的准确性

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.028

T.D. Htet , S. Cassar , M.K. Burggraf , J. Boyle , M. Gibson-Helm , N.K. Stepto , L.J. Moran

引用次数: 0

Managing the ecological limits to food, water and health security: The Asia Pacific 管理食物、水和健康安全的生态极限:亚太地区

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.004

M.L. Wahlqvist

引用次数: 0

Who, what, why & how? a study of nutritional supplement use by Australian adults 谁，什么，为什么和如何?一项关于澳大利亚成年人使用营养补充剂的研究

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.026

G. Peruchot , S.L. Williams , P. Reaburn

引用次数: 1

Soluble fibre intervention improves asthma control, airway inflammation and alters gut microbiome in stable asthma 可溶性纤维干预改善哮喘控制、气道炎症和改变稳定哮喘的肠道微生物群

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.095

B.S. Berthon , R. Zapirain , G.B. Rogers , L.E.X. Leong , K.J. Baines , P.G. Gibson , D. Arnold , L.G. Wood

引用次数: 0

Poor metabolic health, in the absence of obesity, increases risk for gestational diabetes and preeclampsia in pregnant women 在没有肥胖的情况下，不良的代谢健康会增加孕妇患妊娠糖尿病和先兆子痫的风险

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.063

J.A. Grieger , S.Y. Leemaqz , G.A. Dekker , L. Poston , L. McCowan , L. Kenny , J. Myers , N. Simpson , T. Bianco-Miotto , C.T. Roberts

引用次数: 1

Inadequate vitamin d status is associated with altered cellular bioenergetics of peripheral blood mononuclear cells 缺乏维生素d状态与外周血单核细胞的细胞生物能量学改变有关

Journal of nutrition & intermediary metabolism Pub Date : 2017-06-01 DOI: 10.1016/j.jnim.2017.04.084

E.K. Calton , K. Keane , J. Rowlands , P. Newsholme , M.J. Soares

引用次数: 0