{"title":"藏红花(Crocus sativus L.)水酒精提取物对2型糖尿病患者肝肾功能的影响:一项双盲随机对照试验","authors":"Alireza Milajerdi , Shima Jazayeri , Vida Bitarafan , Najmeh Hashemzadeh , Elham Shirzadi , Zhaleh Derakhshan , Mahmood Mahmoodi , Alireza Rayati , Abolghassem Djazayeri , Shahin Akhondzadeh","doi":"10.1016/j.jnim.2017.07.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aim</h3><p>Uncontrolled diabetes causes liver and renal dysfunctions. Since, saffron may improve diabetes control and indicate renal and liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients.</p></div><div><h3>Materials and methods</h3><p>In this double-blind clinical trial, 54 type 2 diabetic patients were randomly recruited to consume either 15 mg saffron extract (n = 27) or placebo capsules (n = 27) twice a day for 8 weeks. Alkaline phosphatase, aspartate and alanine amino transferase, uric acid, blood urea nitrogen, and creatinine of the patients as well as their physical activity, dietary intakes, anthropometric measures and blood pressure were measured. Data were analyzed by SPSS.18 software.</p></div><div><h3>Results</h3><p>Uric acid and blood urea nitrogen were significantly decreased in the saffron group (P < 0.05), however, there were no significant differences between the two groups at the end of the study (p = 0.29 and 0.14, respectively). Moreover, changes in other profiles, including liver enzymes, were not statistically significant in the two groups. Also, no significant changes in blood pressure, dietary intakes, and physical activity were seen among the two groups.</p></div><div><h3>Conclusion</h3><p>Saffron hydro-alcoholic extract did not considerably improve renal and liver functions in T2DM patients in an 8-week randomized clinical trials. The results deserved further investigations with more accurate methods to confirm.</p></div>","PeriodicalId":91757,"journal":{"name":"Journal of nutrition & intermediary metabolism","volume":"9 ","pages":"Pages 6-11"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jnim.2017.07.002","citationCount":"34","resultStr":"{\"title\":\"The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial\",\"authors\":\"Alireza Milajerdi , Shima Jazayeri , Vida Bitarafan , Najmeh Hashemzadeh , Elham Shirzadi , Zhaleh Derakhshan , Mahmood Mahmoodi , Alireza Rayati , Abolghassem Djazayeri , Shahin Akhondzadeh\",\"doi\":\"10.1016/j.jnim.2017.07.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and aim</h3><p>Uncontrolled diabetes causes liver and renal dysfunctions. Since, saffron may improve diabetes control and indicate renal and liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients.</p></div><div><h3>Materials and methods</h3><p>In this double-blind clinical trial, 54 type 2 diabetic patients were randomly recruited to consume either 15 mg saffron extract (n = 27) or placebo capsules (n = 27) twice a day for 8 weeks. Alkaline phosphatase, aspartate and alanine amino transferase, uric acid, blood urea nitrogen, and creatinine of the patients as well as their physical activity, dietary intakes, anthropometric measures and blood pressure were measured. Data were analyzed by SPSS.18 software.</p></div><div><h3>Results</h3><p>Uric acid and blood urea nitrogen were significantly decreased in the saffron group (P < 0.05), however, there were no significant differences between the two groups at the end of the study (p = 0.29 and 0.14, respectively). Moreover, changes in other profiles, including liver enzymes, were not statistically significant in the two groups. Also, no significant changes in blood pressure, dietary intakes, and physical activity were seen among the two groups.</p></div><div><h3>Conclusion</h3><p>Saffron hydro-alcoholic extract did not considerably improve renal and liver functions in T2DM patients in an 8-week randomized clinical trials. The results deserved further investigations with more accurate methods to confirm.</p></div>\",\"PeriodicalId\":91757,\"journal\":{\"name\":\"Journal of nutrition & intermediary metabolism\",\"volume\":\"9 \",\"pages\":\"Pages 6-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jnim.2017.07.002\",\"citationCount\":\"34\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nutrition & intermediary metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S235238591730244X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nutrition & intermediary metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S235238591730244X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial
Background and aim
Uncontrolled diabetes causes liver and renal dysfunctions. Since, saffron may improve diabetes control and indicate renal and liver protection, this study purposed to illustrate for the first time the effects of saffron extract on some liver and renal functional parameters among diabetic patients.
Materials and methods
In this double-blind clinical trial, 54 type 2 diabetic patients were randomly recruited to consume either 15 mg saffron extract (n = 27) or placebo capsules (n = 27) twice a day for 8 weeks. Alkaline phosphatase, aspartate and alanine amino transferase, uric acid, blood urea nitrogen, and creatinine of the patients as well as their physical activity, dietary intakes, anthropometric measures and blood pressure were measured. Data were analyzed by SPSS.18 software.
Results
Uric acid and blood urea nitrogen were significantly decreased in the saffron group (P < 0.05), however, there were no significant differences between the two groups at the end of the study (p = 0.29 and 0.14, respectively). Moreover, changes in other profiles, including liver enzymes, were not statistically significant in the two groups. Also, no significant changes in blood pressure, dietary intakes, and physical activity were seen among the two groups.
Conclusion
Saffron hydro-alcoholic extract did not considerably improve renal and liver functions in T2DM patients in an 8-week randomized clinical trials. The results deserved further investigations with more accurate methods to confirm.
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