Journal of neurology and experimental neuroscience最新文献_第5页

The Amyloid Precursor Protein: More than Just Amyloid- Beta 淀粉样蛋白前体蛋白:不仅仅是淀粉样蛋白- β

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/JNEN.2019-045

Stefan D. Jevtic, J. Provias

{"title":"The Amyloid Precursor Protein: More than Just Amyloid- Beta","authors":"Stefan D. Jevtic, J. Provias","doi":"10.17756/JNEN.2019-045","DOIUrl":"https://doi.org/10.17756/JNEN.2019-045","url":null,"abstract":"Alzheimer disease (AD) is currently the leading cause of dementia worldwide with no disease modifying therapy available. Despite the burden of disease, there is still no consensus on the underlying pathophysiology leading to sporadic AD. The previously held amyloid-beta (Aβ) hypothesis is giving way to a multifactorial model that involves various pathologic components, including Aβ and tau. In this paradigm, other components including inflammatory processes (i.e. microglia), structural components (blood brain barrier), and the amyloid precursor protein (APP) play significant roles in disease. We present here a review on the emerging role of APP in AD, independent of Aβ, including its significance in normal physiology and disease. We briefly describe the various isoforms of APP, its processing pathways, and how this contributes to function. Furthermore, we present our own observations and discussion on APP pathology in AD human tissue. Finally, we combine this knowledge of APP to suggest an interaction with tau that could be applied to AD and other tauopathies such as chronic traumatic encephalopathy. This emerging view of APP places it as an independent-mediator of AD pathology with implications for future research and treatment avenues.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Parkinson’s Disease Dyskinesias Possibly Relate to Greater Dopamine Transporter Losses in the Putamen Over Time 随着时间的推移，帕金森病运动障碍可能与壳核中更多的多巴胺转运体损失有关

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-s1-002

A. Roussakis, D. Towey, M. Gennaro, N. Lao–Kaim, P. Piccini

{"title":"Parkinson’s Disease Dyskinesias Possibly Relate to Greater Dopamine Transporter Losses in the Putamen Over Time","authors":"A. Roussakis, D. Towey, M. Gennaro, N. Lao–Kaim, P. Piccini","doi":"10.17756/jnen.2019-s1-002","DOIUrl":"https://doi.org/10.17756/jnen.2019-s1-002","url":null,"abstract":"The pathophysiology of levodopa-induced dyskinesias in Parkinson’s disease is incompletely understood. This study was designed to investigate in Parkinson’s patients, whether time-related changes in striatal dopamine transporter availability are associated to the appearance of dyskinesias. 15 Parkinson’s patients had dopamine transporter-specific SPECT imaging with 123I-FP-CIT twice: at baseline (when they were drug naïve) and at follow-up (6.31 ± 2.29 years from baseline), and were followed up clinically every six months. At the end of the study, patients were divided in two groups according to whether they had developed dyskinesias or not. Semiquantification of 123I-FP-CIT data was performed using the occipital cortex as the reference region. Specific binding ratios were calculated for the putamen and the caudate. During the clinical follow-up, all Parkinson’s patients were treated pharmaceutically. 8 patients developed dyskinesias, while 7 remained nondyskinetic. At baseline, the two groups had similar 123I-FP-CIT specific binding ratio values for the putamen and the caudate (p > 0.05). Also, between-group differences in age, disease duration, and Hoehn & Yahr scores were not statistically significant. Overtime, the putaminal 123I-FP-CIT specific binding ratio values in the dyskinetic group decreased significantly (p < 0.01). The nondyskinetic patients had smaller reductions (p < 0.05) during the same period of time. At follow-up, the dyskinetic patients had significantly higher Hoehn & Yahr scores (p < 0.01) and were taking higher levodopa equivalent doses (p < 0.001), as compared to the nondyskinetic patients. The development of Parkinson’s dyskinesias is related to a faster progression rate, as reflected by marked putaminal dopamine transporter decreases.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67649003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Encephalomyelitis Resulting from Chronic West Nile Virus Infection: A Case Report 慢性西尼罗病毒感染所致脑脊髓炎1例报告

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-052

R. Rodriguez, Liliana Rincón, Ahmed Yassin, G. Campbell, Bi-hung Peng, Corey Fulton, J. Sarria, D. Walker, X. Fang

引用次数: 1

Progress in Management of Essential and Parkinson Disease Tremor with Botulinum Toxin Injections-Established Efficacy and Less Adverse Effects 注射肉毒毒素治疗原发性震颤和帕金森病震颤的研究进展——疗效确切，不良反应少

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-s1-001

B. Jabbari

引用次数: 0

Lymphocytes T Helper 17 in Multiple Sclerosis: Regulation by Intestinal Microbiota 淋巴细胞T辅助17在多发性硬化症中的作用:肠道微生物群的调节

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/JNEN.2019-051

Bruno Bagatin de Souza Moreira, André Eduardo de Almeida Franzo, M. Gonçalves, O. Nascimento, J. S. Peron

引用次数: 1

Case Report: Length-dependent Small Fiber Polyneuropathy Caused by Coxsackie and Influenza Virus Co- Infection 病例报告:由柯萨奇和流感病毒合并感染引起的长度依赖性小纤维多神经病变

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-061

引用次数: 2

Disuse Left Hand Atrophy and Persistent Left Clenched Fist in an Adult with Catatonic Schizophrenia 成人紧张性精神分裂症患者的废用性左手萎缩和持续性左握拳

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-057

S. Hamed

引用次数: 0

Wernicke’s Encephalopathy: An Overlooked Cause 韦尼克脑病:一个被忽视的原因

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/JNEN.2019-049

L. Muzangwa, C. Rivera, Charlota Jurcik, J. Bibawy, J. Nfonoyim, Vaithilingam Arulthasan, Jose Luis Valdes Bracamontes, Raziul Haq, Samuel J. Beaujean

引用次数: 1

Active Control-Group Designs in Cognitive Rehabilitation Trials: A Qualitative Review of Computer-Based Rehabilitation in Patients with Acquired Brain Injury 认知康复试验中的主动对照组设计:后天性脑损伤患者计算机康复的定性回顾

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-059

Katrine Faerk, Andreas Kirknaes, Katrine Svaerke, Andreas Kirknaes Faerk, A. Løkkegaard, H. Christensen, J. Mogensen

{"title":"Active Control-Group Designs in Cognitive Rehabilitation Trials: A Qualitative Review of Computer-Based Rehabilitation in Patients with Acquired Brain Injury","authors":"Katrine Faerk, Andreas Kirknaes, Katrine Svaerke, Andreas Kirknaes Faerk, A. Løkkegaard, H. Christensen, J. Mogensen","doi":"10.17756/jnen.2019-059","DOIUrl":"https://doi.org/10.17756/jnen.2019-059","url":null,"abstract":"Background and Objectives: To outline experimental variables of relevance to clinical trials employing active control condition (ACC) designs within cognitive rehabilitation after Acquired Brain Injury (ABI), and to qualitatively review the current methodology of trials within this field. Method: Firstly, experimental variables which evidently impact rehabilitation outcome were outlined, based on the authors’ joint knowledge of the research field. Secondly, clinical trials within cognitive rehabilitation after ABI that employed ACC designs were identified and qualitatively evaluated based on the outlined variables. Due to the breadth of this research field, a focus on computer-based cognitive rehabilitation (CBCR) was chosen. Trials were identified through a systematic search in prespecified scientific databases using prespecified inclusion criteria. Results: 10 experimental variables were identified. Nine trials were included in this review. None of the included trials accounted for all experimental variables in their study design. Conclusion: There are methodological shortcomings in the design of trials using ACC’s within the field of CBCR after ABI. Although this methodological review is limited to a subfield within cognitive rehabilitation research, the conclusions drawn here are believed to generalize to the overall field. The experimental variables outlined here may aid researchers in the design phase of future trials using ACC’s.","PeriodicalId":91755,"journal":{"name":"Journal of neurology and experimental neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67648524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nonconvulsive Status Epilepticus (NCSE) Presenting as Acute Confusional State 非惊厥性癫痫持续状态(NCSE)表现为急性神志不清状态

Journal of neurology and experimental neuroscience Pub Date : 2019-01-01 DOI: 10.17756/jnen.2019-060

引用次数: 0