Breast Cancer : Basic and Clinical Research最新文献

{"title":"Human Epidermal Growth Factor Receptor 2-Low Breast Cancer: Prevalence Rate and Scoring Concordance Among Pathologists.","authors":"Maher Sughayer, Ghada Al-Jussani, Ahmed Salem, Yassin Mullahwaish, Fanar Alsmarat, Dua Abuquteish","doi":"10.1177/11782234251363664","DOIUrl":"10.1177/11782234251363664","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer with low expression of human epidermal growth factor receptor 2 (HER2) has emerged as a new category benefiting from anti-HER2 therapies. This study evaluated the prevalence of HER2-low expression and concordance of HER2 scoring among pathologists at King Hussein Cancer Center (KHCC) in Jordan.</p><p><strong>Objectives: </strong>To determine the prevalence of HER2-low breast cancer tumors and evaluate the interpathologist concordance in HER2 scoring using the 2018 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines.</p><p><strong>Design: </strong>This is a retrospective observational study.</p><p><strong>Methods: </strong>In total, 116 breast cancer samples were randomly selected from routine practice at KHCC. Each tumor was scored for HER2 expression by 3 pathologists independently using the 2018 ASCO/CAP guidelines. Concordance among pathologists was evaluated using Fleiss' kappa and Cohen's weighted kappa statistics.</p><p><strong>Results: </strong>The original HER2 scoring revealed 7 tumors (6%) as HER2-negative (0 immunohistochemistry [IHC] score), 84 (72.4%) as HER2-low (including tumors with 1+ IHC score or 2+ IHC score with negative fluorescence in situ hybridization [FISH]), 21 (18.1%) as HER2-positive (including tumors with 3+ IHC score or 2+ IHC score with positive FISH), and 4 (3.4%) as equivocal (2+ IHC score with no FISH). Consensus scoring showed 1+ as the most frequent HER2 score. Complete agreement among all 3 pathologists occurred in 78 tumors (67.2%), while high agreement (agreement among 2 pathologists) occurred in 38 tumors (32.8%). Cohen's weighted kappa ranged from 0.691 to 0.849, indicating substantial agreement. The Fleiss kappa of overall agreement on HER2 scoring was 0.645.</p><p><strong>Conclusion: </strong>This study highlights a significant prevalence of HER2-low tumors among the randomly selected sample of Jordanian breast cancer patients and demonstrates substantial interpathologist agreement in HER2 scoring. These findings underscore the importance of standardized HER2 scoring and the potential impact of emerging therapies on a large patient population in Jordan.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251363664"},"PeriodicalIF":1.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy.","authors":"Cunjun Mai, Huiyang Tang, Guie Lai, Lulin Liu, Wenzhen Huang, Kang He, Qingyang Liu, You Sun, Dongmin Yu","doi":"10.1177/11782234251365941","DOIUrl":"10.1177/11782234251365941","url":null,"abstract":"<p><p>Breast cancer (BC) is the most prevalent malignancy in women. The emergence of targeted therapies and advancements in comprehensive treatment protocols have significantly improved survival outcomes for patients with early-stage BC. However, individuals with refractory BC, particularly those who have received multiple lines of therapy or presented with distant metastases at diagnosis, continue to face challenges due to the limitations of conventional antibodies and cytotoxic agents in meeting therapeutic needs. Thus, the development of novel and effective treatments for BC, along with strategies to prevent recurrence, remains an urgent priority. Research has shown that nanodrug delivery systems can modify the pharmacokinetic profiles of traditional chemotherapeutic agents, thereby markedly reducing adverse drug reactions. Furthermore, studies have demonstrated that innovative approaches, such as hyaluronic acid-based systems, ultrasound-mediated microbubbles, and antibody-drug conjugates (ADCs), enable targeted and controlled drug release, offering advantages including high drug efficacy, reduced toxicity, and significant antitumor effects. Among these, ADCs have gained increasing attention in BC therapy over recent years. This article provides a comprehensive review of the development and progress of various drug delivery systems in BC treatment, offering an in-depth analysis of their potential applications in clinical practice.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251365941"},"PeriodicalIF":1.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Axillary Lymph Node Dissection in Breast Cancer Patients With Residual Nodal Disease After Receiving Neoadjuvant Chemotherapy.","authors":"Kristina Shaffer, Lilian Harris, Lori Gentile, Amelia Merrill, Lori Kellam, Michelle Fillion, Peter Turk","doi":"10.1177/11782234251352996","DOIUrl":"10.1177/11782234251352996","url":null,"abstract":"<p><p><b>Background:</b> While sentinel lymph node biopsy (SLNB) in breast cancer patients with limited axillary disease undergoing upfront surgery is well-accepted, there are insufficient data supporting its safety with residual nodal disease (RND) following neoadjuvant chemotherapy (NAC). <b>Objectives:</b> To evaluate axillary management and oncologic outcomes of patients with RND. <b>Design:</b> A retrospective review comparing patients receiving SLNB to those receiving axillary lymph node dissection (ALND). <b>Methods:</b> Patients treated for breast cancer at our institution between 2015 and 2023, who received NAC and had RND, were identified. Patient and tumor characteristics, treatments, and outcomes information were collected. The relationship between axillary management and oncologic outcomes was examined. <b>Results:</b> Of 155 patients, median age was 55 years (interquartile range [IQR] 46-64) and follow-up 56 months (IQR 34-73). Most patients were pathologic tumor stage 1-2 (105, 67.7%) and nodal stage 1 (106, 68.4%), with ductal histology (127, 81.9%). The most common receptor pattern was estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-negative. A total of 107 (69.0%) underwent mastectomy, 47 (30.3%) lumpectomy, and 138 (89.0%) received adjuvant radiation. Regarding axillary management, 121 (78.1%) underwent ALND and 34 (21.9%) SLNB. Univariate analysis found no differences in overall survival (68.6% vs 70.6%; <i>P</i> = 1), any recurrence (local, axillary, or distant; 36.4% vs 35.3%; <i>P</i> = 1), or specifically axillary recurrence (9.9% vs 8.8%; <i>P</i> = 1), between ALND and SLNB groups, respectively. This was also demonstrated on multivariate analysis. Conversely, there was a significantly increased rate of lymphedema in the ALND, 57.9%, vs the SLNB group, 35.3% (<i>P</i> = 0.03). <b>Conclusions:</b> ALND was not associated with improved survival or recurrence risk compared with SLNB in patients with RND following NAC, but was found to have a higher rate of lymphedema. This study is limited due to its retrospective nature. Further data, such as from the ALLIANCE A011202 trial, will help to further clarify the optimal oncologic management for this group of patients.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251352996"},"PeriodicalIF":1.9,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Insights Into Breast Cancer: Molecular Pathways, Epigenetic Regulation, and Emerging Targeted Therapies.","authors":"Quratulain Maqsood, Muhammad Umer Khan, Tehreem Fatima, Sania Khalid, Zaryab Ikram Malik","doi":"10.1177/11782234251355663","DOIUrl":"10.1177/11782234251355663","url":null,"abstract":"<p><p>Breast cancer remains the most prevalent malignant tumor and a leading cause of cancer-related mortality among women worldwide. The disease comprises distinct molecular subtypes that influence tumor behavior, metastatic potential, and therapeutic response. This review presents recent advances in breast cancer research, with a particular emphasis on molecular and epigenetic mechanisms that contribute to tumor development, progression, and treatment resistance. Key signaling pathways-including estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), Notch, fibroblast growth factor receptor (FGFR), Wnt, and Hedgehog-play essential roles in the regulation of mammary stem cells and oncogenesis. Increasing evidence highlights the significance of epigenetic alterations such as DNA methylation, histone modifications, and microRNA expression in modulating gene activity relevant to tumor initiation and therapy resistance. Epigenetic molecular targets, including DNA methyltransferases (DNMTs), histone deacetylases (HDACs), EZH2, and non-coding RNAs, are gaining attention for their potential use in diagnosis, prognosis, and targeted therapy. Integration of multigene panel testing with epigenetic biomarkers has facilitated improved risk assessment and the development of individualized treatment strategies. Moreover, novel therapeutic approaches-such as CAR-T cell therapy, nanoparticle-mediated drug delivery systems, and the involvement of circular RNAs (circRNAs) in immune modulation-offer promising directions for precision medicine. This review consolidates current insights into the molecular and epigenetic landscape of breast cancer to provide a comprehensive understanding of disease complexity and to inform the development of more effective, personalized treatment options.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251355663"},"PeriodicalIF":1.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Fear of Breast Cancer Among Ghanaian Women via the Champion Breast Cancer Fear Scale.","authors":"Enoch Teye-Kwadjo","doi":"10.1177/11782234251353270","DOIUrl":"10.1177/11782234251353270","url":null,"abstract":"<p><strong>Background: </strong>Screening for breast cancer via mammography is underutilised in Ghana, with fear of the disease influencing women's participation. However, little is known about the role fear of breast cancer plays in screening decisions, partly due to the lack of a Ghana-specific measure to assess this fear. There is a need for a valid and reliable measure to assess breast cancer-related fear among Ghanaian women.</p><p><strong>Objectives: </strong>To evaluate the construct validity and internal consistency reliability of the Champion Breast Cancer Fear Scale among Ghanaian women.</p><p><strong>Design: </strong>Cross-sectional research design.</p><p><strong>Methods: </strong>The participants were women (aged 18-78 years) recruited in the general population through convenience sampling. The total sample was randomly split into 2 equivalent subsamples to perform the construct validity analysis via exploratory factor analysis (n = 428) and confirmatory factor analysis (n = 427), along with internal consistency reliability testing using McDonald omega (ω) and Cronbach alpha (α).</p><p><strong>Results: </strong>The original one-factor structure of the Champion Breast Cancer Fear Scale was supported by both exploratory factor analysis and confirmatory factor analysis in the present study. Omega and alpha coefficients for the total sample (ω = .877; α = .876), subsample 1 (ω = .877; α = .875), and subsample 2 (ω = .879; α = .877), were found to be good. Overall, the confirmatory factor analysis found sound validity evidence, χ²(19) = 62.84, <i>P</i> < .001, comparative fit index = .971, root mean square error of approximation = .074, 90% confidence interval = [.05, .09], standardised root mean square residual = .031, for the use of the Champion Breast Cancer Fear Scale for assessing fear of breast cancer among Ghanaian women in the general population. Other results revealed that most of the participants reported a high fear of breast cancer, whereas a substantial number reported a moderate fear of breast cancer.</p><p><strong>Conclusion: </strong>The study confirms the Champion Breast Cancer Fear Scale as a valid and reliable measure for identifying women with a fear of breast cancer.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251353270"},"PeriodicalIF":1.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in ER, PR, HER2, and Their Association With Disease Outcome in Invasive Breast Carcinoma (IBC) Patients Post-Neo Adjuvant Chemotherapy (NAC) and Surgery.","authors":"Monisha C Ravishankar, Pampa Ch Toi, Biswaji Dubashi, Kadambari Dharanipragada","doi":"10.1177/11782234251342463","DOIUrl":"10.1177/11782234251342463","url":null,"abstract":"<p><strong>Background: </strong>Estrogen-receptor (ER), progesterone-receptor (PR), and human epidermal growth factor-2 (HER2) are performed on pre-neoadjuvant chemotherapy (NAC) biopsies of invasive breast carcinoma (IBC). However, they are not done routinely on post-NAC IBC with residual tumor.</p><p><strong>Objectives: </strong>This study helps in understanding the effect of alteration in expression of ER, PR, and HER2 in pre and post NAC IBC with residual tumors in terms of disease outcome, such as disease-free survival (DFS) and overall survival (OS).</p><p><strong>Design: </strong>This was a Cohort study (Prospective and Retrospective Cohort).</p><p><strong>Methods: </strong>All newly diagnosed cases of IBC who had undergone surgery after NAC with pre-NAC biopsies available with residual tumors in the breast, from January 2017 to January 2020 were enrolled in the study (n = 174) and were followed up till July 2022.</p><p><strong>Results: </strong>There were 174 cases included in this study. Of the 174 cases, 77 (44%) ER+ cases turned -ve, 10 ER +ve cases remained +ve and 87(50%) cases which were ER-ve remained the same. 48(27%) of PR +ve cases turned -ve, 10 PR +ve cases remained +ve and 116 (67%) cases remained -ve. 64(36%) of HER2 +ve cases turned -ve, 4 (2%) of HER2 +ve cases remained +ve; whereas 103(59%) cases remained -ve. The cases with changes in ER and HER2 status from positive to negative showed a longer DFS and OS which was statistically significant.</p><p><strong>Conclusion: </strong>There is a change in the HR and HER2 status in cases of IBC with residual tumor post NAC and patients with changes in the receptor status post-NAC have a better OS and DFS than those whose receptor status do not show a change.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251342463"},"PeriodicalIF":1.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Experience of HER2-Positive Advanced Breast Cancer (ABC) Treatment and Evaluation of Blood Biomarkers in a Public Institution in Latin America (LATAM).","authors":"Guillermo Valencia, Patricia Rioja, Olenka Peralta, Miguel Chirito, Raúl Mantilla, Carlos Castañeda, Zaida Morante, Hugo Fuentes, Tatiana Vidaurre, Mónica Calderón, Silvia Neciosup, Henry L Gómez","doi":"10.1177/11782234251342477","DOIUrl":"10.1177/11782234251342477","url":null,"abstract":"<p><strong>Background: </strong>Advanced breast cancer (ABC) is an incurable disease, with a median overall survival (OS) of 3 years, even in high-income countries. Oncological treatment has improved survival rates, particularly for hormone receptor-positive and HER2-positive subtypes; however, access to new therapies in Latin American (LATAM) countries is limited.</p><p><strong>Objectives: </strong>The impact of sequencing 2 lines of therapy in Peruvian patients with HER2-positive ABC in a single public institution was evaluated. First-line (1L) treatment consisted of trastuzumab and chemotherapy (CT, with taxanes), followed by second-line (2L) treatment with lapatinib plus capecitabine.</p><p><strong>Design: </strong>In this retrospective study, we analyze clínico-pathological features (including blood biomarkers) collected from medical records of patients with HER2-positive ABC treated in a public Peruvian oncologic institution and its association with survival between 2020 and 2022.</p><p><strong>Methods: </strong>Efficacy was measured using OS and progression-free survival (PFS). A discussion was added on the impact of OS based on clinicopathological characteristics, including outcomes in 2L \"long-term responder\" patients (who achieved response to 2L therapy ⩾6 months) and the evaluation of blood biomarkers.</p><p><strong>Results: </strong>Treatment sequencing has been demonstrated to enhance OS in patients with HER2-positive ABC, with a median OS of 34 months. This effect is more pronounced among long-term responders (37 months), particularly those without central nervous system (CNS) involvement, as compared with those with CNS metastases (51 vs 34 months). Blood biomarkers were not found to be prognostic indicators for either PFS or OS.</p><p><strong>Conclusions: </strong>Treatment sequencing has been demonstrated to enhance OS in LATAM patients with HER2-positive ABC. This study did not identify any prognostic blood biomarkers. These outcomes could influence the selection criteria for patients to receive treatment sequencing in countries without full access to innovative oncological therapies.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251342477"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel Lymph Node Biopsy vs. Axillary Lymph Node Dissection for Early-Stage Breast Cancer and Sentinel Lymph Node Metastasis: An Updated Systematic Review and Meta-Analysis With Special Focus on Locoregional Recurrence and Regional Node Irradiation.","authors":"Sanjit Kumar Agrawal, M Mohammed Imran, Shivank Sethi, Sanjay Kumar Yadav, Pawan Agarwal, Dhananjaya Sharma","doi":"10.1177/11782234251335409","DOIUrl":"https://doi.org/10.1177/11782234251335409","url":null,"abstract":"<p><strong>Background: </strong>The management of early breast cancer patients with metastatic sentinel lymph nodes (SLNs) remains a critical decision point in balancing survival outcomes with surgical morbidities. This study addresses whether sentinel lymph node biopsy (SLNB) with or without regional node irradiation (RNI) can offer comparable survival outcomes to axillary lymph node dissection (ALND).</p><p><strong>Objectives: </strong>To evaluate overall survival (OS), disease-free survival (DFS), locoregional recurrence (LRR), and mortality outcomes of SLNB (with or without RNI) compared with ALND in patients with metastasis-positive SLNs.</p><p><strong>Design: </strong>We have performed an updated meta-analysis of randomized controlled trials (RCTs) comparing SLNB alone or with RNI vs. ALND for early breast cancer patients with metastatic SLNs.</p><p><strong>Data sources and methods: </strong>Eligibility criteria included RCTs comparing SLNB ± RNI vs ALND for metastasis-positive SLN. PubMed, EMBASE, the Cochrane library, and online registers were searched for articles comparing SLNB alone vs. ALND for metastasis-positive SLN. Articles were evaluated for risk of bias using Cochrane's revised tool (RoB). The main summary measures using the random effects model were hazard ratio and risk ratio.</p><p><strong>Results: </strong>Seven RCTs were included in the meta-analysis. Overall survival and DFS were superior in the SLNB group compared to the ALND group. Locoregional recurrence and mortality were comparable between both the groups. After stratifying RCTs with regards to adjuvant RNI, these parameters were still comparable to ALND.</p><p><strong>Conclusion: </strong>This meta-analysis suggests that SLNB, with or without RNI, offers comparable OS and DFS to ALND for early breast cancer patients with metastasis-positive SLNs. However, the inclusion of studies that did not differentiate between micrometastases and macrometastases may introduce bias, particularly when assessing the impact of RNI. The role of RNI remains debated specially in those with macrometastases, and future research should focus on stratified analyses to clarify this. While SLNB represents a viable alternative to ALND, further trials are needed to define the optimal role in subgroups with high-risk tumor biology.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251335409"},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study on Copy Number Variation in Subtypes of Breast Phyllodes Tumors.","authors":"Yuqiong Liu, Min Zhang, Huifen Huang, Huayan Ren, Huixiang Li, Chenran Wang","doi":"10.1177/11782234251329209","DOIUrl":"https://doi.org/10.1177/11782234251329209","url":null,"abstract":"<p><strong>Background: </strong>Breast phyllodes tumor (PT) is a biphasic tumor and constitutes about 0.3% to 1% of all breast tumors. The PT is histologically classified as benign, borderline, and malignant subtypes. Unlike epithelial breast cancers, PT is derived from breast fibroepithelial tissues, and the genomic information of PT subtypes is still limited.</p><p><strong>Objectives: </strong>The objectives were to gain a deeper understanding of genomic changes in the progression of PTs from benign and borderline to malignant.</p><p><strong>Design: </strong>In this study, we used an Affymetrix OncoScan Array to analyze the genome-wide copy number variations (CNVs) and nucleotide point mutations from 3 benign PTs, 3 borderline PTs, and 3 malignant PTs collected from the First Affiliated Hospital of Zhengzhou University.</p><p><strong>Methods: </strong>DNA was extracted from formalin-fixed paraffin-embedded (FFPE) specimens using the TIANamp FFPE DNA Kit. The DNA was profiled for genome-wide CNV using the Affymetrix OncoScan Array and analyzed using the Nexus Express Chromosome Analysis Suite.</p><p><strong>Results: </strong>Our in silico variation analysis indicated copy number loss in Xp11.22 to q22.1 of all benign PTs (χ² = 9, <i>P</i> = .0027) and 22q11.23 and Xq23 in all malignant PTs (χ² = 12, <i>P</i> = .0005). A copy number gain was observed in 1p13.3 of all borderline PTs (χ² = 9, <i>P</i> = .0027) and 7p11.2 of all malignant PTs (χ² = 9, <i>P</i> = .0027). We also found consistent loss of heterozygosity (LOH) in 32 loci of benign PTs, 32 loci of borderline PTs, and 23 loci of malignant PTs. Among the 87 LOH, there were 15 overlapping loci across all PT subtypes. We observed missense mutations of <i>NRAS</i>, <i>KRAS</i>, <i>IDH2</i>, <i>TP53</i>, and a frameshift deletion in <i>PTEN</i> of sequenced PT samples, irrespective of their subtype. Interestingly, a point mutation in <i>EGFR/EGFR-AS1</i> was only observed in malignant PTs.</p><p><strong>Conclusions: </strong>Our data suggested that CNV at 7p11.2, 22q11.23, and Xq23 together with a point mutation in <i>EGFR</i>/<i>EGFR-AS1</i> uniquely presented in malignant PTs may correlate with the progression of PTs.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251329209"},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic Factors and Depression in Patients With Breast Cancer: A Multicenter, Cross-sectional Study in Georgia.","authors":"Tamar Kakhniashvili, Nino Okribelashvili, Ivane Kiladze","doi":"10.1177/11782234251323775","DOIUrl":"10.1177/11782234251323775","url":null,"abstract":"<p><strong>Background: </strong>Depression commonly occurs in patients with breast cancer (BC), affecting their quality of life.</p><p><strong>Objectives: </strong>The relationships between depression and different sociodemographic characteristics in patients with BC are under-researched. We conducted a multicenter study to determine the magnitude of depression and its association with different sociodemographic characteristics.</p><p><strong>Design: </strong>In this multi-institutional study, clinical data were collected, prospectively between October 2019 and January 2023 from 207 patients who were on active treatment for BC diagnosis in tertiary oncology hospitals in Georgia.</p><p><strong>Methods: </strong>Patients' sociodemographic characteristics were analyzed and their association with depression was assessed, using Patient Health Questionnaire-9 (PHQ-9) for the identification of depressive symptoms. Patients were stratified using basic information.</p><p><strong>Results: </strong>The median age of participants was 53 years (ranging from 31 to 77). Of the participants, 63.2% were married, 44.5% were employed, and only 16.4% reported having adequate financial status. Based on pro-rated PHQ-9 scores, 42% of patients reported some level of depressive symptoms, and 14.5% met the criteria for probable depressive disorder. Women with very inadequate financial status (10/21, 47.6%) reported significantly more depressive symptoms than those with adequate financial support (3/34, 8.8%) (<i>P</i> = .001). Unemployed women (12/42, 28.6%) were nearly 3 times more likely to experience moderate or severe depressive symptoms compared with employed patients (8/92, 8.7%) (<i>P</i> = .002). A significant difference in depressive symptoms was also observed based on education level, with individuals with higher education (12/119, 10%) reporting fewer depressive symptoms compared with those with middle education (18/88, 20.4%) (<i>P</i> = .036). No statistically significant difference in depressive symptoms was found based on marital status or social support.</p><p><strong>Conclusions: </strong>Our study found a significant relationship between depression and factors such as financial status, education level, and employment. Lower household income and education level were identified as predictors of clinical depression among patients with BC. These findings can help oncologists in Georgia recognize the importance of providing psychological support to cancer patients. Early detection and prompt referral to mental health specialists can play a key role in effectively managing depression.</p>","PeriodicalId":9163,"journal":{"name":"Breast Cancer : Basic and Clinical Research","volume":"19 ","pages":"11782234251323775"},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}