World journal of nephrology and urology最新文献_第2页

Large Renal Cyst Underestimates Split Function on Diuretic Radionuclide Renal Scan 肾大囊肿在利尿核素肾扫描中低估分裂功能

World journal of nephrology and urology Pub Date : 2021-09-01 DOI: 10.14740/wjnu422

S. Solav, S. Savale

引用次数: 0

From Hypokalemic Crisis to Sjogren’s Syndrome: A Case Report and Literature Review 从低钾危机到干燥综合征:一例报告和文献复习

World journal of nephrology and urology Pub Date : 2021-09-01 DOI: 10.14740/wjnu423

M. Mbengue, C. Ouanekpone, S. Diagne, A. Niang

引用次数: 0

A Review of Therapy for Primary Membranous Nephropathy Post-MENTOR 原发性膜性肾病治疗进展

World journal of nephrology and urology Pub Date : 2021-09-01 DOI: 10.14740/wjnu426

V. Srinivasa

引用次数: 0

Case of New Onset Acute Leukemia Complicated by Renal Calculi and Gout Attack: A Case Report 新发急性白血病并发肾结石和痛风发作1例报告

World journal of nephrology and urology Pub Date : 2021-03-16 DOI: 10.14740/wjnu424

Cima Hamieh, M. El-Hussein, Elie Zaghrini

引用次数: 0

Chronic Kidney Disease as a Result of Secondary Oxalate Nephropathy From Excess Dietary Intake of Peanut Butter and Coffee 过量摄入花生酱和咖啡导致继发草酸肾病的慢性肾脏病

World journal of nephrology and urology Pub Date : 2020-02-15 DOI: 10.14740/wjnu399

Ashkan Salamatipour, Tina Moazezi, S. Moten, L. Berg, A. Rauf

{"title":"Chronic Kidney Disease as a Result of Secondary Oxalate Nephropathy From Excess Dietary Intake of Peanut Butter and Coffee","authors":"Ashkan Salamatipour, Tina Moazezi, S. Moten, L. Berg, A. Rauf","doi":"10.14740/wjnu399","DOIUrl":"https://doi.org/10.14740/wjnu399","url":null,"abstract":"Excess production or absorption of oxalate can lead to hyperoxaluria and subsequent kidney injury. While many etiologies of hyperoxaluria have been well studied, diet-induced secondary oxalate nephropathy is a rare cause of renal damage that is still poorly understood. In this report, we present a 71-year-old man who lacked any known risk factors for secondary oxalate nephropathy other than a diet that was unusually high in peanut butter and coffee. The patient developed severe acute kidney injury, which resulted in end-stage renal disease and dependence on hemodialysis. Renal biopsy showed oxalate crystal buildup to be the culprit. It is likely that these cases of diet-induced secondary oxalate nephropathy have a strong genetic component that is yet to be fully understood. As the general public is likely unaware of the significance of dietary oxalate, we believe it is important to quickly identify and educate patients that have relevant risk factors to prevent development of acute or chronic kidney disease. World J Nephrol Urol. 2020;9(1):25-28 doi: https://doi.org/10.14740/wjnu399","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":"9 1","pages":"25-28"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42367716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Novel Truncated Variants Identified From Indian Autosomal Dominant Polycystic Kidney Disease Cases 从印度常染色体显性多囊肾病病例中鉴定的新截断变异的特征

World journal of nephrology and urology Pub Date : 2020-02-15 DOI: 10.14740/wjnu392

Sonam Raj, R. Singh, P. Das

{"title":"Characterization of Novel Truncated Variants Identified From Indian Autosomal Dominant Polycystic Kidney Disease Cases","authors":"Sonam Raj, R. Singh, P. Das","doi":"10.14740/wjnu392","DOIUrl":"https://doi.org/10.14740/wjnu392","url":null,"abstract":"Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common, late-onset and genetically heterogenous disorder. Altered genetic background is the prime cause of ADPKD. Most of the cases showed mutations in PKD1 , PKD2 , GANAB and DNAJB11 . Previous mutation screening studies reported that PKD1 and PKD2 are the major contributors to the disease. Among all types of DNA sequence variants, majority of the variants are protein truncating in nature. Loss of normal polycystin 1 (PC1) and polycystin 2 (PC2) proteins, encoded by PKD1 and PKD2 respectively, leads to the disease manifestation. Methods: Three cases and 100 controls were selected for mutational screening of PKD1 and PKD2 gene using Sanger sequencing. To characterize the variants, in silico (mutation taster, Align-Grantham Variation Grantham Deviation (Align-GVGD), Polymorphism Phenotyping v2 (PolyPhen2), Protein Variation Effect Analyzer (PROVEAN), Sorting Intolerant From Tolerant (SIFT), Polycystic Kidney Disease Mutation Database (PKDB), ProtScale and protein Basic Local Alignment Search Tool (BLAST-p)) as well as in vitro (Western blot) studies were performed. Results: We have identified a total of 14 variants (three truncating, three nonsynonymous, seven synonymous and one intronic). Three deletions ( PKD1: c.445_445delC, PKD2: c.854_854delG and PKD2 : c.1050_1050delC) were confirmed as rare, private and novel mutations in Indian ADPKD cases. Rest 11 variants were previously reported and likely neutral in nature. Loss of conservation of amino acid, decreased hydrophobicity and decreased coil forming ability of truncated proteins were supposed to affect the protein functions. Immunoblotting verified the expression of truncated proteins in cell. Conclusions: We can conclude that identified deletion variants were truncating in nature and hence they were pathogenic mutations responsible for disease manifestation. World J Nephrol Urol. 2020;9(1):15-24 doi: https://doi.org/10.14740/wjnu392","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":"9 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41902080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Are Inflammatory Markers Useful in Predicting Urinary Tract Infection After Transrectal Ultrasound-Guided Biopsy of the Prostate? 炎症标志物在经直肠超声引导前列腺活检后预测尿路感染有用吗?

World journal of nephrology and urology Pub Date : 2020-02-15 DOI: 10.14740/wjnu398

N. A. Heidar, M. Shahait, A. Yaacoubian, R. Nasr

{"title":"Are Inflammatory Markers Useful in Predicting Urinary Tract Infection After Transrectal Ultrasound-Guided Biopsy of the Prostate?","authors":"N. A. Heidar, M. Shahait, A. Yaacoubian, R. Nasr","doi":"10.14740/wjnu398","DOIUrl":"https://doi.org/10.14740/wjnu398","url":null,"abstract":"Background: Sepsis is a serious and life-threatening complication after transrectal ultrasound (TRUS)-guided prostate biopsy. It is critical to predict its occurrence prior to conducting the biopsy. The neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte (PLR) have been proven to be promising diagnostic indicators of infectious complications after various surgical procedures. The aim of this study was to determine whether inflammatory markers, NLR and PLR ratios, are useful surrogates to predict sepsis after TRUS biopsy. Methods: A total of 378 patients underwent TRUS-guided prostate biopsy with no clinical evidence of prostatitis from December 2009 to May 2013 in American University of Beirut Medical Center. Data collected included age, smoking status, prostate size, post-void residual, prostate-specific antigen (PSA) value, blood culture, urine culture, Gleason score, pathology results, neutrophils, leukocyte count and platelet counts. Also, NLR and PLR were calculated. The primary outcome collected was sepsis. All data were entered and analyzed by Statistical Package for Social Sciences. Results: Of the 378 patients who underwent TRUS biopsy, 31 patients developed sepsis. Septic patients were younger (63.7 ± 6.2 years) than non-septic patients (65.5 ± 8.0 years). No association between sepsis and NLR or PLR was observed; however, a significant association between sepsis and pre-biopsy urine analysis and pre-biopsy PSA (P = 0.011) was noted. Conclusion: In this study, none of the pre-procedure NLR and PLR studied was found to predict sepsis after TRUS biopsy. Future efforts should be directed to investigate this relationship in prospective studies. World J Nephrol Urol. 2020;9(1):11-14 doi: https://doi.org/10.14740/wjnu398","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":"9 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47337735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Atypical Case of Emphysematous Cystitis in a Young Non-Diabetic Patient 非糖尿病青年肺气肿性膀胱炎1例

World journal of nephrology and urology Pub Date : 2019-03-09 DOI: 10.14740/WJNU374

Behshad Charkhand, A. Valeshabad, Joseph Farahany, J. Warncke, Artineh Hayrapetian, M. Nehler, Shandra S. Wilson

引用次数: 2

Methicillin-Resistant Staphylococcus aureus Infections in Patients With Renal Disorders: A Review 肾脏疾病患者耐甲氧西林金黄色葡萄球菌感染的研究进展

World journal of nephrology and urology Pub Date : 2019-03-09 DOI: 10.14740/WJNU384

Kailash Singh, V. Raju, R. Nikalji, Sunil Y. Jawale, H. Patel, Jaishid Ahdal, R. Jain

{"title":"Methicillin-Resistant Staphylococcus aureus Infections in Patients With Renal Disorders: A Review","authors":"Kailash Singh, V. Raju, R. Nikalji, Sunil Y. Jawale, H. Patel, Jaishid Ahdal, R. Jain","doi":"10.14740/WJNU384","DOIUrl":"https://doi.org/10.14740/WJNU384","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) infection is a rapidly escalating global health burden. It is not only restricted to patients in the hospital settings but has also rooted deeply in the community settings. With increasing prevalence of life style and kidney diseases, the prevalence of MRSA infections is also expected to rise. MRSA infection plays a major role in renal disorders due to its direct vascular access (VA) thereby making patients undergoing dialysis and renal transplant more vulnerable to infections. Prolonged hospital stay, close proximity to MRSA-infected individual, exposure to broad-spectrum antibiotics, surgery and presence of foreign bodies such as central venous catheters predispose an individual to MRSA infection. Current panel of antibiotic treatment includes vancomycin, teicoplanin, linezolid, daptomycin, tigecycline and ceftaroline. However, emergence of resistant strains and several undesirable features pertaining to safety and tolerability of these drugs have led to limited options available for the management of multidrug-resistant MRSA infection in patients with renal disorders. Therefore, there is an increasing need for developing a new potent antibacterial agent with established renal safety that decreases the mortality and morbidity rates in MRSA-infected renal patients. World J Nephrol Urol. 2019;8(1):8-13 doi: https://doi.org/10.14740/wjnu384","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46680057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Blunt Traumatic Intraperitoneal Bladder Rupture After Alcohol Intake That Responds to Non-Operative Conservative Management 酒精摄入后钝性外伤性腹膜内膀胱破裂对非手术保守治疗的反应

World journal of nephrology and urology Pub Date : 2019-03-09 DOI: 10.14740/WJNU380

K. Ohgaki, M. Sakamoto

{"title":"Blunt Traumatic Intraperitoneal Bladder Rupture After Alcohol Intake That Responds to Non-Operative Conservative Management","authors":"K. Ohgaki, M. Sakamoto","doi":"10.14740/WJNU380","DOIUrl":"https://doi.org/10.14740/WJNU380","url":null,"abstract":"Blunt traumatic intraperitoneal bladder rupture is usually treated by surgical repair. We report a patient with intraperitoneal bladder rupture secondary to blunt abdominal trauma that responded to non-operative conservative management using a transurethral catheter. A 58-year-old woman was admitted to our Department of Internal Medicine complaining of lower abdominal pain and urinary retention after drinking alcohol. Computed tomography (CT) scan revealed collection of fluid in the abdominal cavity and fresh blood clots in the bladder. At 2 days after admission, she was moved from the Department of Internal Medicine to Urology. Cystoscopy revealed an old hematoma in the bladder. She complained of abdominal pain when the Foley catheter was removed. At 3 days after admission, cystoscopy revealed a small tear at the bladder dome, which led to a definitive diagnosis of intraperitoneal bladder rupture. At 4 days after admission, a CT scan detected only a small amount of fluid in the abdominal cavity. Conservative therapy was continued because urine could be constantly drained. At 2 weeks after admission, the bladder rupture had healed. World J Nephrol Urol. 2019;8(1):19-22 doi: https://doi.org/10.14740/wjnu380","PeriodicalId":91634,"journal":{"name":"World journal of nephrology and urology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42293144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2