Biomedical Letters最新文献_第7页

Infection control measures for COVID-19 COVID-19感染控制措施

Biomedical Letters Pub Date : 2020-12-01 DOI: 10.47262/6.2.20201212

引用次数: 1

Molecular analysis of tetracycline resistant gene in gram-negative bacteria isolated from dairy farms 奶牛场革兰氏阴性菌中四环素耐药基因的分子分析

Biomedical Letters Pub Date : 2020-09-17 DOI: 10.47262/6.2.20200724

引用次数: 0

Clinical efficacy and safety of apatinib combined with oral VP-16 for the treatment of advanced ovarian cancer: Preliminary evaluation of a clinical drug regimen 阿帕替尼联合口服VP-16治疗晚期卵巢癌的临床疗效和安全性:临床用药方案的初步评价

Biomedical Letters Pub Date : 2020-06-16 DOI: 10.47262/bl/6.2.20200611

{"title":"Clinical efficacy and safety of apatinib combined with oral VP-16 for the treatment of advanced ovarian cancer: Preliminary evaluation of a clinical drug regimen","authors":"","doi":"10.47262/bl/6.2.20200611","DOIUrl":"https://doi.org/10.47262/bl/6.2.20200611","url":null,"abstract":"To investigate the clinical efficacy and safety of apatinib in combination with oral VP-16 for the treatment of chemotherapy-resistant advanced ovarian carcinoma. Twenty-seven advanced ovarian carcinoma patients were treated with oral VP-16 chemotherapy combined with oral apatinib mesylate (500 mg/d). CA125, VEGF, and CEA were examined every 3-4 weeks, and tumour changes were monitored by CT every 8-12 weeks. PFS was obtained by follow-up after discharge. For all patients, the ORR (including CR and PR) was 25.0%, and the DCR (including CR, PR and SD) was 75.0%. CEA and CA199 significantly decreased (p<0.05), but the decrease in VEGF was not significant. The average PFS was 5.13 months. The ECOG score had a significant effect on PFS (p<0.05), while there were no significant differences in PFS based on age (p=0.394). The main side effects of this regimen were hypertension, proteinuria, hand-foot syndrome and myelosuppression, which were tolerated by patients after active symptomatic treatment. Apatinib combined with oral VP-16 is an effective regimen for the treatment of chemotherapy-resistant advanced ovarian cancer. This combination therapy should be widely used in clinical practice.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78665011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible strategies and treatments of SARS-CoV-2 outbreak SARS-CoV-2爆发的可能策略和治疗方法

Biomedical Letters Pub Date : 2020-06-15 DOI: 10.47262/6.2.20200531

引用次数: 1

COVID-19 epidemic forecasting and attitude of Pakistani nation towards the mighty pandemic 新冠肺炎疫情预测及巴基斯坦人民应对疫情的态度

Biomedical Letters Pub Date : 2020-05-05 DOI: 10.47262/bl/6.2.20200503

引用次数: 0

Soil microorganism impact on the native plant growth under single and co-invasion with invasive plants: Responses through plant-soil feedback 土壤微生物对本土植物单入侵和共入侵生长的影响:植物-土壤反馈的响应

Biomedical Letters Pub Date : 2020-04-30 DOI: 10.47262//bl/6.2.20200432

引用次数: 0

Management of Systemic Lupus Erythematosus complicated with Refractory Immune Thrombocytopenic Purpura and Pulmonary Artery Hypertension 系统性红斑狼疮合并难治性免疫性血小板减少性紫癜和肺动脉高压的治疗

Biomedical Letters Pub Date : 1900-01-01 DOI: 10.47262/bl/7.1.20210112

引用次数: 0

Homology Modeling and Protein-Protein Molecular Docking analyses elucidate the Potential Binding Pockets of ATP7B: A Candidate Wilson’s disease 同源建模和蛋白-蛋白分子对接分析阐明了ATP7B:候选威尔逊病的潜在结合口袋

Biomedical Letters Pub Date : 1900-01-01 DOI: 10.47262/bl/7.1.20210409

{"title":"Homology Modeling and Protein-Protein Molecular Docking analyses elucidate the Potential Binding Pockets of ATP7B: A Candidate Wilson’s disease","authors":"","doi":"10.47262/bl/7.1.20210409","DOIUrl":"https://doi.org/10.47262/bl/7.1.20210409","url":null,"abstract":"There has been progressive improvement in computational drug design from last decade. Numerous computer aided compounds have been reported against neurodegenerative disorders. Wilson’s disease is a common neurodegenerative disease in humans associated with ATP7B that encodes a transmembrane copper-transporting ATPase which induces the copper export from hepatic cells into bile and supplies copper for the functional synthesis of Ceruloplasmin. Almost, 150 mutations of ATP7B have been identified lead to cause Wilson's disease having symptoms of cancers, loss of memory and postural instability. In this research article, 3D structure of ATP7B was predicted by using comparative modelling approaches. The predicted structures were evaluated by utilizing numerous evaluation tools and 98.50% of overall quality factor was observed for the final selected structure. ATOX1 was predicted as the interacting partner of ATP7B and molecular docking analyses of ATP7B and ATOX1 were conducted by using PatchDock. The least global energy of -35.45 Kcal/mol was observed having the interacting residues in the binding pocket. The reported interacting residues may help to target the specific drug development against ATP7B. This research article can be a major initiative to predict the therapeutic drug targets against Wilson’s disease.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81347666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of Acinetobacter baumannii isolated from MDR-TB patients of Northern Punjab, Pakistan 巴基斯坦旁遮普省北部耐多药结核病患者鲍曼不动杆菌分离株的分子特征

Biomedical Letters Pub Date : 1900-01-01 DOI: 10.47262/bl/7.1.20210101

{"title":"Molecular characterization of Acinetobacter baumannii isolated from MDR-TB patients of Northern Punjab, Pakistan","authors":"","doi":"10.47262/bl/7.1.20210101","DOIUrl":"https://doi.org/10.47262/bl/7.1.20210101","url":null,"abstract":"Respiratory tract infections (RTIs) are the most common and severe infectious diseases in developing countries. Acinetobacter baumannii is the bacterium known as causative organism for respiratory tract infections in human populations. The Report suggests that co-infection of Acinetobacter baumannii with Mycobacterium tuberculosis together increases health complications in multidrug resistant tuberculosis (MDR-TB) positive patients and creates fatal damage to the ailing population. In our study, 106 sputum samples of MDR-TB positive patients from Northern Punjab were studied. The isolation of A. baumannii from sputum of MDR-TB patients was done on selective media and initially screened by Oxidase and Catalase based identification followed by microscopic examination. Afterward, only ten suspected isolates of A. baumannii were again selected for further characterization for MDR by using Disc diffusion method. Antibiograms against number of antibiotics were accurately determined. Of these 10 isolates, 8 sample were found resistant to levofloxacin and subjected to molecular characterization using bla-OXA-51 primers. Only 3 out of 106 (2.83 %) isolates were confirmed as MDR strains of A. baumannii. These results show the coexistence of MDR A. bauminnii with MDR-TB patients of Northern Punjab, Pakistan. In Northern Punjab regions a higher percentage (3 cases) of MDR- TB were detected, which were co-infected with Acinetobacter baumannii among hospitalized patients. These findings may show unhygienic hospital environment or practices which leads to the co-infection.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88059750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Alu-repeat Polymorphism and Myocardial Infarction in Pakistani Population 巴基斯坦人群Alu-repeat多态性与心肌梗死的关系

Biomedical Letters Pub Date : 1900-01-01 DOI: 10.47262/bl/7.1.20210111

{"title":"Association of Alu-repeat Polymorphism and Myocardial Infarction in Pakistani Population","authors":"","doi":"10.47262/bl/7.1.20210111","DOIUrl":"https://doi.org/10.47262/bl/7.1.20210111","url":null,"abstract":"Polymorphism of tissue plasminogen activator(t-PA), gene-induced myocardial infarction (MI) is not well-defined in patients suffering from high blood pressure. Plasminogen activator generates the active enzyme by limited proteolysis of zymogen plasminogen to plasmin. Plasmin then degrades the fibrin network of a clot to form soluble product in thrombi. This action of t-PA can be suppressed by plasminogen activator inhibitor type1(PAI-1). This study determined the potential insertion/deletion of polymorphism that may contribute to the development of MI in Pakistani population. The study analyzed blood samples originating from three hundred and fifty patients with MI, two hundred and fifty healthy individuals as controls, and hundred hypertensive study subjects. The genomic DNA was extracted from the blood of each individual, and a Polymerase Chain Reaction was carried out to study polymorphism of Tissue plasminogen Activator (t-PA) gene. The Chi-square method was used to reveal the demographic differences among the groups. Cholesterol's higher levels, triglyceride, LDL-cholesterol, and lower HDL-cholesterol levels had been investigated in cases/patients in contrast with controls. In some cases, the input allele frequency (\"I\") is higher with MI (p = 0.0354). Diabetes, high blood pressure, family history, and smoking had a strong association with MI (p<0.01). No significant association between myocardial infarction and Insertion/Deletion (I/D) and Deletion/Deletion (D/D) polymorphism of t-PA gene, significant association found between Insertion/Insertion(I/I) and MI, which supports the results of previous MI studies.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75792730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0