Biomedical Letters最新文献

Incidence and risk factors associated with peptic ulcer in different cities of Punjab, Pakistan 巴基斯坦旁遮普省不同城市消化性溃疡的发病率和相关风险因素

Biomedical Letters Pub Date : 2024-07-11 DOI: 10.47262/bl/10.1.20240416

{"title":"Incidence and risk factors associated with peptic ulcer in different cities of Punjab, Pakistan","authors":"","doi":"10.47262/bl/10.1.20240416","DOIUrl":"https://doi.org/10.47262/bl/10.1.20240416","url":null,"abstract":"Peptic ulcers are severe digestive tract mucosal lesions. Worldwide, peptic ulcer disease (PUD) increases medical costs and morbidity. PUD is rising in Islamabad, Rawalpindi, and Karachi due to lifestyle and changes in diet. PUD is linked to drug and alcohol use, smoking, lack of exercise, and emotional stress. Infection with Helicobacter pylori, lack of sleep, and obesity also raise ulcer risk. This study examined the lack of PUD research in three main cities of Punjab (Bahawalpur, Multan, and Lahore). These populations were studied for PUD incidence, complications, risk factors, correlations with other diseases, medications, and blood group linkages. Data was collected by a cross-sectional study from November 2022 to June 2023 on peptic ulcer symptoms in participants aged 11 and above. Questionnaires collected demographic, medical, lifestyle, and nutritional data. Heart rate, blood pressure, and H. pylori status were checked. SPSS 25.0 was used to analyze data. Out of 200 participants, 47.5% were men and 52.5% women. There is no correlation between age, gender, or peptic ulcer prevalence in men or women. The sample comprised more rural than urban individuals. Both men and women with peptic ulcers had an O+ blood group. Women had more fever and belly pain. This study shows the prevalence and risk factors of peptic ulcers in urban Pakistan, highlighting the need for prevention and treatment. These findings highlight PUD across genders and suggest future research should consider sample size and self-reporting.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human monkeypox virus: A review on the globally emerging virus 人类猴痘病毒：全球新兴病毒综述

Biomedical Letters Pub Date : 2024-06-05 DOI: 10.47262/bl/10.1.20242161

{"title":"Human monkeypox virus: A review on the globally emerging virus","authors":"","doi":"10.47262/bl/10.1.20242161","DOIUrl":"https://doi.org/10.47262/bl/10.1.20242161","url":null,"abstract":"Monkeypox is a contagious complaint that affects both mortal and beast health and has lately come under the attention of all worlds. A genomic to developments in DNA sequencing, the genomic chart of the contagion has been known, which offers perceptivity into its elaboration and possible modes of transmission across different species. Understanding the complex mechanisms and studying the transmission of monkeypox is pivotal for disseminating the complaint’s spread from beast sources to mortal populations. Global frequency patterns demonstrate the complex connections between source hosts, vectors, and susceptible populations, and the deficit of exploration in Pakistan permits further disquisition into the possible public health counteraccusations. It's matter of great significance to completely explore the inheritable and antigenic parcels of this contagion, with its strong correlation with the etiology of monkeypox. PCR has proven to be a tool for accurate identification in the ongoing fight against this contagious disease. The variety of clinical signs and symptoms, which can vary from mild fever to severe lymphadenopathy, highlights the critical need for effective opinion and treatment strategies. Also, the maturity of available treatment options presently corresponds of probative care and antiviral specifics. Further exploration and cooperative sweats are necessary to increase our understanding and develop feasible therapeutics. This discussion highlights the need for a comprehensive plan to lessen the mischievous goods of monkeypox on the health of people and creatures. Beforehand discovery, visionary surveillance, and substantiation-grounded operation strategies must be put into practice.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in the application of biodegradable metal implants 生物可降解金属植入物应用的最新进展

Biomedical Letters Pub Date : 2024-02-14 DOI: 10.47262/bl/10.1.20231211

引用次数: 0

Recent progress in the application of biodegradable metal implants 生物可降解金属植入物应用的最新进展

Biomedical Letters Pub Date : 2024-02-14 DOI: 10.47262/bl/10.1.20231211

引用次数: 0

Bioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cells 肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)外周血单个核细胞的生物阻抗谱表征

Biomedical Letters Pub Date : 2023-10-06 DOI: 10.47262/bl/9.2.20230220

{"title":"Bioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cells","authors":"","doi":"10.47262/bl/9.2.20230220","DOIUrl":"https://doi.org/10.47262/bl/9.2.20230220","url":null,"abstract":"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling and chronic disease, importantly related to the current COVID-19 pandemic. Currently, there are no specific laboratory tests to directly diagnose ME/CFS. In this work, the use of impedance spectroscopy is studied as a potential technique for the diagnosis of ME/CFS. A specific device for the electrical characterization of peripheral blood mononuclear cells was designed and implemented. Impedance spectroscopy measurements in the range from 1 Hz to 500 MHz were carried out after the osmotic stress of the samples with sodium chloride solution at 1M concentration. The evolution in time after the osmotic stress at two specific frequencies (1.36 kHz and 154 kHz) was analyzed. The device showed its sensitivity to the presence of cells and the evolution of the osmotic processes. Higher values of impedance (around 15% for both the real and imaginary part) were measured at 1.36 kHz in ME/CFS patients compared to control samples. No significant difference was found between patient samples and control samples at 154 kHz. Results help to further understand the diagnosis of ME/CFS patients and the relation of their blood samples with bioimpedance measurements.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135351640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNAs: The next generation of cancer biomarkers microrna:下一代癌症生物标志物

Biomedical Letters Pub Date : 2023-08-13 DOI: 10.47262/bl/9.2.20230429

{"title":"MicroRNAs: The next generation of cancer biomarkers","authors":"","doi":"10.47262/bl/9.2.20230429","DOIUrl":"https://doi.org/10.47262/bl/9.2.20230429","url":null,"abstract":"MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that have been shown to be involved in a wide range of biological processes, including cancer. miRNAs are known to regulate the expression of genes, and their dysregulation has been linked to the development of cancer. In recent years a great deal of attention is received by miRNAs due to their potential as biomarkers for cancer. Biomarkers are measurable indicators of a biological state, and they can be used to diagnose, monitor, and treat diseases. miRNAs can be detected in biological fluids such as blood and saliva. This makes them ideal candidates for early cancer detection and monitoring. We herein reviewed current methods for the isolation of circulating miRNAs. Provide the most recent update about clinical trials aiming at using miRNAs as biomarkers for cancer. Additionally, we highlighted some pitfalls that should be realized to take advantage of the massive potential of miRNAs as a cancer biomarker. However, the potential of miRNAs as cancer biomarkers is very promising but advancements in factors such as miRNA isolation methods, and the type of samples are critical to incorporate miRNA-based diagnostic and prognostic markers in modern-day treatment regimens for cancer. This review concludes that miRNAs have enormous clinical significance as cancer biomarkers and recommends carefully selecting methods for the isolation of miRNAs based on the type of sample, and the downstream applications to generate clinically relevant results.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"11 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135310103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational 3D structure prediction followed by molecular docking to reveal the novel drug targets against ADA 计算三维结构预测，然后进行分子对接，揭示针对ADA的新药物靶点

Biomedical Letters Pub Date : 2023-08-11 DOI: 10.47262/bl/9.2.20230518

Noel Shamaun, M. I. Fareed, Keziah Shaheen, Muhammad Ameer Moaavia, Aksa Khalid, Sonana Nadeem, Sehrish Naz, M. Fareed, MA Moaavia

{"title":"Computational 3D structure prediction followed by molecular docking to reveal the novel drug targets against ADA","authors":"Noel Shamaun, M. I. Fareed, Keziah Shaheen, Muhammad Ameer Moaavia, Aksa Khalid, Sonana Nadeem, Sehrish Naz, M. Fareed, MA Moaavia","doi":"10.47262/bl/9.2.20230518","DOIUrl":"https://doi.org/10.47262/bl/9.2.20230518","url":null,"abstract":"Adenosine deaminase (ADA) is a functional enzyme that transforms deoxyadenosine and adenosine into deoxyinosine and inosine respectively. ADA deficiency causes toxic purine degradation byproducts to build up in the body, which has a particularly negative impact on lymphocytes and results in adenosine deaminase-deficient severe combined immunodeficiency. Different in silico techniques including threading, ab initio and homology modeling for 3D structure prediction were applied for the prediction of ADA structures. Following the three-dimensional structure prediction analyses, an extensive computational assessment of all predicted structures for reliability was performed. The overall quality factor of the predicted ADA structures was observed 62.45% in the predicted 3D models. A Ramachandran plot was created, and 94.80% of the residues were found in the allowed and favored regions of the protein structure plot. The molecular docking analyses were performed in order to identify the potential therapeutic medication targets against ADA. The virtually examined molecules through a virtually high throughput screening may have the ability the regulation the ADA activity. The least binding energy was calculated through the molecular docking analyses and the energy values were observed -8.7 Kcal/mol. The binding residues (Lys-367, Glu-424, Asp-422, Phe-381, Ile-377, Ser-430 and Glu-374) were conserved in all the interactional analyses of the docked complexes. Finding the effective binding domain in a protein three-dimensional structure is crucial for understanding of its structural makeup and determining its functions.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78148136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-visual and alerting impact of light on the physiology of human body 光对人体生理的非视觉和警报影响

Biomedical Letters Pub Date : 2023-07-30 DOI: 10.47262/bl/9.2.20230717

{"title":"Non-visual and alerting impact of light on the physiology of human body","authors":"","doi":"10.47262/bl/9.2.20230717","DOIUrl":"https://doi.org/10.47262/bl/9.2.20230717","url":null,"abstract":"The human body and brain are affected by light both visually and non-visually. Light has extraordinary impact on large group of physiological capabilities, and encompass neuroendocrine regulation, sleep, alertness, cognition, and ocular reflexes, as well as phase-shifting and synchronization of the circadian framework. The blue light exposure is significant for keeping living organisms, cognitive performance prosperity and sharpness. The human eyes may suffer from excessive exposure of the blue light. The lack of light has a negative impact on sleep quality and alertness as well as mood, seasonal affective disorder and neurocognitive cycles. Early morning exposure to strong light delays the peak of melatonin production and alters cortisol, GH, PRL, and nocturnal vasopressin emission. Metabolic capabilities including the reducing levels of glucose resistance and diminished insulin sensitivity are horribly affected by night light exposure. Type 2 diabetes risk increases in an old populace due to the elevation in night light exposure. Ladies presented to night-light moves had sporadic monthly cycles that were much of the time related to dysmenorrhea and metabolic disorder insulin obstruction and liberation of glucose digestion. Estrus cycles, ovulation, sperm production, implantation, and the development of pregnancy are also affected by the desynchronizing effect of altered light signals on the circadian peripheral clocks in female and male conceptive tissues. DNA is harmed directly by UVB radiation. The present effort is to investigate and summarize the non-visual and alerting effect of light on the physiology of the human body.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89908899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural insights and computational molecular docking to explore novel therapeutic drug targets of STAT3 结构洞察和计算分子对接探索STAT3新的治疗药物靶点

Biomedical Letters Pub Date : 2023-06-21 DOI: 10.47262/bl/9.1.20230421

{"title":"Structural insights and computational molecular docking to explore novel therapeutic drug targets of STAT3","authors":"","doi":"10.47262/bl/9.1.20230421","DOIUrl":"https://doi.org/10.47262/bl/9.1.20230421","url":null,"abstract":"Signal transducer and activator of transcription 3 (STAT3) is a transcription factor, that contains a DNA-binding domain, N-terminal domain, and SH2 domain. The dysregulation of STAT3 activity has been associated with various diseases, such as chronic inflammation and autoimmune disorders. In cancer, STAT3 is often constitutively activated and promotes tumor cell survival, proliferation, and immune evasion. Various bioinformatics approaches were employed to predict the 3D structure of STAT3, followed by a comprehensive evaluation of the predicted model. 3D predicted structure of the target protein revealed an overall quality factor of 94. 45%. It was also observed through the Ramachandran plot that 1.26% residues of the predicted structure of STAT3 were present in the outlier region of the protein structure. Computational docking studies were done to identify the novel drug targets against STAT3. The screened compound via high throughput virtual screening may have the potential to regulate the activity of STAT3. The lowest binding energy of -8.7 Kcal/mol was observed. His-457, Tyr-456, Lys-488, Pro-487, Gln-326, Leu-459, Lys-244, Gln-247 conserved residues were observed. The structural insight and functional determination of STAT3 depend on the identification of the potent binding domain in protein 3D structure.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82456590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells 长链非编码RNA RP5-821D11.7促进胶质瘤和胶质瘤干细胞样细胞的增殖、迁移和上皮-间质转化

Biomedical Letters Pub Date : 2023-06-13 DOI: 10.47262/bl/9.2.20230408

引用次数: 0