Journal of integrative cardiology最新文献

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Association between N-terminal Pro-Brain Natriuretic Peptide levels, glomerular filtration rate, and heart failure in the Multi-Ethnic Study of Atherosclerosis. 多民族动脉粥样硬化研究中n端前脑利钠肽水平、肾小球滤过率和心力衰竭之间的关系

Journal of integrative cardiology Pub Date : 2018-06-30 Epub Date: 2018-05-22 DOI: 10.15761/jic.1000246

Daneyal Syed, Stephanie Peshenko, Kiang Liu, Ramon Durazo-Arvizu, Sylvia E Rosas, Michael Shlipak, Mark Sarnak, David Jacobs, David Sickovick, João Lima, Richard Kronmal, Holly Kramer

{"title":"Association between N-terminal Pro-Brain Natriuretic Peptide levels, glomerular filtration rate, and heart failure in the Multi-Ethnic Study of Atherosclerosis.","authors":"Daneyal Syed, Stephanie Peshenko, Kiang Liu, Ramon Durazo-Arvizu, Sylvia E Rosas, Michael Shlipak, Mark Sarnak, David Jacobs, David Sickovick, João Lima, Richard Kronmal, Holly Kramer","doi":"10.15761/jic.1000246","DOIUrl":"https://doi.org/10.15761/jic.1000246","url":null,"abstract":"Background: This study examined the complementary prognostic role of NT-proBNP and eGFR for predicting heart failure (HF) in adults with and without chronic kidney disease (CKD) defined as eGFR<60 ml/min/1.73m2. Methods: We used data from the Multi-Ethnic Study of Atherosclerosis, a cohort of 6814 adults without baseline clinical cardiovascular disease. Five-year risk prediction of HF based on clinical HF risk variables (HFRV) plus NT-proBNP, eGFR or both was assessed using the C-statistic and the net reclassification index (NRI) after stratifying by CKD status. Results: Mean age at baseline was 62.3±10.3 years and CKD were present in 5.9%. A total of 39 and 180 HF events occurred in participants with and without CKD, respectively. Among adults with CKD, the C-statistic for HF risk prediction increased significantly (P =0.04) from 0.71 (95% CI 0.64, 0.78) with HFRV alone to 0.78 (95% CI 0.71, 0.85) with addition of NT-proBNP. In the non-CKD group, the C-statistic increased from 0.77 (95% CI 0.74, 0.80) with HFRV alone to 0.83 (95% CI 0.80, 0.85) with addition of NT-proBNP. Further addition of eGFR to the model did not alter the C-statistic regardless of CKD status. NRI improved by 23.1% and 10.2% in CKD and non-CKD, respectively, with the addition of NT-proBNP alone and findings were similar when both eGFR and NT-proBNP were both added to model. Conclusions: In adults without clinical cardiovascular disease, the addition of NT-proBNP but not eGFR to established HFRV improves HF risk prediction in adults with and without CKD.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38945564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Attitudes of inner city patients with cardiovascular disease towards meditation. 市中心心血管疾病患者对冥想的态度。

Journal of integrative cardiology Pub Date : 2016-01-01 Epub Date: 2016-03-10 DOI: 10.15761/JIC.1000152

Amit J Shah, Robert J Ostfeld

{"title":"Attitudes of inner city patients with cardiovascular disease towards meditation.","authors":"Amit J Shah, Robert J Ostfeld","doi":"10.15761/JIC.1000152","DOIUrl":"https://doi.org/10.15761/JIC.1000152","url":null,"abstract":"Objectives: Meditation is a stress reduction intervention that is of potential benefit to patients with cardiovascular disease, but its interest in inner city cardiology patients is unknown. We surveyed patients at an inner city cardiology clinic about their interest in learning meditation and the impact of stress on their lifestyles.Methods: A survey was distributed to 215 consecutive patients in an inner city cardiology clinic. Chi-square tests were used to compare those interested and not interested in meditation.Results: Of the 215 surveys, 54 were excluded because of 2 or more missing responses, leaving 161 for analysis. The mean age was 61 (+/- 16.5) years; 59% were female, 37% were black non-Hispanic, and 34% were Hispanic, and 18% were white. Overall, 46% expressed interest in learning meditation, and 64% agreed that less stress would facilitate living a healthy lifestyle. In subgroup analysis, the highest levels of interest in meditation classes occurred in patients who were younger than 65 years old (69% interested) and those who agreed that less stress would facilitate living a healthy lifestyle (71% interested).Conclusion: Many of the patients at an inner city cardiology clinic may have interest in learning meditation. Given the effects of stress in this population, clinical trials involving meditation are warranted.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34613397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of serum asymmetric dimethyl arginine levels in patients with coronary artery ectasia 冠状动脉扩张患者血清不对称二甲基精氨酸水平的评估

Journal of integrative cardiology Pub Date : 1900-01-01 DOI: 10.15761/jic.1000270

O. Çelik, B. Çabuk, E. Demirci, M. Kalçık, L. Bekar, M. Yetim, T. Doğan

{"title":"Assessment of serum asymmetric dimethyl arginine levels in patients with coronary artery ectasia","authors":"O. Çelik, B. Çabuk, E. Demirci, M. Kalçık, L. Bekar, M. Yetim, T. Doğan","doi":"10.15761/jic.1000270","DOIUrl":"https://doi.org/10.15761/jic.1000270","url":null,"abstract":"Background: Previous studies have demonstrated that asymmetric dimethyl arginine (ADMA) levels were strongly associated with cardiovascular diseases including endothelial dysfunction and atherosclerosis. Coronary artery ectasia (CAE) has been characterized as a localized or diffuse non-obstructive lesion of the epicardial coronary arteries with a luminal dilation exceeding 1.5-fold the normal adjacent segment or vessel diameter. The etiopathogenesis of this coronary enlargement is completely unknown, and its clinical significance also remains poorly understood. In this study, we aimed to investigate the role of serum ADMA levels in the pathogenesis of CAE. Methods: Twenty-seven patients with CAE (female: 51.9% ; mean age: 60.2 ± 7.4 years) and 29 controls (female: 55.2% ; mean age: 59.3 ± 6.9 years) with normal coronary flow were included in this study. CAE was classified according to its extent and number of vessels involved (Markis classification). Serum ADMA levels were determined by using enzymatic assays from venous blood samples. Results: There was no significant difference in terms of demographic parameters between the patients with CAE and the controls. Serum ADMA levels were higher in the CAE group, however this was not statistically significant (1.22 ± 0.13 vs. 1.16 ± 0.12 μM/L; p=0.091). In subgroup analysis, serum ADMA levels were significantly higher in patients with diffuse CAE as compared to controls (1.25 ± 0.11 vs. 1.16 ± 0.12 μM/L; p=0.024). Conclusion: Increased ADMA levels may play an important role in the pathogenesis of diffuse CAE. Further large-scale studies are required to determine the relationship between ADMA levels and CAE. These findings suggest that increased ADMA level may be associated with endothelial dysfunction leading to the development of CAE. *Correspondence to: Macit Kalcik, Department of Cardiology, Hitit University Faculty of Medicine, Çorum, Turkey, Tel: (90)536 4921789, E-mail: macitkalcik@yahoo.com","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67483516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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