Journal of integrative cardiology最新文献

{"title":"Procedural and long-term outcomes of stent post dilatation during primary percutaneous coronary interventions","authors":"S. Ayad, A. Zaki, M. Sadaka, A. E. Amrawy","doi":"10.15761/JIC.1000299","DOIUrl":"https://doi.org/10.15761/JIC.1000299","url":null,"abstract":"\u0000 \u0000 \u0000 The role of stent post dilatation (SPD) during primary percutaneous intervention (PPCI) is controversial. Currently there are no clear guidelines or consensus regarding when to perform SPD and it is left to the operator decision.\u0000 \u0000 \u0000 \u0000 The aim of this study was to evaluate the procedural and long terms outcomes of SPD during PPCI.\u0000 \u0000 \u0000 \u0000 We collected retrospectively data of 614 STEMI patients who presented to two tertiary centers during one year period. All patients underwent PPCI. We excluded patients with cardiogenic shock, prior CABG, severe LM disease. Patients were divided into two groups according to SPD procedure. Group 1: who had SPD included 424 patients (69.1%). Group 2: no SPD included 190 patients (30.9%). Both groups were well matched with regard to demographic data and lesion characteristics. Procedural outcomes and clinical outcomes at one year were collected.\u0000 \u0000 \u0000 \u0000 SPD patients had significantly higher incidence of no reflow during the procedure (33.7% in group 1 vs. 21.6% in group 2, P=0.026), but the final TIMI flow was similar between two groups. Also, there was no significant difference between two groups regarding other procedural outcomes as dissection, perforation, or cardiac death. After one year follow up SPD patients had significantly higher incidence of reinfarction (5.6% of group 1 vs. 1.5% in group 2, P=0.03) and significantly more target vessel revascularization (TVR) (16.7% in group 1 vs. 4.7% in group 2 P<0.001). There was no significant difference between the two groups regarding the incidence cerebrovascular stroke (CVS), heart failure or cardiac death.\u0000 \u0000 \u0000 \u0000 Our study shows that SPD during PPCI is associated with an increased risk of procedural no reflow and increased risk of reinfarction as well as need for TVR after 1 year follow up. Finally, SPD did not improve clinical outcomes after 1 year follow up. Nonetheless, large-scale randomized trials are required to establish the role of SPD during PPCI.\u0000 \u0000 \u0000 \u0000 Type of funding sources: None.\u0000","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49212028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic thromboemboli pulmonary hypertension in patient with eisenmenger syndrome and large patent ductus arterius","authors":"K. T. Tran, L. Pham, L. H. Quang","doi":"10.15761/jic.1000305","DOIUrl":"https://doi.org/10.15761/jic.1000305","url":null,"abstract":"Chronic thromboemboli pulmonary hypertension (CTEPH) is \u0000 the group 4 of pulmonary hypertension, related to clot blocking \u0000 in the pulmonary arteries in lungs. Patients with CTEPH have \u0000 varies typical or atypical symptoms, which are not specific. So \u0000 the diagnosis of CTEPH is a challenge to clinicians [1,2]. Chronic \u0000 thromboembolic pulmonary hypertension (CTEPH) most \u0000 often results from obstruction of the pulmonary vascular bed \u0000 by non-resolving thromboemboli. Chronic thromboembolic \u0000 pulmonary hypertension can arise in patients after acute or \u0000 recurrent pulmonary emboli or deep venous thrombosis. \u0000 The incidence of CTEPH is not known, but recent studies \u0000 suggest that 1% to 3.8% of patients develop the condition \u0000 within 2 years of acute pulmonary embolism [2]. 64-row CT \u0000 of the pulmonary arteries can yield diagnostically excellent \u0000 image quality and can delineate the typical angiographic \u0000 findings in CTEPH such as complete obstruction, bands and \u0000 webs and intimal irregularities as accurate and reliable as \u0000 DSA. With additional thick MIPs it is possible to get an instant \u0000 overview of the entire pulmonary arterial tree, which helps to \u0000 demonstrate the pathology related of CTEPH similar to DSA \u0000 [3] when the diagnosis of CTEPH is confirmed, anticoagulant \u0000 should be used. Pulmonary thromboendarectomy is the most \u0000 optimal therapeutic beside Pulmonary artery Balloon dilation. \u0000 We found a rare case diagnosed CTEPH with Eisenmenger \u0000syndrome, large PDA by CT scanner and Echocardiography.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43482728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-Cerebral infarction syndrome: definition, diagnosis, pathophysiology, and treatment","authors":"M. Habib","doi":"10.15761/jic.1000308","DOIUrl":"https://doi.org/10.15761/jic.1000308","url":null,"abstract":"Acute ischemic stroke and coronary artery disease are the major causes of death worldwide. The prevalence of coronary artery disease has been reported in one fifth of stroke patients. Although high incidence rate of acute myocardial infarction after acute ischemic stroke and the high risk of acute ischemic stroke after myocardial infarction has been reported in several studies. Any acute or recent problem in the heart or brain that could result in an acute infarction of the other. In this review we describe the definition and new classification of the cardio-cerebral infarction syndrome with 3 subtypes that reflect the pathophysiology and treatment options. *Correspondence to: Mohammed Habib, Cardiology DepartmentAl Shifa Hospital, Gaza, Palestine, E-mail: cardiomohammad@yahoo.com","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amiodarone induced ischemic optic neuropathy: a case report","authors":"N. Ismail, M. Royle, M. Payne, A. Syed, Abdalazeem Ibrahem","doi":"10.15761/jic.1000309","DOIUrl":"https://doi.org/10.15761/jic.1000309","url":null,"abstract":"Amiodarone is an anti-arhythmic drug that is used commonly to treat ventricular and supra ventricular arrhythmia [1]. Its use has increased over the past years due to its efficacy at restoring sinus rhythm and its use in cardiac resuscitation [2]. Despite its increasing popularity, amiodarone has been associated with various side effects. The side effects of amiodarone are due to its cationic amphophilic properties which allow interactions with lipid compounds which accumulate in multiple tissues [3]. Among the tissues affected is the optic nerve which can give rise to optic neuropathy. The reduction in visual acuity has been reported to be significant and permanent, which massively effects patient’s quality of life. Nevertheless, making the diagnosis of amiodarone induced optic neuropathy (AON) is challenging due to the lack of diagnostic tests and is mostly a clinical diagnosis. Furthermore, the alternative differential diagnosis of non-arteritic ischaemic optic neuropathy (NAION) is similarly made on clinical grounds. This makes the diagnosis of AON highly dependent on the typical clinical features seen in AON which makes it a diagnostic challenge when one or more atypical features are present in the clinical presentation. In this case, we present the diagnostic challenge in a case of amiodarone induced ischemic optic neuropathy (AON) which occurred in a 55-year-old man over an atypically shorter time course.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Garcinia kola seed supplementation reduces the blood pressure in patients with high normal blood pressure or grade I hypertension: a single center, single arm non - randomized clinical trial","authors":"Liliane Mfeukeu Kuate, Rolande Carine Negue Kuate, Dieudonné Danwe, E. Nnanga, A. Ménanga, E. Sobngwi","doi":"10.15761/jic.1000310","DOIUrl":"https://doi.org/10.15761/jic.1000310","url":null,"abstract":"","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of social and professional support on health-related quality of life after hospitalization due to neurological or cardiovascular diseases before and during Covid-19 in Germany: Results of a patient survey","authors":"Annemarie Feibel, E. Swart, Friederike von Wangenheim, K. Drewitz","doi":"10.15761/jic.1000311","DOIUrl":"https://doi.org/10.15761/jic.1000311","url":null,"abstract":"","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to peak effect of aspirin-induced platelet inhibition and ex vivo effects of desmopressin: an observational study","authors":"U. Schött, S. Sigurjonsdottir, Owain D Thomas, T. Kander","doi":"10.15761/jic.1000307","DOIUrl":"https://doi.org/10.15761/jic.1000307","url":null,"abstract":"Objective: To investigate time to maximal platelet inhibition after an oral loading dose of ASA. The effect of ex vivo reversal platelet inhibition by desmopressin (DDAVP) was also studied. Methods: Ten healthy volunteers were given a 300 mg ASA-tablet. Blood was sampled at 0, 15, 30, 60, 120 and 180 minutes. DDAVP was added to the samples taken at 120 minutes. Samples were analysed with a Multiplate® platelet aggregometer (MEA) using arachidonic acid (AA), collagen and thrombin aggregation agonists. Results: Platelet inhibition was observed in the sample activated by AA at 15 minutes but not until 120 minutes in the samples activated by collagen. No platelet inhibition was seen in the samples activated by thrombin. The median time to maximal AA-induced platelet inhibition of <30 U was 30 (interquartile range 15-90) minutes. Ex vivo DDAVP did not reverse platelet inhibition. Subgroup analysis did not show any gender differences. Conclusions: ASA induces a strong platelet inhibition within 30 minutes of oral ingestion, with no gender differences. Ex vivo DDAVP did not reverse ASA’s platelet inhibition. (Less)","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess epicardial fat volume in post- menopausal women is associated with increased cardiovascular structural and functional abnormalities","authors":"M. E. Shahawy, Sukanya Mohan, A. Sabatini","doi":"10.15761/jic.1000306","DOIUrl":"https://doi.org/10.15761/jic.1000306","url":null,"abstract":"Epicardial fat volume (EFV) has been associated with an increase in cardiovascular structural and functional abnormalities (CVSFA). The purpose of the study is to assess whether a stepwise excess increase in EFV is associated with a proportional increase in CVSFA. We screened 276 asymptomatic individuals, ages 50 to 89, for cardiovascular disease (CVD) risk using the Rasmussen Risk Score (RRS) and a CT scan for the coronary artery calcium score (CACS) and EFV determination. The RRS scoring system consists of 10 tests; 7 of which are vascular and 3 are cardiac. Additional tests included fasting blood sugar, fasting lipid profile, CRP, Pro-BNP, waist circumference, and BMI. Of the 276 total subjects that were asymptomatic of cardiac symptoms, 144 were post-menopausal women (52.2%). These 144 female subjects were further divided into 5 groups based on their EFV: Group 1 (31 subjects) with an EFV <69 cm 3 , Group 2 (45 subjects) with an EFV between 70 cm 3 and 94 cm 3 , Group 3 (21 subjects) with an EFV between 95 cm 3 and 119 cm 3 , Group 4 (33 subjects) with an EFV between 120 cm 3 and 144 cm 3 , and Group 5 (14 subjects) with an EFV of 145 cm 3 and greater. The statistical analysis used to determine statistical significance of the study results included ANOVA, T-Test and Chi-Square analysis. Based on our data, excess epicardial fat volume is associated with earlier structural and functional abnormalities in comparison to normal epicardial fat volume levels.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67484550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel missence mutation in the transglutaminase-1 gene in an autosomal recessive congenital ichthyosis patient","authors":"A. A. Shadmehri, J. Bazzaz, M. Darbouy, Mohammad Amin Tabatabaiefar","doi":"10.15761/jic.1000283","DOIUrl":"https://doi.org/10.15761/jic.1000283","url":null,"abstract":"Autosomal recessive congenital ichthyosis (ARCI) is a rare hereditary disorder of cornification. ARCI is a congenital recessive skin disorder characterized by generalized scaling and hyperkeratosis. Mutations in the transglutaminase-1 (TGM1) gene, which encodes for the epidermal enzyme transglutaminase-1, are one of the causes of ARCI. The transglutaminase 1enzyme, is critical for the assembly of the cornified cell envelope in terminally differentiating keratinocytes. In this study a nine-year old boy who presented with ARCI. The whole exome sequencing WES of transglutaminase-1 gene was investigated. The patient harbored a homozygeous mutation of C.1165T>C transition located in exon8 of TGM1 gene, resulting in the substitution of argenine by serine at amino acid position 389. The parents and one of the sibs were hetrozygeous for the variant and one was homozygeous for wild allele. The mutated allele was not found in controls. This mutation localized in this study correspond to the core catalytic core domain of enzyme, based on provean algorithm, the variant at position level was predicted to decrease TGM1 Enzyme activity by producing an unstable protein.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67483921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iliocaval stent reconstruction following inferior vena cava filter associated chronic thrombotic occlusion in a patient with factor v leiden mutation – a case report and review of literature","authors":"Khan O Mohammad, J. C. Rodriguez, A. Zafar, T. Siddiqui","doi":"10.15761/JIC.1000295","DOIUrl":"https://doi.org/10.15761/JIC.1000295","url":null,"abstract":"Iliocaval occlusion is an increasingly recognized complication following inferior vena cava (IVC) filter placement with an incidence ranging from 3-30%. While there is evidence that this condition can be managed with endovascular stenting, there has been limited discussion regarding management of patients with iliocaval occlusion who also have hereditary thrombophilias. We describe a case of a 44-year-old male with Factor V Leiden mutation (FVL) who developed IVC filter-related post-thrombotic iliocaval occlusion and was treated using endovascular stenting. This case aims to highlight the utility of endovascular stenting in patients with thrombophilias who develop iliocaval occlusion and discuss the relevant literature.","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67483962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}