International journal of translational science最新文献

{"title":"Porphyromonas gingivalis Infection is Associated with Increased Vascular Inflammation in Patients with and Without Coronary Artery Disease","authors":"Courtney Levit, Hannah Wheeler, Daniel Sindelar, Conville Brown, Nicolas Chronos, Marc S. Penn","doi":"10.13052/ijts2246-8765.2024.026","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.026","url":null,"abstract":"Vascular inflammation is a critical measure of risk for major adverse cardiac events in patients with and without known coronary artery disease. It is recognized that patients with poor oral hygiene tend to have an increased prevalence of coronary artery disease and myocardial infarction. Porphyromonas gingivalis (PG) is the keystone pathogen leading to periodontal disease. Despite evidence suggesting a link between active PG infection and coronary artery disease, there is limited data investigating whether PG can contribute to increased markers of vascular inflammation in patients with coronary artery disease. In this study, we studied 112 consecutive patients who presented at a community preventive cardiology clinic who consented to be assessed for the presence of PG. Subjects were enrolled in a mouth along assessment with measures of vascular inflammation, which was part of their routine clinical care. The average age of patients was 70.4 ± 8.5 years with 48.6% of the patients positive for PG and 20.5% with a history of coronary artery disease (CAD). The distribution of PG positivity was 48.3% and 34.8% in patients without and with a history of CAD, respectively. Patients with CAD have significantly greater levels of high sensitivity C-reactive protein (hsCRP_ (1.3 ± 0.3 vs. 3.2 ± 1.1 mg/dL, p = 0.04) and MPO (245.1 ± 19.4 vs. 371.4 ± 39.1 pmol/L, p = 0.003). Patients without a history of CAD, only Myeloperoxidase (MPO) was significantly increased. Statin use was significantly greater in those patients with a history of CAD. Interestingly, statin use tended to be greater in PG+ patients (71% vs. 62%) regardless of CAD status. The data from this early study demonstrate a link between active PG infection and increase in markers of vascular inflammation, especially in patients with established CAD. The findings suggest PG as a marker of cardiovascular risk, especially in patients with residual inflammatory risk.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Term Rejuvenation of Facial Skin by Transplantation of Autologous Stromal Vascular Fraction and Pre-conditioned Matrix: A Clinical Study","authors":"Phu N. Cuylits, J. L. Nizet, C. Waxweiler, A. Fouarge, B. Dirat, V. Santran","doi":"10.13052/ijts2246-8765.2024.021","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.021","url":null,"abstract":"Background: For skin rejuvenation, today no procedure describes a specific treatment of the extracellular matrix (ECM) combined with stromal vascular fraction (SVF) from adipose tissue. A new product AmeaCell® , allows SVF extraction and ECM preconditioning in hypoxic conditions. Hypoxia significantly increased the adhesion of adipose derived stem cells and enhace their proliferation and differentiation. \u0000Objective: This clinical study aimed to evaluate safety and efficiency of this new procedure, over one year. \u0000Material and methods: The study was performed on 23 patients. After a liposuction and fat proceed, SVF and the matrix were extracted and preconditioned following Ameacell® procedure, then injected into wrinkles. Results were scored for WSRS and GAIS scales at 6, 12 months after surgery. \u0000Results: No serious adverse reactions occurred. Regarding efficiency, whatever the baseline, the Ameacell® procedure triggered an improvement of WSRS score in most patients after one year follow-up: 75% of patients when WSRS score at baseline 2; 83% of patients when WSRS score at baseline 3. This is in accordance with the GAIS scored by both investigators and patients. \u0000Conclusion: This one-year follow-up clinical study using Ameacell® procedure, exhibited an improvement of facial skin appearance.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"111 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Could Explain Delay for Age-Reversal Clinical Trials?","authors":"William Faloon","doi":"10.13052/ijts2246-8765.2024.024","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.024","url":null,"abstract":"This is a commentary article using data reported by the United States Drug Approval (FDA) system for clinical trials. The text surmised reasons for this delay. The data show continued delay to impact drugs reaching patients. Instead of increasing drug approval, the statistics showed a trend of increased numbers of drug on hold. The reason for these delays need to be evaluated, and perhaps to apply new technologies to evaluate the data.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"101 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant Medicine, Psychedelics and the Inner-Sciences of Mental Wellness: Implications for Healthy Longevity and Rejuvenation","authors":"Jeffrey L. McNairy","doi":"10.13052/ijts2246-8765.2024.022","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.022","url":null,"abstract":"Rythmia Life Advancement Center is the first and currently only medically licensed Ayahuasca center in the world. Rythmia is helping to bridge the gap between the Western medical model of health care with the indigenous healing modalities of Latin America. The “Rythmia Way” program uses a variety of modalities, in addition to Ayahuasca, to help individuals find meaning in their lives and overcome depression, anxiety, trauma and PTSD. The quickly growing field of psychedelic medicine is in need of a format to facilitate the use of these substances in the most effective manner. The rapid rate of healing can pose challenges for traditional providers, which is why Rythmia is at the forefront of this field and is collecting hundreds of thousands of data points to effectively tailor and manage a safe plant medicine experience. Self-reported patient data, combined with observational program participation is collected and evaluated to enable individuals to achieve the most effective outcomes regarding their goals and intentions. \u0000Mental health issues are becoming the number one health concern in the post-pandemic world. Depression and anxiety are preventing millions from living a productive life. Mental health issues are the leading cause of suicide globally. The information collected at Rythmia Life Advancement Center in Costa Rica shows a programmatic strategy that is effective at reducing depression, anxiety, and symptoms related to trauma, based on self-reported participant exit surveys. The traditional routes for individuals suffering from these mental health conditions (psychotropic medication, therapy, hospitalization, etc.), are not producing the outcome results necessary for society to thrive. Rythmia L.A.C. is providing a blueprint for the healthcare industry to follow which addresses these problems in a quick and efficient manner. \u0000Rythmia Life Advancement Center is a licensed medical facility from the Costa Rican Ministry of Health, founded by Gerard Powell, and located in the Blue Zone Province of Guanacaste, Costa Rica. Mr. Powell was a self-made multimillionaire who had developed a severe drug and alcohol problem and lived a self-destructive lifestyle up until the age of 50. After 2 failed suicide attempts, an unsuccessful 60-day inpatient stay at a drug rehab, and 5 years of therapy riddled with relapse and depression, Mr. Powell discovered Ayahuasca as a treatment modality that showed benefit to mitigate his mental health issues. The lifechanging impact of Ayahuasca on Mr. Powell’s life was transformational and took place over a very short period of time. Mr. Powell was so enthusiastic about his profound level of healing that he wanted to share what he experienced with the world. In July of 2014, he enlisted the help of his therapist, Dr. Jeff McNairy, to participate in the Ayahuasca experience, and to help establish the first and only medically licensed Ayahuasca center in the world. Upon receiving Dr. McNairy’s personal breakthroughs w","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"112 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Stem Cell and Regenerative Therapies in Autoimmune and Metabolic Diseases: Implications for Healthy Longevity","authors":"Jonathan R. T. Lakey, Michael Alexander, Mike K. S. Chan, Yuriy Nalapko, Michelle B. F. Wong, D. Cox","doi":"10.13052/ijts2246-8765.2024.023","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.023","url":null,"abstract":"Type 1 diabetes (T1D) is an important autoimmune disease characterized by the destruction of insulin-secreting β-cells in pancreatic islets of Langerhans resulting in hyperglycemia. More than 1.3 people in United States are suffering from T1D, and current treatments have failed to offer a lasting cure. T1D management requires lifelong daily injections of exogenous insulin to control blood sugar levels and secondary complications of this progressive disease, unless receiving pancreas or islet transplant with its associated risks from immunosuppression. \u0000Peptide therapy aims to alter the response of cells by inducing or reducing cellular responses appropriate to the type of peptides used. The aim of this study was to investigate the protective effect on autoimmunity of Mito Organelle (MO) Peptides on the function and survival of peptides on pancreatic β-cells in non-obese diabetes (NOD) mice model. MO peptide product (Biopep Inc) is a mixture of organ-specific cellular extracts that were extracted from organ specific cells, homogenized, filtered, and sterilized. \u0000MO Peptides administered twice-weekly (IM) over 17-week period in NOD mice model were able to prevent the progression of autoimmune-mediated β–cell destruction and the onset of hyperglycemia (blood glucose >300 mg dL) as compared to the saline treated control mice. \u0000These studies will help understand the mechanisms of immunological protection in T1D and may serve as a model for other autoimmune disorders with peptides.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restore Veto Property in Low Dose Aspirin/ASA Treated Preeclampsia Placenta Mesenchymal Stem Cells: Insights Into ASA-mediated Clinical Response*","authors":"Kimone A. Powell, L. Sherman, Bobak Shadpoor, Shauna F. Williams, P. Rameshwar","doi":"10.13052/ijts2246-8765.2024.025","DOIUrl":"https://doi.org/10.13052/ijts2246-8765.2024.025","url":null,"abstract":"Preeclampsia (PE) is a pregnancy complication characterized by elevated blood pressure, proteinuria, and other laboratory abnormalities. PE affects 2–8% of pregnancies globally and can lead to preterm birth and other complications for the mother and fetus. Successful pregnancy depends on the ability of the mother’s immune system to tolerate the allogeneic fetus. However, in PE, this immune tolerance is exacerbated by inflammation. Transforming growth factor β (TGF-β) is important to retain an immune balance in healthy pregnancy. In PE, TGF-β level is reduced, with an imbalance of the T-cell subset pool to favor inflammation. Omics studies by our group reported an increase in TGF-β signaling when PE-derived placenta mesenchymal stem cells (P-MSCs) were treated with low dose aspirin (ASA). This correlated with increased cycling quiescence and epigenetic changes, resembling healthy P-MSCs. This study tested the hypothesis that ASA could restore the veto property of P-MSCs to mitigate inflammation. ASA (10 mM) treated P-MSCs from PE and healthy placentas increased TGFβ1 and its receptor. The ASA treated MSCs, when added as third-party cells to a one-way mixed lymphocyte reaction, suppressed T-cell proliferation. Prediction studies with omics data indicated that ASA-mediated TGFβ signaling could explain ASA-induced blunting of cell apoptosis. Together, the findings support ASA-mediated expression of TGFβ1 and its receptor on P-MSCs from PE to restore the ability to be licensed as immune suppressor to mitigate PE inflammation. The findings provide new insight into the benefit of ASA treatment for PE.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"105 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural characteristics of periodontal ligaments in the pig model with experimental periodontitis.","authors":"Mojdeh Eftekhar,&nbsp;Lauren Lee,&nbsp;Atriya Salamati,&nbsp;Zi-Jun Liu","doi":"10.36879/IJTS.21.000106","DOIUrl":"https://doi.org/10.36879/IJTS.21.000106","url":null,"abstract":"<p><p>To investigate how the structure of Sharpey's fibers in the periodontal ligaments (PDL) were affected by experimental periodontitis in a young pig model, 7 were periodically inoculated with four types of bacteria and a ligature around the last maxillary molar for 8 weeks to induce periodontitis (PG), and 10 served as controls (CG). The harvested molar blocks were sectioned coronally and stained with either hematoxylin & eosin (H&E) or Sirius Red (SR). The H&E-stained images were first reviewed. Then, images of each adjacent SR-stained sections were captured at the region close to the apex of mesial roots under polarizing light microscopy. Sharpey's fiber numbers in each bundle, total bundle numbers, connection of the bundle to the cementum and alveoli, as well as bundle angulations to the molar long axis were quantified in the defined area 500μm apical to the root apex. Compared to CG, PG showed the following features: 15.13% less total bundle number; 17.8% less bundle size; significantly less connected fiber bundles; 9.2% more interrupted fiber bundles; and 3.85% more oriented toward the cervical in the bundle angulation. These results suggest that experimental periodontitis alters the PDL structure, leading to more interruptions of Sharpey's fiber attachments to the cementum.</p>","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40480114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum testosterone and its binding globulin during senescence","authors":"","doi":"10.36879/ijts.21.000105","DOIUrl":"https://doi.org/10.36879/ijts.21.000105","url":null,"abstract":"Purpose: The aim of this work is to analyze age-related changes in providing tissues with steroid hormones (androgens [A], mainly testosterone [T])\u0000by means of specific steroid transport protein of the blood (testosterone-binding globulin, [TeBG]) and to propose new informative approach for\u0000reliable early diagnostics of impending hypogonadism in elderly men.\u0000Methods: Methods are analytical.\u0000Results and conclusions: Authors develop new approach for assessment of age-related physiological changes in supply of steroids (in particular\u0000T) by specific transporting them testosterone-binding globulin (TeBG). This work substantiates the following statements: a) existing common beliefs\u0000about circulating A (including ‘exchangeable’ and ‘free’ testosterone levels – [Texch], [Tfree]) do not match their true state of affairs concerning\u0000presence, interaction, interchange and transmission of А into target cells; b) blood pool of ‘ТeBG-Т-ТeBG’-complex should correctly be called the\u0000‘functional Т-dimer’ (FTD); c) venous blood FTD-content ‘mirrors’ the ‘potentially active’ (bioavailable) testosterone molecules conc. ([Tact]) in\u0000arterial blood (i. e. which capable to be transferred into target cells from capillaries, [Tact] = [FTD] ); d) age-dependent rise in circulation of ‘nonfunctional’ TeBG-molecules (ТеBGnf) caused by accumulation with age the ‘senescence factor’ which inhibits needed FTD-formation; e) [FTD]-\u0000measurements can be useful for early diagnosis of impending hypogonadism in elderly men","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48904897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How excess dietary saturated fats induce insulin resistance","authors":"","doi":"10.36879/ijts.21.000104","DOIUrl":"https://doi.org/10.36879/ijts.21.000104","url":null,"abstract":"Excess dietary saturated fatty acids can increase the risk of and progression of type 2 diabetes. We will explore the mechanisms by\u0000which excess saturated fatty acids can reduce insulin sensitivity, suppress insulin production of beta cells through glucolipotoxicity,\u0000raise blood glucose, and lessen energy production in cells. Higher dietary saturated fatty acids, especially palmitic acid, can reduce\u0000the number of insulin receptors to approximately one-half of their normal number. This contributes to hyperinsulinemia, elevated\u0000blood glucose, and reduced mitochondrial energy production. Higher dietary saturated fatty acids also interfere with the signaling\u0000between the insulin receptor and the glucose transporter. This reduces the amount of glucose that can enter the cell and increases the\u0000risk of elevated blood glucose. Excess dietary saturated fatty acids have been found to suppress insulin production of beta cells and\u0000also to stimulate apoptosis of beta cells. Higher dietary saturated fatty acids can reduce the ability of the cells to produce glycogen\u0000from glucose, thus lowering energy storage. Finally, higher dietary saturated fatty acids can reduce mitochondrial energy production.\u0000Conclusion: Reducing dietary saturated fatty acids may help clear blood of excess glucose in type 2 diabetes.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47539388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Metal-Containing Polymers to Combat Cancer","authors":"","doi":"10.36879/ijts.21.000103","DOIUrl":"https://doi.org/10.36879/ijts.21.000103","url":null,"abstract":"","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46556381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}