International journal of translational science最新文献

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Pharmacology of Nilotinib in the Treatment of Parkinson’s Disease Caused by New Pathology 尼洛替尼治疗新病理引起的帕金森病的药理学研究

International journal of translational science Pub Date : 2021-07-13 DOI: 10.36879/ijts.21.000102

{"title":"Pharmacology of Nilotinib in the Treatment of Parkinson’s Disease Caused by New Pathology","authors":"","doi":"10.36879/ijts.21.000102","DOIUrl":"https://doi.org/10.36879/ijts.21.000102","url":null,"abstract":"Parkinson’s disease (PD) is still not curable and controllable, which needs to find new pathology of PD and effective drugs to treat.\u0000To study the new pathology of PD, ten rats composed of half sex as an experimental group were injected with 5 μg α-synuclein\u0000monomer into the substantia nigra in every rats. In the second day after injection, the four main symptoms of PD appeared in the\u0000rats to demonstrate that the standard animal models of PD were established and lasted at least for more than 3 months or became\u0000deteriorating of PD. For the drug experiments of rats by using the same 5 μg α-synuclein injected into the substantia nigra, one\u0000week later, after the symptoms stabilized, every experimental rats were intraperitoneally administered with 0.3 mg nilotinib solution\u0000every morning once a day for 30 consecutive days. Importantly, these treatments could eliminate all symptoms of PD, and then the\u0000rats gradually showed no stiffness, shaking, foot flipping, or dragging and exhibited strong feet, the ability to walk and run, and\u0000smooth fur. After 30 days, treatments were stopped, and the rats continued to show no symptoms of PD and healthily survived. Since\u0000the symptoms of PD were induced by injecting 5 μg α-synuclein into the rats, now no symptoms of PD indicated the elimination of\u0000α-synuclein monomer in the rats under the help of nilotinib. The rat experimental results had demonstrated the PD caused by injecting\u00005 μg α-synuclein was a new pathological process by α-synuclein to block dopamine functional channels (DFCs) reducing the values\u0000of functionalization factor (f) and functional dopamine (GD) content, independent on the content of dopamine and the apoptosis\u0000of dopamine neurons in the rats. The pharmacology of nilotinib used to cure the PD caused by new pathology was by clearing\u0000α-synuclein to unblock DFCs and increase the values of f and GD content..","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41656458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Heart Rate Monitoring to Manage Training Loads and Assess Injury Risk in Male University Soccer Players 使用心率监测来管理训练负荷和评估男性大学足球运动员受伤风险

International journal of translational science Pub Date : 2021-07-04 DOI: 10.36879/ijts.21.000101

{"title":"Use of Heart Rate Monitoring to Manage Training Loads and Assess Injury Risk in Male University Soccer Players","authors":"","doi":"10.36879/ijts.21.000101","DOIUrl":"https://doi.org/10.36879/ijts.21.000101","url":null,"abstract":"Introduction: Injuries are a common occurrence in team sports and have negative consequences on team success. As sudden increases\u0000and decreases in training loads increase injury likelihood, monitoring training loads is essential. The acute:chronic workload ratio\u0000has been established as a useful tool for identifying periods of increased injury likelihood. Markers such as the session Rating of\u0000Perceived Exertion (sRPE) and GPS-based indices are commonly used variables when calculating acute:chronic workload ratios. To\u0000date no work has been presented involving heart rate-based measurements. The goal of this research project was to investigate the\u0000use of heart rate monitoring to manage training loads and assess injury likelihood in university soccer players.\u0000Methods: Training load measures from fourteen university male soccer players were collected over a period of seven weeks. Three\u0000heart-rate based measurements were monitored including Bannister’s TRIMP, Morton’s TRIMP and Stagno TRIMP. sRPEs were\u0000also measured and acute:chronic workload ratios were calculated for each monitored variable. A total of 256 individual training\u0000observations were collected from 22 training sessions with a mean duration of 85 minutes.\u0000Results: Results demonstrated that using the acute:chronic workload ratio for heart rate-based training loads such as Bannister’s\u0000Training Impulse accurately explained variation in injury likelihood (R2\u0000=0.86-0.89).\u0000Conclusion: The results of this study suggest that monitoring of acute:chronic workload ratios using HR indices such as Bannister’s\u0000TRIMP or Stagno TRIMP appears to be a practical method to assess injury likelihood in male university soccer players.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48953792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratinocyte Induced Differentiation of Mesenchymal Stem Cells into Dermal Myofibroblasts: A Role in Effective Wound Healing. 角质细胞诱导间充质干细胞分化为真皮肌成纤维细胞：在伤口有效愈合中的作用。

International journal of translational science Pub Date : 2016-01-01 DOI: 10.13052/ijts2246-8765.2016.002

Pravin J Mishra, Prasun J Mishra, Debabrata Banerjee

{"title":"Keratinocyte Induced Differentiation of Mesenchymal Stem Cells into Dermal Myofibroblasts: A Role in Effective Wound Healing.","authors":"Pravin J Mishra, Prasun J Mishra, Debabrata Banerjee","doi":"10.13052/ijts2246-8765.2016.002","DOIUrl":"10.13052/ijts2246-8765.2016.002","url":null,"abstract":"We have previously demonstrated that human mesenchymal stem cells (hMSCs) migrate toward human keratinocytes as well as toward conditioned medium from cultured human keratinocytes (KCM) indicating that the hMSCs respond to signals from keratinocytes [1]. Using fluorescently labeled cells we now show that in vitro hMSCs appear to surround keratinocytes, and this organization is recapitulated in vivo. Incubation of hMSCs with KCM induced dermal myofibroblast like differentiation characterized by expression of cytoskeletal markers and increased expression of cytokines including SDF-1, IL-8, IL-6 and CXCL5. Interaction of keratinocytes with hMSCs appears to be important in the wound healing process. Therapeutic efficacy of hMSCs in wound healing was examined in two animal models representing normal and chronic wound healing. Accelerated wound healing was observed when hMSCs and KCM exposed hMSCs (KCMSCs) were injected near wound site in nude and NOD/SCID mice. Long term follow up of wound healing revealed that in the hMSC treated wounds there was little evidence of residual scarring. These dermal myofibroblast like hMSCs add to the wound healing process. Together, the keratinocyte and hMSCs morphed dermal myofibroblast like cells as well as the factors secreted by these cells support wound healing with minimal scarring. The ability of hMSCs to support wound healing process represents another striking example of the importance of keratinocyte and hMSCs interplay in the wound microenvironment resulting in effective wound healing with minimal scarring.","PeriodicalId":91519,"journal":{"name":"International journal of translational science","volume":"2016 1","pages":"5-32"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902180/pdf/nihms785579.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34635910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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