Integrative medicine international最新文献

{"title":"Effects of a Food Ingredient Group on Oxidative Stress in Lead-Poisoned Mice","authors":"Yu-Xiu Shang, Yi Zhao, Hong-Yan Qiu, Jingyu Chang, Yu-zhu Chen, Hui-ying Zhang","doi":"10.1159/000433469","DOIUrl":"https://doi.org/10.1159/000433469","url":null,"abstract":"Objective: According to the principle of compatibility of traditional Chinese medicine, a food ingredient group was used to treat lead poisoning of mice. Methods: Ninety Kun-Ming male mice (18-20 g) were randomly divided into the following 6 groups: negative control group (NCG); lead acetate model group (LAG); positive drug group (PDG), and test substance groups with low-, medium-, and high-dose food ingredient group (LDG, MDG, and HDG). The test substance groups were fed with oral gavages containing the food ingredient group. The PDG were fed with gavages containing dimercaptosuccinic acid solution. The LAG and NCG were fed with gavages with deionised water. Results: One month later, both the medium and the high dose of the ingredient group had effectively increased the superoxide dismutase and glutathione peroxidase activity and decreased the malondialdehyde content in the blood, liver, kidney, and brain of the tested mice (p < 0.05). Compared to the PDG, we found that the MDG and HDG recovery from the lead-induced oxidative stress might be attributed to the induction of antioxidant enzyme sensitivity by the dietary supplement. Conclusion: Our findings provide evidence that the proposed food ingredient group has significant impacts on recovering from oxidative damage in lead-poisoned mice.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"49 - 55"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000433469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64878401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of School Environment on Children's Respiratory Health","authors":"P. Fsadni, F. Bezzina, C. Fsadni, N. Aquilina, S. Montefort","doi":"10.1159/000440837","DOIUrl":"https://doi.org/10.1159/000440837","url":null,"abstract":"Background/Aims: School indoor air quality is important because children spend most of their time outside home within the school environment. This study aimed to investigate the school environment and its impact on the respiratory health of the children. Methods: A total of 191 pupils in the 9- to 11-year age group were selected from 5 primary state schools. Validated school and health questionnaires, spirometry, acoustic rhinometry, nasal lavage, urine for environmental tobacco smoke biomarkers and traffic counts were used. Results: Cumulative (32.98%) and current wheezing (17.8%) were in keeping with the International Study of Asthma and Allergies in Childhood Malta data. Southern schools had the highest prevalence of current wheezers (OR 3.77; p = 0.012), rhinoconjunctivitis (OR 3.59; p = 0.003) and nasal eosinophilic cationic protein levels (p < 0.001). Small openable window areas increased rhinitic symptoms (OR 3.14; p = 0.016). Classes facing roads had increased current wheezers (OR 2.27; p = 0.03) and exhaled carbon monoxide (eCO) levels (p < 0.001). Current wheezing was significantly associated with the number of light and heavy vehicles passing near the school (p < 0.001). The presence of smokers at home was significantly associated with urinary cotinine and 3HC (p < 0.001). Proximity to power plants increased the current wheezers (OR 5.89; p = 0.001) who had impaired spirometry (p = 0.003). Asthma symptoms (OR 5.25; p = 0.001) and elevated eCO levels (p < 0.001) were associated with fuel storage facilities near schools. The accumulation of dust on flat surfaces within classrooms was related to wheezing (OR 5.23; p = 0.001). Conclusions: The school environment had a direct impact on the respiratory health of children, with several factors having a direct impact on the children's health.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"129 - 138"},"PeriodicalIF":0.0,"publicationDate":"2015-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000440837","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64918670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status Quo and Prospect of Colorectal Animal Models: Application of Transgenic Technology","authors":"Jiang Haili, L. Xuan, J. Qing, Li Qi","doi":"10.1159/000437425","DOIUrl":"https://doi.org/10.1159/000437425","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common malignant diseases and brings about serious damage to the human body. Presently, the incidence of CRC ranks third among the malignant tumors, and its 5-year survival rate is only about 50%. In recent years, more and more studies have focused on the application of transgenic technology in CRC research in vivo, which involves a great number of genes significantly related to the occurrence and development of CRC. The core of transgenic technology refers to the host chromosome gene accepting exogenous genes, which integrate into the host chromosome expressing it stably, followed by transmission to the next generations. Here, we will present a brief review of the related technologies used in transgenic animal models and provide an overview of the application of transgenic animal models in CRC research.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"41 - 48"},"PeriodicalIF":0.0,"publicationDate":"2015-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000437425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64888432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RegentK: The Scientific Investigation of a 40-Year-Old Method in Regenerative Medicine","authors":"G. Litscher","doi":"10.1159/000437306","DOIUrl":"https://doi.org/10.1159/000437306","url":null,"abstract":"Background: Mohamed Khalifa has been healing even the most severe muscle and joint injuries in Austria for more than 40 years, without surgery, only with his hands by applying pressure on the skin. In this article, the author summarises the first scientific results trying to describe the way of functioning of this unusual form of therapy called RegentK. Historical aspects, regional oxygen saturation of deeper knee tissues, thermographic measurements, and electrodermal mapping are described in detail. Summary: Rupture of the anterior cruciate ligament (ACL) is a high-incidence injury usually treated surgically. According to common knowledge, it does not heal spontaneously, although some claim the opposite. RegentK was developed for injuries of the musculoskeletal system. In one study, it was shown that after 3 months, 47% of the RegentK patients, but no physiotherapy patient, demonstrated an end-to-end homogeneous ACL on magnetic resonance imaging. Key Messages: We conclude that ACL healing can be improved with RegentK.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"32 - 40"},"PeriodicalIF":0.0,"publicationDate":"2015-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000437306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64886945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meraque or Triple Energizer (San Jiao): Actual or Virtual Organ in Traditional Medicine - A Hypothetical Viewpoint","authors":"M. Avijgan, M. Avijgan","doi":"10.1159/000433537","DOIUrl":"https://doi.org/10.1159/000433537","url":null,"abstract":"Background/Objective: In traditional medicine, there are a number of terms and organs that have not yet been reported in Western medicine. For example, ‘Meraque' in Iranian traditional medicine and ‘Triple Energizer' or ‘San Jiao' in traditional Chinese medicine (as one of the Fu organs) are examples of such terms. The organs they refer to can explain many of the clinical signs and symptoms which have been noted as psychosomatic disorders in Western medicine. One hypothesis is that this organ might be a real space. From the viewpoint of embryology and anatomy, this report will try to create a new perception in the reader's mind of the Meraque/Triple Energizer/San Jiao of the human body. Methods: We searched through the major databases for the key words ‘traditional medicine', ‘Meraque', ‘meridians', ‘acupuncture points', ‘San Jiao' and ‘Triple Energizer'. Results: There were no reports on the relevant concepts of San Jiao/Triple Energizer and Meraque. Discussion: During embryonic development and after gastrulation, three layers called the ectoderm, mesoderm and endoderm are formed. The mesoderm is the source of most of the internal organs, dividing into two layers, the somatic and the visceral, with an invisible space in between that is called the coelom. This space could possibly be the same as the Meraque/Triple Energizer/San Jiao (as a hollow organ) and, furthermore, the same as a cavitary tissue forming a pathway to connect the internal organs of the body with the surface of the body. In this case, many of the mechanisms of traditional medicine and acupuncture can be explained. In other words, for the first time the coelom is proposed as the Meraque and the Triple Energizer/San Jiao in Iranian and Chinese traditional medicine, respectively.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"9 - 20"},"PeriodicalIF":0.0,"publicationDate":"2015-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000433537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64878973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of Antiphospholipid Antibodies, Antithyroid Antibodies and Antisperm Antibodies in Female Reproductive Health","authors":"B. Heng, Wen-hsien Huang, Xiufang Zhong, Ping Yin, G. Tong","doi":"10.1159/000381900","DOIUrl":"https://doi.org/10.1159/000381900","url":null,"abstract":"Autoantibodies are implicated in various human diseases. In this review, the effects of three different types of autoantibodies (antiphospholipid antibody, antithyroid antibody, and antisperm antibody) on female reproductive health are critically examined. Antiphospholipid antibodies are being detected more frequently in women undergoing in vitro fertilization, but their presence does not appear to influence the outcome of pregnancy, miscarriage, or live birth rates. Available evidence makes it conclusive that antiphospholipid antibodies play negligible roles in recurrent miscarriage. Treatment with aspirin together with low-molecular-weight heparin appears to be effective for recurrent miscarriage. Although antithyroid antibodies are commonly found in women of reproductive age, implantation rates and miscarriage rates are unaffected when women have normal thyroid function. Women with thyroid dysfunction should be treated with L-thyroxine before conception or at early gestational stages to avoid pregnancy complications. Antisperm antibodies are uncommon but are most often associated with ovarian hypofunction. They are believed to cause fertilization failure when found at high titers in seminal plasma, or in the mucosal immune system of women. Intrauterine artificial insemination and in vitro fertilization/embryo transfer are effective treatment modalities for antisperm antibody-related infertility, although this remains a controversial topic in the field of female infertility.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"21 - 31"},"PeriodicalIF":0.0,"publicationDate":"2015-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000381900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64786966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Skin Luminescence Resulting from the Visualization of Active Acupuncture Points Using Optical Stimulation","authors":"L. G. Navrotsky, A. Blokhin, S. V. Belavskaya, L. I. Lisitsyna, Anna A. Lyutkevich, E. L. Poteryaeva, V. I. Yudin, G. Litscher","doi":"10.1159/000433470","DOIUrl":"https://doi.org/10.1159/000433470","url":null,"abstract":"Background: In recent years, biologically active points (BAPs) have become the topic of intensive scientific discussion. Innovative investigations of this topic are presented. Methods: Types of skin surface luminescence patterns in the areas of BAPs observed after acting on the area with a short light pulse are analyzed. The device was designed as a laboratory model (NSTU, medical electronics laboratory, Novosibirsk, Russia). Pictures were taken with a PENTAX K10 , a PENTAX ist DL as well as a Canon 6D photo camera. Luminescent points can clearly be observed. The pictures were zoomed on a computer and graphically analyzed. Results: Five patterns were found: black center with white ring, black center with 2 rings (white and black), white center with black ring, white center with 2 rings (black and white) and white center with 3 rings (black, white and black). Luminescent BAPs were found on the pericardium and triple energizer meridians. Conclusion: This pilot study can serve as a basis for further investigations in the field of meridian research. The first results are very promising, and future studies are indicated in body acupuncture as well as ear acupuncture.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"158 1","pages":"1 - 8"},"PeriodicalIF":0.0,"publicationDate":"2015-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000433470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64878409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginkgo biloba Extract Inhibits Platelet Activation via Inhibition of Akt","authors":"Shiyong Ye, Xiang Yijia, Zhong Peng, Liu Chong, Wuming Hu, Linchun Lv, Zeng Chunlai","doi":"10.1159/000381744","DOIUrl":"https://doi.org/10.1159/000381744","url":null,"abstract":"Ginkgo biloba extract (GBE) contains flavone glycosides and terpenoids. It can modify vasomotor function, reduce the adhesion of blood cells to the endothelium, and inhibit the activation of platelets, and therefore plays an important role in the treatment of a variety of cardiovascular and neurological disorders. However, the molecular mechanism underlying its significant anticoagulation activity is largely unknown. In this study, we found that GBE adenosine diphosphate, collagen, and U4 (U46619) induced platelet aggregation in both platelet-rich plasma and washed platelets. GBE could reduce the adhesion of platelets to a collagen-coated surface and platelet spreading on fibrinogen. The treatment with GBE significantly inhibited the phosphorylation of Akt, suggesting that its inhibition of platelet activation might be mediated by attenuation of the PI3K/Akt pathway.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"380 1","pages":"234 - 242"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000381744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64785481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chaos Theory and Self-Organization Systems in Recovery Medicine: A Scientific Review","authors":"A. Khadartsev, V. Eskov","doi":"10.1159/000377679","DOIUrl":"https://doi.org/10.1159/000377679","url":null,"abstract":"In this review, the theoretical principles, which provide the possibility of correction of acute stress pathology, are formulated in terms of the theory of chaos and self-organization. We present the concepts of phase space, channels, wildcards, attractors, determinism, synergetics, etc. and give the basic compartment and cluster approach to complex systems. Additionally, we show the interdependence of system analysis and synthesis applied to the development of European and Oriental medicine. Furthermore, the importance of modulation in adaptation programs in the control of the functional systems of a human body, confirmed in the data submitted for 14 patents covering inventions that have led to 2 discoveries, is demonstrated.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"226 - 233"},"PeriodicalIF":0.0,"publicationDate":"2015-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000377679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64773910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Treatment Strategies for Neurodegenerative Diseases by Integrative Medicine","authors":"Xiangjun Chen, Weidong Pan","doi":"10.1159/000381546","DOIUrl":"https://doi.org/10.1159/000381546","url":null,"abstract":"Acute and chronic neurodegenerative diseases, including prion disease, frontotemporal dementia, Pick’s disease, progressive supranuclear palsy, spinocerebellar ataxias, brain trauma, amyotrophic lateral sclerosis (ALS), Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease (PD), are illnesses associated with high morbidity and mortality rates [1, 2] . A characteristic of many neurodegenerative diseases is progressive neuronal cell death [3] . During the past decade, considerable progress has been made in understanding the process of cell death [4] . The symptoms and the exacerbations of these diseases are much different according to their specific pathways of cell death, and having their own mechanisms of cell death leads to novel therapeutic strategies. Today, there is no treatment that can cure degenerative diseases, but we have many symptomatic treatments. There are some advantages of Western medicines for these diseases, such as dopaminergic treatments for PD and movement disorders [5] , cholinesterase inhibitors for cognitive disorders [6] , antipsychotic drugs for behavioral and psychological symptoms of dementia [7] , analgesic drugs for pain [8] , anti-inflammatories for infections [9] , and even the use of deep brain stimulation to stop tremor and refractory movement disorders [10] . Researchers have also aimed to produce medicines to slow the development of diseases, such as Riluzole for ALS, cerebellar ataxia and Huntington’s disease [11–13] , NSAIDs (nonsteroidal anti-inflammatory drugs) for Alzheimer’s disease [14] , and caffein A2A receptor antagonists and CERE-120 (adeno-associated virus serotype 2-neurturin) for the neuroprotection of PD [15, 16] . However, we have not yet progressed very well; there still remain too many problems to administrate the progressive and serious symptoms of these diseases [5] . Including Western medicine and traditional medicine, integrative medicine [17] has its advantages in treating degenerative diseases. Integrative medicine aims to be ‘integrative’ or ‘whole’; it does not only treat the acute symptoms of these diseases, but it also considers all of the related symptoms and tries to improve the quality of activity of daily life (ADL) for the patients [18] . Non-motor disorders is one refractory symptom of PD, such as sleep disorders, Received: March 4, 2015 Accepted after revision: March 10, 2015 Published online: April 28, 2015","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"223 - 225"},"PeriodicalIF":0.0,"publicationDate":"2015-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000381546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64783171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}