Integrative medicine international最新文献_第9页

Recent Research Progress in and Future Perspective on Treatment of Parkinson's Disease 帕金森病治疗的研究进展与展望

Integrative medicine international Pub Date : 2014-07-25 DOI: 10.1159/000365571

Y. Mizuno

{"title":"Recent Research Progress in and Future Perspective on Treatment of Parkinson's Disease","authors":"Y. Mizuno","doi":"10.1159/000365571","DOIUrl":"https://doi.org/10.1159/000365571","url":null,"abstract":"Background: Clinical features, pathogenesis, and treatment of Parkinson's disease (PD) are reviewed as there has been progress in these areas. Summary: PD is a systemic disease of the nervous system as the initial symptom is related to disturbance of the autonomic nervous system, such as constipation or nocturia. Then, the disease progresses to the brain stem involving the nuclei in the pons and the substantia nigra, and inducing sleep and wakefulness disturbances, affect problems such as anxiety and depression, and motor problems when the disease process has reached the substantia nigra. Furthermore, the disease has an effect on the nucleus basalis of Meynert, the amygdaloid complex and the cerebrum manifesting cognitive impairment. The olfactory pathway is also frequently involved. Key Messages: For the treatment of PD, younger patients without dementia should be treated with a nonergot dopamine agonist first and then with levodopa if necessary. Elderly patients or those with dementia should be treated with levodopa. However, after 5 years of levodopa treatment, many patients with PD develop wearing off. Drugs for the treatment of wearing-off symptoms are reviewed. Many of the patients with wearing-off symptoms develop dyskinesia, and amantadine is so far the only drug that can ameliorate dyskinesia. Because of this situation, a new method of treatment is warranted, such as RNA interaction, according to the author's opinion. Recent progress in this field is also reviewed. i 2014 S. Karger AG, Basel","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"67 - 79"},"PeriodicalIF":0.0,"publicationDate":"2014-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000365571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64731107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Spectroscopic Measurements in Patients with Completely Ruptured Anterior Cruciate Ligament before and after RegentK and Physiotherapy 前交叉韧带完全破裂患者摄谱仪测量前后RegentK和物理治疗

Integrative medicine international Pub Date : 2014-06-26 DOI: 10.1159/000365105

D. Litscher, G. Litscher, Michael Ofner, Ingrid Gaischek, D. Malliga

{"title":"Spectroscopic Measurements in Patients with Completely Ruptured Anterior Cruciate Ligament before and after RegentK and Physiotherapy","authors":"D. Litscher, G. Litscher, Michael Ofner, Ingrid Gaischek, D. Malliga","doi":"10.1159/000365105","DOIUrl":"https://doi.org/10.1159/000365105","url":null,"abstract":"Background: The goal of this study was to investigate acute effects of a special kind of manual therapy developed by Mohamed Khalifa (RegentK) compared to standard physiotherapy on regional oxygen saturation (rSO2) of knee tissues in patients with completely ruptured anterior cruciate ligament (ACL). Methods: Twenty patients were enrolled in this study and randomly assigned to receive either RegentK (group A; n = 10, 8 female, 2 male, mean age ± SD 31.3 ± 8.5 years) or physiotherapy (group B; n = 10, 6 female, 4 male, mean age 34.8 ± 10.2 years). The values of rSO2, assessed using near-infrared spectroscopy, were registered anterolaterally and anteromedially on both the injured and the healthy (control) knee. Results: rSO2 increased significantly (p < 0.001) after RegentK on both registration sites of the injured knee, whereas after physiotherapy only the anterolateral side showed significant increases. Interestingly, we found significant increases in rSO2 also on the control knee after RegentK; in group B, these results were insignificant. Conclusion: We conclude that manual therapy influences the hemodynamics of muscles and deeper structures. The results will also serve to quantify the effects of nonpharmacological and nonsurgical interventions (e.g. RegentK) on the microvascular circulation in deep tissue after a complete rupture of the ACL.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"56 - 63"},"PeriodicalIF":0.0,"publicationDate":"2014-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000365105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64727039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Neuroprotective Effect and Probable Mechanism of DL-3-n-Butylphthalide in Brain Diseases dl -3-n-丁苯酞对脑部疾病的神经保护作用及其可能机制

Integrative medicine international Pub Date : 2014-06-25 DOI: 10.1159/000362633

Yinyi Sun, Kangyong Liu, Ting Zhang, Yan Sun, Wenqi Chen, Qian Li, Rongfu Chen, Xiao-Jiang Sun

引用次数: 4

Influence of Xingnaojing Injection on the Expression of c-fos and c-jun Proteins in Brains of Rats in a Kindling Model of Epilepsy Chronically Induced by Pentetrazol 醒脑静注射液对戊四唑慢性癫痫点燃模型大鼠脑c-fos和c-jun蛋白表达的影响

Integrative medicine international Pub Date : 2014-06-04 DOI: 10.1159/000362637

Ji-Wei Cheng, Yu Bai, Xiao-jing Zhang, Lijun Zhang, Yuqing Hou

{"title":"Influence of Xingnaojing Injection on the Expression of c-fos and c-jun Proteins in Brains of Rats in a Kindling Model of Epilepsy Chronically Induced by Pentetrazol","authors":"Ji-Wei Cheng, Yu Bai, Xiao-jing Zhang, Lijun Zhang, Yuqing Hou","doi":"10.1159/000362637","DOIUrl":"https://doi.org/10.1159/000362637","url":null,"abstract":"Objective: To investigate the molecular biological mechanism of the antiepileptic effect of Xingnaojing (XNJ) injection on a rat kindling model of epilepsy (KME). Methods: Fifty healthy 6-week-old male Sprague-Dawley rats were divided into the following five groups: blank control (BC) group, model (M) group, XNJ injection (XI) group, phenobarbital injection (PI) group and XNJ combined with phenobarbital (XP) group. There were 10 rats in each group. The intervention drugs were administered 30 min before the model-building drugs once a day for 5 weeks. The model-building drug pentetrazol was given to each group as an intraperitoneal injection 30 min after the use of the intervention drug once a day for 4 weeks for KME establishment (except for the BC group). The BC group was given physiological saline instead. All drugs were injected intraperitoneally. The behaviors of each group of rats were observed after the use of the model-building drugs for 1 h every day. The last kindling test was carried out at the end of week 5. Then, c-fos and c-jun protein expressions in the rat brains of each group were observed and analyzed by immunohistochemistry at the end of the experiment. Results: There was a large number of cells positive for the c-fos and c-jun proteins in the rat brains of the M group. Compared with the M group, the expression level of the c-fos and c-jun proteins was lower in the rat brains of the XI and PI groups (p < 0.01). There was no statistical difference between the XI and PI groups (p > 0.05). The number of positive cells in the rat brains of the XP group was even smaller than that of the XI or PI groups. Conclusion: The antiepileptic effect of the XNJ injection on the rat KME is probably related to its interruption function on the expression of the c-fos and c-jun proteins in rat brains.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"44 - 50"},"PeriodicalIF":0.0,"publicationDate":"2014-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000362637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64718831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rotigotine Transdermal Patch for the Treatment of Restless Legs Syndrome 罗替戈汀透皮贴片治疗不宁腿综合征

Integrative medicine international Pub Date : 2014-05-23 DOI: 10.1159/000362629

P. Ratti, M. V. Rey, O. Rascol, S. Pérez-Lloret

引用次数: 1

Adenostoma fasciculatum, California Chamise: Chemistry and Use in Skin Conditions 束状腺瘤，加利福尼亚紫菀:化学和在皮肤状况中的使用

Integrative medicine international Pub Date : 2014-05-14 DOI: 10.1159/000362630

Alexis Bouttemy, Osvaldo Ruiter Faria Filho, J. D. Adams, T. Williams

引用次数: 0

Rapid Treatment of Waist Pain by Nanoscale Electric Stimulation 纳米级电刺激快速治疗腰痛

Integrative medicine international Pub Date : 2014-05-13 DOI: 10.1159/000362634

Jaehwi Lee, Jae-Youl Cho, K. Kim

引用次数: 1

Targeting Neurogenesis: A Promising Therapeutic Strategy for Post-Stroke Treatment with Chinese Herbal Medicine 靶向神经发生:中草药治疗脑卒中后的一个有前景的治疗策略

Integrative medicine international Pub Date : 2014-05-10 DOI: 10.1159/000362638

Jiangang Shen, Xing-miao Chen, X. Chen, R. Deng

{"title":"Targeting Neurogenesis: A Promising Therapeutic Strategy for Post-Stroke Treatment with Chinese Herbal Medicine","authors":"Jiangang Shen, Xing-miao Chen, X. Chen, R. Deng","doi":"10.1159/000362638","DOIUrl":"https://doi.org/10.1159/000362638","url":null,"abstract":"Recent progress suggests that neural stem/progenitor cells can potentially develop into new functional neurons in adult brain, offering hope for regeneration therapies for stroke treatment. Targeting adult neurogenesis becomes a novel and promising therapeutic strategy for brain repair and recovery of neurological functions. Traditional Chinese Medicine (TCM) has a long history with accumulated experiences and case reports using herbal formulas to treat stroke disability. The combination of Chinese herbal medicine and stem cell biology approaches provides great potential for post-stroke rehabilitations. In the last decade, large efforts have been made to investigate the molecular targets for the regulation of adult neurogenesis and to explore the active compounds and molecular targets of herbal medicine for regeneration therapy. Herein, we reviewed the current progress concerning the molecular targets and cellular signaling pathways involved in adult neurogenesis after cerebral ischemia. We then briefly introduced Chinese medical theory and herbs for stroke treatment in TCM. Finally, we reviewed the current knowledge about the effects of Chinese herbal formulas, active fractions and active compounds on promoting adult neurogenesis as well as their molecular targets. Although the precise mechanisms and molecular targets of herbal medicine for neurogenesis are still unclear, current progress at least provides a cue for exploring the therapeutic principles of Chinese herbal medicine and developing new drugs for brain repair after stroke.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"1 1","pages":"5 - 18"},"PeriodicalIF":0.0,"publicationDate":"2014-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000362638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64718893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Inclusion of Integrative Medicine in Clinical Practice 将中西医结合纳入临床实践

Integrative medicine international Pub Date : 2014-05-01 DOI: 10.1159/000362628

Weidong Pan, Hua Zhou

引用次数: 24