Brain disorders & therapy最新文献_第7页

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist 抗n-甲基- d -天冬氨酸受体脑炎:会诊联络精神病学家的新挑战

Brain disorders & therapy Pub Date : 2016-05-01 DOI: 10.4172/2168-975X.1000215

G. Maccaferri, A. Rossetti, J. Dalmau, A. Berney

{"title":"Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist","authors":"G. Maccaferri, A. Rossetti, J. Dalmau, A. Berney","doi":"10.4172/2168-975X.1000215","DOIUrl":"https://doi.org/10.4172/2168-975X.1000215","url":null,"abstract":"Background Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively newly identified autoimmune neuropsychiatric disorder that predominantly affects children and young adults. Although psychiatric symptoms are highly prevalent and frequently severe, it has mainly been reported in neurological, but not psychiatric, literature. Understanding this form of encephalitis, its quick diagnosis and which treatment to provide are of utmost importance for consultation-liaison (C-L) psychiatrists. The aim of this paper was to describe a case of anti-NMDAR encephalitis with severe psychiatric manifestations, who showed impressive recovery but required intensive involvement of the C-L psychiatry team. We emphasise the behavioural aspects, psychiatric symptoms and challenges faced by the CL consultant across the different phases of the treatment. Methods We report the different treatment phases for a young woman with anti-NMDAR encephalitis who developed severe neuropsychiatric symptoms, with a focus on the role and challenges faced by the C-L psychiatrist. The literature is reviewed for each of these challenges. Results This case illustrated that even extremely severely affected patients may show impressive recovery, but require long lasting psychiatric care. C-L psychiatrists are faced with numerous challenges where only little literature is available. Conclusion C-L psychiatrists play a pivotal role throughout the multidisciplinary care of patients with anti-NMDAR encephalitis and should be informed about this entity.","PeriodicalId":9146,"journal":{"name":"Brain disorders & therapy","volume":"187 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86312995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist. 抗n-甲基- d -天冬氨酸受体脑炎:会诊联络精神病学家的新挑战。

Brain disorders & therapy Pub Date : 2016-05-01 Epub Date: 2016-05-10

G E Maccaferri, A O Rossetti, J Dalmau, A Berney

{"title":"Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A New Challenging Entity for Consultation-Liaison Psychiatrist.","authors":"G E Maccaferri, A O Rossetti, J Dalmau, A Berney","doi":"","DOIUrl":"","url":null,"abstract":"Background: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively newly identified autoimmune neuropsychiatric disorder that predominantly affects children and young adults. Although psychiatric symptoms are highly prevalent and frequently severe, it has mainly been reported in neurological, but not psychiatric, literature. Understanding this form of encephalitis, its quick diagnosis and which treatment to provide are of utmost importance for consultation-liaison (C-L) psychiatrists. The aim of this paper was to describe a case of anti-NMDAR encephalitis with severe psychiatric manifestations, who showed impressive recovery but required intensive involvement of the C-L psychiatry team. We emphasise the behavioural aspects, psychiatric symptoms and challenges faced by the CL consultant across the different phases of the treatment.Methods: We report the different treatment phases for a young woman with anti-NMDAR encephalitis who developed severe neuropsychiatric symptoms, with a focus on the role and challenges faced by the C-L psychiatrist. The literature is reviewed for each of these challenges.Results: This case illustrated that even extremely severely affected patients may show impressive recovery, but require long lasting psychiatric care. C-L psychiatrists are faced with numerous challenges where only little literature is available.Conclusion: C-L psychiatrists play a pivotal role throughout the multidisciplinary care of patients with anti-NMDAR encephalitis and should be informed about this entity.","PeriodicalId":9146,"journal":{"name":"Brain disorders & therapy","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34322790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Bioethical Aspects of Ending of Life in Unresponsive Wakefulness Syndrome/Vegetative State Patients 无反应性觉醒综合征/植物人患者生命终结的新生物伦理方面

Brain disorders & therapy Pub Date : 2016-04-25 DOI: 10.4172/2168-975X.1000213

F. Arcuri, M. D. Cortese, G. Dolce

引用次数: 1

Lamotrigine Induced Dystonia in a Patient with Bipolar Affective Disorder 拉莫三嗪诱导双相情感障碍患者肌张力障碍

Brain disorders & therapy Pub Date : 2016-04-16 DOI: 10.4172/2168-975X.1000212

Ratan J. Lihite, M. Lahkar, D. Medhi, R. Mathur

引用次数: 0

DNA Methylation of Imprinted Loci on Autosomal Chromosomes and IGF2 are not Affected in Parkinson's Disease Patients Peripheral Blood Monocytes 帕金森病患者外周血单核细胞常染色体上印迹位点和IGF2的DNA甲基化不受影响

Brain disorders & therapy Pub Date : 2016-03-05 DOI: 10.4172/2168-975X.1000211

O. Kaut, Amit Sharma, U. Wüllner

{"title":"DNA Methylation of Imprinted Loci on Autosomal Chromosomes and IGF2 are not Affected in Parkinson's Disease Patients Peripheral Blood Monocytes","authors":"O. Kaut, Amit Sharma, U. Wüllner","doi":"10.4172/2168-975X.1000211","DOIUrl":"https://doi.org/10.4172/2168-975X.1000211","url":null,"abstract":"Genomic imprinting is an epigenetic phenomenon that results in differential expression of alleles depending on their parental origin. The functional significance of DNA methylation in genomic imprinting has been widely investigated and to date, around 100 imprinted genes have been identified in humans. To investigate, if methylation status of these “known” imprinting genes is associated with Parkinson's disease (PD), we analyzed methylation profile of all these “known” imprinting genes using an epigenome wide approach with Illumina's 450K methylation chip. Strikingly, none of these total autosomal annotated genes show changes of DNA methylation between PD and healthy individuals. We further refined our analysis by evaluating DNA methylation for maternally imprinted human gene encoding insulin-like growth factor 2 (IGF2) by using bisulfite sequencing PCR (BSP) and by considering different dosages of L-dopa. Our results demonstrate that methylation profiles specifically at exon 8-9 genomic region of IGF2 gene in PD are neither influenced by the dosage of L-dopa treatment nor by the disease itself. Thus loss or disruption of imprinting in autosomal chromosomes seems not to apparent in PD and is not relevant for the pathogenesis of the disease.","PeriodicalId":9146,"journal":{"name":"Brain disorders & therapy","volume":"10 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87423614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Predicting Real-Life Cognitive Performance from Laboratory Data: A Case for Developmental Studies Using the Attentional Blink 从实验室数据预测现实生活中的认知表现:一个使用注意力眨眼的发展研究案例

Brain disorders & therapy Pub Date : 2016-03-04 DOI: 10.4172/2168-975X.1000210

S. Heim, A. Keil

引用次数: 0

Auditory Processing Deficits Following Sport-Related or Motor VehicleAccident Injuries 运动相关或机动车事故伤害后的听觉处理缺陷

Brain disorders & therapy Pub Date : 2016-01-30 DOI: 10.4172/2168-975X.1000204

S. Atcherson, Claire Steele

{"title":"Auditory Processing Deficits Following Sport-Related or Motor VehicleAccident Injuries","authors":"S. Atcherson, Claire Steele","doi":"10.4172/2168-975X.1000204","DOIUrl":"https://doi.org/10.4172/2168-975X.1000204","url":null,"abstract":"This brief clinical study was designed to investigate further the possible link between traumatic brain injury (TBI) and/or whiplash injury (WI) with acquired auditory processing disorder (APD). Other studies have shown long standing effects of TBI and WI, and a study by Turgeon et al., examined the link between sport-induced concussion and APD. Four participants ages 18 to 30 years of age who self-reported a history of sport-related or motor vehicle accident head injuries participated in the following procedures: case history, behavioral testing, electrophysiological testing including auditory brainstem responses (ABR) and middle latency responses (MLR), and self-report questionnaires of post head and/or whiplash injury symptoms. The results of the testing were individually analyzed to see if results were consistent with a diagnosis of APD, or some evidence of a non-sensory deficit to the auditory system. The overall results of this study were also compared with the results of Turgeon et al., study. The results of the study shows that electrophysiological testing may be outside of normal limits even when behavioral testing does not support an APD diagnosis. Furthermore, the degree of reported symptoms and difficulties in the participants’ case history does not always carry over to the behavioral and electrophysiological testing results.","PeriodicalId":9146,"journal":{"name":"Brain disorders & therapy","volume":"63 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78698721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Synchronous Morphologically Distinct Craniopharyngioma and Pituitary Adenoma: A Rare Collision Entity 颅咽管瘤和垂体腺瘤:一种罕见的碰撞实体

Brain disorders & therapy Pub Date : 2016-01-29 DOI: 10.4172/2168-975X.1000207

H. Bhatoe, P. Deb, S. Sengupta

引用次数: 6

Tyrosine Kinase and Mitogen Activated Protein (MAP) Kinase Pathway onCerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage 动脉瘤性蛛网膜下腔出血后脑血管痉挛的酪氨酸激酶和丝裂原活化蛋白激酶途径

Brain disorders & therapy Pub Date : 2016-01-23 DOI: 10.4172/2168-975X.1000205

F. Romero, M. Zanini

引用次数: 1

Deep Brain Stimulation for Alzheimer's Disease 深部脑刺激治疗阿尔茨海默病

Brain disorders & therapy Pub Date : 2016-01-23 DOI: 10.4172/2168-975X.1000202

A. Lavano, A. Torre, G. Guzzi, F. Deodato, F. Lavano, G. Volpentesta

引用次数: 7