Botanics : targets and therapy最新文献

Phytochemicals in the treatment of hyperpigmentation 植物化学物质治疗色素沉着

Botanics : targets and therapy Pub Date : 2016-09-16 DOI: 10.2147/BTAT.S69113

Ashley K Clark, R. Sivamani

引用次数: 9

Remission roles of the herbal formula B401 in mice with manganese-induced neurotoxicity 中药复方B401对锰致小鼠神经毒性的缓解作用

Botanics : targets and therapy Pub Date : 2016-08-25 DOI: 10.2147/BTAT.S108648

Chung-Hsin Wu, Chih-Hsiang Hsu, sheue-er Wang, Ching-Lung Lin, S. Sheu

引用次数: 2

The role of rose hip ( Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies 玫瑰果(Rosa canina L)粉在缓解关节炎疼痛和炎症中的作用-第二部分动物和人类研究

Botanics : targets and therapy Pub Date : 2016-05-04 DOI: 10.2147/BTAT.S55573

K. Marstrand, J. Campbell-Tofte

{"title":"The role of rose hip ( Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies","authors":"K. Marstrand, J. Campbell-Tofte","doi":"10.2147/BTAT.S55573","DOIUrl":"https://doi.org/10.2147/BTAT.S55573","url":null,"abstract":": Rosa canina fruits (often known as rose hip) have been used in herbal remedies since ancient times. On the basis of anecdotal reports about the effects of rose hip preparations on human health and citations to the same in ancient texts, in vitro and in vivo studies have been conducted that have made it possible to learn about some active ingredients in rose hip, as well as how the component compounds might exert their effects. From such studies, it has been documented that there is a great variation in active ingredients when comparing different rose hip products. Factors which affect the quality and quantity of active ingredients in the rose hip products include the subspecies of the particular R. canina from which the fruits are harvested, the environment during plant growth, time of harvesting, and the amount of seeds and shells/husks incorporated into the preparation. Studies in animals and in humans are of great importance for determining the true bio-effects of rose hip. Such in vivo studies that have only been performed during the last 2 decades indicate that the treatment of patients with different types of joint disease with rose hip powder based on a subspecies of R. canina (Lito) containing a certain galactolipid (GOPO) can alleviate pain, improve daily activity, and even reduce the consumption of regular pain relievers. As several rose hip components have been shown to be anti-inflammatory, it is suggested that anti-inflammatory mechanisms might explain some reductions in symptoms associated with administering rose hip to arthritic conditions. Although the number of publications of randomized and placebo-controlled clinic studies with rose hip is small, the overriding evidence is that the anti-inflammatory effects from administration of rose hip preparations containing both shells and seeds are superior to preparations containing shells alone.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":"6 1","pages":"59-73"},"PeriodicalIF":0.0,"publicationDate":"2016-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S55573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68306708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective 丹参及其丹参酮的抗癌潜力:疗效观察

Botanics : targets and therapy Pub Date : 2016-04-29 DOI: 10.2147/BTAT.S68097

Wei Wu, Yong Zhang, Suni Tang, M. Ye, Junxuan Lu, Cheng Jiang

{"title":"Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective","authors":"Wei Wu, Yong Zhang, Suni Tang, M. Ye, Junxuan Lu, Cheng Jiang","doi":"10.2147/BTAT.S68097","DOIUrl":"https://doi.org/10.2147/BTAT.S68097","url":null,"abstract":": Salvia miltiorrhiza Bunge (Danshen in Chinese or Tanshen in Anglicized literature) is a well-known Traditional Chinese Medicine herbal remedy for treating cardiovascular- and cerebrovascular-related disorders. To date, . 40 hydrophorbic tanshinones and structurally related compounds have been isolated from the Danshen root, as have some 50 hydrophilic phenolics and other minor components. In the past 2 decades, a large quantity of literature has reported inhibitory activities of tanshinones against cancers of various organ sites in cell culture models, and in some cases with efficacy confirmation in preclinical animal cancer models. This study follows up on a 2012 review we published on the sources, pharmacokinetics, and anticancer activities of tanshinones. Here, we update on the recent progress in understanding the anticancer potential of tanshinones and derivatives and critically assess merits of these entities for future research and development. Overall, potency data from in vivo efficacy assessment experiments in preclinical models varied from nil for chemoprevention of a prostate carcinogenesis model to strong inhibition of some xenograft or allograft models. Lack of uniformity of excipients, doses, and routes of administration aside, we caution that the reviewed data should be appreciated in balance of publication bias exemplified by our own data from primary carcinogenesis study and false positivity. Novel formulations and chemical modifications had been made to improve the poor solubility and bioavailability of tanshinones. Human clinical studies so far dealt with case reports of tanshinone IIA use and small-scale trials on Danshen-containing formulas with chemotherapy for cancers of multiple organ sites in People’s Republic of China. Available human data are not sufficient for supporting any anticancer indication of tanshinones.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":"6 1","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"2016-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S68097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68308251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The anticancer properties of phytochemical extracts from Salvia plants 鼠尾草植物化学提取物的抗癌特性

Botanics : targets and therapy Pub Date : 2016-03-30 DOI: 10.2147/BTAT.S98610

Yuanyuan Jiang, Li Zhang, H. Rupasinghe

引用次数: 14

Bioactive ingredients of rose hips (Rosa canina L) with special reference to antioxidative and anti-inflammatory properties: in vitro studies 具有抗氧化和抗炎特性的玫瑰果(Rosa canina L)生物活性成分:体外研究

Botanics : targets and therapy Pub Date : 2016-02-01 DOI: 10.2147/BTAT.S91385

K. Winther, J. Campbell-Tofte, A. Hansen

{"title":"Bioactive ingredients of rose hips (Rosa canina L) with special reference to antioxidative and anti-inflammatory properties: in vitro studies","authors":"K. Winther, J. Campbell-Tofte, A. Hansen","doi":"10.2147/BTAT.S91385","DOIUrl":"https://doi.org/10.2147/BTAT.S91385","url":null,"abstract":": Rosa canina pseudo fruits, often referred to as rose hips, have been used as herbal medicine for more than 2,000 years, yet research has only recently begun to clarify specific mechanisms by which this plant product affects human health. Numerous compounds have been identified, and speculations of their bioactivity have implicated flavonoids, carotenoids, and fatty acids (FAs). With more than 4,500 representatives, flavonoids have been subjected to compre-hensive research, with results that suggest various individual structures may be health-promoting compounds, also in rose hips. The importance of carotenoids from R. canina is currently being debated, because the demonstration of specific bioactivity among this group is presently less clear. The benefits of specific FAs have been investigated for decades, and several types of FAs are termed “essential” for human health. The specific mechanisms for bioactivity associated with three FAs that are abundant in R. canina fruits have been clarified in research. For example, linoleic acid, α -linolenic acid (mostly present in the seeds from R. canina ) and a galactolipid ((2 S )-1,2-di- O -[(9 Z ,12 Z ,15 Z )-octadeca-9-12-15-trienoyl]-3- O - β - d -galactopyranosyl glycerol), referred to as GOPO, have been shown to have anti-inflammatory properties. The aim of this review is to critically analyze the published literature on rose hip research, with emphasis on the broadness and varying significance of the publications. Initially, we describe the chemical ingredients of R. canina pseudo fruits, with some focus on what ingredients are found in the whole pseudo fruit and what we know is confined to the seeds (achene seeds), and/or the shells (hypanthium). Then, we evaluate important papers describing the in vitro investigations of the bioactivity and impacts of the constituents of rose hip.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":"6 1","pages":"11-23"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S91385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68308603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Green tea catechins for well-being and therapy: prospects and opportunities 绿茶儿茶素用于健康和治疗:前景和机遇

Botanics : targets and therapy Pub Date : 2015-12-09 DOI: 10.2147/BTAT.S91784

N. Miyoshi, M. Pervin, Takuji Suzuki, K. Unno, M. Isemura, Yoriyuki Nakamura

{"title":"Green tea catechins for well-being and therapy: prospects and opportunities","authors":"N. Miyoshi, M. Pervin, Takuji Suzuki, K. Unno, M. Isemura, Yoriyuki Nakamura","doi":"10.2147/BTAT.S91784","DOIUrl":"https://doi.org/10.2147/BTAT.S91784","url":null,"abstract":"Tea is derived from the leaves and buds of Camellia sinensis (Theaceae) plant, and is consumed worldwide. Green tea was discovered in the People's Republic of China approxi- mately 3,000 BC. Lu Yu (733-803) published a book that describes the history of tea, the techniques, and utensils used for manufacturing, the method of preparation, and drinking of tea in the People's Republic of China. Green tea contains various components with specific health- promoting effects and is believed to exert protective effects against diseases such as cancer, obesity, diabetes, hepatitis, and neurodegenerative diseases. Of the various tea components, the polyphenol catechins have been the subject of extensive investigation. Among the catechins, (−)-epigallocatechin gallate has the strongest bioactivity in most cases. Caffeine induces alert- ness, decreases the sensation of fatigue, and has a diuretic effect. Theanine and γ-aminobutyric acid can lower the blood pressure and regulate brain function. Vitamin C exhibits antiscorbutic activity, prevents cataracts, and may boost the immune system. Majority of the scientific evi - dence based on cellular and animal experiments as well as a number of human epidemiological and intervention studies indicate that green tea and (−)-epigallocatechin gallate have beneficial health effects against various diseases. However, conflicting results have also been reported. Since confounding factors could affect the results, future studies should be designed to elimi- nate such factors for better understanding of the benefits of green tea on human health. Genetic and environmental factors such as race, sex, age, and lifestyle may also influence the results of human studies. Although care should be taken to avoid the consumption of green tea and supplements with very high catechin content, recent findings suggest that habitual drinking of green tea promotes longevity.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":"55 1","pages":"85-96"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S91784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68308652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

DNA barcoding: a genomic-based tool for authentication of phytomedicinals and its products DNA条形码:一种基于基因组学的植物药及其产品认证工具

Botanics : targets and therapy Pub Date : 2015-12-09 DOI: 10.2147/BTAT.S61121

K. Balachandran, S. Mohanasundaram, S. Ramalingam

引用次数: 14

Standardization of Prasaplai, a Thai traditional preparation for antidysmenorrhea 泰国传统抗痛经制剂Prasaplai的标准化

Botanics : targets and therapy Pub Date : 2015-12-01 DOI: 10.2147/BTAT.S56492

W. Gritsanapan, P. Tangyuenyongwatana

引用次数: 4

Recent perspectives on the medicinal potential of ginger 生姜药用潜力的最新研究进展

Botanics : targets and therapy Pub Date : 2015-10-20 DOI: 10.2147/BTAT.S68099

K. Gunathilake, Vasantha Rupasinghe

引用次数: 36