玫瑰果(Rosa canina L)粉在缓解关节炎疼痛和炎症中的作用-第二部分动物和人类研究

K. Marstrand, J. Campbell-Tofte
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引用次数: 11

摘要

玫瑰果(通常被称为玫瑰果)自古以来就被用于草药治疗。根据关于玫瑰果制剂对人体健康影响的轶事报告和古代文献中对其的引用,已经进行了体外和体内研究,使人们有可能了解玫瑰果中的一些活性成分,以及这些成分化合物如何发挥其作用。从这些研究中,已经有文件证明,在比较不同的玫瑰果产品时,活性成分有很大的差异。影响玫瑰果产品中有效成分的质量和数量的因素包括收获果实的特定犬玫瑰果亚种,植物生长期间的环境,收获时间以及制备中加入的种子和壳/壳的数量。对动物和人类的研究对于确定玫瑰果真正的生物效应具有重要意义。这类在过去20年才进行的体内研究表明,用含有一定半乳糖脂(GOPO)的犬鼠(Lito)亚种玫瑰果粉治疗不同类型关节疾病的患者可以减轻疼痛,改善日常活动,甚至减少常规止痛药的消耗。由于一些玫瑰果成分已被证明具有抗炎作用,因此有人认为,抗炎机制可能解释了服用玫瑰果治疗关节炎相关症状的一些减轻。虽然发表的关于玫瑰果的随机和安慰剂对照临床研究的数量很少,但最重要的证据是,同时含有果壳和种子的玫瑰果制剂的抗炎作用优于单独含有果壳的制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of rose hip ( Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies
: Rosa canina fruits (often known as rose hip) have been used in herbal remedies since ancient times. On the basis of anecdotal reports about the effects of rose hip preparations on human health and citations to the same in ancient texts, in vitro and in vivo studies have been conducted that have made it possible to learn about some active ingredients in rose hip, as well as how the component compounds might exert their effects. From such studies, it has been documented that there is a great variation in active ingredients when comparing different rose hip products. Factors which affect the quality and quantity of active ingredients in the rose hip products include the subspecies of the particular R. canina from which the fruits are harvested, the environment during plant growth, time of harvesting, and the amount of seeds and shells/husks incorporated into the preparation. Studies in animals and in humans are of great importance for determining the true bio-effects of rose hip. Such in vivo studies that have only been performed during the last 2 decades indicate that the treatment of patients with different types of joint disease with rose hip powder based on a subspecies of R. canina (Lito) containing a certain galactolipid (GOPO) can alleviate pain, improve daily activity, and even reduce the consumption of regular pain relievers. As several rose hip components have been shown to be anti-inflammatory, it is suggested that anti-inflammatory mechanisms might explain some reductions in symptoms associated with administering rose hip to arthritic conditions. Although the number of publications of randomized and placebo-controlled clinic studies with rose hip is small, the overriding evidence is that the anti-inflammatory effects from administration of rose hip preparations containing both shells and seeds are superior to preparations containing shells alone.
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