Bioactive ingredients of rose hips (Rosa canina L) with special reference to antioxidative and anti-inflammatory properties: in vitro studies

K. Winther, J. Campbell-Tofte, A. Hansen
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引用次数: 53

Abstract

: Rosa canina pseudo fruits, often referred to as rose hips, have been used as herbal medicine for more than 2,000 years, yet research has only recently begun to clarify specific mechanisms by which this plant product affects human health. Numerous compounds have been identified, and speculations of their bioactivity have implicated flavonoids, carotenoids, and fatty acids (FAs). With more than 4,500 representatives, flavonoids have been subjected to compre-hensive research, with results that suggest various individual structures may be health-promoting compounds, also in rose hips. The importance of carotenoids from R. canina is currently being debated, because the demonstration of specific bioactivity among this group is presently less clear. The benefits of specific FAs have been investigated for decades, and several types of FAs are termed “essential” for human health. The specific mechanisms for bioactivity associated with three FAs that are abundant in R. canina fruits have been clarified in research. For example, linoleic acid, α -linolenic acid (mostly present in the seeds from R. canina ) and a galactolipid ((2 S )-1,2-di- O -[(9 Z ,12 Z ,15 Z )-octadeca-9-12-15-trienoyl]-3- O - β - d -galactopyranosyl glycerol), referred to as GOPO, have been shown to have anti-inflammatory properties. The aim of this review is to critically analyze the published literature on rose hip research, with emphasis on the broadness and varying significance of the publications. Initially, we describe the chemical ingredients of R. canina pseudo fruits, with some focus on what ingredients are found in the whole pseudo fruit and what we know is confined to the seeds (achene seeds), and/or the shells (hypanthium). Then, we evaluate important papers describing the in vitro investigations of the bioactivity and impacts of the constituents of rose hip.
具有抗氧化和抗炎特性的玫瑰果(Rosa canina L)生物活性成分:体外研究
犬蔷薇的假果实,通常被称为玫瑰果,作为草药已经使用了2000多年,但研究直到最近才开始阐明这种植物产品影响人类健康的具体机制。已经鉴定了许多化合物,并推测其生物活性涉及类黄酮,类胡萝卜素和脂肪酸(FAs)。对超过4500名代表的类黄酮进行了全面的研究,结果表明,不同的个体结构可能是促进健康的化合物,玫瑰果也是如此。类胡萝卜素的重要性目前还在争论中,因为在这个群体中具体的生物活性目前还不太清楚。几十年来,人们一直在研究特定脂肪酸的益处,有几种类型的脂肪酸被称为人类健康的“必需”脂肪酸。目前,研究人员已经明确了犬鼠果实中富含的三种脂肪酸的作用机制。例如,亚油酸、α -亚麻酸(主要存在于犬鼠属植物的种子中)和半乳糖脂((2 S)-1,2-二- O -[(9 Z,12 Z,15 Z)-十八烷基-9-12-15-三烯基]-3- O - β -d -半乳糖酰丙基甘油),被称为GOPO,已被证明具有抗炎特性。本综述的目的是批判性地分析已发表的玫瑰果研究文献,重点是出版物的广泛性和不同的意义。首先,我们描述了狗狗假果实的化学成分,重点介绍了在整个假果实中发现的成分,以及我们所知道的仅限于种子(瘦果种子)和/或壳(托杯)的成分。然后,我们评估了描述玫瑰果成分生物活性和影响的体外研究的重要论文。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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