Pediatrics & therapeutics : current research最新文献

{"title":"ITP, IVIG and I","authors":"K. Lee","doi":"10.4172/2161-0665-C1-048","DOIUrl":"https://doi.org/10.4172/2161-0665-C1-048","url":null,"abstract":"An 8-yr-old Japanese boy was hospitalized, complaining of active hematochezia. He was shown to have a cherry-red, blood-oozing area of vascular dilation with mucosal prominence in the sigmoid colon by endoscopy, but had no other mucocutaneous vascular abnormalities. A family history was noncontributory. Under the clinical diagnosis of angiodysplasia of the sigmoid colon, he underwent an elliptical resection of the part, based on the intraoperative endoscopic findings. However, histological examination of the surgical specimen revealed a totally different picture from that seen in angiodysplasia: the thin-walled, markedly ectatic, nontortuous veins with hemorrhage were seen only just below the muscularis mucosae, around which the normal ones were shown to coexist. He has had no rebleeding for the past 3 yr. This lesion is considered to be an isolated congenital visceral telangiectasia involving veins.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70487945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural influences on public school nutrition along the US-Mexico border","authors":"A. MillsBWMootzA, Anchondo","doi":"10.4172/2161-0665-C1-049","DOIUrl":"https://doi.org/10.4172/2161-0665-C1-049","url":null,"abstract":"Fluoride: • Fluoride varnish, a high concentration of fluoride applied to the teeth, leaves a coating of fluoride material on the tooth enamel that is available for intake by saliva and plaque. • Statistically reduced percentage of children with caries incidence when given fluoride (two to four treatments) versus no fluoride. Ø Incidence decreased as number of fluoride applications increased • Fluoride varnish added approximately two minutes to the visit for parent explanation and application (Lewis et al., 2005) and provides an opportunity to perform an oral exam.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcome of Kawasaki disease complicated by a large coronary aneurysm","authors":"J. Jung","doi":"10.4172/2161-0665-C10-079","DOIUrl":"https://doi.org/10.4172/2161-0665-C10-079","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42430137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Ileocolic Intussusception Caused by Introducing Solid Food Before 6 Months Old: A Case Report","authors":"P. Gunawan","doi":"10.4172/2161-0665.1000343","DOIUrl":"https://doi.org/10.4172/2161-0665.1000343","url":null,"abstract":"A 7-months-old girl presented with bloody diarrhea and vomiting. She had been fed with red rice since she was 5 months old. She was restless, defecated red currant jelly stool and sausage-shaped mass was palpable on the inferior of umbilical region. The ultrasound showed a 3.16 × 2.58 cm mass with a target-like appearance which is consistent with intussusception. She underwent exploratory laparotomy, invagination release (milking) and appendectomy. Pathologic examination of the lymph node on the mesenteric side of caecum revealed lymphoid tissue hyperplasia. The introduction to solid food before 6 months in this patient was suspected as the predisposing factor of the intussusception. More effective counseling about the timing of solid food introduction by pediatrician or primary health care provider may prevent other similar cases like this from happening.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"8 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41411152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Expression of Migration Inhibitory Factor mRNA in Peripheral Blood of Children with Systemic Lupus Erythematosus","authors":"S. Reda, S. El-Sayed, Shereen Elsayed, S. Felix","doi":"10.4172/2161-0665.1000342","DOIUrl":"https://doi.org/10.4172/2161-0665.1000342","url":null,"abstract":"Aim: This study was aiming at evaluation of the importance and the change in the level of macrophage migration inhibitory factor (MIF) in serum studied by ELISA and in peripheral blood mononuclear cell (PMBC) through the expression of mRNA of MIF studied by reverse PCR and its correlation with disease activity index in patients with systemic lupus erythematosus (SLE). Also, the relationship of MIF with the treatment by corticosteroids and renal involvement was taken into consideration.Material and methods: For this purpose, twenty lupus patients, regularly attending the Pediatric Allergy and Immunology Clinic, Children Hospital, Ain Shams University and fulfilling the American Rheumatism Association Revised Criteria for diagnosis of SLE, were studied in comparison to thirty-five healthy subjects as normal controls. According to the presence or absence of clinical renal involvement, lupus patients were divided into two groups: Group Ia: included 10 patients with clinical renal involvement and Group Ib: comprised 10 patients without clinical renal involvement. Full history taking and clinical examination were done and the SLEDAI was assessed. Also, the following laboratory investigations were performed ESR, routine microscopic urine analysis, 24 hours urine proteins, serum ANA, C3, serum anti-DNA, serum creatinine, serum MIF by ELISA and MIF gene expression through the mRNA in PBMC by rPCR.Results: The results of the present study showed that the MIF in serum and in PBMC were significantly higher among lupus patients as compared to normal controls. In addition, both were significantly higher among lupus patients with clinically evident nephritis than those without. Serum MIF and MIF gene expression were both significantly higher among lupus patients who suffered from symptoms suggestive of lupus nephritis as edema, hematuria, hypertension and positive anti DNA levels than other patients who did not experience these symptoms. In our study, different correlation analysis were done with serum MIF and MIF gene expression and proved to be significantly positive with SLEDAI score, ESR, cumulative dose of steroids, serum creatinine, 24 hour urinary protein and duration of illness in all lupus patients.Conclusions: In conclusion, MIF both in the serum and MIF gene expression by reverse PCR in macrophages were significantly higher in all lupus patients in comparison to healthy controls being significantly higher in those lupus patients with clinically evident nephritis than those without. Also MIF had a significant positive correlation to SLEDAI score and ESR indicating its correlation with disease activity.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"8 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pearson Syndrome as a Rare Cause of Failure to Thrive, Anemia and Exocrine Pancreatic Insufficiency: A Case Report","authors":"T. Kitano, Sayaka Yoshida","doi":"10.4172/2161-0665.1000341","DOIUrl":"https://doi.org/10.4172/2161-0665.1000341","url":null,"abstract":"Pearson syndrome is a rare mitochondrial disorder. We present a 1-year-old girl with Pearson syndrome confirmed by the deletion of mtDNA (a 2.7-kb deletion, m.11244_13981del2738). She presented with failure to thrive, anemia, exocrine pancreatic insufficiency and severe liver failure. She also had elevated serum lactate and alanine level and renal tubular dysfunction. She required multiple packed red blood cell transfusions, which led to iron chelation therapy due to her elevated serum ferritin level. Nutritional management including vitamin supplement was performed, which did not help save her life. In conclusion, although Pearson syndrome is a rare disorder, we need to consider the possibility of Pearson syndrome in case of failure to thrive in addition to multiple organ involvement such as bone marrow, liver, kidney and pancreatic insufficiency.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"75 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus reuteri DSM 17938: Review of Evidence in Functional Gastrointestinal Disorders","authors":"R. Srinivasan, D. Kesavelu, Krishna Chaitanya Velig, La, Shashi Kanth Muni, S. Mehta","doi":"10.4172/2161-0665.1000350","DOIUrl":"https://doi.org/10.4172/2161-0665.1000350","url":null,"abstract":"Lactobacillus reuteri DSM 17938 has been one of the most extensively studied probiotic in children and adults with functional gastrointestinal disorders. In order to gather evidence on the efficacy of Lactobacillus reuteri DSM 17938 for treating and preventing some of these disorders. MEDLINE and the Cochrane Library were searched till February 2018 for relevant randomized controlled trials, retrospective studies, and meta-analyses with no language restrictions. The recent probiotic literature strongly suggests that Lactobacillus reuteri may be effective in the prevention and treatment of certain clinical conditions, such as infantile colic, infantile regurgitation, functional constipation, acute gastroenteritis, acute diarrhea, antibiotic-associated diarrhea, and necrotizing enterocolitis. No safety concerns with regard to the use of Lactobacillus reuteri in non-immunocompromised subjects were identified. A recent meta-analysis also supports the safety of using Lactobacillus reuteri even in preterm infants. This review presents the history of Lactobacillus reuteri DSM 17938 and the evidence base for its application in the health and disease.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"08 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-0665.1000350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Diet and Symptoms of Allergic Diseases in Children Aged from 8 to 12 in Public Schools in Beirut and Mount Lebanon","authors":"Lahoud Odette, Salameh Pascale, Raherison Chantal, Boutros Celina, Khafaja Sarah, Saadeh Danielle","doi":"10.4172/2161-0665.1000349","DOIUrl":"https://doi.org/10.4172/2161-0665.1000349","url":null,"abstract":"Background: The prevalence of allergic diseases including asthma, rhinoconjunctivitis and eczema, has increased in the Western world in recent decades, particularly in children, becoming a major public health problem in the whole world. Therefore, the objective of this 12 months study is to evaluate the relationship between eating habits and the symptoms of allergic diseases in children. Methods: This cross-sectional epidemiological observational study was conducted among children (n=3104) in various public schools in Beirut and Mount Lebanon. A self-administered questionnaire, based on the “International Study of Asthma and Allergies in Childhood (ISAAC) and a Food Frequency Questionnaire (FFQ)” was used to evaluate the children's eating habits. The study took place between February and April 2016. The data collected were coded, entered and then analyzed using the Statistical Package for Social Sciences (SPSS). Results: The prevalence of symptoms of asthma, rhino conjunctivitis, and eczema during the past 12 months reported 7.8%, 11.4% and 4.1%, respectively. The onset of allergic diseases symptoms, especially asthma, seems to be reduced by the consumption of certain food products, such as raw and cooked vegetables, grains, fish, dairy products, and fresh fruit juices. On the other hand, “salt” was associated with an increased risk for all studied allergic diseases. Bivariate and multivariate analyses were performed to identify the relationship between a certain diet and the symptoms of allergic diseases during 12 months. Conclusion: This study explicates the association between eating habits and allergic diseases. Indeed, some foods belonging to the Western diet can be considered as risk factors, while others belonging to the Mediterranean diet proved to be protective. This leaves the door open to further studies from a different perspective.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"08 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethylene Glycols with or without Electrolytes for Constipation in Children: A Network Meta-Analysis","authors":"N. Cranswick, P. Katelaris, V. Naganathan, John Gullotta, George Krassas, Ken Liu","doi":"10.4172/2161-0665.1000344","DOIUrl":"https://doi.org/10.4172/2161-0665.1000344","url":null,"abstract":"Background: Polyethylene glycol laxatives are the cornerstone of the management of constipation in children. They are available with and without electrolytes.Aims: The aims of this network meta-analysis (NMA) were to assess the relative efficacy, safety and tolerability of polyethylene glycol with (PEG+E) or without electrolytes (PEG) in the management of constipation in children.Methods: A systematic review and NMA was undertaken to identify and analyse all published randomised controlled clinical trials of polyethylene glycol in children with constipation. Text word searches were carried out using MEDLINE, MEDLINE in Progress, EMBASE, Cochrane Database and Systematic Reviews databases covering inception to April 2015. The primary efficacy analysis was the mean number of bowel movements per week. Secondary endpoints assessed safety, tolerability and compliance.Results: 15 studies (involving 1,384 patients) were included in the NMA. PEG and PEG+E are both more effective than placebo, increasing the mean number of bowel movements per week by 2.3 (95% Crl 0.3, 4.4) and 2.2 (95% Crl 0.1, 4.7) respectively. Direct comparison of PEG+E with PEG identified no differences in efficacy, safety, or tolerability, with the exception of one study demonstrating better tolerability with PEG. Compared to PEG+E, PEG was easier to take, with a trend towards improved compliance.Conclusion: This NMA provides no evidence to support the clinical utility of added electrolytes to polyethylene glycol in the management of constipation in children. PEG alone is as effective as PEG+E and both therapies are well tolerated. This analysis supports the ongoing use of polyethylene glycol as a first-line treatment of constipation in children. Formulations without electrolytes should be considered first to optimize patient acceptability and adherence.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"8 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-0665.1000344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Few Facts: A Premature Baby and Common Problems","authors":"D. Sorte","doi":"10.4172/2161-0665.1000E131","DOIUrl":"https://doi.org/10.4172/2161-0665.1000E131","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"8 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-0665.1000E131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}