Pediatrics & therapeutics : current research最新文献

{"title":"Neonatal resuscitation: Evolving strategies","authors":"pEric Kwame Firip","doi":"10.4172/2161-0665-C2-055","DOIUrl":"https://doi.org/10.4172/2161-0665-C2-055","url":null,"abstract":"M in infants in lowto middle-income countries is a complex problem caused, in part, by underfeeding and an increased prevalence of gastrointestinal (GI) disease. To understand and separate the effects of nutrition and disease on infant growth, a physiologically-based mathematical model was developed describing fat mass (FM) and fat-free mass (FFM) from birth to 2 years. This effort was based on a published model describing growth dynamics, expanded to include effects of infection and nutritional status on nutrient absorption in the gut. Model calibration used published data to quantify the physiology of healthy and non-healthy GI function and resulting physical growth, including: Macronutrient absorption efficiencies, deposition of metabolizable energy into FM and FFM, total energy expenditure, dynamics of severe bacterial and viral infections, effects of malnutrition on GI/immune function, recovery from malnutrition. The model was validated using individual data from different geographical locations representing various phenotypes, dietary intakes, disease susceptibilities and child rearing patterns. One important insight from this work resulted from the differential FM and FFM composition of weight loss during infection and weight gain during recovery, dependent on the degree of malnutrition and individual phenotype. For example, an interesting phenotype has been seen in infants at risk of malnutrition whereby FM is increased despite energy intakes smaller than age-appropriate requirements. The model was able to mechanistically recapitulate this phenotype by imposing repeated cycles of weight loss/gain due to infections or underfeeding, indicating the potentially large impact of non-dietary factors on infant growth outcomes.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine use in neonates undergoing norwood procedure does not limit narcotic exposure","authors":"BarbaraJo Achuffp","doi":"10.4172/2161-0665-C2-054","DOIUrl":"https://doi.org/10.4172/2161-0665-C2-054","url":null,"abstract":"Methodology: A retrospective observational study done including 603 neonates ≤ 32 weeks of gestational age admitted in a tertiary care neonatal centre from January 2015 to December 2017. Growth parameters at discharge from hospital were plotted on Fenton 2013(3) growth charts and neonates falling below the 10th percentile were considered as EUGR. Neonatal data during the birth and hospital stay was analysed for identification of predictors of EUGR.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetic basis of neuroblastoma predisposition","authors":"pSharon J Diskinp","doi":"10.4172/2161-0665-C6-065","DOIUrl":"https://doi.org/10.4172/2161-0665-C6-065","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Np73/ETS2 complex drives Angiopoietin-1 and Tie2 expression to promote angiogenesis in glioblastoma","authors":"pHakan Camp","doi":"10.4172/2161-0665-C6-067","DOIUrl":"https://doi.org/10.4172/2161-0665-C6-067","url":null,"abstract":"BACKGROUND\u0000Asparaginase is an effective antileukemic agent which is included in most front-line protocols for pediatric acute lymphoblastic leukemia (ALL) worldwide. Since asparaginase is a bacterial protein, it may induce formation of antibodies. The reported frequency of anti-asparaginase antibodies is highly variable: antibodies have been reported in as many as 79% of adults and as many as 70% of children after intravenous or intramuscular administration of E.coli asparaginase.\u0000\u0000\u0000PURPOSE\u0000The aim of this study was to determine if the presence of antibodies during induction and continuation phases in newly diagnosed children with ALL and lymphoblastic lymphoma during therapy with E.coli asparaginase, had any correlation with various factors such as: age, gender, hypersensitivity reactions, response to therapy and Event Free Survival (EFS).\u0000\u0000\u0000PATIENTS AND METHODS\u0000Between the period from March 2005 to May 2007, sixty-four children who attended the Menia outpatient pediatric oncology clinic, or were admitted to the inpatient department of the Menia oncology center, were enrolled in the study. Forty children had newly diagnosed ALL and 24 had lymphoblastic lymphoma. Patients were 48 males (75%) and 16 females (25%) with a male:female ratio 3:1. Their ages ranged from 3.5 to 17 years with mean age of 9.6 years. All patients received asparaginase therapy according to the St. Jude Total XIII protocol, in a dose of 10,000 IU/m(2)/dose, intramuscularly for 6-9 doses during the induction phase and another 6-9 doses during continuation phase according to disease status.\u0000\u0000\u0000RESULTS\u0000Forty one patients achieved complete remission, 9 had partial remission, and 14 were lost to followup at different intervals of treatment. Antiasparaginase antibodies were detected in 36 patients (56%) out of 64 patients, and 37 patients (60%) out of 62 patients who were treated with asparaginase at day 8 and day 27 of induction phase respectively. Moreover, 33 patients (61%) out of 54 patients, and 41 patients (83%) out of 50 patients had positive antiasparaginase antibodies at week 10 and week 21 of continuation phase respectively. The 2-year EFS of the whole group was 50%. There was no statistically significant relation between positivity of antiasparaginase antibodies and the following: age, gender, hypersensitivity reaction, response to therapy and EFS.\u0000\u0000\u0000CONCLUSIONS\u0000The presence of antiasparaginase antibodies was unrelated to age, gender, hypersensitivity reaction, response to therapy and event free survival of newly diagnosed children with acute lymphoblastic leukemia and lymphoblastic lymphoma.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Completing the circle of pediatric hematopoietic stem cell transplant care; revaccinations: When and how","authors":"pEllen M Levy, Anne Wohlschlaegerp","doi":"10.4172/2161-0665-C6-066","DOIUrl":"https://doi.org/10.4172/2161-0665-C6-066","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of lipid profile and other cardiovascular risk factors in children born to parents having premature ischemic heart disease","authors":"pM R Savithap","doi":"10.4172/2161-0665-C5-063","DOIUrl":"https://doi.org/10.4172/2161-0665-C5-063","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46462236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of the Newborn Screening Test: A Case Report Detecting Congenital Hypothyroidism and Indirect Hyperbilirubinemia","authors":"M. Engin","doi":"10.4172/2161-0665-C3-058","DOIUrl":"https://doi.org/10.4172/2161-0665-C3-058","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"08 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition in children: South Africa’s present scenario","authors":"M. Anwar","doi":"10.4172/2161-0665-C3-056","DOIUrl":"https://doi.org/10.4172/2161-0665-C3-056","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of socioeconomic status with mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS) in Japan","authors":"Yasuo Imanishi","doi":"10.4172/2161-0665-C1-051","DOIUrl":"https://doi.org/10.4172/2161-0665-C1-051","url":null,"abstract":"INTRODUCTION Nephrotic syndrome is a heterogeneous disease in children, with nearly 10% categorized as steroid-resistant. In this study we evaluated disease related mutations within NPHS1, NPHS2 and new potential variants in other genes. METHODS In the first phase of study, 25 patients with SRNS were analyzed by Sanger sequencing for NPHS1 (exon 2, 26) and all exons of NPHS2 genes. In the next step, whole exome sequencing was performed on 10 patients with no mutation in NPHS1 and NPHS2. RESULTS WES analysis revealed a novel mutation in FAT1 (c.10570C > A; Q3524K). We identified 4 pathogenic mutations, located in exon 4 and 5 of NPHS2 gene in 20% of patients (V180M, P118L, R168C and Leu156Phe). Also our study has contributed to the description of previously known pathogenic mutations across WT1 (R205C) and SMARCAL1 (R764Q) and a novel polymorphism in CRB2. CONCLUSION It seems that NPHS2, especially exons 4 and 5, should be considered as the first step in genetic evaluation of Iranian patients. We suggest conducting WES after NPHS2 screening to identify the potential genes associated with SRNS, Further studies are required to examine more common genes in the first step and then designing native laboratory panels.","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70488254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-demographic profile and outcome of twin pregnancies in a tertiary government hospital: A three-year retrospective study","authors":"Meidelin Hoei","doi":"10.4172/2161-0665-C7-070","DOIUrl":"https://doi.org/10.4172/2161-0665-C7-070","url":null,"abstract":"","PeriodicalId":91373,"journal":{"name":"Pediatrics & therapeutics : current research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43701861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}