BMJ Supportive & Palliative Care最新文献

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Assessment of palliative care training in gynaecological oncology: a survey among European Network of Young Gynae-Oncologists (ENYGO) members. 妇科肿瘤姑息治疗培训评估:欧洲青年妇科肿瘤学家网络(ENYGO)成员调查。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/bmjspcare-2020-002233
Mariaclelia La Russa, Ignacio Zapardiel, Kamil Zalewski, Rene Laky, Polat Dursun, Vladyslav Sukhin, David Lindquist, Kristina Lindemann
{"title":"Assessment of palliative care training in gynaecological oncology: a survey among European Network of Young Gynae-Oncologists (ENYGO) members.","authors":"Mariaclelia La Russa, Ignacio Zapardiel, Kamil Zalewski, Rene Laky, Polat Dursun, Vladyslav Sukhin, David Lindquist, Kristina Lindemann","doi":"10.1136/bmjspcare-2020-002233","DOIUrl":"10.1136/bmjspcare-2020-002233","url":null,"abstract":"<p><strong>Introduction: </strong>Palliative care is an important aspect of gynaecological oncology practice. In order to successfully integrate end-of-life (EOL) care in the disease trajectory, it is crucial to incorporate systematic training in subspecialty programmes in gynaecological oncology. We aimed to evaluate the quality of training in palliative care across gynaecological oncology fellows in Europe and to provide a framework to facilitate learning opportunities.</p><p><strong>Methods: </strong>A web-based questionnaire was sent to members of the European Network of Young Gynae-Oncologists (ENYGO). The survey consisted of 36 items covering six domains: respondents' characteristics, quality and quantity of teaching, curriculum achievements, observation and feedback, EOL clinical practice and attitudes about palliative care.</p><p><strong>Results: </strong>Of the 703 clinicians enrolled in the study, 142 responded (20.2%). Although the majority worked in university hospitals, only half of them (47%) were in a formal subspecialty programme. The majority of respondents (60%) were trained without a mandatory rotation in palliative care units and considered the quality of EOL care teaching as 'very poor' or 'poor' (57.7%). The majority of respondents (71.6%) did not receive any supervision or feedback at the time of their first consultation on changing the goals of care.</p><p><strong>Conclusion: </strong>Our study underlines lack of structured teaching and supervision in palliative care contents among European fellows in gynaecological oncology. Broad education of healthcare providers is a key factor to achieve the integration of palliative care in gynaecological oncology practice. Stakeholders like European Society of Gynaecological Oncology/ENYGO play an important role to facilitate educational activities and training programmes targeting to EOL care.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"104-107"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38404531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIH stroke scale and unfavourable outcomes in acute ischaemic stroke: retrospective study. NIH 卒中量表与急性缺血性卒中的不利预后:回顾性研究。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2022-003791
Maiara Silva Tramonte, Ana Claudia Pires Carvalho, Ana Elisa Vayego Fornazari, Gustavo Di Lorenzo Villas Boas, Gabriel Pinheiro Modolo, Natalia Cristina Ferreira, Marcos Christiano Lange, Marcos Ferreira Minicucci, Rodrigo Bazan, Laura Cardia Gomes Lopes
{"title":"NIH stroke scale and unfavourable outcomes in acute ischaemic stroke: retrospective study.","authors":"Maiara Silva Tramonte, Ana Claudia Pires Carvalho, Ana Elisa Vayego Fornazari, Gustavo Di Lorenzo Villas Boas, Gabriel Pinheiro Modolo, Natalia Cristina Ferreira, Marcos Christiano Lange, Marcos Ferreira Minicucci, Rodrigo Bazan, Laura Cardia Gomes Lopes","doi":"10.1136/spcare-2022-003791","DOIUrl":"10.1136/spcare-2022-003791","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the determining factors of severe functional impairment (SFI) outcome at discharge and in-hospital mortality in patients who had an acute ischaemic stroke and thus favouring early implementation of primary palliative care (PC).</p><p><strong>Methods: </strong>A retrospective descriptive study by the analysis of 515 patients who had an acute ischaemic stroke admitted at stroke unit, aged≥18 years, from January 2017 to December 2018. Previous clinical and functional status data, National Institute of Health Stroke Scale (NIHSS) on admission, and data related to the evolution during hospitalisation were evaluated, relating them to the SFI outcome at discharge and death. The significance level was set at 5%.</p><p><strong>Results: </strong>Of 515 patients included, 15% (77) died, 23.3%(120) had an SFI outcome and 9.1% (47) were evaluated by the PC team. It was observed that NIHSS Score≥16 is responsible for a 15.5-fold increase in the occurrence of death outcome. The presence of atrial fibrillation was responsible for a 3.5-fold increase in the risk of this outcome.</p><p><strong>Conclusion: </strong>NIHSS Score is an independent predictor of in-hospital death and SFI outcomes at discharge. Knowledge about the prognosis and risk of developing unfavourable outcomes is important for planning the care of patients affected by a potentially fatal and limiting acute vascular insult.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"112-115"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9396467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taste changes in paediatric oncology: longitudinal evaluation. “儿童肿瘤学口味变化:纵向评估”。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2023-004409
Ida Mehrdadi, Neeraj Dhaliwal, Lauren Chakkalackal, Gloria Green, Tal Schechter, Sue Zupanec, L Lee Dupuis, Lillian Sung
{"title":"Taste changes in paediatric oncology: longitudinal evaluation.","authors":"Ida Mehrdadi, Neeraj Dhaliwal, Lauren Chakkalackal, Gloria Green, Tal Schechter, Sue Zupanec, L Lee Dupuis, Lillian Sung","doi":"10.1136/spcare-2023-004409","DOIUrl":"10.1136/spcare-2023-004409","url":null,"abstract":"<p><strong>Objectives: </strong>Changes in taste is a common symptom in paediatric patients receiving cancer therapies. The primary objective was to describe the prevalence of taste changes longitudinally over a 6-month time frame among paediatric patients with newly diagnosed cancer. Secondary objective was to identify factors associated with taste changes over time.</p><p><strong>Methods: </strong>In this longitudinal, single centre study, we included paediatric patients newly diagnosed with cancer within the previous 8 weeks who were 4-18 years of age. Interviews were conducted once monthly for 6 months. We asked participants about their experience with taste changes, whether potential interventions were successful and whether taste changes influenced eating. Risk factors were evaluated using generalised linear mixed-effects models.</p><p><strong>Results: </strong>Overall, 60 participants were included. At baseline, 23 (38.3%) participants reported experiencing changes in taste, with the proportion significantly declining over time to 13 (21.7%) at 6 months. The most common specific taste changes were food tasting different, bad or bland. The most common helpful strategies were eating liked foods only, brushing teeth or using mouthwash, drinking more liquids and eating food with strong flavour. Taste change was commonly associated with eating less than usual and reduced enjoyment in eating. Nausea, dry mouth and recent vincristine were independent risk factors for taste changes.</p><p><strong>Conclusions: </strong>Changes in taste were common within 8 weeks of cancer diagnosis and declined significantly over time. Nausea, dry mouth and recent vincristine were independent risk factors. Future studies should develop and evaluate interventions for managing taste changes in paediatric patients with cancer.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"65-71"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136396304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure ulcer prevention: family caregiver training effectiveness. 预防褥疮:家庭护理人员培训的有效性。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2023-004711
Hümeyra Hançer Tok, Lütfiye Nur Uzun
{"title":"Pressure ulcer prevention: family caregiver training effectiveness.","authors":"Hümeyra Hançer Tok, Lütfiye Nur Uzun","doi":"10.1136/spcare-2023-004711","DOIUrl":"10.1136/spcare-2023-004711","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effectiveness of pressure ulcer prevention training for the relatives of palliative care inpatients.</p><p><strong>Methods: </strong>This study had a pretest-post-test design with parallel groups and a randomised control group, and it was conducted with 70 (experimental n=35, control n=35) patient relatives. A personal information form and Pressure Ulcer Knowledge Test were used as data collection tools. Parametric tests were performed for statistical analysis.</p><p><strong>Results: </strong>The pressure ulcer prevention training given to the relatives of palliative care patients in the experimental group was significantly effective in increasing their level of knowledge about these ulcers (p<0.05). However, the routine ward discharge training given to the relatives of palliative care patients in the control group was not significantly effective in increasing their level of knowledge about them (p>0.05).</p><p><strong>Conclusions: </strong>Specialised training regarding pressure ulcers should be given to the relatives of patients receiving palliative care. It is important that the educational materials used in this trainings appeal to all sensory organs in order to improve the educational outcomes.</p><p><strong>Trial registration number: </strong>NCT05979402.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"72-78"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geriatric screening and comprehensive geriatric assessment during initial oncology appointments. 在肿瘤科初次就诊时进行老年病筛查和综合老年病评估。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2024-004822
Tânia Madureira, Joana Magalhães, Pedro Vilas, Elsa Campôa, Paulo Luz, Filipe Coutinho
{"title":"Geriatric screening and comprehensive geriatric assessment during initial oncology appointments.","authors":"Tânia Madureira, Joana Magalhães, Pedro Vilas, Elsa Campôa, Paulo Luz, Filipe Coutinho","doi":"10.1136/spcare-2024-004822","DOIUrl":"10.1136/spcare-2024-004822","url":null,"abstract":"<p><strong>Introduction: </strong>Geriatric oncology underscores the significance of assessing functional age in guiding medical decisions, endeavouring to delineate practical and efficacious methodologies for evaluating functionality, adapting therapeutic regimens and attenuating the risks of treatment-related deterioration.</p><p><strong>Objectives and methods: </strong>In this prospective study, we aimed to delineate the characteristics of older patients presenting for their initial oncology appointment by using geriatric screening (G8 score) and comprehensive geriatric assessment (CGA), while also assessing the feasibility of these evaluations. Secondary objectives included comparing the initial Eastern Cooperative Oncology Group (ECOG) performance status and any deviations from standard therapeutic strategies against the identified frailty in geriatric assessment.</p><p><strong>Results: </strong>Most patients exhibited a G8 score ≤14 and underwent comprehensive geriatric assessment. While oncologists typically perceive patients' general conditions, CGA enables a systematic assessment, providing a comprehensive characterisation of elderly patients to inform therapeutic decisions and address identified fragilities. The CGA highlighted vulnerabilities across all primary domains. Notably, even among patients with ECOG scores of 0 and 1, the application of G8 score and CGA revealed numerous fragilities. Consistent with existing literature, these scales offered additional insights beyond ECOG evaluation alone, suggesting their potential to guide therapeutic adaptations for this demographic.</p><p><strong>Conclusion: </strong>Ongoing research and continuous evaluation are imperative to refine and broaden the implementation of geriatric-focused interventions.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"121-124"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence and large language models in palliative medicine clinical practice and education. 人工智能和大型语言模型在姑息医学临床实践和教育中的应用。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2024-005217
Mark Taubert, Robyn Hackett, Simon Tavabie
{"title":"Artificial intelligence and large language models in palliative medicine clinical practice and education.","authors":"Mark Taubert, Robyn Hackett, Simon Tavabie","doi":"10.1136/spcare-2024-005217","DOIUrl":"10.1136/spcare-2024-005217","url":null,"abstract":"<p><p>As we approach 2034, we anticipate significant advancements in digital technologies and their impact across various domains, including palliative and end-of-life care and perhaps higher education more generally. Predicting technological breakthroughs, especially in the realm of artificial intelligence (AI), is notoriously difficult. In a sense, you might need an AI to do this effectively. While some digital challenges can surprise us, others prove more elusive than expected. For example, AI's ability to be creative with language and comprehension has been genuinely remarkable and will likely be of interest to those whose 'bread and butter' at work is communication. Similarly, those who teach skills required of clinicians in palliative and end-of-life care, including breaking bad news and nuanced conversations around holistic complexity and treatment preferences are likely to see significant changes and shifts in their practice.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"61-64"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
End-of-life preferences of people with advanced chronic obstructive pulmonary disease. 晚期慢性阻塞性肺病患者的临终选择。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2024-005067
M Aurora Mendes, Anouk Jl Muijsenberg, Sarah Houben-Wilke, Carmen Hm Houben, Martijn A Spruit, Alda Marques, Daisy J A Janssen
{"title":"End-of-life preferences of people with advanced chronic obstructive pulmonary disease.","authors":"M Aurora Mendes, Anouk Jl Muijsenberg, Sarah Houben-Wilke, Carmen Hm Houben, Martijn A Spruit, Alda Marques, Daisy J A Janssen","doi":"10.1136/spcare-2024-005067","DOIUrl":"10.1136/spcare-2024-005067","url":null,"abstract":"<p><strong>Objectives: </strong>To identify end-of-life preferences of people with advanced chronic obstructive pulmonary disease (COPD) and to compare characteristics between those who wish to discuss the end-of-life and those who do not.</p><p><strong>Methods: </strong>An analysis of the baseline data of a randomised controlled trial was performed including people with COPD GOLD stages III-IV or former quadrant D with modified Medical Research Council questionnaire grade ≥2, after hospital discharge following an exacerbation. Participants were interviewed using the End-of-Life Preferences Interview.</p><p><strong>Results: </strong>A total of 165 individuals (53% men; 68±9 years old; 55% care dependent) were included. Most participants wished to take part in shared decision-making (78%), to be informed about a short life expectancy (82%), to discuss the end-of-life (82%), to have loved ones around at death (87%) and to choose when to die (70%). They also reported accepting opioids (74%). Preferences for who to provide physical care, the place, consciousness and atmosphere at death as well as life-sustaining treatments were heterogeneous. Participants who wanted to discuss the end-of-life had a significantly higher educational level (p=0.030) and worse health status than participants who did not (p=0.007).</p><p><strong>Conclusions: </strong>End-of-life preferences of people with advanced COPD were heterogeneous, however, most wished to discuss it, especially those with higher educational level and worse health status.</p><p><strong>Trial registration number: </strong>NTR3940.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"134-140"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalised virtual reality in palliative care: clinically meaningful symptom improvement for some. 个性化虚拟现实技术在姑息治疗中的应用:对某些症状的改善具有临床意义。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2024-004815
Kaylin Altman, Dimitrios Saredakis, Hannah Keage, Amanda Hutchinson, Megan Corlis, Ross T Smith, Gregory Brian Crawford, Tobias Loetscher
{"title":"Personalised virtual reality in palliative care: clinically meaningful symptom improvement for some.","authors":"Kaylin Altman, Dimitrios Saredakis, Hannah Keage, Amanda Hutchinson, Megan Corlis, Ross T Smith, Gregory Brian Crawford, Tobias Loetscher","doi":"10.1136/spcare-2024-004815","DOIUrl":"10.1136/spcare-2024-004815","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the effects of virtual reality (VR) among palliative care patients at an acute ward. Objectives included evaluating VR therapy benefits across three sessions, assessing its differential impact on emotional versus physical symptoms and determining the proportion of patients experiencing clinically meaningful improvements after each session.</p><p><strong>Methods: </strong>A mixed-methods design was employed. Sixteen palliative inpatients completed three personalised 20 min VR sessions. Symptom burden was assessed using the Edmonton Symptom Assessment Scale-Revised and quality of life with the Functional Assessment of Chronic Illness Therapy (FACIT-Pal-14). Standardised criteria assessed clinically meaningful changes. Quantitative data were analysed using linear mixed models.</p><p><strong>Results: </strong>Quality of life improved significantly pre-VR to post-VR with a large effect size (Cohen's d: 0.98). Total symptom burden decreased after 20 min VR sessions (Cohen's d: 0.75), with similar effect sizes for emotional (Cohen's d: 0.67) and physical symptoms (Cohen's d: 0.63). Over 50% of patients experienced clinically meaningful improvements per session, though substantial individual variability occurred.</p><p><strong>Conclusions: </strong>This study reveals the nuanced efficacy of personalised VR therapy in palliative care, with over half of the patients experiencing meaningful benefits in emotional and physical symptoms. The marked variability in responses underscores the need for realistic expectations when implementing VR therapy.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"116-120"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-arm clinical trials: design, ethics, principles. 单臂临床试验:设计、伦理和原则。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2024-004984
Minyan Wang, Huan Ma, Yun Shi, Haojie Ni, Chu Qin, Conghua Ji
{"title":"Single-arm clinical trials: design, ethics, principles.","authors":"Minyan Wang, Huan Ma, Yun Shi, Haojie Ni, Chu Qin, Conghua Ji","doi":"10.1136/spcare-2024-004984","DOIUrl":"10.1136/spcare-2024-004984","url":null,"abstract":"<p><p>Although randomised controlled trials are considered the gold standard in clinical research, they are not always feasible due to limitations in the study population, challenges in obtaining evidence, high costs and ethical considerations. As a result, single-arm trial designs have emerged as one of the methods to address these issues. Single-arm trials are commonly applied to study advanced-stage cancer, rare diseases, emerging infectious diseases, new treatment methods and medical devices. Single-arm trials have certain ethical advantages over randomised controlled trials, such as providing equitable treatment, respecting patient preferences, addressing rare diseases and timely management of adverse events. While single-arm trials do not adhere to the principles of randomisation and blinding in terms of scientific rigour, they still incorporate principles of control, balance and replication, making the design scientifically reasonable. Compared with randomised controlled trials, single-arm trials require fewer sample sizes and have shorter trial durations, which can help save costs. Compared with cohort studies, single-arm trials involve intervention measures and reduce external interference, resulting in higher levels of evidence. However, single-arm trials also have limitations. Without a parallel control group, there may be biases in interpreting the results. In addition, single-arm trials cannot meet the requirements of randomisation and blinding, thereby limiting their evidence capacity compared with randomised controlled trials. Therefore, researchers consider using single-arm trials as a trial design method only when randomised controlled trials are not feasible.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"46-54"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical menthol for chemotherapy-induced peripheral neuropathy: a randomised controlled trial in breast cancer. 外用薄荷醇治疗化疗引起的周围神经病变:乳腺癌随机对照试验。
IF 2 4区 医学
BMJ Supportive & Palliative Care Pub Date : 2024-12-25 DOI: 10.1136/spcare-2023-004483
Deniz Ozdemir, Selda Arslan, Mehmet Artac, Fatih Karaarslan
{"title":"Topical menthol for chemotherapy-induced peripheral neuropathy: a randomised controlled trial in breast cancer.","authors":"Deniz Ozdemir, Selda Arslan, Mehmet Artac, Fatih Karaarslan","doi":"10.1136/spcare-2023-004483","DOIUrl":"10.1136/spcare-2023-004483","url":null,"abstract":"<p><strong>Objectives: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) symptom is one of the side effects of paclitaxel in breast cancer patients. This randomised controlled study was conducted to investigate the effect of topical menthol applied on the hands and feet of breast cancer patients receiving chemotherapy on CIPN symptoms.</p><p><strong>Methods: </strong>60 breast cancer patients receiving chemotherapy were randomly assigned to an intervention group (n=30), which received topical menthol treatment, or a control group (n=30), which received standard care. Both groups continued their routine pharmacological treatments throughout the study. The intervention group applied 1% menthol topically to their hands and feet two times a day. The effect of the intervention on CIPN symptoms was evaluated 3 weeks and 6 weeks after the intervention.</p><p><strong>Results: </strong>The intervention group showed a significantly greater improvement in CIPN symptoms over time compared with the control group, with an effect size of η<sup>2</sup>=0.214 for the group×time interaction. Additionally, the intervention group exhibited a notable positive change in the exposure subscale of the CIPN rating scale, with an effect size of η<sup>2</sup>=0.114.</p><p><strong>Conclusions: </strong>Topical application of menthol significantly mitigates the symptoms of CIPN in breast cancer patients. This study supports the use of menthol as an effective adjunctive treatment for CIPN.</p><p><strong>Trial registration number: </strong>NCT05429814.</p>","PeriodicalId":9136,"journal":{"name":"BMJ Supportive & Palliative Care","volume":" ","pages":"79-86"},"PeriodicalIF":2.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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