{"title":"Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients","authors":"J. Menczer, L. Schreiber, E. Berger, T. Levy","doi":"10.5455/jihp.20150713121418","DOIUrl":"https://doi.org/10.5455/jihp.20150713121418","url":null,"abstract":"Uterine serous carcinoma (USC) represents only about 10% of endometrial cancer cases. It is an aggressive tumor with a poor prognosis that is diagnosed in advanced stages in about 40% of the cases and it accounts for a disproportionate number of uterine cancer-related deaths. Even in apparent clinical early stage disease, USC is found to have unfavorable pathological prognostic factors such as lymphovascular space invasion, lymph node involvement, and microscopic intraperitoneal spread [1,2].","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"102-104"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roumina Hasan, Anuradha Rao, Sandeep Kumar, S. Gopal, N. Jain
{"title":"Large Multiloculated Splenic Mesothelial Cyst: A Rare Case Report","authors":"Roumina Hasan, Anuradha Rao, Sandeep Kumar, S. Gopal, N. Jain","doi":"10.5455/JIHP.20151130122548","DOIUrl":"https://doi.org/10.5455/JIHP.20151130122548","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"146-148"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Kaplan, I. Allon, B. Shlomi, V. Raiser, D. Allon
{"title":"A Comparative Study of Oral Hamartoma and Choristoma","authors":"I. Kaplan, I. Allon, B. Shlomi, V. Raiser, D. Allon","doi":"10.5455/JIHP.20151020122441","DOIUrl":"https://doi.org/10.5455/JIHP.20151020122441","url":null,"abstract":"Aim: To compare the clinical and microscopic characteristics of hamartoma and choristoma of the oral mucosa and jaws and discuss the challenges in diagnosis. Materials and Methods: Analysis of patients diagnosed between 2000 and 2012, and literature review of the same years. A sub-classification into “single tissue” or “mixed-tissue” types was applied for all the diagnoses according to the histopathological description. Results: A total of 61 new cases of hamartoma or choristoma were retrieved, the majority were hamartoma. The literature analysis yielded 155 cases, of which 44.5% were choristoma. The majority of hamartoma were mixed. Among these, neurovascular hamartoma was the most prevalent type (36.7%). Of the choristoma, 59.4% were single tissue, with respiratory, gastric and cartilaginous being the most prevalent single tissue types. The tongue was the most frequent location of both groups. Conclusion: Differentiating choristoma from hamartoma depends to a great extent on the recognition of the normal tissues expected at every individual location.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolated Juvenile Xanthogranuloma in Thoracic Spine: Intraoperative Cytological Diagnosis of a Rare Presentation","authors":"Shashi Singhvi, S. Bhargava","doi":"10.5455/JIHP.20140601071010","DOIUrl":"https://doi.org/10.5455/JIHP.20140601071010","url":null,"abstract":"Juvenile Xanthogranulomas (JXG) are benign proliferative disorders of non-Langerhans histiocytes, which present in children as multiple, self-limited, cutaneous lesions. The extracutaneous manifestations of JXG are uncommon, and isolated JXG involving the spinal column is extremely rare. \u0000We report here a case of isolated juvenile xanthogranuloma in thoracic spine correctly diagnosed intraoperatively on crush smear cytology and later confirmed by histopathological and immunohistochemical studies. \u0000This case report draws attention to the fact that isolated xanthogranuloma should be considered among possible diagnoses of spinal tumor in children. Also, since the long term survival depends on complete surgical resection, a correct intraoperative diagnosis is extremely important for optimal management and prognosis of the patient.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"7 1","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Rivasi, L. Roncati, G. Barbolini, E. Petrella, R. Boldorini
{"title":"False Immunohistochemical Results for Herpesviridae and Other Clusters of Differentiation Due To Biotin Intranuclear Inclusions in the Gestational Endometrium","authors":"F. Rivasi, L. Roncati, G. Barbolini, E. Petrella, R. Boldorini","doi":"10.5455/JIHP.20130905124106","DOIUrl":"https://doi.org/10.5455/JIHP.20130905124106","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Warfarin Related Nephropathy and Beyond. What Renal Pathologists Need To Suspect in A Kidney Biopsy.","authors":"S. Brodsky, A. Satoskar, T. Nadasdy","doi":"10.5455/JIHP.20140725053203","DOIUrl":"https://doi.org/10.5455/JIHP.20140725053203","url":null,"abstract":"We have recently described a new clinical syndrome in patients receiving warfarin for anticoagulation. First, we identified that warfarin therapy can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients. This syndrome has been named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly susceptible. We defined WRN as an acute increase in INR to greater than 3.0, followed by evidence of AKI (defined as a sustained increase in serum creatinine of greater than or equal to 0.3 mg/dl) within a week of the INR increase. We believe that anticoagulant-related kidney injury should be suspected in a patient on an anticoagulation therapy, if there is a disproportion between the number of RBC tubular casts, ATN and the degree of an underlying kidney lesion (such as glomerular immune complex depositions, GBM thickness abnormalities etc) in kidney biopsy. Detailed evaluation of coagulation data and medications is recommended for all patients with RBC casts and AKI.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"184-186"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extraovarian Primary Peritoneal Carcinoma: A Clinicopathological Gray Zone -","authors":"Kajal B. Punyashetty, A. Shankar, T. Katti","doi":"10.5455/JIHP.20140214013415","DOIUrl":"https://doi.org/10.5455/JIHP.20140214013415","url":null,"abstract":"Extraovarian primary peritoneal carcinoma (EOPPC) is a rare disease entity, arising from extra ovarian peritoneum with abdominal carcinomatosis, uninvolved or minimally involved ovaries and no identifiable primary. Since an overlap of clinical manifestations and histologic appearances of EOPPC and papillary serous ovarian carcinoma exists, various diagnostic modalities like cytology, tumor markers, gross and histomorphological features, collectively help in arriving at a definitive diagnosis. As very few cases have been reported in literature, we hereby document one such interesting case.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Chaudhuri, S. Datta, P. Paul, S. Mukherjee, S. Malo
{"title":"Cytologically Diagnosed Ovarian Carcinoma Turned Out To Be a Case of Chronic Ectopic Pregnancy","authors":"S. Chaudhuri, S. Datta, P. Paul, S. Mukherjee, S. Malo","doi":"10.5455/JIHP.20140218010028","DOIUrl":"https://doi.org/10.5455/JIHP.20140218010028","url":null,"abstract":"The diagnosis of chronic ectopic pregnancy is often difficult as there is a shortage of literature in which this disease is diagnosed as an entity separate from the condition of acute ectopic pregnancy. Experience with fine needle aspiration cytology in chronic ectopic pregnancy is not reported previously. A 29-year-old para 3 woman presented with lower abdominal pain and irregular menstruation since two months. Transvaginal ultrasonography showed a well-defined heterogeneous, solid-cystic right adnexal mass with normal serum beta HCG, and mildly elevated CA 125 level. Fine needle aspiration cytology (FNAC) from the mass was performed, and cytological findings suggested possibility of serous cystadenocarcinoma. Abdominal hysterectomy with bilateral salpingo-oophorectomy and infra-colic omentectomy was done. Pathological findings were consistent with chronic ectopic pregnancy. It is possible to retrieve trophoblastic cells through fine needle aspiration even after 2 months of tubal rupture and this experience can be utilized to diagnose chronic ectopic pregnancy preoperatively.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"116-120"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of the First Year Publishing Experience and the Future Goals","authors":"A. Ozcan","doi":"10.5455/jihp.20140227081417","DOIUrl":"https://doi.org/10.5455/jihp.20140227081417","url":null,"abstract":"Journal of Interdisciplinary Histopathology (JIHP) began to be published as a vivid source of research 15 months ago. At the current state, we are pleased for having successfully finalized our first volume on time with published 5 issues, as announced. Now, with this new issue, the second volume of our journal starts to be published quarterly. JIHP follows an open access publication policy with no fees from the authors or the readers under the sponsorship of the publisher. We do not have a plan to charge fees in the near future, too.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"24 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma","authors":"S. Zaheer, A. Nagi","doi":"10.5455/JIHP.20141029023315","DOIUrl":"https://doi.org/10.5455/JIHP.20141029023315","url":null,"abstract":"Objectives: Mammary serine protease inhibitor (MASPIN) has numerous interactions with tumor pathogenesis and progression. Its relationships with apoptosis and angiogenesis have proven the impact on prognosis. However, its exact role is not known and needs further work in relation to various human cancers. Current study was planned to investigate the subcellular expression of MASPIN in oral squamous cell carcinoma (OSCC) and to observe its relation with tumor grade. Methods: It was a descriptive study, conducted at the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. Histological diagnosis of squamous cell carcinoma was confirmed in 50 cases, and expression of MASPIN was determined by avidinbiotin-peroxidase complex method of immunohistochemical staining. MASPIN expression was scored on the basis of intensity of staining and the percentage of the cells that stained positively. Data was analyzed with SPSS using appropriate statistical procedures. Results: Mean age of the patients was 56.84 ± 1.58 years with male to female ratio 1.3:1. All tumors were locally advancing (Stage III). Histologically, 58% tumors were Grade 1, other grades were less common. MASPIN expression was observed in 32 (64%) cases, and it was localized to the cytoplasm of the tumor cells in all cases. Among the positive cases, its expression was focal in 15 (44.1%), diffuse but moderate in 13 (38.2%) and diffuse and intense in 6(17.7%) cases. MASPIN expression was significantly associated (P: 0.043) and negatively correlated (P: 0.034) with tumor grade. Conclusions: MASPIN expression was observed in the majority of OSCC. However, it was localized to the cytoplasm of tumor cells in all cases. Loss of MASPIN expression was observed more frequently in poorly differentiated cancers.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"213-216"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}