Journal of interdisciplinary histopathology最新文献

{"title":"A Rare Finding of Coexisting Fibroadenoma and Duct Ectasia in Axillary Ectopic Breast Tissue","authors":"Sunita Singh, H. Yadav, Divya Srivastava, R. Sen","doi":"10.5455/jihp.20150717124211","DOIUrl":"https://doi.org/10.5455/jihp.20150717124211","url":null,"abstract":"Ectopic breast tissue (EBT) can present anywhere along the milk line from axilla to groin. It can harbor all the pathological conditions as that of the normal breast though incidence is very low. Fibroadenoma is rare in accessory breast and only a few cases have been reported in the literature. Here, we report a 30-year-old female presented with a firm and freely mobile right axillary lump measuring 6 cm A— 4 cm. Fine-needle aspiration cytology revealed it as accessory breast tissue. However, the excision biopsy of the same showed fibroadenoma along with duct ectasia in EBT. This case has been reported due to its rarity and for consideration of fibroadenoma in differential diagnoses of axillary swellings.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"110-112"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granular Cell Tumor of the Breast: An Unusual Tumor of the Breast Masquerading As Malignancy -","authors":"P. Jaiprakash, K. Pai","doi":"10.5455/jihp.20150211113147","DOIUrl":"https://doi.org/10.5455/jihp.20150211113147","url":null,"abstract":"Granular cell tumor (GCT) is a rare neoplasm of the breast, accounting for <0.1% of breast tumors. GCT may mimic a malignant tumor clinically and radiologically, thereby causing overtreatment in a few cases. We present a case of a 28-year-old woman who presented with a breast lump of short duration, which was highly suggestive of malignancy radiologically. Wide local excision of the lump showed histological features suggestive of GCT, which was confirmed by immunohistochemical studies.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"39-41"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study on Qualitative Assessment of Copper Content in Oral Leukoplakia, Submucous Fibrosis and Squamous Cell Carcinoma with Rhodamine Stain -","authors":"P. Joshi, Bhagyalaxmi Hongal, Neha Agnihotri, Rutuja Shridhar Kempwade","doi":"10.5455/JIHP.20150717124034","DOIUrl":"https://doi.org/10.5455/JIHP.20150717124034","url":null,"abstract":"Background: Trace elements are required in small concentrations as essential active components of biological enzyme systems. They are in the form of metalloenzymes and copper is one such component. Copper metabolism is profoundly altered in neoplastic disease. Copper plays an important role in tumor angiogenesis especially in early stages and is also necessary for endothelial cell activation. Copper content in tissues of oral leukoplakia (OL), oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) has not been studied extensively. Hence, we attempted this retrospective study to analyze copper content in the tissues by using rhodamine stain for better understanding of pathogenesis. Aim and Objectives: To evaluate and compare the copper content and its depth of penetration in tissue sections of diagnosed cases of oral precancer and cancer by using rhodamine staining method. Materials and Methods: This retrospective analytical study was conducted on histologically diagnosed 10 cases each of OL, OSMF, and OSCC. Ten cases of normal mucosa served as control. The selected cases were subjected to staining with rhodamine for qualitative analysis of copper content. Results: Paired t-test showed a significant increase in copper content in the study group (P = 0.516) as compared to control group. Krushall–Wallis non-parametric test showed higher mean value of copper content in cases of OSMF (2.00) than the cases of OL (1.20) and OSCC (1.70). Conclusion: Copper content by rhodamine staining technique was found to be higher in OSMF than OL and OSCC this staining technique can be used as a prognostic indicator for assessment of disease progression.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendiceal Hyperplastic Polyp: Case Report -","authors":"F. Limaiem, S. Bouraoui, Maroua Bouahmed, G. Sahraoui, A. Lahmar, S. Mzabi-regaya","doi":"10.5455/JIHP.20150203022914","DOIUrl":"https://doi.org/10.5455/JIHP.20150203022914","url":null,"abstract":"Serrated lesions morphologically analogous to those seen in the colorectum are found in the appendix. Appendiceal hyperplastic polyps are very rare, and their true incidence is unknown. A 52-year-old male previously healthy patient with no particular past medical history, presented with a 24-h history of abdominal pain localized to the right lower quadrant. On physical examination, he was tender to palpation in the lower right quadrant. As acute appendicitis was highly suspected, laparoscopic appendectomy was performed. Histological examination of the surgical specimen showed acute inflammation of the appendiceal wall. The crypts were focally elongated but relatively straight with serrations that were visible mainly near the luminal end of the crypts. Columnar cells with or without apical mucous vacuoles alternated with large goblet cells. The crypt bases were not serrated and were lined by regular cells with small nuclei. The muscularis mucosa was intact. The postoperative course was uneventful, and the patient was discharged on postoperative day 1. The final pathological diagnosis was acute appendicitis associated with hyperplastic polyp. Hyperplastic lesions of the appendix are often incidental findings although they can be associated with acute appendicitis. They are significantly associated with adenocarcinoma elsewhere in the large intestine and the finding of mucosal hyperplasia in an appendectomy is an indication for further investigations to exclude colorectal neoplasia.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"36-38"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Superficial Myofibroblastoma and Stromal polyp of the Vagina: Report of A Case Supporting Common Histogenesis of Both Lesions","authors":"M. Zamecnik, Roman Sucansky","doi":"10.5455/JIHP.20150220120049","DOIUrl":"https://doi.org/10.5455/JIHP.20150220120049","url":null,"abstract":"Rare simultaneous occurrence of vaginal superficial cervicovaginal myofibroblastoma and vaginal stromal polyp is described. The lesions were found in a 90-years-old patient, in the anterior wall of the vagina. The diameter of the lesions was 6cm and 2cm, respectively. Between them, a 3cm part of normal appearing vaginal wall was present. Both lesions showed similar myoid appearing morphology and myofibroblastic desmin+/actin-/h-caldesmon-/CD34- immunophenotype, with positivity for CD10, CD99, estrogen receptor and progesterone receptor. Larger lesion was diagnosed as benign cervicovaginal myofibroblastoma, and the smaller one had typical features of vaginal stromal polyp. This case of simultaneous occurrence of cervicovaginal myofibroblastoma and vaginal stromal polyp supports previously suggested histogenetic relationship between these lesions.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"63-67"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preventable Complication of a Slow Growing Cancer: Lessons Learned and a Literature Review -","authors":"A. Tan, P. Gill, Haitham Kashaba, S. Hales, F. Fahmy","doi":"10.5455/JIHP.20150424041646","DOIUrl":"https://doi.org/10.5455/JIHP.20150424041646","url":null,"abstract":"Malignant tumors of the hand are rare. Chondrosarcoma presenting in the hand are usually low grade with low risk of metastasis. To our knowledge and following literature review, there are nine reported cases of metastatic chondrosarcoma of the hand worldwide in the English literature, with only two reported cases of axillary lymphadenopathy. We describe a case of an unusual presentation of chondrosarcoma of the left little finger with distant axillary and pulmonary metastases. We also review management issues unique to this patient and reflective learning points to improve care. Our patient could have had a satisfactory outcome if treated early. We recommend referral of suspicious hand lesions to a specialist hand surgeon, for early assessment and management, in order to reduce patient morbidity and mortality.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of HER2 Gene/Protein and Ki67 Protein Expressions in Colorectal Carcinoma Variants With Relation To Clinicopathological Parameters and Prognosis: An Immunohistochemical and Fluorescence In Situ Hybridization Study","authors":"A. Foda, E. Abdelzaher, I. Talaat","doi":"10.5455/JIHP.20151002124135","DOIUrl":"https://doi.org/10.5455/JIHP.20151002124135","url":null,"abstract":"Objective The data on the frequency and pattern of HER2 expression in colorectal carcinoma (CRC) and its clinical signifi¬cance are ambiguous. In addition, little is known about HER2 status in CRC variants and its relation with proliferative activity and clinical outcome. Such knowledge may be of potential value for therapeutic decision making in CRCs. Methods The HER2 gene/protein status was assessed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) in a tissue microarray of 150 CRCs and correlated with the expression of the proliferation marker Ki67, clinicopathological factors, and prognosis. Results CRCs were categorized into conventional adenocarcinoma (CA), 47 cases; adenocarcinoma with mucinous component (AMC), 28 cases; mucinous adenocarcinoma (MA), 56 cases; and signet ring cell carcinoma (SRCC), 19 cases. Compared to other variants, CA was significantly associated with favorable clinicopathological features, higher overall survival (OS) and disease-free survival (DFS), while SRCC and MA were significantly associated with ominous clinicopathological features, lower OS and DFS. Cytoplasmic HER2 overexpression was detected in 14.2% of CRC cases and showed a significant agreement with gene amplification. HER2 overexpression was significantly associated with favorable clinicopathological features notably early stages. High Ki67 expression was detected in 48% of CRC cases. HER2 and Ki67 were significantly different among CRC variants with AMC showing the greatest frequency of HER2 overexpression and Ki67 high expression than the other variants. The interrelation between HER2 and Ki67 expression was statistically insignificant and neither had any significant relation to OS or DFS in any of the CRC variants. Conclusions We conclude that mucinous histology infers an adverse prognosis in CRC. A subset of early stage CRC patients, with HER2 overexpression and possibly a distinct variant, may benefit from HER2 targeted therapy. IHC can be used as a method for screening of HER2 gene amplification in CRCs.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"120-128"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagenous Gastritis: A Rare Entity -","authors":"F. Limaiem, S. Mzabi","doi":"10.5455/jihp.20150318115932","DOIUrl":"https://doi.org/10.5455/jihp.20150318115932","url":null,"abstract":"Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the stomach. Biopsies of the duodenum and colon were unremarkable. However, biopsies of the gastric fundus revealed a mild chronic gastritis characterized by lymphocytic and plasma cell infiltration of deep mucosa, without lymphoid follicle formation or active inflammation. No microorganisms were identified on routine hematoxylin and eosin or Giemsa-stained sections. Subepithelial collagen in the gastric biopsies was thickened and showed entrapped capillaries. Subepithelial collagen was highlighted by Masson’s trichrome staining and was negative for amyloid by Congo Red. In the areas containing thickened collagen, there were no intraepithelial lymphocytes. The final pathological diagnosis was collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic and pathologic findings to make a correct diagnosis. Specific therapy for this rare entity has not yet been established.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"64 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Menopause and Diabetes on the Rat Thyroid Gland: A Histopathological and Stereological Examining -","authors":"Zeliha Yetim, D. Unal, S. A. Karamese, T. Mercantepe, J. Selli, E. Polat, B. Buyuk","doi":"10.5455/JIHP.20150324080114","DOIUrl":"https://doi.org/10.5455/JIHP.20150324080114","url":null,"abstract":"Objective: Menopause is described as the arrest of the menstruation cycle and ending of reproductive potential. Diabetes mellitus (DM) occurs with Type 1 diabetes that is originated from the absence of insulin and Type 2 diabetes depending on insulin resistance. It is one of the most common endocrine disorders encountered in clinical practice that can cause serious health complications. Therefore, the objective of the present thesis was to investigate the effects of menopause and diabetes upon the thyroid using a rat model. Materials and Methods: 24, 12 weeks old female Sprague-Dawley rats were divided randomly into; non-diabetic healthy control group (Group I, n = 6), diabetic group (Group II, n = 6), ovariectomy group (Group III, n = 6), and ovariectomy plus diabetic group (Group IV, n = 6), respectively. Results: In histopathological examinations, the thyroid gland of the diabetic group had large follicles with cuboidal or almost squamous epithelial lining surrounding wide lumen. There were areas of disorganized follicles with decreased colloid. In the ovariectomized (OVX) rats, there was hyperplasia of the thyroid follicles and disorganized follicles with complete obstruction of their lumina. Mitotic cells were available. Some parafollicular cells had lack of cytoplasm. Post ovariectomy diabetes-induced group (Group IV), there were some species between follicles and remarkable reduction of colloid. Hyperplasia of the thyroid follicles, solid cell nests, and mitotic cells were also seen increasingly in this group. Follicular lumen area of ovariectomy group is closer to the control group. The increase of the lumen area in the DM group was the largest, diabetes+ovariectomy group also had an increase in the follicular lumen area. Conclusion: Finally; postmenopausal aging and diabetes in rats, may cause thyroid degeneration. DM and menopause both cause oxidative stress. But their damages on thyroid tissue are different. It means they cause oxidative stress via different ways. DM + OVX group compared to other groups has the greatest damage.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Flow Cytometry for the Diagnosis of Lung Neuroendocrine Carcinoma With Samples From Endobronchial Ultrasound Fine Needle Aspiration and Pleural Fluid","authors":"Mark E. Costaldi, A. Lall, R. Burack, Zhongren Zhou","doi":"10.5455/JIHP.20141201025029","DOIUrl":"https://doi.org/10.5455/JIHP.20141201025029","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}