BMC Cancer最新文献

{"title":"Targeting the HIF1A-UCA1-PTBP3 axis: a potential therapeutic strategy for head and neck cancer.","authors":"Lydia Chin-Ling Sim, Yi-Zih Kuo, Tsun-Chih Cheng, Chih-Ling Chen, Jenn-Ren Hsiao, Mei-Xuan Ooi, Zixi Yun, Hung-Ying Kao, Sen-Tien Tsai, Li-Wha Wu","doi":"10.1186/s12885-025-15020-z","DOIUrl":"10.1186/s12885-025-15020-z","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1536"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate risk and 5-year cumulative risk of high-grade cervical lesions in high-risk HPV-positive patients with minor cytological abnormalities: a retrospective single-center study in China.","authors":"Linghua Kong, Xiaoping Xiao, Ru Wan, Shuanzheng Zhao, Wei Wang","doi":"10.1186/s12885-025-14972-6","DOIUrl":"10.1186/s12885-025-14972-6","url":null,"abstract":"<p><strong>Background: </strong>Although minor cytological abnormalities predict a low risk of high-grade lesions, their high reporting rates lead to a considerable number of high-grade lesion cases. We carried out this study to analyze the immediate risk and 5-year cumulative risk of high-grade cervical lesions in high-risk human papillomavirus (Hr-HPV)-positive patients with minor cytological abnormalities and to investigate the clinical significance of minor cytological abnormalities during follow-up in our single-center.</p><p><strong>Methods: </strong>A total of 1892 patients with positive Hr-HPV, cytology result of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL) and also underwent colposcopy and biopsy were selected to analyze the immediate risk of high-grade cervical lesions. Besides, a total of 832 patients with baseline histological results of CIN1 or below and 5-year follow-up data available were further used to analyze the 5-year cumulative risk of high-grade cervical lesions.</p><p><strong>Results: </strong>The immediate incidence rates of CIN3 + in the ASC-US and LSIL groups were 6.27% (63/1005) and 5.64% (50/887), respectively. When CIN3 + was used as the study endpoint, the multivariate logistic regression analysis indicated that there was no significant difference in either the immediate risk or the 5-year cumulative risk of CIN3 + between the ASC-US and LSIL groups.</p><p><strong>Conclusions: </strong>In summary, since both the immediate and 5-year follow-up risks for CIN3 + were similar in patients with ASC-US and LSIL, routine follow-up should be performed in minor cytological abnormalities, regardless of whether the cytology result is ASC-US or LSIL. Through the risk assessment of Hr-HPV and cytology combined screening, the 2019 ASCCP guidelines were suitable for cervical cancer screening at our single center.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1541"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective multicenter validation of a next-generation sequencing panel using cytology specimens for lung cancer: cPANEL.","authors":"Kei Morikawa, Yuta Takashima, Masahide Oki, Akifumi Tsuzuku, Shuji Murakami, Daisuke Minami, Shinji Fujii, Naofumi Shinagawa, Fumihiro Asano, Seiji Nakamura, Yoshiharu Sato, Yumi Ueda, Fumihiko Suzuki, Tomoyuki Yokose, Kenichiro Tanabe, Masamichi Mineshita","doi":"10.1186/s12885-025-14770-0","DOIUrl":"10.1186/s12885-025-14770-0","url":null,"abstract":"<p><strong>Background: </strong>There are no prospective studies to estimate whether cytology specimens can replace tissue samples using lung cancer gene panel analysis. We evaluated the success rate of gene panel testing and nucleic acid yield and quality when using cytology specimens for lung cancer over tissue specimens.</p><p><strong>Methods: </strong>In this prospective study, clinical cytology specimens collected via transbronchial brushing, needle aspiration washing, and pleural effusion were stored in a nucleic acid stabilizer. The primary endpoint was the superior success rate of gene analysis using cytology specimens over the conventional success rate using tissue specimens.</p><p><strong>Results: </strong>The full analysis set included 248 cases. The success rate for gene panel analysis using cytology specimens was 98.4% (95% confidence interval (CI), 95.9-99.6%) with a positive concordance rate of 97.3% (95% CI, 90.7-99.7%) by other companion diagnostic kits. The median value for nucleic acid yield and quality (DNA/RNA integrated number) of cytology specimens was 546.0/426.5 ng and 9.2/4.7 for DNA/RNA, respectively. The Pearson correlation coefficient of variant allele frequency between tissue formalin-fixed and paraffin-embedded (FFPE) sample and cytology specimens for mutant cases was 0.815. The ratio of double-stranded to total DNA showed that cytology specimens were of significantly higher quality than FFPE specimens.</p><p><strong>Conclusions: </strong>The success rate of cytology specimens in gene analysis was significantly higher than conventional data. Because of the sufficient nucleic acid yield, high quality, and high correlation of mutant allele frequency compared to FFPE specimens, cytology specimens are suitable for panel testing as tissue substitutes.</p><p><strong>Trial registration: </strong>UMIN Registry UMIN000047215 (cPANEL trial).  https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053766 .</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1538"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between urine output and time to methotrexate clearance in pediatric leukemia patients receiving high-dose methotrexate therapy.","authors":"Yi-Lun Wang, Tsung-Yen Chang, Shih-Hsiang Chen, Yi-Wen Hsiao, Yu-Chuan Wen, Tang-Her Jaing","doi":"10.1186/s12885-025-15064-1","DOIUrl":"10.1186/s12885-025-15064-1","url":null,"abstract":"<p><strong>Background: </strong>High-dose methotrexate (HD-MTX) is a cornerstone of pediatric acute lymphoblastic leukemia (ALL) treatment but poses a risk for delayed clearance and associated toxicities. While hydration is standard to enhance methotrexate (MTX) excretion, the relationship between urine output (UO) and time to MTX clearance remains underexplored.</p><p><strong>Methods: </strong>We conducted a retrospective study of pediatric ALL patients treated with HD-MTX at Chang Gung Memorial Hospital between August 2023 and February 2025. Patients were stratified into higher (H-UO) and lower urine output (L-UO) groups using a 5.0 mL/kg/hr cutoff. Clinical outcomes including time to MTX normalization, delayed MTX clearance, hospitalization duration, and use of adjunctive diuretics were analyzed.</p><p><strong>Results: </strong>Thirty-nine patients were included. The H-UO group showed significantly faster MTX clearance (2.0 vs. 4.0 days, P = 0.0035), lower incidence of delayed clearance (18.2% vs. 70.6%, P = 0.0025), and shorter hospital stays (5.0 vs. 7.0 days, P = 0.019). Diuretic use was higher in the L-UO group, primarily as a reactive measure. No significant difference in MTX-related major toxicities was observed.</p><p><strong>Conclusions: </strong>Higher UO is associated with more efficient time to MTX clearance and shorter hospitalization in pediatric ALL patients receiving HD-MTX. Prospective studies are warranted to optimize supportive care protocols.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1545"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy in HR+/HR2- patients with advanced or metastatic breast cancer: a systematic review and network meta-analysis.","authors":"Yuan Liu, Tongtong Ren, Xu Chen, Qinglan He, Xinchun Wang, Lisha Tang","doi":"10.1186/s12885-025-14841-2","DOIUrl":"10.1186/s12885-025-14841-2","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1535"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germline and somatic mutational variants of Tunisian high grade serous ovarian cancer identified by next-generation sequencing.","authors":"Nihel Ammous-Boukhris, Rania Abdelmaksoud-Dammak, Wala Ben Kridis, Dorra Ben-Ayed-Guerfali, Arwa Shtaiwi Abed, Souhir Guidara, Slim Charfi, Ameni Feki, Tahia Sellami-Boudawara, Hassen Kamoun, Afef Khanfir, Jamel Daoud, Raja Mokdad-Gargouri","doi":"10.1186/s12885-025-14989-x","DOIUrl":"10.1186/s12885-025-14989-x","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer (OC) is one of the leading causes of death from gynecological cancers in the world, primarily due to late stage diagnosis. Genetic mutations in genes involved in key cellular functions such as BRCA1, and BRCA2 significantly contribute to ovarian tumorigenesis. This study investigates the genetic landscape of Tunisian patients with familial or sporadic high-grade serous ovarian carcinoma (HGSOC) to guide therapeutic strategies and genetic counseling.</p><p><strong>Methods: </strong>We conducted a genetic study by targeted Next-Generation Sequencing (NGS) on 54 Tunisian HGSOC patients. A cancer panel including 31 cancer-associated genes was used to analyze DNA extracted from both paraffin-embedded (FFPE) tumor tissues and blood samples.</p><p><strong>Results: </strong>Germline and somatic pathogenic variants (PVs) were detected in 20.3% and 27.77% of patients respectively. Five patients carried both germline and somatic BRCA1 PVs. Somatic PVs were identified in Homologous Recombination-related genes including ATM, RAD50, and BRIP1. Interestingly, four recurrent BRCA1 PVs were observed, one of them is novel. Germline BRCA1/2 PVs were significantly more frequent in patients under 50 years of age and were associated with improved overall survival. Additionally, 19 variants of uncertain significance (VUS) were detected.</p><p><strong>Conclusion: </strong>This study provides the first comprehensive genetic profiling of Tunisian HGSOC patients, highlighting the prevalence of pathogenic mutations in key cancer-related genes. These findings emphasize the importance of genetic screening in the management and treatment of OC particularly in populations with unique genetic backgrounds.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1542"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological significance of tertiary lymphoid structure in esophageal squamous cell carcinoma: a systematic review and meta-analysis review.","authors":"Chu-Ting Yu, Ye Gao, Ru-Yue Liu, Yu-Ang Ding, Luo-Wei Wang","doi":"10.1186/s12885-025-14997-x","DOIUrl":"10.1186/s12885-025-14997-x","url":null,"abstract":"<p><p>Tertiary lymphoid structures (TLS), ectopic immune cell aggregates in non-lymphoid tissues, have emerged as potential predictors of esophageal squamous cell carcinoma (ESCC) outcomes. Given increasing evidence, we conducted an updated meta-analysis to systematically evaluate their prognostic and clinicopathological significance. A comprehensive literature search was performed through PubMed, Embase, Web of Science, Scopus, and Cochrane Library (up to June 2024) for studies assessing TLS associations with TNM staging and survival outcomes (OS/PFS) in ESCC. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using random-effects models. This meta-analysis incorporated seven studies comprising nine separate datasets that evaluated the impact of TLS in ESCC. The pooled analysis demonstrated a significant positive correlation between TLS presence and more advanced T stage (OR = 2.65, 95%CI: 1.86-3.78; p < 0.01) but not N stage (OR = 1.27, 95%CI: 0.85-1.89; p = 0.24). Additionally, TLS presence was significantly associated with enhanced overall survival (HR = 0.49, 95%CI: 0.41-0.58, p < 0.01) as well as progression-free survival (HR = 0.56, 95%CI: 0.45-0.69, p < 0.01). Notably, when assessed using combined HE and IHC criteria, the prognostic benefit of TLS was more pronounced, with HRs further decreasing to 0.40 (95% CI: 0.31-0.51) for OS and 0.50 (95% CI: 0.41-0.60) for PFS. These findings confirm that the presence of TLS, particularly when verified through combined HE staining and IHC, is an independent favorable prognostic factor in ESCC patients.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1544"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma.","authors":"Chen-Yang Huang, Angel Chao, Chiao-Yun Lin, Steven G Rozen, An-Shine Chao, Chen-Bin Chang, Hsiu-Jung Tung, Ren-Chin Wu, Chyong-Huey Lai","doi":"10.1186/s12885-025-15053-4","DOIUrl":"10.1186/s12885-025-15053-4","url":null,"abstract":"<p><strong>Background: </strong>Endometrial cancer represents a significant global health challenge, with undifferentiated and dedifferentiated endometrial carcinoma (UDEC) being a particularly aggressive subset.</p><p><strong>Methods: </strong>We employed whole-exome sequencing (WES) to comprehensively characterize the molecular landscape of 29 UDECs in a single institution cohort. We analyzed driver mutations, molecular subgroups, SWI/SNF complex, DNA mismatch repair (MMR) pathways, and somatic copy number alterations (SCNAs).</p><p><strong>Results: </strong>We identified 5 (17%) ultramutated tumors, 14 (48%) DNA mismatch repair (MMR)-deficient tumors, and 10 (35%) mutation-low tumors in this cohort. Mutations in the SWI/SNF family and other driver genes are common, including PTEN, ARID1A, KMT2B, ARID1B, SMARCA4, and PIK3CA. Genomic inactivation of SWI/SNF complex genes occurred in 19 of 29 (66%) of cases, highlighting the frequent chromatin remodeling dysfunction in UDEC. We observed frequent homopolymer mutations in UDECs with MMR deficiency, with RPL22^K15Rfs*5 mutation found in 10 of 14 (71%) MMR-deficient tumors. Notably, ultramutated tumors demonstrated superior survival compared to the other two subtypes.</p><p><strong>Conclusions: </strong>Our analysis revealed distinct architectures and actionable alterations in UDEC. The identification of molecular subgroups provides a promising framework for prognostic stratification. Collectively, our findings not only advance our understanding of UDEC biology but also illuminate potential translational applications.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1540"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The surgical effect of inferior mesenteric artery ligation level in rectal cancer and sigmoid colon cancer: a meta-analysis of randomized controlled trials.","authors":"Jing-Hong You, Yan-Bin Deng, Yu-Bing Li, Yong Zhang, Shi-Yun Yang","doi":"10.1186/s12885-025-14959-3","DOIUrl":"10.1186/s12885-025-14959-3","url":null,"abstract":"<p><strong>Background: </strong>In radical surgery for sigmoid and rectal cancer, two main approaches are used to ligate the inferior mesenteric artery (IMA): high ligation at the root of the IMA and low ligation at the distal origin of the left colonic artery (LCA). There has been debate as to which technique is more optimal.</p><p><strong>Methods: </strong>PubMed, EMBASE, Cochrane Library, Web of Science, and CNKI databases were searched for relevant information from their inception to March 10, 2025. Methodological quality of reviews was assessed by the AMSTAR-2 tool.</p><p><strong>Results: </strong>Sixteen relevant studies involving a total of 1778 patients were included in the meta-analysis. Compared with high ligation, low-position ligation of the IMA was associated with a significantly lower incidence of anastomotic leakage (RR: 0.44, 95% CI: 0.26-0.72, P < 0.05) and faster postoperative recovery of gastrointestinal function (SMD: -0.21, 95% CI: -0.37 -0.05, P < 0.05). No significant differences were observed in the length of hospitalization, tumor recurrence, lymph node harvest, urinary retention, urinary incontinence, operative bleeding, overall survival at 5 years, disease‑free survival at 5 years and sexual dysfunction were not statistically significant (P > 0.05).</p><p><strong>Conclusion: </strong>In colorectal cancer surgery, low ligation of the IMA can reduce the incidence of anastomotic leakage and improve postoperative defecation function without increasing intraoperative blood loss, the risk of tumor recurrence, or affecting sexual function. Therefore, low ligation may a better technique than high ligation in this context.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1531"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life exposures and risk of hematological malignancies in adulthood: a cohort study, meta-analysis and Mendelian randomization analysis.","authors":"Yuelin Guo, Jing Zheng, Hongli Huang, Lili Pan, Haomin Yang","doi":"10.1186/s12885-025-14780-y","DOIUrl":"10.1186/s12885-025-14780-y","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"1532"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}