Journal of arthritis最新文献

{"title":"Details of a Tendon–Sparing Posterior Approach in Hemiarthroplasty in the Treatment of Displaced Intracapsular Neck of Femur Fracture","authors":"P. Lee, J. Charity, J. Timperley","doi":"10.4172/2167-7921.1000243","DOIUrl":"https://doi.org/10.4172/2167-7921.1000243","url":null,"abstract":"This paper details a tendon–sparing surgical technique allowing hemiarthroplasty through a posterior approach in all cases whilst preserving the Quadriceps coxa. The SPAIRE (Sparing Piriformis and Internus, Repair Externus) technique, described by Hanly et al. for routine use in total hip replacement, theoretically offers the functional benefits of the posterior approach with reduced risk of dislocation. It may also facilitate early mobilisation after hip fracture surgery with potential reduction in medical complications and mortality. In this study, we report our initial experience using the same SPAIRE technique for hemiarthroplasty to treat all patients with displaced intracapsular neck of femur fractures, irrespective of skeletal dimension and BMI. Our results suggest that the SPAIRE technique is feasible and safe to be used in all cases requiring hemiarthroplasty. Further research should be encouraged to investigate the role of the SPAIRE technique in fractured neck of femur surgery.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2017 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46271882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Arthritis and Osteoporosis: A Case Study","authors":"P. Raghavan","doi":"10.4172/2167-7921.1000240","DOIUrl":"https://doi.org/10.4172/2167-7921.1000240","url":null,"abstract":"Metadichol® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, \u0000 sugar cane, wheat, and peanuts. Metadichol® acts on Nuclear Vitamin D receptors (VDR) that are present in cells \u0000 throughout the body to stimulate the immune system and inhibit a variety of disease processes, resulting from \u0000 inflammation to infection [1]. \u0000We present a case study of a patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and \u0000 ESR levels, and low bone mineral density leading to osteoporosis. The case report shows how Metadichol® by its \u0000 actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects. Also, \u0000 his bone density improved dramatically. \u0000Metadichol® is safe because it consists of natural components of conventional foods and has no known adverse \u0000 side effects. Its constituents are present in many foods that we consume every day. \u0000Metadichol® has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune \u0000 diseases that confront the world today.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44719887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-typhoidal Salmonella Osteomyelitis of the Femoral Neck in an Immunocompetent Child","authors":"Yin-Hsiang Kung, Jiun-Lung Liang, K. Kuo","doi":"10.4172/2167-7921.1000241","DOIUrl":"https://doi.org/10.4172/2167-7921.1000241","url":null,"abstract":"We report a case of Salmonella osteomyelitis of the femoral neck in a healthy child. Such an occurrence in an \u0000 immunocompetent child is extremely rare and has not yet been reported in the English literature. Salmonella should \u0000 be considered among the causative agents in acute osteomyelitis. Prompt antibiotic treatment is pivotal for \u0000 preventing complications and decreasing the disease burden.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46479380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nicotinamide Adenine Dinucleotide (NAD)-Dependent Deacetylase Sirtuin-1 Regulates Chondrocyte Energy Metabolism through the Modulation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Osteoarthritis(OA)","authors":"Hajime Kobayashi, Koh Terauchi, N. Yui, K. Yatabe, T. Kamada, H. Fujiya, H. Niki, H. Musha, K. Yudoh","doi":"10.4172/2167-7921.1000238","DOIUrl":"https://doi.org/10.4172/2167-7921.1000238","url":null,"abstract":"To clarify how the osteoarthritis (OA)-induced catabolic factor interleukin (IL)-1β affects chondrocyte energy metabolism, and especially to define the downstream pathway linking nicotinamide adenine dinucleotide (NAD)- \u0000 dependent deacetylase Sirtuin-1 (Sirt-1) to energy metabolism in OA chondrocytes. Human chondrocytes were \u0000 isolated from articular cartilage samples of patients with OA. The level of energy metabolism of OA chondrocytes \u0000 was evaluated by monitoring the activity of the energy metabolic sensor, adenosine monophosphate-activated \u0000 protein kinase (AMPK) and the level of production of adenosine triphosphate (ATP) in chondrocytes in the presence \u0000 or absence of t IL-1β (10 ng/mL). Effects of IL-1β on anabolic and catabolic activities of chondrocytes were analyzed \u0000 by the levels of production of proteoglycan and matrix metalloproteinase (MMP)-13, respectively. Experiments \u0000 involving pre-treatment with Sirt-1 inhibitor were also performed to investigate the underlying regulatory mechanism \u0000 linking Sirt-1 to chondrocyte energy metabolism. IL-1β significantly inhibited the activity of AMPK and production of \u0000 ATP in OA chondrocytes. The energy metabolism disruption mediated by IL-1β was further decreased by pretreatment \u0000 with Sirt-1 inhibitor in OA chondrocytes. Treatment with IL-1β significantly decreased the level of \u0000 proteoglycan production and significantly increased the level of MMP-13 secretion by chondrocytes. These \u0000 chondrocyte activities were also reduced by pre-treatment with the Sirt-1 inhibitor in OA chondrocytes. IL-1β inhibits \u0000 the AMPK - ATP energy metabolic pathway in OA chondrocytes. Our findings also suggest that Sirt-1 activity is \u0000 involved in anabolic and catabolic cellular activities and that Sirt-1 modulates ATP production through functional \u0000 regulation of the energy sensor AMPK in chondrocytes.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"6 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43971356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Deformation of Hip Articular Cartilage Under A High Load Before and After Labral Excision","authors":"Hiroshi Ito, Toshiki Nakamura, Tatsuya Sato, Yasuhiro Nishida, H. Tanino, M. Higa","doi":"10.4172/2167-7921.1000237","DOIUrl":"https://doi.org/10.4172/2167-7921.1000237","url":null,"abstract":"Background: It has been reported that the function of the labrum is to ensure that an increased surface area encountered the femoral head and spares the cartilage from excessive strain. The purpose of this study was to determine whether early deformation of the hip articular cartilage occurs under high-load conditions in the presence/absence of the labrum. Methods: The hip joints of 4 beagle dogs were retrieved. A continuous static load of 80 Kg was applied for 2.5 hours. Magnetic resonance imaging (MRI) was performed immediately after the loading and at 30, 60, 90, 120, and 150 minutes after the loading. The load was then removed, and the specimens were stored for 14 h to allow the cartilage to recover. The labrum was then carefully removed, and the experiment was performed again. Results: The maximum percentage change in cartilage thickness was 35.3 ± 17.4% when the labrum was intact and 55.7 ± 7.5% after the labrum had been excised (p=0.060). Labral excision resulted in a reduction in cartilage thickness. Cartilage thickness was significantly decreased in the normal and labral excision models immediately after loading (p=0.003 and p=0.022, respectively). Conclusion: The labrum plays a role in dispersing loads equally across the joint cartilage and reduces the load placed on the maximum weight-bearing region of cartilage. Early articular cartilage deformation occurred under high-load conditions both before and after the excision of the labrum.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45025086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Helicobacter Pylori Infection with Oxidative DNA Damage andAtherosclerosis in Rheumatoid Arthritis Patients","authors":"D. Nada, Amal El-Barbary, Sally Abd El monem El Nawasany, R. Gaber, R. M. El-sharaby, Muhammad Tarek Abdel Ghafar, H. Zaytoun","doi":"10.4172/2167-7921.1000234","DOIUrl":"https://doi.org/10.4172/2167-7921.1000234","url":null,"abstract":"Objectives: to evaluate the associations between Helicobacter pylori (HP) with oxidative DNA damage and subclinical atherosclerosis in rheumatoid arthritis (RA) patients. Methods: Eighty RA patients were divided into two groups according to the presence of anti-HP antibodies. In addition, to forty healthy volunteers. All patients were subjected to DAS-28, ESR , hsCRP ,RF, Anti-CCP, Lipid profiles, serum anti-HP antibodies, 8-hydroxydeoxyguanosine, Oxidized LDL, IL-6,carotid intima media thickness (cIMT) and flow mediated dilatation of the brachial artery (FMD). Results: HP positive RA patients revealed significantly higher disease activity, RF, Anti-CCP, dyslipidemia, 8- OHdG, ox-LDL, cIMT and lower FMD% compared to HP negative patients. There was positive correlation between anti-HP antibodies with disease activity parameters, ox-LDL, 8-OHdG and cIMT as well as negative correlation with FMDâ„\u0085. In multiple regression analysis, IgG antibodies against H pylori were associated with DAS-28 (p=p<0.001), hsCRP (p=p<0.01), 8-OHdG (p<0.01), cIMT (p<0.001) and FMDâ„\u0085 (p<0.001). Conclusions: Chronic infection with HP in RA patients is significantly associated with oxidative stress and DNA damage. Detection and eradication of HP infection in RA patients may reduce the burden of atherosclerosis and its associated morbidity and mortality.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43190693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Crowned Dens Syndrome with Huge Calcifications","authors":"Masao Sato","doi":"10.4172/2167-7921.1000I103","DOIUrl":"https://doi.org/10.4172/2167-7921.1000I103","url":null,"abstract":"An 81-year-old woman presented to our hospital with a 1-month history of headache and neck pain. She had no neurological symptoms, articulation disorder, or swallowing disorder. The plain radiograph showed calcification deposits around the atlantoaxial joint and anterior vertebral body (Figure 1). The computed tomography scan of her neck showed details of these calcifications (Figures 2-4). Huge crownshaped deposits of hydroxyapatite or calcium pyrophosphate dihydrate were seen. The C-reactive protein level was slightly increased to 0.78 mg/dL. Oral non-steroidal anti-inflammatory drug (NSAID) therapy resulted in complete improvement of her symptoms.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46985712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Vitamin D Slow Progression of Osteoarthritis","authors":"V. Ch, J. Prakash, Md. Tashfeen Ashraf, Varsha Gupta","doi":"10.4172/2167-7921.1000232","DOIUrl":"https://doi.org/10.4172/2167-7921.1000232","url":null,"abstract":"Osteoarthritis (OA) is a chronic and prevalent joint disease resulting in degenerative changes in the cartilage. Now-a-days vitamin-D is emerging as an important component which has a wide biological effects. The studies are evaluating the beneficial effects of vitamin-D in osteoarthritis therefore the present investigation was planned to analyze i) levels of vitamin-D in selected controls and OA patients, ii) monitor gene expression changes in CYP2R1, CYP3A4, CYP27B1, CYP24A1 and CYP27A1, whose products are involved in vitamin D metabolism. Our result shows that there was no significant difference in the vitamin-D levels in OA versus controls. The mean vitamin D levels in controls was 35.9 ng/ml (3 had ViD<20g/ml) and in OA patients was 35.66 ng/ml (3 had Vit D<20ng/ml). However gene expression of CYP2R1, CYP3A4 was reduced CYP24A1, CYP27B1 showed no variation in expression and CYP27A1 was upregulated in OA patients as compared to control. We could not observe significant difference in the levels of vitamin D in control and patient showing that onset of primary OA may not be because of vitamin D deficiency or vitamin D may not be responsible for symptoms of OA. However its supplementation may have therapeutic benefits to all including control and patients as vitamin D levels are not optimum in both. Lower gene expression of cytochrome p 450 genes suggest some effects on OA patients but these are related to age or post-menopausal stage or OA is not clear as in our study we were unable to obtain primary OA patients without any comorbidity with <55 years of age. OA in less than 55 years are mostly associated with comorbid conditions as diabetes, hypertention, thyroid, obesity, chronic gastrointestinal disturbance, kidney or liver disease, with trauma etc.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48736805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scintimetric Evaluation of the Rheumatoid Arthritis Involvement by Dr. V. Siva’s Retention Ratio-(Preliminary Report)","authors":"Sivasubramaniyan, K. Venkataramaniah","doi":"10.4172/2167-7921.1000231","DOIUrl":"https://doi.org/10.4172/2167-7921.1000231","url":null,"abstract":"Aim: This study aims to propose the utility of Scintimetric Characterization of the tracer activity uptake in the joints afflicted by Rheumatoid arthritis in the bone scans. Materials and method: Three out of five patients of confirmed Rheumatoid arthritis who had bone scans for Bone and joint pains showed presence of skeletal hot spots in various joints. They were subjected to the scintimetric evaluation of the skeletal hot spots by Dr. V. Siva’s retention ratio by repeating the 24 hr delayed bone scans. The 58 skeletal hotspots seen in various joint spaces were subjected to the calculation of maximum counts in 3 hr and 24 hr bone scans. They were tabulated and 3/24 hr Dr. V. Siva’s Retention Ratio was calculated and analysed. Results: They showed a mean of 5.91 ± 0.35 and standard error of means as 0.3496. The estimated variance was 8.8408 and the estimated standard deviation was 2.9734. For this sample size the estimated variance was 6.6306 and estimated standard deviation was 2.575 by HOJO’s modification. This was unavoidable due to very small size of the Sample population. Conclusion: Thus this study had shown that the scintimetric evaluation of the skeletal hotspots in the Rheumatoid Arthritis Patients showed a definitive benign value. This could provide a firm base line value to assess the response to treatment and progression as well.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44645605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee Osteoarthritis and Running: Is there any Evidence for Association?","authors":"M. Nair","doi":"10.4172/2167-7921.1000257","DOIUrl":"https://doi.org/10.4172/2167-7921.1000257","url":null,"abstract":"The knee is the most common lower limb joint affected with Osteoarthritis (OA), which is a debilitating illness. The relationship between OA knee and running is not clear-cut, yet they are always associated with one another. The multitude of people suffering from lifestyle diseases is approaching epidemic proportions and Governments have to spend millions of dollars to manage these disorders. This has forced authorities to think about primary prevention rather than managing them after their onset. Slowly and steadily, the awareness about physical activity is increasing among the public. Due to this, there has been a surge in the number of people participating in activities for health reasons. The number of people taking part in running has also increased significantly. Many people resort to jogging and running because it is cost effective and convenient when compared to other types of exercises which need equipment or memberships. However, in addition to this, the concerns of damage to the knee joint have attracted the attention of clinicians and researchers. The common notion is that running damages the knees. Recent studies show that this concern is misplaced. The existing scientific evidence could not establish a link between the two, except in joints with a history of previous injury. Interestingly, results of some studies show that the chances of undergoing surgery for OA are less in runners. This article reviews the relevance of high-quality literature that looks at the link between running and the development of knee osteoarthritis.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"6 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70836060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}