Journal of arthritis最新文献_第10页

A Meta-analysis Comparing Lateral Decubitus with Supine Position for Surgery for Intertrochanteric Fractures 比较侧卧位和仰卧位在粗隆间骨折手术中的meta分析

Journal of arthritis Pub Date : 2016-07-18 DOI: 10.4172/2167-7921.1000211

F. Liu, Han Xie, Weiguo Liang, Dongping Ye, Yicun Yao

{"title":"A Meta-analysis Comparing Lateral Decubitus with Supine Position for Surgery for Intertrochanteric Fractures","authors":"F. Liu, Han Xie, Weiguo Liang, Dongping Ye, Yicun Yao","doi":"10.4172/2167-7921.1000211","DOIUrl":"https://doi.org/10.4172/2167-7921.1000211","url":null,"abstract":"Purpose: There are few studies compares surgery with proximal femoral nail antirotation (PFNA) in lateral decubitus with that in supine position about their advantages and disadvantages for patients with intertrochanteric femoral fractures. Previous studies reported conflicting findings. This meta-analysis was to compare the efficacy and safety of surgery with PFNA in different surgical positions. \u0000Methods: Relevant randomized controlled trials comparing surgery with PFNA in lateral decubitus with surgery in supine position for intertrochanteric fractures patients were included into this meta-analysis. Inclusion criteria of this meta-analysis were: randomized controlled trials comparing lateral decubitus with supine position for surgery for intertrochanteric fractures and reporting at least one of the main outcomes, including blood loss, operating time, hospital stay, and length of incision, Harris values and union time. \u0000Results: Six randomized controlled trials were finally included into this meta-analysis. Pooled results showed that there were less blood loss, less operation time, smaller incision and higher Harris values score in lateral decubitus group. Sensitivity analysis by sequential omission of individual studies showed the significance of weighted mean difference was robust, which suggested this outcome was credible. \u0000Conclusions: Surgery with PFNA in lateral decubitus can benefit intertrochanteric fractures patients with less blood loss, less operation time, shorter incision and high Harris values scores compared with surgery in supine position according to our research.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"5 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Brief Report on Academic Productions on Rheumatic Diseases in China 中国风湿病学术成果简报

Journal of arthritis Pub Date : 2016-07-11 DOI: 10.4172/2167-7921.1000209

Ying Gao, X. Liu, Lanling Zhang, T. Xia, Dong-Bao Zhao

引用次数: 2

A Radiological and Clinical Evaluation of Acromioclavicular Joint Reconstruction Using Dog Bone Double Endobutton Technique 犬双骨内扣技术重建肩锁关节的影像学及临床评价

Journal of arthritis Pub Date : 2016-07-09 DOI: 10.4172/2167-7921.1000207

P. Lee, James P. Brock, C. Woodford, A. Robertson

{"title":"A Radiological and Clinical Evaluation of Acromioclavicular Joint Reconstruction Using Dog Bone Double Endobutton Technique","authors":"P. Lee, James P. Brock, C. Woodford, A. Robertson","doi":"10.4172/2167-7921.1000207","DOIUrl":"https://doi.org/10.4172/2167-7921.1000207","url":null,"abstract":"We report the clinical and radiological outcomes of acromioclavicular (AC) joint reconstructive surgery using Arthrex Dog Bone Button FibertapeConstruct. 33 Patients were identified between April 2013 and April 2015 who had undergone AC joint repair using the Dog Bone double Endobutton for Rockwood Grade III-V injuries. Radiological follow up was made by measuring coracoclavicular distance (CCD). Patients were clinically evaluated using DASH (Disabilities of Arm, Shoulder and Hand) and ASES (American Shoulder and Elbow Surgeons) scores. Radiologically there was a mean CCD reduction of 7.1 mm (n=26) and mean post-operative CCD of 13.1 (Normal range 11-13 mm) Clinically, the mean post-operative ASES was 89.4 (n=22) (Best score 100). A mean reduction of 50.5 was reported from pre to post-operative DASH scores, with a mean post-operative score of 12.5 (n=18) (Best score 0). One dislocation (due to a fall in the post-operative period) and one infection were reported. Arthroscopic stabilisation of AC joint using Arthrex Dog Bone Fibertape construct is minimally invasive and shows good anatomic restoration of the joint. Early clinical results are promising but more numbers and longer term follow up are needed.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"52 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Does Epstein-Barr Virus Infection Contribute to Disease Flares in Rheumatoid Arthritis? eb病毒感染会导致类风湿关节炎的疾病发作吗?

Journal of arthritis Pub Date : 2016-07-09 DOI: 10.4172/2167-7921.1000208

Jacques P. Brown, J. Gosselin

引用次数: 4

Antioxidant Enzymes in Rheumatoid Arthritis 类风湿关节炎中的抗氧化酶

Journal of arthritis Pub Date : 2016-07-05 DOI: 10.4172/2167-7921.1000206

Vivek Kumar, J. Prakash, Varsha Gupta, M. Y. Khan

{"title":"Antioxidant Enzymes in Rheumatoid Arthritis","authors":"Vivek Kumar, J. Prakash, Varsha Gupta, M. Y. Khan","doi":"10.4172/2167-7921.1000206","DOIUrl":"https://doi.org/10.4172/2167-7921.1000206","url":null,"abstract":"Joint destruction in rheumatoid arthritis (RA) is due to tissue injury in the area caused by inflammatory reactions, release of MMPs and free radicals produced by neutrophils and macrophages. The control of free radical production may have therapeutic roles thus the study was done to check the status of lipid peroxidation product malondialdehyde (MDA) and a few antioxidant enzymes in RA patients. 45 RA patients and 40 controls were selected. Controls were asymptomatic and RA patients were selected according to ACR criteria. RA patients had significantly high MDA, SOD and ALP and reduced activity of catalase and GR as compared to controls. SOD showed positive correlation with ALP. GR was positively related with MDA, SOD and ALP. The study shows that MDA is involved in the pathogenesis of RA. The system is trying to quench free radicals by high SOD activity. Higher production of H2O2 or some other mechanism is responsible for inhibition of catalase and GR. However system is trying to reduce the damage by neutralizing superoxide anion. Therapeutic intervention of the oxidative stress may be considered for effective control of inflammation in RA patients.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Therapeutic Effects of Intra-articular Botulinum Toxin Type A in Knee Osteoarthritis A型肉毒毒素治疗膝关节骨性关节炎的疗效

Journal of arthritis Pub Date : 2016-06-30 DOI: 10.4172/2167-7921.1000E112

Wang Lin, C. Chou

{"title":"Therapeutic Effects of Intra-articular Botulinum Toxin Type A in Knee Osteoarthritis","authors":"Wang Lin, C. Chou","doi":"10.4172/2167-7921.1000E112","DOIUrl":"https://doi.org/10.4172/2167-7921.1000E112","url":null,"abstract":"Knee osteoarthritis (KOA) is an intractable and devastating consequence of degeneration that results in tremendous impact on daily activities. Painful disabling KOA occurs in more than 10% of people who are over 55 years old. Those who are severely disabled account for up to 25% of aging people and KOA is a major cause of total knee replacement [1-3]. Current osteoarthritis therapies largely rely on rest, weight loss, bracing and assistive devices, physical modalities, therapeutic exercises, and pharmacological interventions [4] which are unsatisfactory for the majority of severe disabled patients, who are left with ambulation deficit despite vigorous treatment intervention. Although numerous patients can be treated with surgery, some of them are not good candidates due to multiple co-morbidities. For these reasons, intra-articular (IA) treatments that reduce chronic joint pain and improve function is the long-term effective and safe alternative options. In a number of recent studies, pain intensity and functional performance resulted from osteoarthritis has been improved after IA injection of botulinum toxin type A (BoNT-A).","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000E112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-articular Injections for Osteoarthritis: From Bench to Bedside, can we Teach Old Drugs New Tricks? 关节内注射治疗骨关节炎:从实验室到临床，我们能教老药新把戏吗?

Journal of arthritis Pub Date : 2016-06-30 DOI: 10.4172/2167-7921.1000E111

P. Lee, James P. Brock

{"title":"Intra-articular Injections for Osteoarthritis: From Bench to Bedside, can we Teach Old Drugs New Tricks?","authors":"P. Lee, James P. Brock","doi":"10.4172/2167-7921.1000E111","DOIUrl":"https://doi.org/10.4172/2167-7921.1000E111","url":null,"abstract":"The two articles in this month’s press of e Journal of Arthritis, one by Ekinci et al. titled ‘A New Treatment Option in Osteoarthritis: Prolotherapy Injections’ and the other by Senatorov et al. titled ‘Clinical Outcome of Hylan G-F 20 Injections in Shoulder and Hip Osteoarthritis: A Retrospective Review’ raise several important points surrounding the topic of intra-articular injections [1,2]. Firstly that there is a paucity of high quality literature in the eld that o en leads to inconclusive or misrepresented conclusions on drug e cacy in established treatments [1,2]. e articles also highlight the heterogeneity in injection procedure, site, concentration, preparation and outcome measurements [1,2]. is editorial will, therefore, provide a concise review on some of the current injection therapies and suggest possible improvements to methodological structure to inspire readers strive for high quality data. Further, through an example of a possible novel therapy, Actovegin, this editorial will hopefully challenge readers’ way of thinking to consider the reapplication of established drugs; posing the question can you teach an old drug new tricks?","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7921.1000E111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70837117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Clinical Outcomes of Tibial Tubercle Transfer for Anterior Knee Pain and Patello-femoral Instability 胫骨结节转移治疗前膝关节疼痛和髌骨-股不稳的临床效果

Journal of arthritis Pub Date : 2016-06-17 DOI: 10.4172/2167-7921.1000204

S. Gul, P. Lee, A. Davies

{"title":"Clinical Outcomes of Tibial Tubercle Transfer for Anterior Knee Pain and Patello-femoral Instability","authors":"S. Gul, P. Lee, A. Davies","doi":"10.4172/2167-7921.1000204","DOIUrl":"https://doi.org/10.4172/2167-7921.1000204","url":null,"abstract":"Anterior knee pain and patellofemoral instability have a multi-factorial aetiology and are therefore difficult to treat. A variety of surgical treatment options have been proposed for such patients. Tibial tubercle transfer is one such option and has been described using different surgical techniques. There is however a paucity of literature regarding the procedure itself and its clinical outcomes. Purpose: This study describes the clinical efficacy and outcome of a Tibial Tubercle Transfer (TTT). Study Design: Case series. Methods: 86 consecutive patients who underwent TTT for anterior knee pain and/or patellofemoral instability were studied prospectively. All patients received the same rehabilitation protocol postoperatively. Clinical outcome was measured using the Kujala knee score pre-operatively and at follow-up. Patients were also asked to rate their satisfaction with the procedure. Mean duration of follow up was 1.7 years (6 months to 3 years). Results: 94% of patients were satisfied with their decision to undergo the operation at the latest follow up. The mean Kujala score pre-operatively was 46 points with a Standard deviation (SD) of 14.35. At 6 months the mean Kujala score had improved to 70 points with a standard deviation of 20.25. Patients with patella-femoral instability alone showed greater improvement of Kujala scores compared to patients with anterior knee pain alone or pain plus instability. Conclusion: Our experience suggests that tibial tubercle transfer provides a safe and effective surgical treatment option for patients with anterior knee pain and patellofemoral instability. Patients with patellofemoral instability preoperatively derived the most benefit.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"22 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Polymerizing Bone Cement can Roughen a Polyethylene Bearing Surface on Total Hip Replacement A Surface Analysis 聚合骨水泥可使全髋关节置换术中聚乙烯轴承表面粗糙化

Journal of arthritis Pub Date : 2016-06-15 DOI: 10.4172/2167-7921.1000203

P. Lee, P. Alderman, P. Roberts

{"title":"Polymerizing Bone Cement can Roughen a Polyethylene Bearing Surface on Total Hip Replacement A Surface Analysis","authors":"P. Lee, P. Alderman, P. Roberts","doi":"10.4172/2167-7921.1000203","DOIUrl":"https://doi.org/10.4172/2167-7921.1000203","url":null,"abstract":"The tribological behaviour of the bearing surface in hip arthroplasty is greatly influenced by its surface roughness. During cemented hip arthroplasty, bone cement may contaminate the bearing surface. Hence, the aim of this study was to investigate the effect of cement polymerization on a highly cross-linked polyethylene(HCLP) bearing surface as any process influences the surface roughness of the bearing surface can have potential long term effect on the wear rate. Three new HCLP liners were used. A map of the surface topography of each liner was obtained using a white light interferometric microscope at five different locations in accordance with the standard BSEN ISO 4288:1998. Bone cement was then applied to the bearing surface and allowed to polymerise, then removed and irrigated with saline. The surface roughness measurement procedure was repeated again for all samples. The Ra results showed a 21% increase in mean surface roughness after cement contamination (p=0.01). The average Ra value pre-contamination was 190 nm while post-contamination was 230 nm. There were also changes in the surface topography observed with 3D surface mapping. Our study indicates that bone cement contamination of the HCLP surface can significantly increase its surface roughness and alter its surface topography. Surgeons should be aware of this potentially serious effect on the bearing and be vigilant to avoid bone cement contamination during arthroplasty surgery.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"2016 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative Serum Proteomic Analysis of Differentially Regulated Proteins in Patients with Rheumatoid Arthritis and Healthy Volunteers 类风湿关节炎患者与健康志愿者血清差异调节蛋白的比较蛋白质组学分析

Journal of arthritis Pub Date : 2016-06-11 DOI: 10.4172/2167-7921.1000201

R. Vasko, S. Blaschke, J. Streich, G. Müller, P. Korsten, H. Dihazi

{"title":"Comparative Serum Proteomic Analysis of Differentially Regulated Proteins in Patients with Rheumatoid Arthritis and Healthy Volunteers","authors":"R. Vasko, S. Blaschke, J. Streich, G. Müller, P. Korsten, H. Dihazi","doi":"10.4172/2167-7921.1000201","DOIUrl":"https://doi.org/10.4172/2167-7921.1000201","url":null,"abstract":"Background: To identify differentially regulated serum proteins, we compared proteome profiles of sera from patients with rheumatoid arthritis (RA) and healthy controls using proteomics. Methods: Sera were collected from 43 patients with RA and 48 healthy volunteers. The samples were cleared of the most abundant major proteins by immunoaffinity chromatography. Serum protein profiles between the two groups were compared by two-dimensional differential gel electrophoresis (2D-DIGE) and differentially regulated proteins were studied using mass spectrometry. Results: We identified 26 differentially expressed serum proteins between patients with RA and healthy controls. A quantitatively significant change of protein levels was defined as at least 1.5-fold upregulation or 0.6-fold downregulation respectively. Using these criteria, patients with RA exhibited significantly higher levels of leucine-rich alpha-2-glycoprotein (p<0.01), apolipoprotein A-IV (p<0.001), clusterin (p<0.001), haptoglobin (p<0.001), Ig alpha-1 chain C region (p<0.05), retinol-binding protein 4 (p<0.001), serum amyloid A (p<0.01) and alpha-1-antichymotrypsin (p<0.01). The levels of serotransferrin were significantly decreased in RA patients (p<0.01). Conclusion: We identified eight proteins with significantly increased and one protein with significantly decreased serum levels in RA patients compared to healthy controls. Several of these proteins may be implicated in the pathogenesis of RA and may have potential in diagnostics and activity assessment of RA.","PeriodicalId":91304,"journal":{"name":"Journal of arthritis","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7