BMC Gastroenterology最新文献

{"title":"Association between daily calcium intake and the prevalence of chronic diarrhea: an analysis of NHANES 2005-2010 data.","authors":"Nan Hu, Jian Qin, Hui Dong, Deng-Chao Wang, Miao Yu","doi":"10.1186/s12876-025-04282-3","DOIUrl":"10.1186/s12876-025-04282-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic diarrhea significantly affects quality of life, yet the potential role of calcium intake in its prevention remains underexplored. This study aims to investigate the association between daily calcium intake and chronic diarrhea using data from the 2005 to 2010 National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Data from NHANES 2005-2010 were analyzed, focusing on participants over the age of 20. The association between daily calcium intake and the prevalence of chronic diarrhea was assessed using weighted logistic regression models, calculating odds ratios (OR) and their 95% confidence intervals (CI), while controlling for potential confounding factors. Restricted cubic splines (RCS) were used to explore the potential non-linear association between calcium intake and the prevalence of chronic diarrhea, and subgroup analyses were conducted to evaluate the effect differences across various population groups. Potential interactions between different subgroups and the association between calcium intake and the prevalence of chronic diarrhea were also examined.</p><p><strong>Results: </strong>A total of 8,317 eligible participants were included in this study, with a median age of 39.0 years (IQR: 28.0-52.0) and a median daily calcium intake of 0.9 g/day (IQR: 0.6-1.2 g/day). A total of 507 participants were identified as having chronic diarrhea, including 214 males and 293 females. After adjusting for multiple covariates, higher calcium intake was significantly associated with a reduced prevalence of chronic diarrhea (OR = 0.68, 95% CI: 0.49-0.95, P = 0.028). RCS analysis did not reveal any significant non-linear relationship (P = 0.724). Subgroup analyses stratified by age, gender, education level, marital status, race, poverty income ratio, body mass index, smoking status, depression, daily use of prednisone or cortisone, dietary fiber intake, total fat intake, and total dairy intake showed no significant interaction between calcium intake and the prevalence of chronic diarrhea (all P-values > 0.05).</p><p><strong>Conclusion: </strong>These findings suggest that promoting adequate calcium intake may play a role in preventing chronic diarrhea, warranting further investigation in prospective studies.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"694"},"PeriodicalIF":2.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TPD52 promotes the proliferation and metastasis of gastric cancer cells.","authors":"Shunhao Zhang, Zhixin Geng, Jian Sun, Nan Chen, Man Liu, Yuting Wang, Xinliang Gu, Bing Pei","doi":"10.1186/s12876-025-04295-y","DOIUrl":"10.1186/s12876-025-04295-y","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"690"},"PeriodicalIF":2.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum total bilirubin levels and primary loss of response to Infliximab therapy in Crohn's disease patients.","authors":"Jingjing Liu, Dingzhe Zhang, Yu Wang, Yiping Zhang, Jianhua Wang, Yunhui Li, Xiao Chen","doi":"10.1186/s12876-025-04318-8","DOIUrl":"10.1186/s12876-025-04318-8","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"683"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease detected through screening is associated with superior survival outcomes in stage III colorectal cancer: a retrospective study in a Chinese high-volume cancer center.","authors":"Fan Chen, Dakui Luo, Xun Jiang, Jiayu Chen, Ruoxin Zhang, Qingguo Li, Xinxiang Li","doi":"10.1186/s12876-025-04294-z","DOIUrl":"10.1186/s12876-025-04294-z","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"675"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Federated learning for early severity prediction in acute pancreatitis: a multi-center study.","authors":"Yuqiang Shen, Zheng Li, Songping Li, Lixue Zhou, Yang Chen, Kexiong Dong, Huidong Wang, Dekun Wang, Yingying Hu, Jinghui Li, Chunpu Li","doi":"10.1186/s12876-025-04265-4","DOIUrl":"10.1186/s12876-025-04265-4","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"681"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and histopathological spectrum of gastrointestinal tract disorders: a decade of records from the UAE.","authors":"Preetha J Shetty, Prasanna Appiya Premvignesh, Sana Imadeddin Albaghdadi, Latifa Nabeel Alsaad, Sunil Kumar Bylappa, Jayadevan Sreedharan, Jayakumary Muttappallymyalil","doi":"10.1186/s12876-025-04302-2","DOIUrl":"10.1186/s12876-025-04302-2","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"677"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct conversion of ustekinumab therapy is more beneficial than infliximab-optimized therapy in patients with Crohn's disease who develop secondary loss of response to infliximab.","authors":"Lin Li, Xuemei Xu, Jing Wang, Li Xie, Xiaoping Niu","doi":"10.1186/s12876-025-04319-7","DOIUrl":"10.1186/s12876-025-04319-7","url":null,"abstract":"<p><strong>Background: </strong>For patients with Crohn's disease (CD) who develop secondary loss of response (SLR) to infliximab (IFX), it remains unclear whether IFX optimization or direct conversion to ustekinumab (UST) offers better outcomes. This study aimed to identify risk factors for IFX optimization failure and to compare the clinical efficacy of IFX optimization versus UST conversion.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from patients with CD admitted to the First Affiliated Hospital of Wannan Medical College and the First Affiliated Hospital of the University of Science and Technology of China between January 2017 and January 2025. Rates of clinical, steroid-free, and endoscopic remission were assessed. Univariate and multivariate analyses were performed to identify independent risk factors for IFX optimization failure.</p><p><strong>Results: </strong>In total, 65 patients with CD who developed SLR to IFX were included. The patients were divided into three groups: IFX optimization success (Group 1), IFX optimization failure followed by UST (Group 2), and direct UST conversion (Group 3). Of the 28 patients who received IFX optimization, only 6 achieved success, yielding a failure rate of 78.6%. Multivariate logistic regression showed that a baseline albumin concentration of < 40 g/L was an independent predictor of IFX optimization failure (p = 0.047, odds ratio: 15.00, 95% confidence interval: 1.031-218.300). When comparing UST-treated groups, the rate of clinical response at week 6 was significantly higher in Group 3 than in Group 2 (35.1% vs. 9.1%, p = 0.039). By week 52, clinical remission rates were similar (86.4% vs. 89.2%, p > 0.05).</p><p><strong>Conclusions: </strong>Given the high failure rate of IFX optimization, direct conversion to UST may provide greater benefit and reduce treatment costs in patients with CD who develop SLR to IFX.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"685"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of colonoscopic auxiliary devices in reducing the polyp miss rate: a prospective randomized controlled study.","authors":"Bo Li, Qian Liang, Ye Chen, Wenhan Luo, Huihui Sun, Jie Xiong, Ying Chen, Shuchang Xu, Guangsu Xiong","doi":"10.1186/s12876-025-04313-z","DOIUrl":"10.1186/s12876-025-04313-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of a novel-designed colonoscopic distal attachment on the diagnosis of polyps during colonoscopy.</p><p><strong>Method: </strong>All consecutive patients who underwent routine colonoscopic examinations at Tongji Hospital endoscopy centers in China were enrolled. Participants were randomly assigned in a 1:1 ratio to the auxiliary devices colonoscopy (Experimental Group) or standard colonoscopy groups (Control Group). Adenoma detection rate (ADR), polyp detection rate (PDR), inspection time, duration of treatment and adverse events were recorded.</p><p><strong>Result: </strong>A total of 264 patients were randomized into the experimental group (EG, n = 132) and the control group (CG, n = 132). The PDR in the EG was significantly higher than in the CG (p = 0.013), while no significant difference was found in the ADR between the two groups (p = 0.078). Insertion and withdrawal times for colonoscopy were showed no statistically significant difference (p = 0.096 and p = 0.868, respectively). Analysis of polyp detection conditions revealed that the EG had a higher number of polyps detected(p = 0.013), and detected more polyps ≤ 5 mm (p = 0.018), and there was no significant difference in the location distribution of detected polyps between the two groups (p = 0.950). Treatment times were showed statistically significant differences, with the EG having shorter treatment times (p = 0.004).</p><p><strong>Conclusion: </strong>The use of auxiliary devices in colonoscopy significantly improves the PDR, espicialy no-adnoma or smaller polyp, and reduces treatment times compared to standard colonoscopy.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry (ChiCTR), ChiCTR2500097582, February 21, 2025. Retrospectively registered.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"684"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of mechanical bowel preparation in elective colorectal surgery: an updated meta-analysis and systematic review.","authors":"Junjie Lai, Zhouhan Wu, Yonghui Xu, Ao Han, Pingliang Sun","doi":"10.1186/s12876-025-04304-0","DOIUrl":"10.1186/s12876-025-04304-0","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"672"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the costs of delayed Celiac disease diagnosis.","authors":"Mohammad Rahmanian, Mehdi Azizmohammad Looha, Mohadeseh Mahmoudi Ghehsareh, Nastaran Asri, Somayeh Jahani-Sherafat, Mostafa Rezaei Tavirani, Mohammad Rostami-Nejad","doi":"10.1186/s12876-025-04278-z","DOIUrl":"10.1186/s12876-025-04278-z","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"673"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}