BMC Gastroenterology最新文献

{"title":"A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines.","authors":"María A Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé","doi":"10.1186/s12876-025-03796-0","DOIUrl":"10.1186/s12876-025-03796-0","url":null,"abstract":"<p><strong>Background: </strong>Despite significant advances in prevention and early detection, colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Inadequate adherence and/or lack of knowledge of guidelines have shown to prevent adequate screening and surveillance recommendations and hinder effective screening programs.</p><p><strong>Objective: </strong>Evaluate the implementation and real-world impact of a mobile app designed to optimize CRC screening and surveillance in accordance to recently updated guidelines.</p><p><strong>Methods: </strong>A mobile app including ergonomic algorithms integrating all pertinent guideline information was created by a group of experts. Data were collected from Catalonia healthcare professionals using the app between February 2023 and May 2024. Users' characteristics, consultation types, and patient data were analyzed to assess app's implementation, usage patterns, and impact on CRC screening and surveillance outcomes.</p><p><strong>Results: </strong>A total of 12,481 consultations were recorded; 3,054 (24.4%) screening and 9,427 (75.6%) post-polypectomy surveillance consultations. The app was increasingly and repeatedly used by professionals during the study period (72% retention rate). Among screening consultations, 2,082 (68.2%) patients were classified as average risk, suggesting the use of fecal occult blood test (FOBT) instead of colonoscopy. Among surveillance consultations, the app advised deferring follow-up colonoscopies and using FOBT instead in 4,748 (50%) patients based on negative index colonoscopy or the presence of low-risk polyps. Standard surveillance with colonoscopy at 3 years was recommended for 3,224 (34.1%) patients and intensive surveillance, requiring a colonoscopy at 1 year, was indicated for 749 (7.9%) patients.</p><p><strong>Conclusions: </strong>A CRC screening and surveillance mobile app showed remarkable acceptance and uptake among healthcare professionals. Proper implementation of updated guidelines aided by the use of the app could significantly reduce the number of unnecessary screening and post-polypectomy surveillance colonoscopies, as well as help identifying high risk patients who require intensive surveillance.</p><p><strong>Clinical trial: </strong>Not applicable.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"203"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between atherogenic index of plasma and chronic diarrhea: a cross-sectional study of the NHANES 2005-2010.","authors":"Rongpeng Chen, Zexin Fu, Zhicheng Feng, Feng Xiao, Guoqiang Wang","doi":"10.1186/s12876-025-03784-4","DOIUrl":"10.1186/s12876-025-03784-4","url":null,"abstract":"<p><strong>Background: </strong>Chronic diarrhea (CD), a common chronic condition resulting from various mechanisms, has chronic inflammation as a primary determinant. Despite recent research exploring the potential mechanisms linking lipids and diarrhea, clinical studies on the relationship between lipids and the onset of CD are limited. This study aimed to investigate the association between the atherogenic index of plasma (AIP) and CD risk.</p><p><strong>Methods: </strong>This cross-sectional study used data from the 2005-2010 NHANES. The association between AIP and CD was examined through multiple linear regression analyses. A smooth curve-fitting algorithm was applied to assess the potential non-linear dose-response relationship between AIP and CD, and subgroup analyses were conducted.</p><p><strong>Results: </strong>Among 5,948 participants, 440 (7.4%) had CD. After adjusting for potential confounders, AIP was significantly associated with CD (OR, 1.57; 95% CI, 1.08-2.30; P = 0.018). The highest AIP quartile (Q4; 0.18 to 0.92) showed an adjusted OR for CD of 1.51 (95% CI, 1.10-2.07; P = 0.011) versus the lowest quartile (Q1; -1.15 to -0.25). Subgroup analyses indicated that diabetic individuals with higher AIP had a higher CD risk (OR, 3.84; 95% CI, 1.45-10.15), with an observed additive interaction (P for interaction = 0.045).</p><p><strong>Conclusions: </strong>This study demonstrates a significant association between AIP and CD risk. AIP may serve as a promising indicator for assessing CD risk, offering valuable insights for prevention and treatment strategies.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"201"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between anthropometric measures and the risk of incident Metabolic dysfunction-associated steatotic liver disease: a longitudinal study.","authors":"Takahiro Ichikawa, Yoshitaka Hashimoto, Takuro Okamura, Akihiro Obora, Takao Kojima, Hiroshi Okada, Masahide Hamaguchi, Michiaki Fukui","doi":"10.1186/s12876-025-03780-8","DOIUrl":"10.1186/s12876-025-03780-8","url":null,"abstract":"<p><strong>Background: </strong>Waist circumference (WC) and body mass index (BMI) are considered useful for the diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to investigate the association between the body roundness index (BRI) and a body shape index (ABSI) with incident MASLD, in comparison to WC and BMI.</p><p><strong>Methods: </strong>Retrospective cohort data from a Japanese health check-up program were analyzed. Logistic regression model was used to evaluate the associations between anthropometric measure quartiles and MASLD, and receiver operating characteristic (ROC) analysis was performed to evaluate the associations between anthropometric measures and incident MASLD, stratified by sex.</p><p><strong>Results: </strong>A total of 10,561 males and 7,187 females were included, of whom 3,182 males and 914 females developed MASLD. Multivariate analysis revealed that higher WC, BMI, and BRI were associated with incident MASLD in both sexes, whereas higher ABSI was significantly associated with incident MASLD only in females. Among males, the area under the ROC curve (AUC) of BMI was higher than that of WC, BRI, and ABSI. Conversely, among females, the AUC of BMI was higher than that of ABSI, whereas it was comparable to that of WC or BRI. The AUC and the optimal cut-off values of BMI for predicting incident MASLD were 0.77 and 23.9 kg/m² in males, and 0.86 and 22.2 kg/m² in females. The optimal cut-off values of WC were 82.0 cm for males and 76.3 cm for females, respectively.</p><p><strong>Conclusions: </strong>We demonstrated the strongest association between BMI and incident MASLD compared to other measures, particularly in males, while also showing a strong association in females. Additionally, specific WC criteria for Asians to improve MASLD diagnosis are needed.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"202"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characteristics of adults avoiding gluten without celiac disease: a long-term population-based follow-up study.","authors":"Miska Tiainen, Kalle Kurppa, Tuija Jääskeläinen, Niina Kaartinen, Heini Huhtala, Katri Kaukinen, Juha Taavela","doi":"10.1186/s12876-025-03799-x","DOIUrl":"10.1186/s12876-025-03799-x","url":null,"abstract":"<p><strong>Objective: </strong>Nationwide prevalence studies on people avoiding gluten without celiac disease (PWAG) are lacking, and in particular, long-term follow-up studies are unavailable. We aimed to evaluate the prevalence, incidence, and characteristics of PWAG in a population-based cohort in 2000 and 2011.</p><p><strong>Methods: </strong>Health and diet-related data were collected in nationwide Health 2000 and 2011 surveys, which comprised 5,777 and 3,866 individuals, respectively, representing 2,682,733 and 1,967,876 Finnish adults. Serum samples were taken for the measurement of transglutaminase autoantibodies. In total 3,296 individuals participated in both surveys, forming a prospective cohort. PWAG refers to subjects avoiding gluten without celiac disease or positive autoantibodies. Psychological health was assessed with General Health Questionnaire and the Beck Depression Inventory.</p><p><strong>Results: </strong>The prevalence of PWAG increased significantly from 0.2% (2000) to 0.7% (2011) (p < 0.001), with the highest prevalence (1.3%) detected in individuals > 70 years old. An annual incidence rate of 42 (95% confidence interval 25-71) per 100,000 persons was noted. The PWAG group was more likely to maintain additional special diets than those not avoiding gluten, including e.g. lactose-free diet (41.7% vs. 12.0% in 2011, p < 0.001) and food restriction for allergy (12.5% vs. 3.0%, p = 0.007). Beck Depression Inventory indicated more depression (p = 0.023) among PWAG in 2000, while no difference was seen in 2011 or in General Health Questionnaire. Celiac disease-related risk factors, including female gender, anemia, autoimmune diseases or antibody levels near the upper limit of normal in 2000, did not predict later gluten avoidance.</p><p><strong>Conclusions: </strong>The prevalence of PWAG multiplied over a decade, reaching 0.7% in 2011 in Finland. The PWAG group maintained more likely additional dietary restrictions than those not avoiding gluten and had signs of psychosocial burden. No predicting factors for the condition were identified.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"199"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of using double balloon enteroscopy combined with endoscopic ultrasound to evaluate Crohn's disease of the small bowel: a retrospective study.","authors":"Liu Zhongcheng, Tang Chao, Guo Qin","doi":"10.1186/s12876-025-03791-5","DOIUrl":"10.1186/s12876-025-03791-5","url":null,"abstract":"<p><strong>Background: </strong>Diagnosing and assessing Crohn's disease, which involves only the small bowel, is challenging. This study investigated the clinical value of combining double balloon enteroscopy with endoscopic ultrasound to evaluate this disease.</p><p><strong>Methods: </strong>This single-center retrospective study included patients with Crohn's disease of the small intestine between October 2022 and October 2023. Relevant clinical data were collected. Double balloon enteroscopy and ultrasound endoscopy of the small intestine were performed.</p><p><strong>Results: </strong>Among the 50 patients, 10, 34, and 6 had mild, moderate, and severe active phase Crohn's disease, respectively. Ten patients scored between 1 and 4 points on the modified partial simple endoscopic score for Crohn's disease (mpSES-CD), 24 scored between 5 and 8 points, and 16 scored more than 8 points. Forty patients had thickening of the intestinal wall (total thickness, 4.14 ± 0.98 mm). Submucosal and intrinsic muscle layer thickening was primarily observed. Ten patients were in remission, and all mucosal-submucosal and submucosal-intrinsic muscle boundaries could be distinguished. Thirty-four patients had moderate-phase Crohn's disease, of whom 26 (76.47%) had distinguishable mucosal-submucosal boundaries, and 28 (82.35%) had distinguishable submucosal-intrinsic muscular boundaries. Of the six patients with severe phase Crohn's disease, four (66.67%) had distinguishable mucosal submucosal boundaries, and two (33.33%) had distinguishable submucosal-intrinsic muscular boundaries.</p><p><strong>Conclusions: </strong>The mpSES-CD and Harvey-Bradshaw Index correlate well. Endoscopic ultrasound can determine disease severity by measuring each bowel wall layer's thickness and observing the distinction between the layers. This combination of techniques can compensate for the shortcomings in diagnosing the depth of the vertical infiltration of Crohn's disease using white-light endoscopy.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"200"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the diagnostic accuracy of the acFibroMASH index for at-risk MASH in patients with metabolic dysfunction-associated steatotic liver disease.","authors":"Yunfei Wu, Yan Han, Liming Zheng, Longgen Liu, Wenjian Li, Fan Zhang","doi":"10.1186/s12876-025-03781-7","DOIUrl":"10.1186/s12876-025-03781-7","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to validate the diagnostic accuracy of the acFibroMASH index in a population of metabolic dysfunction-associated steatotic liver disease (MASLD) patients with at-risk metabolic dysfunction-associated steatohepatitis (MASH) and to compare it with other scoring systems.</p><p><strong>Methods: </strong>394 patients with biopsy-proven MASLD were retrospectively enrolled. The patients were divided into the at-risk MASH (NAFLD activity score ≥ 4 and significant fibrosis) group (n = 103) and the non-at-risk MASH group (n = 291). The diagnostic performance of the acFibroMASH index was compared to that of fibroScan-aspartate aminotransferase (FAST) and other noninvasive fibrosis scores by plotting the receiver operating characteristic curve (ROC), including the area under the curve (AUC), sensitivity, and specificity. Cut-offs of the acFibroMASH index for sensitivity (≥ 0.90) and specificity (≥ 0.90) were obtained in our cohort.</p><p><strong>Results: </strong>The AUC of the acFibroMASH index in assessing at-risk MASH was 0.780, while the AUC of FAST was 0.770. The comparison of acFibroMASH with FAST showed no significant difference (P = 0.542). When the cut-off value for acFibroMASH was < 0.15, 95.5% of at-risk MASH patients could be excluded in 89 patients correctly. Conversely, when the cut-off value was set at > 0.39, 49.3% of at-risk MASH patients could be diagnosed in 140 patients correctly. When the NPV was set at 0.900, the critical value for exclusion was determined to be 0.23, with a sensitivity of 0.835 and a specificity of 0.526.</p><p><strong>Conclusion: </strong>This study validated the efficacy of the acFibroMASH index in predicting at-risk MASH in a population of MASLD patients, demonstrating comparable performance to that of the FAST. The acFibroMASH index may provide a valuable clinical basis for screening and identifying at-risk MASH in primary care settings.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"196"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing outcomes in acute pancreatitis: the impact of of heparin therapy duration on mortality in a multi-center retrospective study.","authors":"Linlin Fu, Hanyang Li, Qian Ni, Qiaoling Zhu, Baoyan Wang","doi":"10.1186/s12876-025-03763-9","DOIUrl":"10.1186/s12876-025-03763-9","url":null,"abstract":"<p><strong>Objective: </strong>Acute pancreatitis is a critical condition in the intensive care unit (ICU), often complicated by systemic issues, which may benefit from heparin therapy due to its anti-inflammatory and anticoagulant properties. However, the optimal duration of heparin therapy remained unclear. This retrospective study aimed to evaluate the association between heparin therapy duration and mortality outcomes in patients diagnosed with acute pancreatitis.</p><p><strong>Method: </strong>This retrospective study utilized data from the Medical Information Mart for Intensive Care (MIMIC-IV) and eICU Collaborative Research Database (eICU-CRD), including 1705 patients diagnosed with acute pancreatitis between 2008 and 2019. Restricted cubic splines (RCS) were employed to analyze the non-linear relationship between heparin therapy duration and 30-day and 90-day mortality. Patients were categorized into four groups based on quartiles: < 4 days, 4-7 days, 8-14 days, and > 14 days, using characteristics identified in the RCS curves, with 4-7 days as the reference. Cox multivariate regression and Kaplan-Meier analysis assessed the association between these groups and mortality, with 30-day mortality as the primary outcome and 90-day mortality as the secondary outcome.</p><p><strong>Result: </strong>The relationship between heparin therapy duration and mortality at 30 and 90 days in patients with acute pancreatitis exhibited a J-shaped curve, with the lowest mortality observed around 7 days for both 30-day and 90-day mortality. Heparin therapy durations less than 4 days were significantly associated with higher 30-day mortality (HR: 2.57, 95% CI: 1.53-4.30) and increased 90-day mortality (HR: 1.57, 95% CI: 1.07-2.32), with mortality stabilizing beyond 7 days of therapy. Subgroup analysis stratified by severity consistently supported these findings.</p><p><strong>Conclusion: </strong>In critically ill patients with acute pancreatitis, heparin therapy lasting less than 4 days was associated with increased 30-day and 90-day mortality, whereas the lowest mortality was observed among patients receiving heparin therapy for approximately 7 days.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"195"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative quantitative quadriceps muscle ultrasound to predict POD for gastrointestinal surgery in older patients.","authors":"Cunjin Wang, Xiaowei Song, Lan Cao, Fang Guo, Ju Gao","doi":"10.1186/s12876-025-03782-6","DOIUrl":"10.1186/s12876-025-03782-6","url":null,"abstract":"<p><strong>Objective: </strong>Postoperative delirium (POD) is generally associated with increased postoperative adverse events. We aimed to investigate whether preoperative quantitative quadriceps muscle ultrasound could predict POD in older patients after gastrointestinal surgery in order to provide more targeted prevention and treatment measures.</p><p><strong>Methods: </strong>We prospectively collected data from elderly patients who underwent elective gastrointestinal surgery from August to December 2023 at a tertiary hospital in China. Intergroup difference analysis and univariate and multivariate logistic regression analyses were used to explore independent risk factors. We calculated and assessed the parameters via sensitivity, specificity, the Youden index, and the area under the receiver operating characteristic curve (AUC), calibration curves and the Hosmer-Lemeshow test. The nomogram was validated internally through bootstrap resampling. The decision curve analysis (DCA) was used to evaluate its clinical validity.</p><p><strong>Results: </strong>A total of 695 patients who underwent gastrointestinal surgery were analyzed in this investigation, among which 137 patients experienced POD with an incidence rate of 19.7%. After conducting multivariate logistic regression analyses using R software, six independent risk factors associated with POD were identified, including age, quadriceps muscle thickness (Q-MT), quadriceps echo intensity (Q-EI), Charlson Comorbidity Index (CCI), preoperative frailty and preoperative Minimum Mental State Examination (MMSE) scores. The AUC value of the model was 0.966 (95% CI: 0.950-0.982; p < 0.05). The calibration curve revealed that the predicted probability of the nomogram was consistent with the actual probability, and the Hosmer-Lemeshow goodness-of-fit test value was 0.811. DCA revealed that the nomogram has a net benefit for POD.</p><p><strong>Conclusion: </strong>Quantitative quadriceps ultrasound parameters, including the Q-MT and Q-EI, could predict POD after gastrointestinal surgery in older patients. We have developed a new nomogram for predicting POD in older patients who undergo gastrointestinal surgery.</p><p><strong>Study registration: </strong>The trial was registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ) on August 3, 2023, with the registration number of ChiCTR2300074304.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"198"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary potassium intake and the prevalence of gallstones in American adults: an assessment of data from the national health and nutrition examination survey.","authors":"Shangru Yang, Na Jiao, Jingyuan Wang, Tong Zhang","doi":"10.1186/s12876-025-03744-y","DOIUrl":"10.1186/s12876-025-03744-y","url":null,"abstract":"<p><strong>Background: </strong>Gallstones are a common disease of the digestive system, and its complications pose serious risks to human health and impose a significant economic burden on society. Inadequate dietary potassium intake may be associated with the development of gallstones, however, there is a lack of current epidemiological research on this topic.</p><p><strong>Objective: </strong>The purpose of this research was a preliminarily exploration of the relationship between dietary potassium intake and the prevalence of gallstones, providing direction for the next step of quantitativeanalysis on the association between dietary potassium intake and the prevalence of gallstones.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to 2020 were used for a cross-sectional analysis. The presence of gallstones was assessed based on the NHANES questionnaire data for the corresponding time frame. To investigate the link between dietary potassium consumption and the likelihood of developing gallstones, multiple logistic regression models were used. Subgroup analyses were conducted based on variables such as age, gender, poverty-to-income ratio (PIR), body mass index (BMI), hypertension, diabetes, dietary supplement use, and physical activity. An analysis of linear associations was carried out using smoothing curves.</p><p><strong>Results: </strong>The study comprised 6,223 participants aged 20 years and older, excluding pregnant individuals. Among these participants, 671 were diagnosed with gallstones. In the final adjusted model, with a 95% confidence interval (CI) of 0.70 to 0.93, it was determined that dietary potassium intake and gallstone incidence were negatively correlated (OR = 0.81, p = 0.003). Individuals in the highest tertile of dietary potassium intake experienced a 31% lower risk of developing gallstones compare to those in the lowest tertile (OR = 0.69, 95% CI: 0.51-0.94, p = 0.017). In Model 1, the prevalence of gallstones exhibited an inverse relationship with dietary potassium intake. This negative association persisted even after stratifying by variables such as age, gender, PIR, BMI, hypertension, diabetes, dietary supplement use, and physical activity. Sensitivity analyses demonstrated the stability of this relationship.</p><p><strong>Conclusion: </strong>Our research revealed that increased dietary potassium intake is associated with a lower prevalence of gallstones. Nevertheless, additional prospective studies are required to confirm a precise dietary potassium intake level and the long-term effects of potassium metabolism on gallstone formation.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"197"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnet-assisted diverticuloplasty for treating the symptomatic esophageal diverticulum: a case series (with video).","authors":"Ruide Liu, Xianhui Zeng, Xianglei Yuan, Wei Liu, Shuang Liu, Yinong Zhu, Bing Hu","doi":"10.1186/s12876-025-03783-5","DOIUrl":"10.1186/s12876-025-03783-5","url":null,"abstract":"<p><strong>Background: </strong>The development of the magnetic compression technique (MCT) for the gastrointestinal (GI) tract has been widely applied in the treatment of biliary strictures, esophageal atresia, and GI anastomoses. Our team combined the MCT and minimally invasive endoscopic operation to propose a novel alternative procedure called magnet-assisted diverticuloplasty (MAD) for treating various esophageal diverticula. This case series aimed to report the effectiveness, safety, and our experience of MAD.</p><p><strong>Methods: </strong>This retrospective case series included patients with symptomatic esophageal diverticulum (SED) who underwent MAD between November 2017 and June 2022 in West China Hospital, Sichuan University. The patients' symptomatic scores were accessed by Eckardt symptomatic scores. The telephone follow-up period ended in March 2023. The primary outcome of the study was clinical success. Secondary outcomes included the technical success of MAD, procedure time, hospitalization, recurrence, and adverse events.</p><p><strong>Results: </strong>We reported 6 patients with SED who underwent MAD (3 with Zenker's, 1 with middle, and 2 with lower esophageal diverticulum). The technical success rate was 100% (6/6) and no adverse events were reported. The median procedural duration was 22.5 min (interquartile range (IQR) 18.5). The mean hospitalization was 2 days (range 1-3). The median time of follow-up endoscopy was on postoperative day 18 (IQR 31), revealing a shortened diverticular septum under endoscopic examination. After a median telephone follow-up of 23 months (IQR 36), the median total symptomatic score decreased significantly from 4.00 (IQR 3.25) to 1.00 (IQR 2.00) (P = 0.015). The clinical success rate was 83.3% (5/6), and only one patient had recurrent symptoms two years after MAD.</p><p><strong>Conclusion: </strong>MAD provided a novel method for treating SED. Our limited experience suggested that MAD could be minimally invasive and effective. More extensive, multicenter prospective studies were needed to assess this technique further.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"193"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}