BMC Gastroenterology最新文献

{"title":"The double-edged sword: impact of antibiotic use on immunotherapy efficacy in advanced hepatocellular carcinoma.","authors":"Yang Li, Ziwei Feng, Canhua Liang, Shaohuan Lu, GuangZhao Wang, Guangyi Meng","doi":"10.1186/s12876-025-03819-w","DOIUrl":"10.1186/s12876-025-03819-w","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study aims to evaluate the impact of antibiotics (ATBs) use on the efficacy of immunotherapy in patients with advanced hepatocellular carcinoma (HCC), providing insights into the prudent use of ATBs in patients undergoing immunotherapy.</p><p><strong>Methods: </strong>We retrospectively collected data from patients with advanced HCC treated with immune checkpoint inhibitors (ICIs) at our institution between January 1, 2021, and December 30, 2023. Patients were divided into two groups based on ATBs use: an ATB group and a non-ATB group. Clinical baseline characteristics were analyzed, and survival curves were plotted using the Kaplan-Meier model. A Cox proportional hazards model was employed to analyze influencing factors.</p><p><strong>Results: </strong>Among the 102 advanced HCC patients receiving ICIs treatment, 29 were in the ATB group, and 73 were in the non-ATB group. The progression-free survival (PFS) (P = 0.034) and overall survival (OS) (P = 0.021) were significantly shorter in the ATB group compared to the non-ATB group. The difference in PFS between the two groups was associated with ATBs use and patients' AFP levels, while ATBs use was identified as an independent risk factor for the difference in OS between the groups.</p><p><strong>Conclusion: </strong>ATB use in the context of immunotherapy for advanced HCC is associated with reduced PFS and OS. Caution is warranted in the administration of ATBs to patients undergoing immunotherapy.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"221"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged time interval from neoadjuvant immunotherapy combined with chemotherapy to surgery is related to unimproved pathological response and poor survival prognosis for esophageal squamous cell carcinoma.","authors":"Guanzhi Ye, Gaojian Pan, Xiaolei Zhu, Hongming Liu, Ning Li, Guojun Geng, Jie Jiang","doi":"10.1186/s12876-025-03802-5","DOIUrl":"10.1186/s12876-025-03802-5","url":null,"abstract":"<p><strong>Background: </strong>The optimal time interval from neoadjuvant immunotherapy combined with chemotherapy to surgery for esophageal squamous cell carcinoma remains unknown. This research aims to assess the impact of time interval on pathological response and survival prognosis.</p><p><strong>Methods: </strong>Esophageal squamous cell carcinoma patients receiving neoadjuvant immunotherapy combined with chemotherapy followed by esophagectomy between January 2021 and March 2024 were included. The pathological response, survival outcomes, surgical outcomes, and postoperative complications were compared between the timely surgery group (time interval ≤ 6 weeks) and the delayed surgery group (time interval > 6 weeks).</p><p><strong>Results: </strong>A total of 133 cases were included in this research. The pathological complete response (pCR) rates in timely surgery group and delayed surgery group were 23.4% and 12.8% (P = 0.167). There were no statistically significant differences between the two groups in terms of anastomotic fistula (P = 0.321), pulmonary infection (P = 0.427), chylothorax (P = 0.502), multiple organ dysfunction syndrome (P = 0.206), operation time (P = 0.359), blood loss (P = 0.093), number of resected lymph nodes (P = 0.091), hospital stay (P = 0.167), and R0 resection rate (P = 0.523). The 3-year overall survival (OS) rates were 77.5% in timely surgery group, and 63.5% in delayed surgery group (P = 0.046). The 3-year disease-free survival (DFS) rates were 59.1% and 38.4% in the two groups, respectively (P = 0.037). Additionally, multivariate Cox regression analyses indicated that the time interval from immunochemotherapy to surgery was independent prognostic factor for both OS (P = 0.049) and DFS (P = 0.025).</p><p><strong>Conclusions: </strong>Prolonged time interval from neoadjuvant immunotherapy combined with chemotherapy to surgery did not improve pCR rate and was associated with worse OS and DFS in esophageal squamous cell carcinoma.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"223"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of electrode position in electric field treatment for pancreatic cancer.","authors":"Sangcheol Kim, Yousun Ko, Dongho Shin, Haksoo Kim, Sung Uk Lee, Jonghyun Kim, Tae Hyun Kim, Myonggeun Yoon","doi":"10.1186/s12876-025-03807-0","DOIUrl":"10.1186/s12876-025-03807-0","url":null,"abstract":"<p><strong>Background: </strong>In electric field-based cancer treatment, the intensity of the electric field applied to the tumor depends on the position of the electrode array, directly affecting the efficacy of treatment. The present study evaluated the effects of changing the position of the electrode array on the efficacy of electric field treatment for pancreatic cancer.</p><p><strong>Methods: </strong>A 3D model was created based on computed tomography images of 13 pancreatic cancer patients. An electrode array was placed on the surface of the model at various positions, and the electric field was calculated for each. Six treatment plans were created for each patient by rotating each electrode array ± 15⁰, ± 30⁰ in the axial plane, and ± 10⁰ in the sagittal plane relative to the reference plan. The frequency was set at 150 kHz and the current density at 31 mArms/cm² for calculation of all treatment plans. The mean electric field, minimum electric field, homogeneity index (HI) and coverage index (CI) calculated from the six simulated plans were compared with the reference plan to evaluate the effects of each simulated plan on the tumor.</p><p><strong>Results: </strong>Comparisons of the simulated plans for each patient with the reference plan showed differences of -2.61 ∼ 11.31% in the mean electric field, -7.03 ∼ 13.87% in the minimum electric field, -64.14 ∼ 13.12% in the HI, and - 24.23 ∼ 11.00% in the CI. Compared with the reference plan, the optimal plans created by changing the electrode position improved the mean electric field 7.41%, the minimum electric field 7.20%, the HI 4.57%, and the CI 8.46%.</p><p><strong>Conclusions: </strong>Use of a treatment planning system to determine the optimal placement of the electrode array based on the anatomical characteristics of each patient can improve the intensity of the electric field applied to the tumor.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"222"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia.","authors":"Qian-Qian Wang, Ning Zhang, Xiang Xu, Si-Ang Lv, Zhuo-Deng Huang, Xi-Dai Long, Jun Wu","doi":"10.1186/s12876-025-03786-2","DOIUrl":"10.1186/s12876-025-03786-2","url":null,"abstract":"<p><strong>Background/aims: </strong>The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) among individuals with hyperuricemia is significantly high. The aim of this study was to identify effective biomarkers for the detection of MASLD among patients with hyperuricemia.</p><p><strong>Method: </strong>We conducted an analysis involving 3424 participants with hyperuricemia from the National Health and Nutrition Examination Survey (1999-2020). To identify potential significant variables, we employed Boruta's algorithm, SHapley Additive exPlanations (SHAP) and random forests. Multivariable logistic regression models were utilized to assess the odds ratio (OR) of developing MASLD. To evaluate the accuracy and clinical value of our prediction model, we employed receiver operating characteristic (ROC) curves and decision curve analysis (DCA) curves.</p><p><strong>Results: </strong>Among the study population of 3424 participants (mean [SD] age, 54 [20] years, 1788 [52.22%] males) with hyperuricemia, 1670 participants had MASLD. Using Boruta's algorithm, SHAP and random forests, our analysis suggested that Triglyceride Glucose-Waist Circumference (TyG_WC) was one of the most significant variables in predicting MASLD risk, with an area under the receiver operating characteristic (AUROC) of 0.865. The restricted curve spline (RCS) revealed a positive association between the odds ratio of TyG_WC and MASLD, when compared with lowest quantile of TyG_WC, the risk of MASLD for highest quantile was 137.96 times higher. The predictive strategy incorporating TyG_WC notably enhanced the clinical model, with threshold probabilities spanning from approximately 0% to 100%, resulting in a significant improvement of the net benefit.</p><p><strong>Conclusions: </strong>Our analysis found that TyG_WC was one of the most significant variables in predicting MASLD risk among individuals with hyperuricemia.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"220"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017-2020.","authors":"Huachao Zheng, Bo Wu, Caixiang Zhuang, Jiesheng Mao, Min Li, Yuncheng Luo, Lidong Huang, Sisi Lin, Feiyang Zhao, Yiren Hu","doi":"10.1186/s12876-025-03777-3","DOIUrl":"10.1186/s12876-025-03777-3","url":null,"abstract":"<p><strong>Background: </strong>The Cardiometabolic Index (CMI), a composite marker integrating lipid profiles (triglycerides-to-HDL-C ratio) and abdominal obesity (waist-to-height ratio), we aimed to assess its association with gallstone prevalence.</p><p><strong>Methods: </strong>We analyzed data from 2,692 participants in the NHANES 2017-2020 dataset. Gallstones were identified through self-reported data, which may introduce bias in the diagnosis. This limitation should be considered when interpreting the results. Logistic regression modelling, smoothed curve fitting and threshold effect analysis assessed the association between CMI and gallstones.</p><p><strong>Result: </strong>Higher CMI was significantly associated with an increased risk of gallstones (OR = 1.90, 95% CI: 1.37-2.62, P < 0.0001). A threshold effect was observed at CMI = 0.85, below which risk increased significantly (OR = 2.62, 95% CI:1.34-5.12, P = 0.0049), but became non-significant above this value. The association was stronger in women.</p><p><strong>Conclusion: </strong>Our findings support the use of CMI as a potential predictive marker for gallstone risk, suggesting its integration into clinical assessments for early detection and prevention.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"218"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized open label pilot study evaluating the efficacy of two dosing regimens of rifamycin SV MMX in the treatment of small intestinal bacterial overgrowth.","authors":"Bradley A Connor, Marina Rogova, Jefferson Garcia, Morgan Gardner, Charandeep Waraich, Victoria Averill","doi":"10.1186/s12876-025-03804-3","DOIUrl":"10.1186/s12876-025-03804-3","url":null,"abstract":"<p><p>Antibiotics have demonstrated efficacy in the eradication of the underlying overgrowth bacteria and improvement of symptoms of small intestinal bacterial overgrowth (SIBO). The use of standard antibiotics may cause intolerable side effects such as development of multidrug-resistant enteric bacteria, Clostridioides difficile infections and dysbiosis. Nonabsorbable antibiotics have the advantage of minimized side effects. Rifaximin, an antibiotic of the ansamycin class has been shown to be effective in the treatment of SIBO. We evaluated the use of another ansamycin antibiotic, rifamycin SV MMX (AEMCOLO) in the treatment of SIBO. One difference from rifaximin is the site of delivery of AEMCOLO which appears to be the distal small intestine and colon. Hence by maintaining the microbial milieu of the proximal small intestine, the clearance of the overgrowth bacteria might be enhanced. The side effect profile of Rifamycin SV MMX has been described elsewhere in the pivotal trials; there were no safety signals noted in this study. This randomized open label pilot study evaluated the efficacy of two dosing regimens of AEMCOLO in treating SIBO. We used a simple randomization method to assign participants into study groups. The participants included 31 patients, split between two treatment arms: one receiving the medication twice daily and the other - three times daily. The outcomes were assessed based on symptom improvement and breath test normalization. The results indicated a beneficial response with both dosing regimens leading to symptom improvement and breath test normalization. Further evaluation revealed that in the three-time daily regimen, greater symptomatic improvement was observed. For clinicians treating SIBO, this study suggests that AEMCOLO is a viable treatment option. A double-blind, placebo-controlled design will probably be necessary to ascertain the true efficacy of different dosing regimens of AEMCOLO in treating SIBO.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"219"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of Barrett 's esophagus in Iranian patients with gastrointestinal symptoms: a systematic review and meta-analysis.","authors":"Maryam Rashidian, Fatemeh Bastan, Hedieh Soltani, Reza Ghosheni, Kiyarash Bakhshande, Mahdi Mohammaditabar, Yasin Tabatabaei Mehr, Khaled Rahmani, Mahmood Bakhtiyari, Mostafa Qorbani, Mojgan Forootan, Mahsa Mohammadi, Mohsen Rajabnia","doi":"10.1186/s12876-025-03822-1","DOIUrl":"10.1186/s12876-025-03822-1","url":null,"abstract":"<p><strong>Background: </strong>Barrett's esophagus (BE) is a premalignant columnar metaplasia of the esophagus that predisposes victims to esophageal adenocarcinoma (EAC). Depending on differences in the study population and risk factors, the prevalence of BE may vary, from 0.4 to 20% globally. The current study aimed to systematically review and analyse the prevalence of BE in in patients with gastrointestinal symptoms in Iran. Furthermore, gastrointestinal malignancies are among the most common tumours in Iran, making this study even more significant.</p><p><strong>Methods: </strong>A systematic search was carried out in PubMed, Web of Science, Scopus, and EMBASE as well as some domestic databases including SID, Magiran, IranDoc, IranMedex from inception to the end of 2023. We included all cross-sectional studies which reported the prevalence of BE and calculated pooled prevalence.</p><p><strong>Results: </strong>The results of the analysis, including 9 studies in a total of 4978 cases (213 Barret diagnoses), revealed that by the results of these studies, the prevalence of Barret's esophagus is 4.4% [I2 = 94.9% [92.2%; 96.6%]/p-value < 0.0001]. Subgroup analysis, divided by region and year, revealed significant differences between groups.</p><p><strong>Conclusions: </strong>The epidemiology of BE in Iran is not completely identified. This is the first systematic review and meta-analysis evaluating the prevalence and of BE in Iran. Due to the importance of BE in progressing to esophageal adenocarcinoma, much importance should be given to its timely diagnosis. It is strongly recommended to conduct more comprehensive studies including more patients in this field.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"217"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between wet-bulb globe temperature with peptic ulcer disease in different geographic regions in a large Taiwanese population study.","authors":"Yuh-Ching Gau, Chia-Yu Kuo, Wei-Yu Su, Wan-Ling Tsai, Ying-Jhen Wu, Ping-Hsun Wu, Ming-Yen Lin, Chih-Da Wu, Chao-Hung Kuo, Szu-Chia Chen","doi":"10.1186/s12876-025-03803-4","DOIUrl":"10.1186/s12876-025-03803-4","url":null,"abstract":"<p><strong>Background: </strong>Peptic ulcer disease (PUD) is a common and important cause of morbidity worldwide, with a large impact on healthcare costs. Little research has been conducted on the association between wet-bulb globe temperature (WBGT) and PUD. The aim of this study was to explore this association among different geographical regions of Taiwan in a large sample of participants.</p><p><strong>Methods: </strong>This is a cross-sectional study. The study participants (n = 120,424) were enrolled from the Taiwan Biobank (TWB) and resided across northern, central, southern and eastern Taiwan. Self-reported questionnaires were used to ascertain the occurrence of PUD. Average WBGT values were recorded during working hours (8:00 AM to 5:00 PM) and the noon period (11:00 AM to 2:00 PM) for each participant at 1, 3, and 5 years before the TWB survey year. The association between WBGT and PUD was examined with logistic regression analysis.</p><p><strong>Results: </strong>The 1-year and 5-year noon WBGT values per 1℃ increase were significantly associated with a low prevalence of PUD in northern Taiwan (odds ratio [OR], 0.960, 95% confidence interval [CI], 0.925-0.955; OR, 0.962, 95% CI, 0.929-0.997; respectively). In contrast, there were no significant associations between WBGT and PUD in central Taiwan. In southern Taiwan, the 1-, 3-, and 5-year WBGT values per 1℃ increase during the noon period (OR, 0.875, 95% CI, 0.873-0.909; OR, 0.860, 95% CI, 0.825-0.896; OR, 0.848, 95% CI, 0.812-0.885; respectively) and working period (OR, 0.852, 95% CI, 0.825-0.880; OR, 0.845, 95% CI, 0.816-0.876; OR, 0.832, 95% CI, 0.0.801-0.863; respectively) were significantly associated with a low prevalence of PUD. However, in eastern Taiwan, the 1-, 3-, and 5-year WBGT values per 1℃ increase during the noon period (OR, 1.074, 95% CI, 1.022-1.127; OR, 1.058, 95% CI, 1.013-1.104; OR, 1.058, 95% CI, 1.013-1.105; respectively), and the 3- and 5-year WBGT values per 1℃ increase during the working period were significantly associated with a high prevalence of PUD (OR, 1.049, 95% CI, 1.003-1.097; OR, 1.047, 95% CI, 1.001-1.095; respectively). Based on nonlinear trend analysis, WBGT was categorized into three groups for the noon period or work period, and the results were similar to and generally consistent with those in linear models.</p><p><strong>Conclusion: </strong>The associations between WBGT and PUD differed across the geographical regions of Taiwan. In northern and southern Taiwan, increases in average WBGT values were significantly associated with a low prevalence of PUD. In addition, this relationship was much stronger in southern Taiwan than in northern Taiwan. Of note, there was a reverse relationship between WBGT and PUD during the noon and working periods in eastern Taiwan. Further studies are needed to elucidate the effects of WBGT on PUD.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"216"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a novel nomogram based on the log odds of positive lymph nodes to predict cancer-specific survival in elderly patients with gastric adenocarcinoma after radical surgery.","authors":"Lei Wang, Jingjing Ge, Yihua Fang, Huiqiong Han, Yanru Qin","doi":"10.1186/s12876-025-03813-2","DOIUrl":"10.1186/s12876-025-03813-2","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the efficacy of the log odds of positive lymph nodes (LODDS) in survival prediction of elderly patients with gastric adenocarcinoma (GAC) after gastrectomy, and to construct a relevant survival prediction model.</p><p><strong>Methods: </strong>In this study, patient data was collected from both the Surveillance, Epidemiology, and End Results (SEER) database and a medical records database at a hospital in China. Least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox analysis were used to identify independent risk factors for cancer-specific survival (CSS) and a nomogram was constructed based on the results of multivariate Cox regression. Using consistency index (C-index), calibration curve, time-dependent receiver operating characteristic curve (tdROC) and decision curve analysis (DCA) to evaluate the predictive performance of nomogram. Generating Kaplan-Meier survival curves to show the difference in CSS between different groups.</p><p><strong>Results: </strong>Multivariate Cox analysis indicated that race, site, T stage, size, and LODDS were independently associated with the CSS. The C-index and AUC of the nomogram both exceed 0.71, while the calibration curve suggests that the nomogram accurately predicts CSS. Additionally, DCA curve results demonstrate superior clinical net benefits of the nomogram over TNM staging. High-risk patients identified by the predictive model exhibit inferior survival outcomes compared to low-risk patients. In addition, group comparison showed that only high-risk patients or high-LODDS group could benefit from chemotherapy and radiotherapy.</p><p><strong>Conclusions: </strong>The LODDS is an independent prognostic factor for elderly GAC patients after gastrectomy. The nomogram based on LODDS has better predictive ability than the traditional TNM staging system, assisting clinical doctors in evaluating patient prognosis and guiding treatment.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"215"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDH1 genetic variants and its aberrant expression are the risk factors for colorectal cancer metastasis.","authors":"Yunbo Wu, Ying Yu, Danyan Li, Yunkai Dai, Jianyu Wu, Zijing Zhang, Huaigeng Pan, Weijing Chen, Ruliu Li, Ling Hu","doi":"10.1186/s12876-025-03797-z","DOIUrl":"10.1186/s12876-025-03797-z","url":null,"abstract":"<p><p>E-cadherin, encoded by the CDH1 gene, plays an essential role in epithelial cellular adhesion, and the loss of it has been reported to be associated with tumor progression and metastasis, potentially offer a glimpse in to the development of colorectal cancer. The present study aimed to explore effect of CDH1-160 polymorphism, CDH1 transcription and its protein E-cadherin expression on colorectal cancer, meanwhile uncovering the underlying mechanism. Specimens from cancer loci, adjacent cancer tissue, and distal normal tissue from colorectal cancer patients were collected for Hematoxylin-eosin staining to detect the histopathological change of colorectal mucosa. Direct sequencing and Quantitative Real-Time PCR were used to detect the CDH1 genotype and its mRNA expression, respectively. E-cadherin expression was detected using the ElivisionTM plus method. As a result, we found that the A allele of the CDH1-160 may be a protective gene against colorectal cancer, and the C > A polymorphism may regulate its transcription activity and expression of E-cadherin. The decrease of the CDH1 mRNA transcription level and the absence of E-cadherin on the cytomembrane may promote intestinal mucosal carcinogenesis and accelerate cancer cell metastasis. Deficiency of cytomembrane expression of E-cadherin protein may have some early warning signs for malignant lesions of the gut mucosa.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"214"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}