BMC Gastroenterology最新文献

{"title":"Feasibility, effectiveness, and safety of simultaneous side-by-side deployment of uncovered self-expandable metal stents for malignant hilar biliary obstruction: a retrospective single-center study.","authors":"Chengcheng Christine Zhang, Marcus Kantowski, Cyrill Wehling, Patrick Michl, Ronald Koschny, Peter Sauer","doi":"10.1186/s12876-025-04053-0","DOIUrl":"10.1186/s12876-025-04053-0","url":null,"abstract":"<p><strong>Background: </strong>Malignant hilar biliary obstruction is associated with a poor prognosis, making biliary drainage important for improving the quality of life. Endoscopic simultaneous side-by-side deployment of uncovered self-expandable metal stents is a novel approach. However, reliable clinical data on this method are limited. This retrospective, single-center study aimed to evaluate the feasibility, effectiveness, and safety of simultaneous side-by-side deployment of self-expandable metal stents for malignant hilar biliary obstruction.</p><p><strong>Methods: </strong>Data from all patients treated for malignant hilar biliary obstruction at our institution between May 2019 and February 2023 were retrospectively analyzed. The primary endpoints were the technical and clinical success rates, while the secondary endpoints included complications, recurrent biliary obstruction, time to recurrent obstruction, reintervention rate, and mortality.</p><p><strong>Results: </strong>Fifteen patients (mean age, 63 years; 8 men) were treated with simultaneous side-by-side deployment of metal stents for malignant hilar biliary obstruction. The location of the biliary obstruction was classified as Bismuth type III (n = 1) or IV (n = 14). Technical and clinical success rates were both 100%. Three patients underwent side-by-side placement of uncovered self-expandable metal stents using the combined percutaneous endoscopic rendezvous technique. The complication rate was 13.3%, with two patients experiencing recurrent biliary obstruction and cholangitis. The median time to recurrent obstruction was 97.5 days (range: 93-102 days). Both patients required reintervention. Moreover, the 30-day mortality rate was 6.7% (n = 1).</p><p><strong>Conclusions: </strong>Endoscopic simultaneous side-by-side deployment of uncovered self-expandable metal stents for unresectable malignant hilar biliary obstruction is feasible and safe, with high success rates. This technique not only effectively controls symptoms through successful biliary drainage, but can also be a promising option for complex anatomic situations when combined with the percutaneous endoscopic rendezvous technique.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"431"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive accuracy of fecal calprotectin in assessing clinical activity and disease severity in patients with Ulcerative Colitis and Crohn's disease.","authors":"Ankit V Jain, Sandeep Gopal, Anurag J Shetty, Suresh Shenoy, B V Tantry, B Unnikrishnan, Ramesh Holla, Rishit Anand","doi":"10.1186/s12876-025-04035-2","DOIUrl":"10.1186/s12876-025-04035-2","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) is an idiopathic disorder characterized by repeated relapses and remissions. Endoscopy, the gold standard for diagnosis and monitoring of these patients is time consuming, expensive, and invasive. Hence, faecal calprotectin (FCP) has been suggested as marker to determine the degree of intestinal inflammation and predict relapse in IBD.</p><p><strong>Objective: </strong>To use FCP as a predictor of clinical activity and endoscopic severity in IBD patients in a tertiary care hospital in Southern India.</p><p><strong>Methods: </strong>Study subjects underwent clinical examination, endoscopy, blood tests and stool FCP. For Endoscopic activity simple endoscopic score for Crohn's disease (SES-CD) and Ulcerative Colitis endoscopic index of severity (UCEIS) scores were used, and clinical activity was assessed by Crohn's disease activity index (CDAI) and simple clinical colitis index (SCCAI) for CD and UC respectively. At six months, blood, and stool FCP test were repeated which were compared with endoscopic and clinical activity indices.</p><p><strong>Results: </strong>The number of males was higher in both CD (13/8) and UC (19/14). At first visit and follow up, CDAI and FCP were positively correlated (r-0.689, p- 0.016) (r- 0.425, p-value < 0.05). In CD, the sensitivity and specificity of FCP in detecting active disease and remission were 93.8% and 80% respectively (AUC-0.869). At follow up, the sensitivity and specificity were 80% and 93.3% respectively (AUC-0.867). In patients with UC, SCCAI score and FCP levels positively correlated (r-0.231/0.387, p-value 0.001/0.001) at both the first and follow up visits. The sensitivity of FCP in detecting UC in active and remission states was 92.6% whereas the specificity was 83.3%. AUC was 0.88. At the time of follow up, the sensitivity of FCP in detecting UC in active and remission states was 89.9% whereas the specificity was 87.0% and AUC was 0.879.</p><p><strong>Conclusion: </strong>This study confirmed that FCP level shows strong association with clinical and endoscopic activity indices in patients of IBD. Therefore, FCP levels could be used as a surrogate marker for monitoring mucosal status as well as predicting endoscopic remission in IBD patients.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"429"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative literature analysis on efficacy and safety of balloon-occluded transarterial chemoembolization for hepatocellular carcinoma.","authors":"Wei Fan Sui, Yu Xin Duan, Ze Feng Cai, Jian Yun Li, Jian Hua Fu","doi":"10.1186/s12876-025-03851-w","DOIUrl":"10.1186/s12876-025-03851-w","url":null,"abstract":"<p><strong>Aim: </strong>To analyze the efficacy and safety of balloon-occluded transarterial chemoembolization (B-TACE) of hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>We searched English databases, assessed the quality of the selected studies, analyzed the extracted data, tested heterogeneity of data, explored the resources of heterogeneity, and tested publication bias.</p><p><strong>Results: </strong>After inclusion and exclusion criterion, totally 7 studies included in our analysis. The numbers of complete response (CR) in B-TACE were significantly more than in Non B-TACE (P = 0.003). There were no significant difference in partial response (PR), stable disease (SD) and progressive disease (PD) between B-TACE and Non B-TACE. Moderate heterogeneity existed in CR and PR (I² = 60%). Low heterogeneity existed in SD (I² = 36%). Heterogeneity did not exist in PD (I² = 0%). The numbers of treatment effect (TE) 4-1 in B-TACE were significantly more than in Non B-TACE, respectively (P = 0.000007, P < 0.00001). Heterogeneity did not exist in TE4 (I² = 0%). Low heterogeneity existed in T3 - 1 (I² = 48%). The numbers of post embolization syndrome(PES) in B-TACE were significantly more than in Non B-TACE, respectively(P = 0.000007, P < 0.00001). There were no significant difference in adverse events (AEs) of grade 3 and 2 between B-TACE and Non B-TACE, respectively(P = 0.57, 0.12). High heterogeneity existed in PES (I² = 76%). Moderate heterogeneity existed in AEs of grade 2(I² = 57%). Heterogeneity did not exist in AEs of grade 3(I² = 0%).</p><p><strong>Conclusion: </strong>B-TACE was safe. It showed promising efficacy in achieving higher CR rates in short term compared to Non B-TACE.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"430"},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative serum imidazole propionate profiling in colorectal adenoma and cancer by UPLC-MS/MS.","authors":"Jie Lv, Qianqian Chen, Lu Yang, Jing Guan, Sheng Wang, Gen Gui, Zhaoyun Yang, Xu Wang, Bin Sun","doi":"10.1186/s12876-025-04040-5","DOIUrl":"10.1186/s12876-025-04040-5","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of colorectal cancer (CRC) is increasing with colorectal adenomas recognized as key precancerous lesions. Emerging evidence suggests that Imidazole propionate (ImP), a metabolite of gut microbiota, is elevated in patients, indicating a potential role in tumorigenesis of CRC.</p><p><strong>Objectives: </strong>This study aimed to validate a novel method for detecting serum ImP using 3-piperazin-1-yl-propionic acid as an internal standard (IS), and to compare ImP levels between patients with colorectal adenomas and colorectal cancer.</p><p><strong>Methods: </strong>Serum ImP were measured using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) with 3-piperazin-1-yl-propionic acid as the IS. Four distinct patient groups were analyzed.</p><p><strong>Results: </strong>The use of 3-piperazin-1-yl-propionic acid as an IS was successfully validated for the quantification of ImP. Serum ImP differed significantly among the groups, showing a stepwise increase from healthy controls to patients with colorectal adenomas and CRC. Notably, ImP concentrations were significantly higher in CRC patients than in other groups.</p><p><strong>Conclusion: </strong>This study demonstrates the successful application of 3-piperazin-1-yl-propionic acid as an IS provides a viable method for measuring serum ImP concentrations. The results suggest a potential link between ImP and colorectal cancer development.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"426"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in incidence and mortality of early-onset gastrointestinal cancers: a comprehensive study.","authors":"Chengwei Xia, Yini Liu, Xin Qing","doi":"10.1186/s12876-025-04015-6","DOIUrl":"10.1186/s12876-025-04015-6","url":null,"abstract":"<p><strong>Background: </strong>Early-Onset Gastrointestinal Cancers concerns tumors in people under 50. Accumulating evidence suggests a significant increase in the burden of colorectal cancer in young adults. We investigated the global burden and spatiotemporal trends of the 6 major gastrointestinal (GI) cancers, including colon and rectum cancer (CRC), esophageal cancer (EC), gallbladder and biliary tract cancer (GBTC), liver cancer (LC), pancreatic cancer (PC), and stomach cancer (SC). in young adults, based on cancer-specific incidence and mortality.</p><p><strong>Methods: </strong>All data for 6 early-onset (EO) GI cancers were obtained from the Global Burden of Disease study. Age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and corresponding estimated annual percentage change (EAPC) were calculated to assess temporal trends from 1990 to 2019.</p><p><strong>Results: </strong>The global number of cases and deaths from all EO-GI cancers has risen since 1990, reaching 539,750 and 309,200, respectively in 2019. ASIR and ASDR decreased for most EO-GI cancers (total, esophageal, gallbladder and biliary tract (GBTC), liver, and stomach cancers), while EO-pancreatic cancer showed an upward trend. EO colorectal cancer had increased incidence and stable mortality. However, these trends varied by sex, age, region, and economic status. Men had a higher burden of EO GI cancers (except GBTC), and older populations were more affected. Asia, particularly East Asia, had a significant burden, while the Americas showed the largest increase. Areas with Middle and High-middle sociodemographic indices had a relatively high burden of EO-GI cancers.</p><p><strong>Conclusions: </strong>The absolute burden of EO-GI cancers is rising worldwide, but the standardized burden has decreased, This indicates that we have made considerable progress in treatment and early detection.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"424"},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of inflammatory bowel disease in persons aged 60-89 years from 1992 to 2021.","authors":"Zhou Zhang, Na Du, Chun-Mei Xu, Wei Chen, Ting-Ting-Chen, Yu Xiao","doi":"10.1186/s12876-025-04042-3","DOIUrl":"10.1186/s12876-025-04042-3","url":null,"abstract":"<p><strong>Background: </strong>The global burden of inflammatory bowel disease (IBD) is increasing, but detailed data on older adults remain scarce.</p><p><strong>Objective: </strong>This study describes trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of IBD among individuals aged 60-89 years from 1992 to 2021 at global, regional, and national levels, and forecasts the epidemiological status for 2030.</p><p><strong>Methods: </strong>We used the Global Burden of Disease (GBD) database, covering 204 countries and territories. Temporal trends were analyzed using Joinpoint regression models. Decomposition analysis assessed the impacts of population growth, aging, and epidemiological changes. The Nordpred model forecasted 2030 incidence, prevalence, mortality, and DALYs of IBD among older adults.</p><p><strong>Results: </strong>From 1992 to 2021, the global age-standardized incidence rate (ASIR) of IBD among older adults increased (AAPC 0.34). Conversely, the prevalence rate (ASPR) slightly decreased (AAPC - 0.04). Both mortality (ASMR) and DALYs significantly declined (AAPC - 0.60 and - 0.49, respectively). High SDI regions had the highest ASIR and ASPR, with Middle SDI regions experiencing the fastest ASIR growth. Population growth accounted for 117.77% of the overall increase in the IBD burden. By 2030, the incidence rate is expected to rise, but prevalence, mortality, and DALYs rates are predicted to decrease.</p><p><strong>Conclusion: </strong>The incidence rate of IBD among older adults is rising, while prevalence, mortality, and DALYs rates are declining. Significant regional variations underscore the need for targeted public health policies.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"425"},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of short videos as health information sources for chronic pancreatitis in China: a cross-sectional study.","authors":"Xiaojing Yin, Yongkang Lai, Weiquan Zhu, Ningsheng Xie","doi":"10.1186/s12876-025-04005-8","DOIUrl":"10.1186/s12876-025-04005-8","url":null,"abstract":"<p><strong>Background: </strong>Chronic pancreatitis is a chronic inflammatory disease of the pancreatic tissue caused by genetic or environmental factors; it has a complex etiology and is difficult to diagnose and treat clinically, severely affecting the physical and mental health of patients. Currently, the treatment of chronic pancreatitis often relies on lifelong self-health management by patients. However, the quality of videos related to chronic pancreatitis on short video platforms remains to be determined, and these videos may contain erroneous information that patients cannot recognize. This study aims to assess the quality of information in short videos related to chronic pancreatitis on the Chinese platforms TikTok and Bilibili.</p><p><strong>Methods: </strong>Based on comprehensive rankings, the top 100 videos related to chronic pancreatitis on TikTok and Bilibili were searched, filtered, and evaluated by two independent gastroenterologists via the Global Quality Score and the improved DISCERN tool. The content of the videos was analyzed from six aspects: definition, symptoms, risk factors, diagnosis, treatment, and outcomes.</p><p><strong>Results: </strong>A total of 112 videos related to chronic pancreatitis were collected, with the majority (80.36%) being from health professionals, including 20.55% from gastrointestinal health experts and 26.79% from pancreatic surgery specialists. The overall quality and reliability of the videos were relatively low, with DISCERN and GQS scores of 2 (IQR: 2-3) and 3 (IQR: 2-3), respectively. In comparison, videos from gastrointestinal health professionals were more comprehensive in covering chronic pancreatitis content and showed the highest reliability and quality, with DISCERN scores of 3 (IQR: 2-3) and GQS scores of 3 (IQR: 2-3).</p><p><strong>Conclusion: </strong>Overall, the content and quality of video information related to chronic pancreatitis on the two short video platforms in China still require improvement. In the future, health professionals need to provide high-quality videos to promote effective self-disease management among patients with chronic pancreatitis.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"423"},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a nomogram for predicting early recurrence in patients undergoing different courses of postoperative adjuvant transarterial chemoembolisation.","authors":"Hongkun Tan, Yuyan Xu, Cheng Zhang, Kaihang Zhong, Yaohong Wen, Chunming Wang, Zhoubin Feng, Jianan Feng, Shunjun Fu, Guolin He, Lei Cai, Mingxin Pan","doi":"10.1186/s12876-025-04023-6","DOIUrl":"10.1186/s12876-025-04023-6","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is associated with a high rate of postoperative recurrence. Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) is effective in preventing recurrence. However, the effect of different courses of PA-TACE on tumor prognosis remains unclear. As such, this study aimed to develop and validate a nomogram that incorporates different courses of PA-TACE to predict early tumor recurrence.</p><p><strong>Methods: </strong>Data from 307 high-risk patients who underwent PA-TACE were divided into training and test cohorts at a 6:4 ratio. A nomogram was developed in the training group using least absolute shrinkage and selection operator (LASSO) regression to identify independent prognostic factors and subsequently tested in the test group. Patients were classified into high-, moderate-, and low-risk categories using X-tile software (Rimm Lab, Yale School of Medicine, New Haven, CT, USA), and survival was analyzed.</p><p><strong>Results: </strong>A nomogram was developed based on independent prognostic factors, including age, tumor diameter, multiplicity, satellite nodules, PA-TACE course, and aspartate transaminase (AST) level. The nomogram demonstrated strong discriminatory power in the training cohort (C-index 0.718, 95% confidence interval [CI]: 0.672-0.763) and validated in a test cohort (C-index 0.759, 95% CI: 0.701-0.817). Calibration and decision curve analyses confirmed predictive accuracy and clinical utility. Kaplan-Meier curves revealed significant discriminatory power among the high-, moderate-, and low-risk groups. No significant differences in PA-TACE-related adverse reactions were observed across the treatment courses, except for allergic reactions.</p><p><strong>Conclusion: </strong>This study developed and validated a nomogram that accurately predicted the risk for early recurrence after PA-TACE treatment in patients with HCC at a high risk for recurrence. Importantly, the nomogram identified PA-TACE as a key prognostic factor with significant clinical utility.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"422"},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the dietary index of gut microbiota and abnormal bowel symptoms in U.S. adults: a cross-sectional study based on NHANES 2007-2010.","authors":"Sicheng Shen, Huayi Feng, Chuyue Wang, Yingqi Yang, Zhiyang Chen, Xiaopeng Wang, Jiacheng Li","doi":"10.1186/s12876-025-04021-8","DOIUrl":"10.1186/s12876-025-04021-8","url":null,"abstract":"<p><strong>Background: </strong>The Dietary Index of Gut Microbiota (DI-GM) is a newly developed measure for assessing diet quality in relation to the diversity of the gut microbiome. However, whether it is associated with the risk of chronic constipation and chronic diarrhea remains unclear.</p><p><strong>Methods: </strong>We analyzed data from 7,943 U.S. adults aged 20 years and older who participated in the 2007-2010 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression, subgroup analysis, and restricted cubic spline (RCS) models were used to assess the association between the DI-GM and abnormal bowel symptoms.</p><p><strong>Results: </strong>A higher DI-GM score was significantly associated with a reduced risk of abnormal bowel symptoms. For each 1-point increase in the DI-GM, the risk of constipation decreased by 12.4% (OR = 0.876, 95% CI = 0.806-0.951, p = 0.002), and the risk of diarrhea decreased by 14.1% (OR = 0.859, 95% CI = 0.789-0.936, p < 0.001). Compared with the lowest DI-GM quartile, the highest quartile showed a markedly lower risk of both constipation (OR = 0.487, 95% CI = 0.340-0.696, p < 0.001) and diarrhea (OR = 0.480, 95% CI = 0.338-0.682, p < 0.001). RCS analysis indicated a significant linear association between the DI-GM and the risks of both constipation (nonlinear p = 0.686) and diarrhea (nonlinear p = 0.136).</p><p><strong>Conclusions: </strong>The DI-GM was negatively associated with the prevalence of abnormal bowel symptoms. Further longitudinal studies are warranted to confirm these findings and to inform dietary strategies for gut health.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"419"},"PeriodicalIF":2.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol-modified prognostic nutritional index as an independent prognostic biomarker in primary biliary cholangitis patients.","authors":"Huiling Zhu, Mengyao Zheng, Wenbin Li, Yaqin Huang, Lili Zhang, Wenting Yang, Jinhui Yang","doi":"10.1186/s12876-025-04013-8","DOIUrl":"10.1186/s12876-025-04013-8","url":null,"abstract":"<p><strong>Background: </strong>Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by inflammation of the interlobular bile ducts, often associated with malabsorption of fat-soluble vitamins and osteoporosis. Thus, evaluating the nutritional status of patients with PBC and implementing appropriate interventions are significant. But CPNI in determining the nutritional status and forecasting survival outcome among patients with PBC remains unclear.</p><p><strong>Methods: </strong>A total of 262 patients with PBC were retrospectively enrolled at the Second Affiliated Hospital of Kunming Medical University between January 2013 and November 2023. We used the receiver operating characteristic (ROC) curve, Kaplan-Meier survival curve, and logistic regression analysis to evaluate the predictive effects of several nutritional assessments. These assessments included the controlling nutritional status (CONUT), geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), and Cholesterol-modified Prognostic Nutritional Index (CPNI), which were evaluated for their predictive effect on the prognosis of PBC patients.</p><p><strong>Results: </strong>In our study, after adjusting for various confounding factors, multivariate cox regression analyses revealed that CPNI (HR: 1.114, 95% CI: 1.003-1.237, P = 0.044), age (HR: 1.071, 95% CI: 1.018-1.127, P < 0.009), total bilirubin (HR:1.019, 95% CI:1.009-1.09, P < 0.001) were independent risk factors for death in patients with PBC. The Kaplan-Meier curves and ROC curves used to assess predictive accuracy showed that CPNI(0.788) had superior prognostic performance for OS compared to other nutritional indices, such as CONUT(0.724), GNRI(0.755), PNI(0.776), and UK-PBC(0.660)(P < 0.05).</p><p><strong>Conclusions: </strong>CPNI is superior to other nutritional scores in the prognostic assessment of PBC patients.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"421"},"PeriodicalIF":2.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}