Neuroscience journal最新文献_第2页

Spatial Directionality Found in Frontal-Parietal Attentional Networks. 在额-顶叶注意网络中发现空间方向性。

Neuroscience journal Pub Date : 2018-08-30 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7879895

Gahangir Hossain, Mark H Myers, Robert Kozma

{"title":"Spatial Directionality Found in Frontal-Parietal Attentional Networks.","authors":"Gahangir Hossain, Mark H Myers, Robert Kozma","doi":"10.1155/2018/7879895","DOIUrl":"https://doi.org/10.1155/2018/7879895","url":null,"abstract":"Research in last few years on neurophysiology focused on several areas across the cortex during cognitive processing to determine the dominant direction of electrical activity. However, information about the frequency and direction of episodic synchronization related to higher cognitive functions remain unclear. Our aim was to determine whether neural oscillations carry perceptual information as spatial patterns across the cortex, which could be found in the scalp EEG of human subjects while being engaged in visual sensory stimulation. Magnitude squared coherence of neural activity during task states that \"finger movement with Eyes Open (EO) or Eyes Wandering (EW)\" among all electrode combinations has the smallest standard deviation and variations. Additionally, the highest coherence among the electrode pairs occurred between alpha (8-12 Hz) and beta (12-16 Hz) ranges. Our results indicate that alpha rhythms seem to be regulated during activities when an individual is focused on a given task. Beta activity, which has also been implicated in cognitive processing to neural oscillations, is seen in our work as a manner to integrate external stimuli to higher cognitive activation. We have found spatial network organization which served to classify the EEG epochs in time with respect to the stimuli class. Our findings suggest that cortical neural signaling utilizes alpha-beta phase coupling during cognitive processing states, where beta activity has been implicated in shifting cognitive states. Significance. Our approach has found frontoparietal attentional mechanisms in shifting brain states which could provide new insights into understanding the global cerebral dynamics of intentional activity and reflect how the brain allocates resources during tasking and cognitive processing states.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2018 ","pages":"7879895"},"PeriodicalIF":0.0,"publicationDate":"2018-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7879895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36503649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders. 海马病理生理学:颞叶癫痫和精神疾病的共性。

Neuroscience journal Pub Date : 2018-01-22 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4852359

Soichiro Nakahara, Megumi Adachi, Hiroyuki Ito, Mitsuyuki Matsumoto, Katsunori Tajinda, Theo G M van Erp

引用次数: 41

Determining the Optimal Number of Stimuli per Cranial Site during Transcranial Magnetic Stimulation Mapping. 在经颅磁刺激制图中确定每个颅部位的最佳刺激数。

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-02-26 DOI: 10.1155/2017/6328569

Rocco Cavaleri, Siobhan M Schabrun, Lucy S Chipchase

{"title":"Determining the Optimal Number of Stimuli per Cranial Site during Transcranial Magnetic Stimulation Mapping.","authors":"Rocco Cavaleri, Siobhan M Schabrun, Lucy S Chipchase","doi":"10.1155/2017/6328569","DOIUrl":"https://doi.org/10.1155/2017/6328569","url":null,"abstract":"The delivery of five stimuli to each cranial site is recommended during transcranial magnetic stimulation (TMS) mapping. However, this time-consuming practice restricts the use of TMS mapping beyond the research environment. While reducing the number of stimuli administered to each cranial site may improve efficiency and decrease physiological demand, doing so may also compromise the procedure's validity. Therefore, the aim of this study was to determine the minimum number of stimuli per cranial site required to obtain valid outcomes during TMS mapping. Map volume and centre of gravity (CoG) recordings obtained using five stimuli per cranial site were retrospectively compared to those obtained using one, two, three, and four stimuli per cranial site. For CoG longitude, one stimulus per cranial site produced valid recordings (ICC = 0.91, 95% CI 0.82 to 0.95). However, this outcome is rarely explored in isolation. As two stimuli per cranial site were required to obtain valid CoG latitude (ICC = 0.99, 95% CI 0.99 to 0.99) and map volume (ICC = 0.99, 95% CI 0.99 to 0.99) recordings, it is recommended that a minimum of two stimuli be delivered to each cranial site during TMS mapping in order to obtain valid outcomes.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2017 ","pages":"6328569"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6328569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34845634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Variability in Diagnosing Brain Death at an Academic Medical Center. 在学术医疗中心诊断脑死亡的可变性。

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-03-02 DOI: 10.1155/2017/6017958

Ashutosh Pandey, Pradeep Sahota, Premkumar Nattanmai, Christopher R Newey

{"title":"Variability in Diagnosing Brain Death at an Academic Medical Center.","authors":"Ashutosh Pandey, Pradeep Sahota, Premkumar Nattanmai, Christopher R Newey","doi":"10.1155/2017/6017958","DOIUrl":"https://doi.org/10.1155/2017/6017958","url":null,"abstract":"Objective. Research continues to highlight variability in hospital policy and documentation of brain death. The aim of our study was to characterize how strictly new guidelines of American Academy of Neurology (AAN) for death by neurological criteria were practiced in our hospital prior to appointment of neurointensivists. Method. This is a retrospective study of adults diagnosed as brain dead from 2011 to 2015. Descriptive statistics compared five categories: preclinical testing, neurological examination, apnea tests, ancillary test, and documentation of time of death. Strict adherence to AAN guidelines for brain death determination was determined. Result. 76 patients were included in this study. Preclinical prerequisites were fulfilled in 53.9% and complete neurological examinations were documented in 76.3%. Apnea test was completed in 39.5%. Ancillary test was completed in 29.8%. Accurate documentation of time of death occurred in 59.2%. Overall, strict adherence to current AAN guidelines for death by neurological criteria was correctly documented in 38.2%. Conclusion. Our study shows wide variability in diagnosing brain death. These findings led us to update our death by neurological criteria policy and increase awareness of brain death determination with the goal of improving our documentation following current AAN guidelines.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2017 ","pages":"6017958"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6017958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34864257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Impact of Blood Vessel Quantity and Vascular Expression of CD133 and ICAM-1 on Survival of Glioblastoma Patients. 血管数量及血管CD133和ICAM-1表达对胶质母细胞瘤患者生存的影响

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-11-08 DOI: 10.1155/2017/5629563

Ave Minajeva, Marju Kase, Mikk Saretok, Aidi Adamson-Raieste, Sandra Kase, Kristi Niinepuu, Markus Vardja, Toomas Asser, Jana Jaal

{"title":"Impact of Blood Vessel Quantity and Vascular Expression of CD133 and ICAM-1 on Survival of Glioblastoma Patients.","authors":"Ave Minajeva, Marju Kase, Mikk Saretok, Aidi Adamson-Raieste, Sandra Kase, Kristi Niinepuu, Markus Vardja, Toomas Asser, Jana Jaal","doi":"10.1155/2017/5629563","DOIUrl":"https://doi.org/10.1155/2017/5629563","url":null,"abstract":"Glioblastoma (GB) is the most angiogenic tumor. Nevertheless, antiangiogenic therapy has not shown significant clinical efficacy. The aim of this study was to assess blood vessel characteristics on survival of GB patients. Surgically excised GB tissues were histologically examined for overall proportion of glomeruloid microvascular proliferation (MP) and the total number of blood vessels. Also, immunohistochemical vascular staining intensities of CD133 and ICAM-1 were determined. Vessel parameters were correlated with patients' overall survival. The survival time depended on the number of blood vessels (p = 0.03) but not on the proportion of MP. Median survival times for patients with low (<median) and high (≥median) number of blood vessels were 9.0 months (95% CI: 7.5-10.5) and 12.0 months (95% CI: 9.3-14.7). Also, median survival times for patients with low (<median) and high (≥median) vascular expression level of CD133 were 9.0 months (95% CI: 8.0-10.1) and 12.0 months (95% CI: 10.3-13.7). In contrast, the staining intensity of vascular ICAM-1 did not affect survival. In multivariate analysis, the number of blood vessels emerged as an independent predictor for longer overall survival (HR: 2.4, 95% CI: 1.2-5.0, p = 0.02). For success in antiangiogenic therapy, better understanding about tumor vasculature biology is needed.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2017 ","pages":"5629563"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5629563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35664641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Corrigendum to "Young-Adult Male Rats' Vulnerability to Chronic Mild Stress Is Reflected by Anxious-Like instead of Depressive-Like Behaviors". “年轻成年雄性大鼠对慢性轻度压力的脆弱性是通过焦虑样行为而不是抑郁样行为来反映的”的更正。

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-04-06 DOI: 10.1155/2017/8952079

José Jaime Herrera-Pérez, Venus Benítez-Coronel, Graciela Jiménez-Rubio, Olivia Tania Hernández-Hernández, Lucía Martínez-Mota

引用次数: 2

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation. 全面性惊厥发作的检测和网络动力学:走向闭环神经调节的合理设计。

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-12-13 DOI: 10.1155/2017/9606213

Puneet Dheer, Ganne Chaitanya, Diana Pizarro, Rosana Esteller, Kaushik Majumdar, Sandipan Pati

{"title":"Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.","authors":"Puneet Dheer, Ganne Chaitanya, Diana Pizarro, Rosana Esteller, Kaushik Majumdar, Sandipan Pati","doi":"10.1155/2017/9606213","DOIUrl":"https://doi.org/10.1155/2017/9606213","url":null,"abstract":"Objective: Studies have demonstrated the utility of closed-loop neuromodulation in treating focal onset seizures. There is an utmost need of neurostimulation therapy for generalized tonic-clonic seizures. The study goals are to map the thalamocortical network dynamics during the generalized convulsive seizures and identify targets for reliable seizure detection.Methods: Local field potentials were recorded from bilateral cortex, hippocampi, and centromedian thalami in Sprague-Dawley rats. Pentylenetetrazol was used to induce multiple convulsive seizures. The performances of two automated seizure detection methods (line length and P-operators) as a function of different cortical and subcortical structures were estimated. Multiple linear correlations-Granger's Causality was used to determine the effective connectivity.Results: Of the 29 generalized tonic-clonic seizures analyzed, line length detected 100% of seizures in all the channels while the P-operator detected only 35% of seizures. The detection latencies were shortest in the thalamus in comparison to the cortex. There was a decrease in amplitude correlation within the thalamocortical network during the seizure, and flow of information was decreased from thalamus to hippocampal-parietal nodes.Significance: The preclinical study confirms thalamus as a superior target for automated detection of generalized seizures and modulation of synchrony to increase coupling may be a strategy to abate seizures.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2017 ","pages":"9606213"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9606213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35781755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Gait Training in Chronic Stroke Using Walk-Even Feedback Device: A Pilot Study 使用步行均匀反馈装置进行慢性中风的步态训练:一项初步研究

Neuroscience journal Pub Date : 2016-11-24 DOI: 10.1155/2016/6808319

Vennila Krishnan, I-Hung Khoo, P. Marayong, K. Demars, J. Cormack

{"title":"Gait Training in Chronic Stroke Using Walk-Even Feedback Device: A Pilot Study","authors":"Vennila Krishnan, I-Hung Khoo, P. Marayong, K. Demars, J. Cormack","doi":"10.1155/2016/6808319","DOIUrl":"https://doi.org/10.1155/2016/6808319","url":null,"abstract":"Asymmetrical gait and a reduction in weight bearing on the affected side are a common finding in chronic stroke survivors. The purpose of this pilot study was to determine the effectiveness of a shoe insole device that we developed, called Walk-Even, in correcting asymmetric gait in chronic stroke survivors. Six individuals with chronic (>6 months) stroke underwent 8 weeks of intervention with 2 sessions/week, each consisting of 20 minutes of gait training and 20 minutes of lower-extremity strength training. The 2 control participants underwent conventional gait training, while 4 participants underwent gait training using the Walk-Even. Following intervention, all the participants improved on most of the gait measures: peak pressure of the foot, time of transfer of weight from heel-to-forefoot, center of pressure (COP) trajectory, COP velocity, asymmetry ratio of stance, mean-force-heel, mean-force-metatarsals, Timed “Up and Go,” and Activities-specific Balance Scale. The improvement was more pronounced in the 4 participants that underwent training with Walk-Even compared to the control participants. This pilot study suggests that a combination of strength and gait training with real-time feedback may reduce temporal asymmetry and enhance weight-bearing on the affected side in chronic stroke survivors. A large randomized controlled study is needed to confirm its efficacy.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6808319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64490524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Evaluation of Knee Proprioception and Factors Related to Parkinson's Disease 膝关节本体感觉与帕金森病相关因素的评价

Neuroscience journal Pub Date : 2016-09-08 DOI: 10.1155/2016/6746010

Nathalie Ribeiro Artigas, G. D. Eltz, Alexandre Severo do Pinho, V. Torman, A. Hilbig, C. Rieder

{"title":"Evaluation of Knee Proprioception and Factors Related to Parkinson's Disease","authors":"Nathalie Ribeiro Artigas, G. D. Eltz, Alexandre Severo do Pinho, V. Torman, A. Hilbig, C. Rieder","doi":"10.1155/2016/6746010","DOIUrl":"https://doi.org/10.1155/2016/6746010","url":null,"abstract":"Background. Changes in proprioception may contribute to postural instability in individuals with neurological disorders. Objectives. Evaluate proprioception in the lower limbs of patients with Parkinson's disease (PD) and the association between proprioception and cognitive ability, motor symptoms, postural instability, and disease severity. Methods. This is a cross-sectional, controlled study that evaluated proprioception in PD patients and healthy age- and sex-matched individuals. Kinetic postural proprioception of the knee was evaluated using an isokinetic dynamometer (Biodex® Multi-Joint System 4 Pro). Participants were evaluated using the Montreal Cognitive Assessment (MoCA), the Hoehn and Yahr rating scale and postural instability (pull test and stabilometric analysis), and motor function (UPDRS-III) tests. Results. A total of 40 individuals were enrolled in the study: 20 PD patients and 20 healthy controls (CG). The PD patients had higher angular errors on the proprioceptive ratings than the CG participants (p = 0.002). Oscillations of the center of pressure (p = 0.002) were higher in individuals with PD than in the controls. Proprioceptive errors in the PD patients were associated with the presence of tremors as the dominant symptom and more impaired motor performance. Conclusion. These findings show that individuals with PD have proprioceptive deficits, which are related to decreased cognitive ability and impaired motor symptoms.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6746010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64488426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

An Outcome Study of Anterior Cervical Discectomy and Fusion among Iranian Population 伊朗人群前路颈椎椎间盘切除术和融合的结果研究

Neuroscience journal Pub Date : 2016-08-18 DOI: 10.1155/2016/4654109

A. Haghnegahdar, M. Sedighi

{"title":"An Outcome Study of Anterior Cervical Discectomy and Fusion among Iranian Population","authors":"A. Haghnegahdar, M. Sedighi","doi":"10.1155/2016/4654109","DOIUrl":"https://doi.org/10.1155/2016/4654109","url":null,"abstract":"Background and Aim. First-line treatment strategy for managing cervical disc herniation is conservative measures. In some cases, surgery is indicated either due to signs/symptoms of severe/progressive neurological deficits, or because of persistence of radicular pain despite 12 weeks of conservative treatment. Success for treatment of cervical disc herniation using ACDF has been successfully reported in the literature. We aim to determine the outcome of ACDF in treatment of cervical disc herniation among Iranians. Methods and Materials/Patients. In a retrospective cohort study, we evaluated 68 patients who had undergone ACDF for cervical disc herniation from March 2006 to March 2011. Outcome tools were as follows: (1) study-designed questionnaire that addressed residual and/or new complaints and subjective satisfaction with the operation; (2) recent (one week prior to the interview) postoperative VAS for neck and upper extremity radicular pain; (3) Japanese Orthopaedic Association Myelopathy Evaluation Questionnaire (JOACMEQ) (standard Persian version); and (4) follow-up cervical Magnetic Resonance Imaging (MRI) and lateral X-ray. Results. With mean follow-up time of 52.93 (months) ± 31.89 SD (range: 13–131 months), we had success rates with regard to ΔVAS for neck and radicular pain of 88.2% and 89.7%, respectively. Except QOL functional score of JOAMEQ, 100% success rate for the other 4 functional scores of JOAMEQ was achieved. Conclusion. ACDF is a successful surgical technique for the management of cervical disc herniation among Iranian population.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4654109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64390847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4