全面性惊厥发作的检测和网络动力学:走向闭环神经调节的合理设计。

Neuroscience journal Pub Date : 2017-01-01 Epub Date: 2017-12-13 DOI:10.1155/2017/9606213
Puneet Dheer, Ganne Chaitanya, Diana Pizarro, Rosana Esteller, Kaushik Majumdar, Sandipan Pati
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引用次数: 3

摘要

目的:研究表明闭环神经调节在治疗局灶性癫痫发作中的作用。对于全身性强直阵挛性癫痫,迫切需要神经刺激治疗。研究的目的是绘制全身性惊厥发作时丘脑皮质网络的动态,并确定可靠的癫痫发作检测的目标。方法:分别记录sd大鼠双侧皮质、海马和丘脑中央区的局部场电位。戊四唑用于诱导多次惊厥发作。估计了两种自动癫痫检测方法(线长和p算子)作为不同皮层和皮层下结构函数的性能。多重线性相关-格兰杰因果关系用于确定有效连通性。结果:在分析的29例全身性强直阵挛发作中,线长检测到所有通道中100%的癫痫发作,而p算子仅检测到35%的癫痫发作。与大脑皮层相比,丘脑的检测潜伏期最短。在癫痫发作期间,丘脑皮质网络内的振幅相关性降低,从丘脑到海马顶叶节点的信息流减少。意义:临床前研究证实丘脑是自动检测全身性癫痫发作的优越靶点,调节同步以增加耦合可能是减轻癫痫发作的一种策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.

Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.

Objective: Studies have demonstrated the utility of closed-loop neuromodulation in treating focal onset seizures. There is an utmost need of neurostimulation therapy for generalized tonic-clonic seizures. The study goals are to map the thalamocortical network dynamics during the generalized convulsive seizures and identify targets for reliable seizure detection.

Methods: Local field potentials were recorded from bilateral cortex, hippocampi, and centromedian thalami in Sprague-Dawley rats. Pentylenetetrazol was used to induce multiple convulsive seizures. The performances of two automated seizure detection methods (line length and P-operators) as a function of different cortical and subcortical structures were estimated. Multiple linear correlations-Granger's Causality was used to determine the effective connectivity.

Results: Of the 29 generalized tonic-clonic seizures analyzed, line length detected 100% of seizures in all the channels while the P-operator detected only 35% of seizures. The detection latencies were shortest in the thalamus in comparison to the cortex. There was a decrease in amplitude correlation within the thalamocortical network during the seizure, and flow of information was decreased from thalamus to hippocampal-parietal nodes.

Significance: The preclinical study confirms thalamus as a superior target for automated detection of generalized seizures and modulation of synchrony to increase coupling may be a strategy to abate seizures.

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