Boletín médico del Hospital Infantil de México最新文献

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Feeding difficulties and eating disorders in pediatric patients with cancer 儿童癌症患者的喂养困难和饮食失调
Boletín médico del Hospital Infantil de México Pub Date : 2023-11-02 DOI: 10.24875/bmhime.m19000065
Erika Damasco-Ávila, Liliana Velasco-Hidalgo, Marta Zapata-Tarrés, Rocío Cárdenas-Cardos, Roberto Rivera-Luna
{"title":"Feeding difficulties and eating disorders in pediatric patients with cancer","authors":"Erika Damasco-Ávila, Liliana Velasco-Hidalgo, Marta Zapata-Tarrés, Rocío Cárdenas-Cardos, Roberto Rivera-Luna","doi":"10.24875/bmhime.m19000065","DOIUrl":"https://doi.org/10.24875/bmhime.m19000065","url":null,"abstract":"","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"8 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of monoclonal antibodies in cancer immunotherapy: types and mechanisms of action. 单克隆抗体在癌症免疫治疗中的应用:类型和作用机制。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-07-13 DOI: 10.24875/bmhim.22000123
P. Damián-Blanco, Selene Ahuexoteco-Sánchez, Adrián A. Carbajal-Gallardo, Fredi C. Coctecon-Chávelas, C. Rodríguez-Nava, A. Vences-Velázquez, Yolanda Medina-Flores, O. Mata-Ruíz, Lourdes Lloret-Sánchez, K. Cortés-Sarabia
{"title":"Use of monoclonal antibodies in cancer immunotherapy: types and mechanisms of action.","authors":"P. Damián-Blanco, Selene Ahuexoteco-Sánchez, Adrián A. Carbajal-Gallardo, Fredi C. Coctecon-Chávelas, C. Rodríguez-Nava, A. Vences-Velázquez, Yolanda Medina-Flores, O. Mata-Ruíz, Lourdes Lloret-Sánchez, K. Cortés-Sarabia","doi":"10.24875/bmhim.22000123","DOIUrl":"https://doi.org/10.24875/bmhim.22000123","url":null,"abstract":"Immunotherapy is one of the most innovative treatments in the current field of oncology and consists of stimulating the immune system to eliminate tumoral cells. Monoclonal antibodies (mAbs) are glycoproteins secreted by B-cells capable of recognizing and neutralizing foreign organisms or antigens. Structurally, they are composed of two heavy and two light chains. The generation of therapeutic mAbs is one of the most developed and fastest-growing areas of the biotechnological and pharmaceutical industries and is an important adjunct to cancer therapy. Several antibodies have been approved for human administration and can be mouse-derived, chimeric, humanized, or fully human. mAbs main mechanism of action includes the lysis of the tumoral cells through inducing apoptosis, phagocytosis, complement activation, or signaling inhibition.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"7 1","pages":"153-164"},"PeriodicalIF":0.9,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84290056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robinow syndrome and its response to growth hormone treatment: a case report and review of the literature. Robinow综合征及其对生长激素治疗的反应:1例报告及文献复习。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-07-12 DOI: 10.24875/BMHIM.22000101
Mariana Goitia-Cárdenas, Coztli O Azotla-Vilchis, América L Miranda-Lora
{"title":"Robinow syndrome and its response to growth hormone treatment: a case report and review of the literature.","authors":"Mariana Goitia-Cárdenas,&nbsp;Coztli O Azotla-Vilchis,&nbsp;América L Miranda-Lora","doi":"10.24875/BMHIM.22000101","DOIUrl":"https://doi.org/10.24875/BMHIM.22000101","url":null,"abstract":"<p><strong>Background: </strong>Robinow syndrome is a rare disease with short stature, characteristic phenotypical abnormalities, and intellectual integrity in most cases.</p><p><strong>Case report: </strong>We present the case of a 13-year and one-month-old male who came for medical consultation at 3 years of age due to short stature. Additionally, the patient showed craniofacial dysmorphia, congenital heart disease, and growth hormone deficiency. As per family history, the mother presented the same phenotype. The genetic study identified an unreported variant of the WNT5A gene.</p><p><strong>Conclusions: </strong>The patient initiated growth hormone treatment at a dose of 0.7 U/kg/week at 4 years of age with favorable results, increasing his height from the < 1<sup>st</sup> percentile to the 44<sup>th</sup> percentile.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 Supl 1","pages":"040-046"},"PeriodicalIF":0.9,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9921646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated mucormycosis in a child with acute lymphoblastic leukemia: a case report and autopsy findings. 急性淋巴细胞白血病患儿播散性毛霉病:1例报告和尸检结果。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-07-12 DOI: 10.24875/BMHIM.22000050
Javier A Teco-Cortés, Myrna D Arrecillas-Zamora
{"title":"Disseminated mucormycosis in a child with acute lymphoblastic leukemia: a case report and autopsy findings.","authors":"Javier A Teco-Cortés,&nbsp;Myrna D Arrecillas-Zamora","doi":"10.24875/BMHIM.22000050","DOIUrl":"https://doi.org/10.24875/BMHIM.22000050","url":null,"abstract":"<p><strong>Background: </strong>Mucormycosis is a rare infection caused by ubiquitous fungi of the Mucorales order that mainly affects immunocompromised patients. These fungi have an important tropism for blood vessels that allows them to spread rapidly and cause thromboembolic events.</p><p><strong>Case report: </strong>We present a case of an 8-year-old male patient diagnosed with acute lymphoblastic leukemia treated with chemotherapy. He presented icteric syndrome, hepato-splenomegaly, and data of intestinal obstruction. Although he underwent intestinal resection, he did not improve and died. The autopsy identified disseminated mucormycosis involving the brain, lungs, esophagus, small intestine, colon, and pancreas.</p><p><strong>Conclusions: </strong>Hematological neoplastic diseases and their treatment are important risk factors for developing infections by opportunistic microorganisms such as mucormycosis. Early diagnosis and adequate treatment are essential due to their intrinsic difficulty and the high mortality rate of these cases.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 Supl 1","pages":"001-006"},"PeriodicalIF":0.9,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10248787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperferritinemic sepsis secondary to invasive Toxoplasma gondii in a child with untreated HIV. 未经治疗的HIV患儿侵袭性刚地弓形虫继发的高铁素血症败血症。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-03-14 DOI: 10.24875/BMHIM.22000051
Jesús Domínguez-Rojas, Jackeline Caute-Lara, Patrick Caqui-Vilca, Mario Cruz-Arpi, Carlos Martel-Ramírez, Miguel Quispe-Chipana, Abel Sánchez-Rodríguez, Noé Atamari-Anahui
{"title":"Hyperferritinemic sepsis secondary to invasive <i>Toxoplasma gondii</i> in a child with untreated HIV.","authors":"Jesús Domínguez-Rojas,&nbsp;Jackeline Caute-Lara,&nbsp;Patrick Caqui-Vilca,&nbsp;Mario Cruz-Arpi,&nbsp;Carlos Martel-Ramírez,&nbsp;Miguel Quispe-Chipana,&nbsp;Abel Sánchez-Rodríguez,&nbsp;Noé Atamari-Anahui","doi":"10.24875/BMHIM.22000051","DOIUrl":"https://doi.org/10.24875/BMHIM.22000051","url":null,"abstract":"<p><strong>Background: </strong>Untreated human immunodeficiency virus (HIV)-immunosuppressed pediatric patients show high morbidity and mortality from opportunistic infections. Limited cases of hyperferritinemic sepsis have been described in patients with toxoplasmosis.</p><p><strong>Case report: </strong>We describe the case of a 13-year-old female patient with a history of untreated HIV who presented with hyperferritinemic sepsis secondary to Toxoplasma gondii infection and Pneumocystis jirovecci pneumonia. She received ventilatory support, inotropic drugs, treatment for opportunistic germs, and high-dose corticosteroids, but with unfavorable evolution.</p><p><strong>Conclusions: </strong>The global approach to sepsis with elevated ferritin guides to using of therapies aimed at neutralizing the severe inflammatory response. A timely diagnosis would allow prompt treatment and minimize complications.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9465820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigmented neurofibroma with hypertrichosis. 色素性神经纤维瘤伴多毛症。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-01-01 DOI: 10.24875/BMHIM.21000197
Juan A Godínez-Chaparro, Adriana M Valencia-Herrera, Carlos A Mena-Cedillos, Sonia Toussaint-Caire, Mario R Duarte-Abdala, Omar Loza-Escutia, Mirna E Toledo-Bahena
{"title":"Pigmented neurofibroma with hypertrichosis.","authors":"Juan A Godínez-Chaparro,&nbsp;Adriana M Valencia-Herrera,&nbsp;Carlos A Mena-Cedillos,&nbsp;Sonia Toussaint-Caire,&nbsp;Mario R Duarte-Abdala,&nbsp;Omar Loza-Escutia,&nbsp;Mirna E Toledo-Bahena","doi":"10.24875/BMHIM.21000197","DOIUrl":"https://doi.org/10.24875/BMHIM.21000197","url":null,"abstract":"<p><strong>Background: </strong>Pigmented (or melanocytic) neurofibroma (PN) constitutes only 1% of cases and is considered a rare variant of neurofibroma containing melanin-producing cells. In addition, the association of PN with hypertrichosis is infrequent.</p><p><strong>Case report: </strong>We describe the case of an 8-year-old male with a neurofibromatosis type 1 (NF1) diagnosis, who presented a light brown hyperpigmented plaque, smooth and well-demarcated, and hypertrichosis on the left thigh. The skin biopsy showed characteristics of neurofibroma; however, in the deep portion of the lesion, melanin deposits positive for S100, Melan-A, and HMB45 were observed, thus establishing the diagnosis of pigmented neurofibroma.</p><p><strong>Conclusions: </strong>Although PN is a rare subtype of neurofibroma, it is considered a chronically progressive benign tumor containing melanin-producing cells. These lesions can appear alone or in association with neurofibromatosis. Since this is a tumor that can be confused with other skin lesions, biopsy analysis is essential to differentiate it from other pigmented skin tumors, such as melanocytic schwannoma, dermatofibrosarcoma protuberans, neurocristic hamartoma, or neuronevus. Surveillance is part of the treatment, and surgical resection is sometimes performed.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 1","pages":"57-62"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9192791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Zika syndrome. 先天性寨卡综合症。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-01-01 DOI: 10.24875/BMHIM.22000110
Israel E Crisanto-López, Pablo López-De Jesús, Jacqueline López-Quecho, Juan C Flores-Alonso
{"title":"Congenital Zika syndrome.","authors":"Israel E Crisanto-López,&nbsp;Pablo López-De Jesús,&nbsp;Jacqueline López-Quecho,&nbsp;Juan C Flores-Alonso","doi":"10.24875/BMHIM.22000110","DOIUrl":"https://doi.org/10.24875/BMHIM.22000110","url":null,"abstract":"<p><p>In February 2016, the World Health Organization declared Zika virus (ZIKV) infection a public health emergency of international concern because it caused congenital Zika syndrome (CZS). The CZS is considered a specific pattern of birth defects caused by ZIKV infection, which is transmitted by the bite of the Aedes aegypti mosquito. The CZS clinical manifestations are broad and nonspecific, including microcephaly, subcortical calcifications, ocular alterations, congenital contractures, early hypertonia, and pyramidal as well as extrapyramidal symptoms. The ZIKV has gained great importance because it has affected a large percentage of the population worldwide during the last few years, despite the measures implemented by international organizations. The pathophysiology and non-vectorial transmission routes of the virus are still under study. The diagnosis is made upon suspicion of ZIKV infection, the patient's clinical manifestations, and it is confirmed by molecular laboratory tests demonstrating the presence of viral particles. Unfortunately, there is no specific treatment or vaccine for this condition; however, patients receive multidisciplinary care and constant monitoring. Therefore, the strategies that have been implemented are directed toward preventive measures and vector control.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 1","pages":"3-14"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9192795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of urinary tract infection in infants under 3 months with fever without a source: reliability of urinalysis and urine culture. 3个月以下无源发热婴儿尿路感染的诊断:尿液分析和尿液培养的可靠性
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-01-01 DOI: 10.24875/BMHIM.23000030
Benigno M Méndez-Espinola, Emilio Gallardo-Aravena
{"title":"Diagnosis of urinary tract infection in infants under 3 months with fever without a source: reliability of urinalysis and urine culture.","authors":"Benigno M Méndez-Espinola, Emilio Gallardo-Aravena","doi":"10.24875/BMHIM.23000030","DOIUrl":"10.24875/BMHIM.23000030","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infection (UTI) is infants' most common serious bacterial infection. This study aimed to investigate the reliability of urianalysis (UA) to predict UTI, to specify the colony forming units (CFU)/ml threshold for diagnosis, and to identify variables that help suspect bacteremia in infants under 3 months with UTI.</p><p><strong>Methods: </strong>We reviewed clinical records of children under 3 months hospitalized for a fever without source and recorded age, sex, days of fever pre-consultation, temperature and severity at admission, discharge diagnoses, laboratory tests, and treatments. According to the discharge diagnosis, we divided them into UTIs (-) and (+) with or without bacteremia.</p><p><strong>Results: </strong>A total of 467 infants were admitted: 334 with UTI and 133 without UTI. In UTIs (+), the pyuria had a sensitivity of 95.8% and bacteria (+) 88.3%; specificity was high, especially for nitrites (96.2%) and bacteria (+) (92.5%). Positive predictive value (PPV) for nitrites was 95.9%, for bacteria 96.7%, and oyuria 92.5%. Escherichia coli was present in 83.8% of urine and 87% of blood cultures. UTIs with bacteremia had inflammatory urinalysis, urine culture > 100,000 CFU/ml, and higher percentage of C reactive protein (CRP) > 50 mg (p= 0.002); 94.6% of the urine culture had > 50,000 CFU.</p><p><strong>Conclusions: </strong>The pyuria and bacteria (+) in urine obtained by catheterization predict UTI. The cut-off point for diagnosis was ≥ 50,000 CFU/ml. No variables to suspect bacteremia were identified in this study.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 5","pages":"288-295"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107590217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate and pH values in newborns with a history of acute fetal distress. 有急性胎儿窘迫史的新生儿的乳酸和pH值。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-01-01 DOI: 10.24875/BMHIM.23000033
Diana Labastida-García, Guzmán Díaz-Gabriel, Fernando López-Díaz, Luis E Gutierrez-Chable, Máximo A García-Flores, Socorro Méndez-Martínez
{"title":"Lactate and pH values in newborns with a history of acute fetal distress.","authors":"Diana Labastida-García,&nbsp;Guzmán Díaz-Gabriel,&nbsp;Fernando López-Díaz,&nbsp;Luis E Gutierrez-Chable,&nbsp;Máximo A García-Flores,&nbsp;Socorro Méndez-Martínez","doi":"10.24875/BMHIM.23000033","DOIUrl":"10.24875/BMHIM.23000033","url":null,"abstract":"<p><strong>Background: </strong>Acute fetal distress (AFD) is a condition that requires timely diagnosis because it generates hypoxia, acidosis, and even intrauterine death. This study aimed to determine lactate and pH values in the umbilical cord in full-term newborns (NBs) with a history of AFD.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in full-term NBs of mothers with at least one perinatal, neonatal, or gasometric AFD antecedent. Neonatal morbidity was considered: if 1-min Apgar ≤ 6, or advanced neonatal maneuvers, or neonatal intensive care unit (NICU) admissions were necessary. The cutoff points were lactate > 4mmol/L and pH < 7.2.</p><p><strong>Results: </strong>Of 66 NBs, 33.3% of mothers presented at least one antecedent for developing AFD; 22.7% presented hypertensive pregnancy disease, 13.6% oligohydramnios, and 63.6% other factors. Perinatally, 28.7% required advanced neonatal resuscitation maneuvers and 7.5% admission to the NICU. In the gasometry, the lactate and pH values for the neonatal morbidity of the NBs' group were 4.726 ± 1.401 and 7.293 ± 0.056, respectively, versus 2.240 ± 0.318 and 7.359 ± 0.022 (p < 0.05) for the group without associated neonatal morbidity.</p><p><strong>Conclusions: </strong>Lactate values in the umbilical cord increased by 25%, and pH decreased by one percent in NBs with a history of AFD and associated morbidity.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 4","pages":"247-252"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10607345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coumel tachycardia in children. 儿童库梅尔性心动过速。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2023-01-01 DOI: 10.24875/BMHIM.22000127
Enrique Velázquez-Rodríguez, Norberto García-Hernández, Arturo Martínez-Sánchez, Carlos Alva-Espinoza, Lucelly Yáñez-Gutiérrez, Santiago Jiménez-Arteaga
{"title":"Coumel tachycardia in children.","authors":"Enrique Velázquez-Rodríguez,&nbsp;Norberto García-Hernández,&nbsp;Arturo Martínez-Sánchez,&nbsp;Carlos Alva-Espinoza,&nbsp;Lucelly Yáñez-Gutiérrez,&nbsp;Santiago Jiménez-Arteaga","doi":"10.24875/BMHIM.22000127","DOIUrl":"https://doi.org/10.24875/BMHIM.22000127","url":null,"abstract":"<p><strong>Background: </strong>Coumel tachycardia is an infrequent form of supraventricular tachycardia (SVT) that usually occurs in infants and children. It is a tachycardia mediated by an accessory pathway with retrograde slow conduction that explains the classic ECG pattern with long RP' interval and negative P waves in leads II, III, and aVF. In this study, we describe the clinical course and management of Coumel tachycardia in children.</p><p><strong>Case report: </strong>We conducted a retrospective review of five consecutive pediatric patients, mean age 11 ± 3 years (range 6 to 14). The first episode of SVT was at a mean age of 10.4 ± 4.8 years (range 2 to 14) with a mean evolution of 7.4 ± 9.4 months (range 1 to 24). Pharmacological therapy was unsuccessful despite the combination of antiarrhythmic drugs. The tachycardia was incessant with a density > 85% by 24-hour Holter monitoring; one patient developed tachycardia-induced cardiomyopathy. All children underwent successful radiofrequency catheter ablation, mean 5 ± 3 applications (range 1 to 8) with a single session and with no complications. After a mean follow-up of 24 ± 16 months, all patients were asymptomatic and recurrence-free without antiarrhythmic treatment.</p><p><strong>Conclusions: </strong>Coumel tachycardia is clinically persistent and usually refractory to antiarrhythmic treatment with substantial risk of tachycardia-mediated cardiomyopathy. Catheter ablation is effective and safe in children; thus, it should be indicated promptly and based on individual selection.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"80 Supl 1","pages":"69-76"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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