Paemi Sino最新文献

{"title":"GESTATIONAL DIABETES MELLITUS: MODERN GLYCEMIA MONITORING SYSTEMS","authors":"Y. Dudareva, V. A. Guryeva, G. V. Nemtseva","doi":"10.25005/2074-0581-2022-24-1-97-102","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-97-102","url":null,"abstract":"This review evaluates the role of continuous glucose monitoring (CGM) during pregnancy in women with gestational diabetes mellitus (GDM). Globally, GDM has been associated with an increased risk of adverse maternal and fetal health outcomes. It has been shown that currently existing methods of glycemic control in patients with GDM do not always provide adequate assessment of daily glycemic variability, and, unfortunately, the incidence of obstetric complications and diabetic fetopathy does not decrease. The system of CGM is a rather promising method which makes it possible to effectively assess the daily variability of glycemia, to detect high levels of postprandial glycemia and nocturnal hypoglycemiA. Keywords: Gestational diabetes mellitus, fetopathy, glycemic variability, continuous glucose monitoring.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN TYPE I TAKAYASU ARTERITIS","authors":"A. Gaibov, O. Nematzoda, B. I. Kobilbekov, Yu. M. Kosimov, S. Ali-Zade","doi":"10.25005/2074-0581-2022-24-2-185-192","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-2-185-192","url":null,"abstract":"Objective: To study the features of lipid peroxidation (LPO) and the antioxidant system (AOS) in blood in Takayasu arteritis (NF) with a predominant lesion of brachiocephalic vessels. Methods: Several markers of LPO (malondialdehyde – MDA), AOS (superoxide dismutase – SOD, ascorbic acid – AA) and inflammation (sialic acid – SA) were studied in 16 patients with type I TA, where the inflammatory process was localized mainly in the aortic arch and its branches. Most commonly TA was observed among females (n=14; 87.5%), the average age of patients was 20.8±0.8 years. The study of the above markers was carried out in two stages: upon admission of patients in the stage of exacerbation of inflammation and after targeted anti-inflammatory, immunomodulatory and antioxidant therapy – in the stage of remission of the inflammatory process. Results: The study of LPO and AOS showed that in all patients, upon admission, there was a considerable oxidant-antioxidant imbalance due to an acute inflammatory process. MDA was increased by 2.6 times constituting 3.9±0.1 μmol/l. After pathogenetically targeted therapy, its significant decrease to 2.9±0.1 μmol/l (р˂0.001) was achieved. Activation of LPO was paralleled with a significant decrease of the body's AOS markers. The activity of SOD and concentration of AA during acute inflammatory process was reduced by 1.4 and 1.3 times, and amounted to 13.3±0.1 c.u./l and 57.8±0.3 μmol/l, respectively. After pulse therapy these indicators showed a significant increase compared with the initial data: up to 15.9±0.2 c.u./l and 63.9±0.4 μmol/l, respectively. The content of SA, which is one of the important components of cell membrane glycoproteins and glycolipids, was increased by 2.3 times (6.1±0.1 mmol/l), while after treatment it significantly decreased to 3.4±0.1 mmol/l (p˂0.001). Gender and age did not affect the dynamics of the specified markers, except for SA, which showed higher values in women (p<0.05). Conclusion: With TA in the stage of acute inflammation, increased content of MDA was found, indicating development of the oxidative stress. On this background the AOS indicators were decreased, which should be taken into account during preoperative preparation of patients for upcoming revascularization. The inclusion antioxidants in the protocol of standard TA therapy may improve the patients’ outcomes. Keywords: Takayasu arteritis, lipid peroxidation , antioxidant system, malondialdehyde, superoxide dismutase, ascorbic acid, sialic acid.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF RESEARCH ACTIVITY OF KAZAKHSTAN MEDICAL UNIVERSITIES","authors":"D.T. AZHIBAEVA-KUPENOVA, A. M. Duysenova","doi":"10.25005/2074-0581-2022-24-1-29-38","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-29-38","url":null,"abstract":"Objective: To conduct a comparative analysis of the research activity of medical universities in Kazakhstan. Methods: The following universities were enrolled in the study: Asfendiyarov Kazakh National Medical University (KazNMU), Medical University of Karaganda (MUK), Semey Medical University (SMU), Astana Medical University (AMU), West Kazakhstan Medical University named after M. Ospanov (WKMU), South Kazakhstan Medical Academy (SKMA), Kazakh Medical University of Continuing Education (KazMUCE), Yasawi University (International Kazakh-Turkish University named after Khoja Ahmed Yasawi, IKTU) and Kazakh-Russian Medical University (KRMU). Data from the Center for the Development of Education and Science of the Ministry of Health of the Republic of Kazakhstan were used in the study. The rating assessment of medical universities was carried out on six indicators: the volume of research carried out; the number of publications in peer-reviewed international databases (Thomson Reuters, Scopus, Springer, Google Scholar); the number of references to the research publications within the last 5 years; the number of patents and copyrights; the level of commercialization of research products in medical universities in Kazakhstan; participation in international conferences. The analyzed period is between 2018 and 2020. Results: By the end of 2020, KazNMU became the leader in the total value of all indicators by a small margin, followed by MUK and WKMU. The data obtained indicate that some of the medical universities, according to the total indicators’ value have a well-coordinated scientific environment, including KazNMU, MUK, WKMU, SMU, SKMA, AMU. Shaping of the conducive scientific environment in these universities is associated with a high level of the academic degrees of the staff, its large academic experience, and the volume of funding. The rest of the universities are young, with their scientific environment being still at its formative stage. These indicators contribute to the assessment of the results of research and innovative activities of medical universities, though they also have certain drawbacks. Conclusion: Despite the fluctuation of different evaluation parameters in the medical universities over the years, there is a general increase in their main performance indicators per staff capita: the number of publications has increased by more than 5-6 times, while citations were raised by more than 50 times; and the number of patents has grown by an order of magnitude. The level of commercialization at most universities has not changed, with the exception of WKMU, KMU, SKMA, KazMUCE, SMU. Keywords: Science, research environment, medicine, indicator, research activity, university.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOTIVATION OF THE PUBLICATION ACTIVITY OF LECTURERS IN A MEDICAL UNIVERSITY","authors":"A. M. Duysenova","doi":"10.25005/2074-0581-2022-24-1-39-49","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-39-49","url":null,"abstract":"Objective: To study and evaluate the impact and/or connection between the financial motivation of the employees of the South Kazakhstan Medical Academy (SKMA) and their scientific and publication activities. Methods: An analysis of the publication activity of SKMA employees for the 2018-2020 period was carried out. Based on the “Regulations on reimbursement of expenses and payment of remuneration for the publication of research results in the scientific journals and proceedings” developed in the SKMA, data from the accounting department of the SKMA, which made payments annually and quarterly, from 2018 to 2020, were used and processed. Results: While in 2018 the number of publications in the Scopus and Web of Science databases was 21, thereafter in 2019 this number was increased by 12.5%, and in 2020 – by 40% (compared to 2018). In 2021, there was a decrease in the total number of articles by 14.3% compared to 2020. However, the number of articles in the Q1-Q2 Web of Science journals in 2021 almost doubled compared to 2020. For publications in 2018, an amount of 1,076,350 tenge was paid in the form of remuneration, which in 2019 and 2020 increased to 1,300,120 and 1,845,480 tenge respectively. A positive and statistically significant relationship was found between the number of published papers and the amount of the respective remuneration (r=0.97; p<0.05). Conclusion: The proposed system of motivation in SKMA is an effective stimulating mechanism and can be used to intensify publication activity in other universities, including non-medical ones. Keywords: Publications, publication activity, motivation, faculty, international peer-reviewed publications.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NUTRITION CONSIDERATIONS FOR CHILDREN AND ADOLESCENTS OF THE CULTURE AND ART EDUCATIONAL INSTITUTIONS","authors":"I. Kerimbaeva, M. Esenamanova, F. Kochkorova, T. Tsivinskaya","doi":"10.25005/2074-0581-2022-24-2-235-243","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-2-235-243","url":null,"abstract":"The review analyzed the results of research on the nutritional status of students of choreography and music schools. The following databases were used as sources of information: PubMed, RSCI, Google Scholar, CyberLeninka, Web of Science, Scopus, MEDLINE. During the literature search scarce research data were found regarding nutrition of students of choreography and music schools, while many more information was available regarding their physical development. According to available data, the physical development of students of ballet schools is characterized by unique features depending on gender, age, ethnicity and region of residence, in contrast to students of music and comprehensive schools. Meanwhile, nutrition of children and adolescents professionally trained in choreography and instrumental music was worked out without taking into account the age and gender of students, as well as training-related physical and neuro-emotional load. This fact indicates the need for additional research on rationalization of their nutrition. Keywords: Nutrition, nutritional status, children and adolescents, physical development, morbidity, music school, choreographic school.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POPULATION HEALTH STATUS AS ONE OF THE INDICATORS OF MODERN SOCIETY DEVELOPMENT","authors":"A. Chernyshyov, D. Irzhaev, A. Zolotukhina","doi":"10.25005/2074-0581-2022-24-1-103-112","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-103-112","url":null,"abstract":"The article discusses the health status of different age groups: children, adolescents and adults. Issues related to the development of pathological processes in terms of some occupational diseases are discussed. The influence of various factors on the state of health of the population, in particular, physical activity, conditions and nature of nutrition, is revealed. Attention is focused on the role of the health care system in maintaining the health of the population at the proper level. It is noted that the fundamental condition for the proper organization of a healthy lifestyle and maintaining a high level of health is the creation of a coordinated system of various state and public organizations that optimally interact with each other. Keywords: health status, health risk factors, population health.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69317765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL TREATMENT OF INGUINAL HERNIA COMBINED WITH CRYPTORCHIDISM","authors":"M. Malikov, F. Khamidov, F. B. Bokiev, O. Khudoydodov, I. Khomidov, N. A. Makhmadkulova","doi":"10.25005/2074-0581-2022-24-1-85-96","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-85-96","url":null,"abstract":"Objective: To evaluate outcomes of single-stage surgery performed for inguinal hernia combined with cryptorchidism. Methods: Between 2005 and 2020, 22 patients aged 3 to 28 years underwent surgery for inguinal hernias combined with cryptorchidism. All surgeries were performed using instrumentation, affording surgical precision through enhanced visualisation and magnification. The combination of the hernia with cryptorchidism was noted in 12 (54.5%) and 8 (36.4%) patients on the right and left sides, respectively. In addition, bilateral localisation of hernia and cryptorchidism was observed in 2 (9.1%) patients. In addition to clinical investigation, ultrasonography (US), Doppler ultrasonography (DU) and, to a limited extent, computed tomography (CT) were used preoperatively and in the long-term postoperative period. Dynamical changes in the threedimensional testicular measurements, testicular volumes and the time-averaged maximum velocity (TAMAX, cm/s) in the testicular arteries were evaluated. Results: In the immediate postoperative period, seroma formation and suppuration of wounds were not noted. However, in 3 (13.6%) cases, transient swelling of the scrotum was observed. According to ultrasound data, 6 months after single-stage operations, there was a statistically significant increase in all parameters of the operated testicle compared to the initial values, including three-dimensional testicular measurements and volume (p<0.05) in all age groups. In addition, 6 months after the operation, the sizes of surgically brought down and healthy testicles in all age groups became equal, except for the thickness of the testis in children aged 3-5 years. At the same time, according to DU data, there was also a statistically significant increase in TAMAX in the testicular artery on the side of the lesion (p<0.001). Conclusion: The use of instrumentation, affording surgical precision through enhanced visualisation and magnification when performing surgery for inguinal hernia and cryptorchidism, is the gold standard treatment. Because it prevents iatrogenic damage to critical anatomical structures, allows maximum mobilisation of the vascular pedicle of the retained testicle and contributes to the safe bringing down of the latter without much tension. The selection of an appropriate hernial orifice reconstruction method, along with the recurrence prevention, also helps to avoid compression of the elements of the spermatic cord and thus improve the fertile function. Keywords: Inguinal hernia, cryptorchidism, a combination of inguinal hernia and cryptorchidism.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF ANTIBACTERIAL AND FUNGICIDAL ACTIVITY OF ALLIUM OSHANINII AND ALLIUM SUWOROWII DEPENDING ON THE ALTITUDE OF PLANT GROWTH","authors":"F. Mirzoeva","doi":"10.25005/2074-0581-2022-24-1-66-84","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-1-66-84","url":null,"abstract":"Objective: To study the biological properties of plants of the genus Allium and their correlation with antimicrobial and fungicidal activity depending on the altitude of plant growth. Methods: Seeds, leaves and bulbs of widespread wild and endemic species of the genus Allium growing in various regions of the Republic of Tajikistan were the objects of the study. The antimicrobial activity of the obtained extracts was studied against standard museum microorganisms (test strains): Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930), Klebsiella pneumoniae (ATCC 4927), Escherichia coli (ATCC 4928). Antifungal activity was studied against Candida species. Results: Correlation of varying strength was discovered between the content of biocomponents with antimicrobial and fungicidal activity, the altitude of plant growth and place of its collection. The content of total polyphenols and the antioxidant activity of extracts obtained from various parts of the plants varied over a wide range. In some cases, there were direct correlations of varying strength between the content of polyphenols, antioxidative, antimicrobial and fungicidal properties of the plants. Conclusion: This study showed the insignificant correlations between the content of biocomponents and antimicrobial, and fungicidal properties of the studied types of onions, which did not depend on the growing zone. Keywords: Onion, plant, growth inhibition, extract, reference bacterial strains.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VARIANT ANATOMY OF THE BRACHIAL PLEXUS","authors":"A. Sufianov, R. Sagdiev, V. Sorin, V. Piterov","doi":"10.25005/2074-0581-2022-24-2-229-234","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-2-229-234","url":null,"abstract":"The brachial plexus (BP) is a complex of nerve structures arising from the ventral rami of the lower four cervical (C5-C8) and upper thoracic (Th1) spinal nerves. The number of described variants of BP has been increasing every decade. This paper analyzes the world literature data on the anatomy of the BP. The sources of information used included: PubMed, Web of Science, Scopus, MEDLINE, EMBASE, Biosis Citation Index, SciELO Citation Index, RSCI data bases. It was noted that the anatomy of the BP is variable, its \"classic\" variant of the structure occurs in less than 50% of cases. In other cases, there were significant differences in structure and course from the \"classic\" version. Keywords: Brachial plexus, trunk, bundle, variant anatomy, \"classic\" scheme.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENHANCED RECOVERY (FAST-TRACK) PROGRAM IN ELECTIVE ARTHROPLASTY OF WEIGHT-BEARING JOINTS","authors":"A. M. Ageenko, D. S. Nikiforov, T. Nikiforova, M. Lebedeva","doi":"10.25005/2074-0581-2022-24-2-168-175","DOIUrl":"https://doi.org/10.25005/2074-0581-2022-24-2-168-175","url":null,"abstract":"Objective: To evaluate the effect of feeding with a whey protein plus carbohydrate drink on metabolic parameters, general state of the patient and recovery time after knee and hip arthroplasty. Methods: The results of the perioperative period of 60 patients with osteoarthritis (OA) of the hip and knee were evaluated between March and July 2021. All patients underwent hip or knee arthroplasty under spinal anaesthesia. In addition, patients of the study group received the ProvideXtra® Drink 2 hours before surgery. Otherwise, the management of patients in the perioperative period was the standard. Mobilisation and verticalisation of patients were carried out after achieving physical fitness, resolution of the spinal block and haemodynamic stability on the day of surgery or the next day. Results: In all patients after 4 hours, increased glucose levels were recorded in both groups, statistically significant in the control group – 7.15±0.94 versus 7.88±1.18 mmol/l (p=0.02). The decrease in haemoglobin level had no difference in the study groups and before discharge was 100±16 g/l versus 101±18 g/l (p=0.86). The difference in total protein level before discharge was in favour of the study group, 63.1±6.1 versus 59.2±5.9 g/l (p=0.17). Verticalisation timing in the study group was as follows: 10 patients were verticalised on the day of surgery, and the remaining 20 patients – were on the next day. In the control group – 8 patients were verticalised on the day of surgery and 22 – on the next day. In the control group, 2 cases of postoperative nausea requiring correction were observed. Conclusion: The modern surgical approaches include the maximal preservation of natural feeding, based on the Enhanced Recovery after Surgery (ERAS®) concept. However, guidelines for choosing a particular diet on the day of surgery remain to be finally established. Using ready-made carbohydrate-protein mixtures is a convenient solution that delivers the required amount of energy and protein. Therefore, the effect of the mixture on protein metabolism in the postoperative period remains to be elucidated through further studies. Keywords: Accelerated rehabilitation, nutrient mixture, hip arthroplasty, knee arthroplasty.","PeriodicalId":91037,"journal":{"name":"Paemi Sino","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69318445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}