Journal of oral biology (Northborough, Mass.)最新文献

{"title":"Ectopic Geographic Lingua","authors":"Gowri P. Bhandarkar","doi":"10.13188/2377-987x.1000038","DOIUrl":"https://doi.org/10.13188/2377-987x.1000038","url":null,"abstract":"Oral cavity has always been a victim of many developmental and acquired disorders and few of them known and few unknown. Inspite of many theories proposed mystery continues. Tongue the muscular organ of oral cavity undergoes various physiologic and pathologic changes. Ectopic geographic linguais one amongst the many changes documented. Siddharth Hanamasagar, Vijayendranath Nayak S*, Girish YR, Raghavendra Kini, Prasanna Kumar Rao, Gowri P. Bhandarkar and Roopashri Rajesh Kashyap","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46139803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cariogram and Oratest in Caries Risk Assessment for School Children","authors":"W. Elkwatehy, Rabab I Salama","doi":"10.13188/2377-987x.1000042","DOIUrl":"https://doi.org/10.13188/2377-987x.1000042","url":null,"abstract":"Aims and objectives: The present study was carried out to evaluate the correlation between Cariogram and Oratest in caries risk assessment among school children. Materials and Methods: A clinical diagnostic trial including 240 healthy school children using Cariogram and Oratest to predict the dental caries risk for each individual. The data required for Cariogram construction (diet contents and frequency, the related general diseases, the use of fluoridated toothpaste, tooth brushing and other fluoride supplements, past dental history and dental plaque scores) were collected by dietary questionnaire, interview and clinical examination. Oratest was carried out for the same patients after performing the Cariogram. The analysis of collected data was performed using SPSS version 22 software program. The p-values ≤ 0.05 was considered statistically significant. Results: There were statistically significant differences for all risk factors and Oratest scores between low and high caries risk individuals classified by Cariogram. A highly significant positive correlation between the green sector of Cariogram (chance of avoiding development of caries in future) and Oratest scores, highly significant negative correlations between both Cariogram and Oratest and dental caries status were found. Children with Oratest time less than 64.43 minutes are at high caries risk. Conclusion: The present study indicated that Oratest has a definite clinical relationship with the green sector of Cariogram of each individual and can be used as a separate test for predicting caries susceptibility. Wahdan M. Elkwatehy1* and Rabab I Salama2 1Lecturer of Dental Public Health, Faculty of dentistry, Mansoura University, Egypt 2Assistant professor of Dental Public Health, Faculty of dentistry, Mansoura University, Egypt *Address for Correspondence Wahdan M. Elkwatehy, Faculty of Dentistry, Department of Public Health and Preventive Dentistry, Mansoura University, Egypt, Tel: 00201000993389; E-mail: wahdanelkwatehy@yahoo.com Submission: 19 April, 2018 Accepted: 21 May, 2018 Published: 31 May, 2018 Copyright: © 2018 Elkwatehy WM, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Research Article Open Access Journal of Oral Biology Introduction Dental caries has a multi factorial etiology, host including saliva and teeth, the microflora or biofilm, the substrate as diet and time. The modifiable risk factors can be modified and amenable to intervention. Whereas, the non-modifiable risk factors are quite challenging to health care professionals [1]. Understanding caries etiology and its progression is very important for planning preventive programs for dental caries and this has been made easy with concomitant advances in science and technology [2,3]. Dental caries risk model is used when it is important to identify ","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44663188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Selection Criteria for Predictable Immediate Implant Placement and Immediate Provisionalization","authors":"H. Selina, Somji, S. Florio, Takanori Suzuki","doi":"10.13188/2377-987x.1000039","DOIUrl":"https://doi.org/10.13188/2377-987x.1000039","url":null,"abstract":"Immediate implant placement and immediate provisionalization in the esthetic zone represents a therapeutic option particularly appreciated by patients. Reducing the number of surgical interventions and eliminating the need for a transitional removable prosthesis are clear advantages of this technique. However, performing this technique is not always possible and careful evaluation and case selection is crucial to achieve a predictable result. A 5-factor decision tree is presented in order to successfully perform immediate implant placement and immediate provisionalization or select a more appropriate treatment modality according to the different clinical situation encountered. Asmita Bhekare*, Mohamed Elghannam, Selina H Somji, Salvatore Florio and Takanori Suzuki Department of Periodontology and Implant Dentistry, New York University, USA *Address for Correspondence Asmita Bhekare, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1-929 294 3785; E-mail: Arb719@ nyu.edu Submission: 15 January, 2018 Accepted: 20 April, 2018 Published: 27 April, 2018 Copyright: © 2018 Bhekare A, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Open Access Journal of Oral Biology Introduction When having to replace a failing tooth in the esthetic zone, a dental implant is a predictable and successful treatment option that does not involve the preparation of adjacent teeth [1-2]. However, when compared to tooth-supported prostheses, dental implants usually require longer periods of treatment. Following tooth extraction, 12-16 weeks is typically needed to obtain substantial clinical or radiographic bone fill of the socket in order to place an implant [3]. An additional 3-6 months of sub mucosal healing prior to functional loading are essential for its osseointegration [4]. During this time interval, a removable provisional restoration can be used to replace the missing tooth but oftentimes, patients do not tolerate such prostheses well. In order to reduce the duration of treatment, several variations to the conventional protocol have been reported in the literature [5-7]. The immediate implant placement and immediate provisionalization (IIPIP) technique involves placement of the implant immediately after tooth extraction and providing an implant-supported fixed restoration. Numerous studies have shown that IIPIP attains high success rates comparable with single implants placed in healed sites that are either immediately provisionalized or treated with the conventional delayed loading approach [8-16]. Patients particularly appreciate this solution since it reduces the number of surgical interventions and eliminates the need for a temporary removable prosthesis. Although the rationale behind immediate plac","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43110705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Options for Atrophic Ridges Based on Anatomical Locations of the Missing Teeth","authors":"Stuti Muchhala, Motoharu Unozawa, C. Wendy, Wang, Cheryl G Robins","doi":"10.13188/2377-987x.1000037","DOIUrl":"https://doi.org/10.13188/2377-987x.1000037","url":null,"abstract":"Differences in anatomy, biomechanical loading and aesthetic demands make treatment needs for implant placement at different anatomical locations distinct from one another. In the atrophic posterior maxilla, vertical bone deficiency can be predictably augmented with sinus augmentation procedure. In the edentulous anterior mandible, the improvements in the mechanical properties of titanium alloys and implant designs have enabled the use of dental implants in limited mesial-distal space. Various techniques have also yielded predictable results for horizontal ridge augmentation. However, challenges remain in the atrophic anterior maxilla where soft tissue aesthetics is of paramount importance to the success of the restoration; and in the atrophic posterior mandible where the presence of inferior alveolar nerve limits the quantity of bone volume. The aim of this article is to discuss the challenges encountered at different anatomical locations and to present the various surgical treatment options available for each site. Stuti Muchhala*, Motoharu Unozawa, Wendy CW Wang and Cheryl G Robins Department of Periodontology and Implant Dentistry, New York University, USA *Address for Correspondence Stuti Muchhala, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1-347-726-0888; E-mail: Sdm460@nyu.edu Submission: 15 January, 2018 Accepted: 16 February, 2018 Published: 26 February, 2018 Copyright: © 2018 Muchhala S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Open Access Journal of Oral Biology","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43346666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Concepts in Implant Prosthodontics-Materials, Technology, and Occlusion","authors":"A. Valladares, Alessandro Grisa, Arshin, Hotchandani, Kirkor Cinarli, M. Kang","doi":"10.13188/2377-987x.1000035","DOIUrl":"https://doi.org/10.13188/2377-987x.1000035","url":null,"abstract":"Dental implants as a form of replacing missing teeth are being used now more than ever. The success of endosseous implants had led to increased quality of life for these patients. The design of an implant prosthesis is often determined by the position and angulation of the supporting osseointegrated implants. Adequate pre-surgical prosthetic design is essential to the accurate placement of implants for an esthetically acceptable and functional result. Currently, a variety of restorative options are available for the clinician to restore osseointegrated implants in terms of materials used, mode of connection to implants and occlusal schemes. However, the clinical decision regarding which restorative design to use and the choice of material has been a topic of constant debate. This article aims to give the advantages and disadvantages as well as clinical scenarios indicated for different implant restorations. Agnetha Valladares*, Alessandro Grisa, Arshin Hotchandani, Kirkor Cinarli and Mary Kang Department of Periodontology and Implant Dentistry, New York University, USA *Address for Correspondence Agnetha Valladares, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1-917-854-7300; E-mail: av1836@nyu.edu Submission: 14 January, 2018 Accepted: 12 February, 2018 Published: 20 February, 2018 Copyright: © 2018 Valladares A, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Open Access Journal of Oral Biology","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44355867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision Tree to Minimize Intraoperative Complications during Maxillary Sinus Augmentation Procedures","authors":"N. Boreak, Panpicha Maketone, Julien Mourlaas, W. C. Wang, P. Yu","doi":"10.13188/2377-987x.1000041","DOIUrl":"https://doi.org/10.13188/2377-987x.1000041","url":null,"abstract":"Rehabilitation of patients with endosseous implants in the posterior maxilla poses a challenge as a result of sinus pneumatization and ridge atrophy. Sinus augmentation has been established to be a reliable procedure to facilitate implant therapy. However, despite the predictability of the techniques and biomaterials employed in sinus graft procedures, intra-operative complications still occur leading to increased surgical time, abortion of the surgery, post-operative infections and loss of implant. Based on the clinical findings and literature review, a hierarchical decision tree to minimize intra-operative complication is proposed. Several host-related factors, which can influence the outcome of the procedure, are identified. The factors are health status of the sinus, size and location of the endosseous anastomosis, lateral wall thickness, membrane thickness, remaining residual bone height, and presence of sinus floor cortication. Nezar Boreak*, Panpicha Maketone, Julien Mourlaas, Wendy CW Wang and Paul YC Yu Department of Periodontology and Implant Dentistry, New York University, USA *Address for Correspondence Nezar Boreak, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1-646-715-5230; E-mail: Nmb428@nyu.edu Submission: 15 January, 2018 Accepted: 30 April, 2018 Published: 07 May, 2018 Copyright: © 2018 Boreak N, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Open Access Journal of Oral Biology","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46672440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problem Solving Guidelines for Aesthetically Compromised Maxillary Anterior Implant Restorations","authors":"","doi":"10.13188/2377-987x.1000040","DOIUrl":"https://doi.org/10.13188/2377-987x.1000040","url":null,"abstract":"The objective of modern implant dentistry is to provide a long lasting restoration that harmoniously replicates the contours of the neighbouring hard and soft tissue. Improvements in implant designs, materials, surfaces and surgical techniques have allowed for osseointegration to be achieved predictably. However, dimensional differences between the implant and the extracted tooth, as well as biological limitations at the site make aesthetics of the restoration the greater challenge. Over the years, several methods of assessing the aesthetics of an implant restoration using various visual analogue scales have been proposed, though they have mostly been used as a means for clinicians to assess the outcome of their restoration. Nevertheless, the final aesthetic outcome depends on the patient’s satisfaction of their restoration. Based on clinical findings and a review of the literature, a guideline has been proposed highlighting the common complaints a patient has towards their implant supported restoration, and several methods of addressing these complaints have been discussed. Shalin Vinayak*, Lara Ceballos, Carlos Diaz-Mauriño, Stephen Chi and Yung Cheng Paul Yu Department of Periodontology and Implant Dentistry, New York University *Address for Correspondence Shalin Vinayak, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1 (212)-992-7040; E-mail: sv1506@nyu.edu Submission: 15 January, 2018 Accepted: 30 April, 2018 Published: 06 May, 2018 Copyright: © 2018 Vinayak S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Open Access","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43332775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Presentations and Evolution in Concepts of Immediate Loading in Edentulous Mandible","authors":"Ki Bum Kim, Bhupesh Mandali, W. C. Wang, Z. Bagheri","doi":"10.13188/2377-987x.1000036","DOIUrl":"https://doi.org/10.13188/2377-987x.1000036","url":null,"abstract":"The purpose of this case series is to demonstrate an innovative paralleling device and a step by step surgical and prosthetic approach for achieving buccolingual and mesiodistal parallelism of immediately loaded implants. Clinical outcomes including success rates, indications, advantages, complications and limitations of this technique in cases using an Immediate Loading (IL) protocol will be discussed. Thirteen consecutive cases from the database that were treated with an IL protocol utilizing a paralleling device were included in this study. The treatment sites included the interforamina area in 8 totally edentulous and 5 partially edentulous mandibles. In this case series the average survival rate was 98.4% with a loading period of 6-28 months. There was one implant failure, one provisional restoration fractured and two cases with cement wash out during the follow-up period. Results of this case series demonstrated that implant placement in optimal position and angulation using the suggested IL protocol and paralleling device produces predictable results. It is also simpler, faster and more cost effective than the screw retained protocol. Ki Bum Kim*, Bhupesh Mandali, Wendy CW Wang and Zahra Bagheri Department of Periodontology and Implant Dentistry, New York University, USA *Address for Correspondence Ki Bum Kim, Department of Periodontology and Implant Dentistry, New York University, Clinic 5W, 345 E 24th St, New York, NY 10010, USA, Tel: +1-212-992-7040; E-mail: kbk211@nyu.edu Submission: 15 January, 2018 Accepted: 16 February, 2018 Published: 26 February, 2018 Copyright: © 2018 Kim KB, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Case Report Open Access Journal of Oral Biology","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48260422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Fissured Tongue: The Incidental Icelands - A Case Report","authors":"G. Pauly, R. Kashyap, P. Gowri, Bhandarkar, Raghavendra Kini, Prasanna N. Kumar, Rao, V. Holla","doi":"10.13188/2377-987x.1000034","DOIUrl":"https://doi.org/10.13188/2377-987x.1000034","url":null,"abstract":"The tongue plays an important role in speech, taste and deglutition. Any disease of the tongue makes the intake of food difficult thereby depriving the individual of adequate essential nutrients. Fissured tongue is a commonly encountered tongue disorder in dental practice. But, a lack of knowledge amongst the dental practitioners on its appearance, different patterns, severity, and association of fissuring with various systemic disorders and other tongue anomalies is an area usually neglected or ignored, thus a problem looming at large. Thus, it is essentially important and the need of the hour that every dentist should be made well aware of such underrated pathologies and its possible implications. Geon Pauly*, Roopashri Rajesh Kashyap, Gowri P Bhandarkar, Raghavendra Kini, Prasanna Kumar Rao and Vidya A Holla","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47594380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses.","authors":"Vladimir Ilievski,&nbsp;Jason M Kinchen,&nbsp;Ramya Prabhu,&nbsp;Fadi Rim,&nbsp;Lara Leoni,&nbsp;Terry G Unterman,&nbsp;Keiko Watanabe","doi":"10.13188/2377-987X.1000020","DOIUrl":"https://doi.org/10.13188/2377-987X.1000020","url":null,"abstract":"<p><p>Results from epidemiological studies suggest that there is an association between periodontitis and prediabetes, however, causality is not known. The results from our previous studies suggest that induction of periodontitis leads to hyperinsulinemia glucose intolerance and insulin resistance, all hallmarks of prediabetes. However, global effects of periodontitis on critical organs in terms of metabolic alterations are unknown. We determined the metabolic effects of periodontitis on brain, liver, heart and plasma resulting from Porphyromonas gingivalis induced periodontitis in mice. Periodontitis was induced by oral application of the periodontal pathogen, Porphyromonas gingivalis for 22 weeks. Global untargeted biochemical profiles in samples from these organs/plasma were determined by liquid and gas chromatography/mass spectrometry and compared between controls and animals with periodontitis. Oral application of Porphyromonas gingivalis induced chronic periodontitis and hallmarks of prediabetes. The results of sample analyses indicated a number of changes in metabolic readouts, including changes in metabolites related to glucose and arginine metabolism, inflammation and redox homeostasis. Changes in biochemicals suggested subtle systemic effects related to periodontal disease, with increases in markers of inflammation and oxidative stress most prominent in the liver. Signs of changes in redox homeostasis were also seen in the brain and heart. Elevated bile acids in liver were suggestive of increased biosynthesis, which may reflect changes in liver function. Interestingly, signs of decreasing glucose availability were seen in the brain. In all three organs and plasma, there was a significant increase in the microbiome-derived bioactive metabolite 4-ethylphenylsulfate sulfate in animals with periodontitis. The results of metabolic profiling suggest that periodontitis/bacterial products alter metabolomic signatures of brain, heart, liver, and plasma in the prediabetic state. These data provide scientific community valuable metabolic signatures that become the basis for understanding the impact of periodontitis on a systemic disease and potentially targets for therapeutic intervention.</p>","PeriodicalId":91029,"journal":{"name":"Journal of oral biology (Northborough, Mass.)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932845/pdf/nihms784284.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34648530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}