BioResearch Open Access最新文献_第9页

Process Review for Development of Quantitative Risk Analyses for Transboundary Animal Disease to Pathogen-Free Territories. 无病原体地区跨境动物疾病定量风险分析研究进展综述

BioResearch Open Access Pub Date : 2017-10-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2016.0046

Jonathan Miller, Ken Burton, Joe Fund, Adrian Self

{"title":"Process Review for Development of Quantitative Risk Analyses for Transboundary Animal Disease to Pathogen-Free Territories.","authors":"Jonathan Miller, Ken Burton, Joe Fund, Adrian Self","doi":"10.1089/biores.2016.0046","DOIUrl":"https://doi.org/10.1089/biores.2016.0046","url":null,"abstract":"Outbreaks of transboundary animal diseases (TADs) have the potential to cause significant detriment to animal, human, and environmental health; severe economic implications; and national security. Challenges concerning data sharing, model development, decision support, and disease emergence science have recently been promoted. These challenges and recommendations have been recognized and advocated in the disciplines intersecting with outbreak prediction and forecast modeling regarding infectious diseases. To advance the effective application of computation and risk communication, analytical products ought to follow a collaboratively agreed common plan for implementation. Research articles should seek to inform and assist prioritization of national and international strategies in developing established criteria to identify and follow best practice standards to assess risk model attributes and performance. A well-defined framework to help eliminate gaps in policy, process, and planning knowledge areas would help alleviate the intense need for the formation of a comprehensive strategy for countering TAD outbreak risks. A quantitative assessment that accurately captures the risk of introduction of a TAD through various pathways can be a powerful tool in guiding where government, academic, and industry resources ought to be allocated, whether implementation of additional risk management solutions is merited, and where research efforts should be directed to minimize risk. This review outlines a part of a process for the development of quantitative risk analysis to collect, analyze, and communicate this knowledge. A more comprehensive and unabridged manual was also developed. The framework used in supporting the application of aligning computational tools for readiness continues our approach to apply a preparedness mindset to challenges concerning threats to global biosecurity, secure food systems, and risk-mitigated agricultural economies.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2016.0046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35566971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Gut Microbiota and Salivary Diagnostics: The Mouth Is Salivating to Tell Us Something. 肠道微生物群与唾液诊断：嘴巴流口水是在告诉我们什么。

BioResearch Open Access Pub Date : 2017-10-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0020

Krishna Kodukula, Douglas V Faller, David N Harpp, Iphigenia Kanara, Julie Pernokas, Mark Pernokas, Whitney R Powers, Nikolaos S Soukos, Kosta Steliou, Walter H Moos

引用次数: 0

Effects of Atrial Natriuretic Peptide on p53 and Estrogen Receptor in Breast Cancer Cells. 心房利钠肽对乳腺癌细胞p53和雌激素受体的影响。

BioResearch Open Access Pub Date : 2017-10-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0009

Katie Aleck, Kelly Hallman, Meghan Quigley, Victoria Lloyd, Monica Szmyd, Dana Ruskin, Tyler Bedgood, Sumi Dinda

{"title":"Effects of Atrial Natriuretic Peptide on p53 and Estrogen Receptor in Breast Cancer Cells.","authors":"Katie Aleck, Kelly Hallman, Meghan Quigley, Victoria Lloyd, Monica Szmyd, Dana Ruskin, Tyler Bedgood, Sumi Dinda","doi":"10.1089/biores.2017.0009","DOIUrl":"https://doi.org/10.1089/biores.2017.0009","url":null,"abstract":"The atrial natriuretic peptide (ANP) hormone is secreted by cardiac atrial myocytes and acts to regulate blood pressure homeostasis in humans. Previous research indicates ANP treatment significantly decreases the proliferation of human prostate cancer cells, pancreatic adenocarcinoma, and breast cancer cells. Minimal studies have been conducted with regard to ANP regulating tumor suppressor genes and steroid hormone receptors in breast cancer cells. Our study analyzed the effects of ANP in combination with 17β-estradiol (E2) and antiestrogen treatments on p53 and ERα levels in T-47D breast cancer cells. Preliminary studies through Western blot analysis showed that ANP treatment decreases p53 and ERα expression levels in a concentration-dependent (10-100 nM) manner. Treatment with ANP alone, at a 100 nM concentration, causes a decrease of p53 and ERα expression compared with Cs (control stripped), but with E2 and antiestrogen combinations, expression of both protein levels decreased compared with treatments without ANP. Combined treatment with E2, an estrogen antagonist, and ANP decreased cellular proliferation compared with treatments without ANP, except in the case of raloxifene (RAL). Our studies indicate that ANP has potential as a therapeutic breast cancer treatment and should inspire further studies on the molecular mechanism of ANP in T-47D breast cancer cells.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35566973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Human Chorionic Gonadotropin Mediated Generation of Reactive Oxygen Species Is Sufficient to Induce Meiotic Exit but Not Apoptosis in Rat Oocytes. 人绒毛膜促性腺激素介导的活性氧的产生足以诱导大鼠卵母细胞减数分裂退出而不是凋亡。

BioResearch Open Access Pub Date : 2017-09-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0018

Meenakshi Tiwari, Shail K Chaube

{"title":"Human Chorionic Gonadotropin Mediated Generation of Reactive Oxygen Species Is Sufficient to Induce Meiotic Exit but Not Apoptosis in Rat Oocytes.","authors":"Meenakshi Tiwari, Shail K Chaube","doi":"10.1089/biores.2017.0018","DOIUrl":"https://doi.org/10.1089/biores.2017.0018","url":null,"abstract":"Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meiotic exit and/or apoptosis in rat oocytes. For this purpose, cumulus-oocyte complexes (COCs) were collected from ovary of experimental rats injected with 20 IU pregnant mare's serum gonadotropin for 48 h followed by 20 IU hCG for 0, 7, 14, and 21 h. The morphological changes in COCs, meiotic status of oocyte, total ROS, hydrogen peroxide (H2O2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), Bax, Bcl-2, cytochrome c, telomerase reverse transcriptase (TERT) expression levels, and DNA fragmentation were analyzed in COCs. Our data suggest that hCG surge increased total ROS as well as H2O2 levels but decreased iNOS expression and total NO level in oocytes. The hCG-mediated increased level of ROS was sufficient to induce meiotic cell cycle resumption in majority of oocytes as evidenced by meiotic exit from diplotene as well as metaphase-II (M-II) arrest and their meiotic status. However, increase of ROS level due to hCG surge was not sufficient to trigger Bax and cytochrome c expression levels and DNA fragmentation in COCs. In addition, increased TERT activity was observed in oocytes collected 21 h post-hCG surge showing onset of oocyte aging. Taken together, these results suggest that hCG induces generation of ROS sufficient to trigger meiotic exit from diplotene, as well as M-II arrest, but not good enough to induce apoptosis in rat oocytes.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35566970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration. 支持单碳循环恢复低生育能力妇女卵巢储备:与尿双酚A浓度无相关性。

BioResearch Open Access Pub Date : 2017-08-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0016

Erica Silvestris, Marc Cohen, Dominique Cornet, Laetitia Jacquesson-Fournols, Patrice Clement, Jacques Chouteau, Marc Schneider, Thierry Besnard, Yves Ménézo

{"title":"Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration.","authors":"Erica Silvestris, Marc Cohen, Dominique Cornet, Laetitia Jacquesson-Fournols, Patrice Clement, Jacques Chouteau, Marc Schneider, Thierry Besnard, Yves Ménézo","doi":"10.1089/biores.2017.0016","DOIUrl":"https://doi.org/10.1089/biores.2017.0016","url":null,"abstract":"Environmental endocrine disrupting chemicals (EDCs), including bisphenol A (BPA), induce DNA methylation errors and oxidative stress, and alter fertility. Animal studies have demonstrated that supporting the one-carbon cycle (1-CC) with appropriate dietary supplements can reduce the effects of EDCs. Anti-Mullerian hormone (AMH), a marker of ovarian functionality, has been tested in subfertile female patients, to control this hypothesis in humans. Fifty-five women with a history of 3-7 years of infertility, with at least two assisted reproductive technology (ART) treatment failures, and low serum levels of AMH were enrolled in the study. Before starting any further ART treatment, they were tested for AMH and for follicular count. A urinary control of BPA was proposed. Then a support of the 1-CC, already tested in other clinical studies, was initiated and continued for 4 months. At the end of this period, antral follicle count and serum AMH levels were re-evaluated. The AMH levels before and after treatment were compared using the Wilcoxon test (nonparametric test, non-Gaussian population). Out of the 55 patients, 35 accepted a BPA dosage in the urine. No correlation was found between BPA and serum AMH concentrations. Forty-nine patients followed the full treatment with 1-CC supplements, which resulted in increased AMH levels, independent of initial AMH levels and maternal age (in the range studied), p = 0.0001. Eight patients spontaneously conceived ongoing pregnancies within 3 months, at the end of the protocol. A support of the 1-CC can partly alleviate metabolic derangements induced by environment, as observed in animal models, and improve endocrine background in women.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35503499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Prevalence and Risk Factors of Osteoporosis Among Jordanian Postmenopausal Women Attending the National Center for Diabetes, Endocrinology and Genetics in Jordan. 在约旦国家糖尿病、内分泌学和遗传学中心就诊的约旦绝经后妇女中骨质疏松症的患病率和风险因素。

BioResearch Open Access Pub Date : 2017-07-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2016.0045

Dana Hyassat, Taghreed Alyan, Hashem Jaddou, Kamel M Ajlouni

{"title":"Prevalence and Risk Factors of Osteoporosis Among Jordanian Postmenopausal Women Attending the National Center for Diabetes, Endocrinology and Genetics in Jordan.","authors":"Dana Hyassat, Taghreed Alyan, Hashem Jaddou, Kamel M Ajlouni","doi":"10.1089/biores.2016.0045","DOIUrl":"10.1089/biores.2016.0045","url":null,"abstract":"To assess the prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women attending the National Center for Diabetes, Endocrinology, and Genetics (NCDEG), and to determine the potential associated risk factors. A cross-sectional study was conducted at (NCDEG) in Amman, Jordan. A total of 1079 Jordanian postmenopausal women aged between 45 and 84 years were included in this study that was conducted during the period between April 2013 and December 2014. All patients underwent bone mineral density measurement through dual-energy X-ray absorptiometry (DEXA) scan. DEXA scan was interpreted in terms of T score as per World Health Organization guidelines. The overall prevalence of osteoporosis and osteopenia was 37.5% and 44.6%, respectively. The maximum prevalence of osteoporosis was observed at the lumbar spine (32.4%) followed by the left femoral neck (14.4%), while the maximum prevalence of osteopenia was observed at the left femoral neck (56.1%) followed by the lumbar spine (41.3%). Patients with longer menopausal duration, normal or overweight body mass index, high parity, physical inactivity, positive family history of osteoporosis, inadequate sun exposure, high daily caffeine intake, low daily calcium intake, and delay in the age of menarche were all positively associated with osteoporosis. On the other hand, women with type 2 diabetes mellitus had lower risk of osteoporosis. There is a high prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women. Necessary steps are needed for more public education and a wider dissemination of information about osteoporosis and its prevention.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35192695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants. 骨科植入物对二氧化钛的局部细胞反应。

BioResearch Open Access Pub Date : 2017-07-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0017

Jie J Yao, Eric A Lewallen, William H Trousdale, Wei Xu, Roman Thaler, Christopher G Salib, Nicolas Reina, Matthew P Abdel, David G Lewallen, Andre J van Wijnen

引用次数: 31

Induced Pluripotent Stem Cells: Global Research Trends. 诱导多能干细胞:全球研究趋势。

BioResearch Open Access Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0013

Takaharu Negoro, Hanayuki Okura, Akifumi Matsuyama

{"title":"Induced Pluripotent Stem Cells: Global Research Trends.","authors":"Takaharu Negoro, Hanayuki Okura, Akifumi Matsuyama","doi":"10.1089/biores.2017.0013","DOIUrl":"https://doi.org/10.1089/biores.2017.0013","url":null,"abstract":"The induced pluripotent stem cell (iPSC) was first described more than 10 years ago and is currently used in various basic science and clinical research fields. The aim of this report is to examine the trends in research using iPSCs over the last 10 years. The 2006-2016 PubMed database was searched using the MeSH term \"induced pluripotent stem cells.\" Only original research articles were selected, with a total of 3323 articles. These were classified according to research theme into reprogramming, differentiation protocols for specific cells and/or tissues, pathophysiological research on diseases, and discovery of new drugs, and then the trends over the years were analyzed. We also focused on 232 research publications on the pathophysiological causes of diseases and drug discovery with impact factor (IF; Thomson Reuters) of six or more. The IF of each article was summed up by year, by main target disease, and by country, and the total IF score was expressed as trends of research. The trends of research activities of reprogramming and differentiation on specific cells and/or tissues reached maxima in 2013/2014. On the other hand, research on pathophysiology and drug discovery increased continuously. The 232 articles with IF ≥6 dealt with neurological, immunological/hematological, cardiovascular, and digestive tract diseases, in that order. The majority of articles were published from the United States, followed by Japan, Germany, and United Kingdom. In conclusion, iPSCs have become a general tool for pathophysiological research on disease and drug discovery.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35192797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Top 50 Most Cited Articles in Cartilage Regeneration. 软骨再生领域被引用最多的50篇文章。

BioResearch Open Access Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2017.0006

Ciaran K Mc Donald, Peter Moriarty, Manvydas Varzgalis, Colin Murphy

{"title":"The Top 50 Most Cited Articles in Cartilage Regeneration.","authors":"Ciaran K Mc Donald, Peter Moriarty, Manvydas Varzgalis, Colin Murphy","doi":"10.1089/biores.2017.0006","DOIUrl":"https://doi.org/10.1089/biores.2017.0006","url":null,"abstract":"The aim of this study was to identify and analyze the top 50 most cited articles in cartilage regeneration. The impact of a scientific journal can be gauged by the total number of citations it has accrued. The top 50 most cited articles involving cartilage regeneration represent the most quoted level of evidence among this new subspecialty. This study aims to identify and analyze the 50 most cited articles in cartilage regeneration. The Web of Science™ citation indexing service was utilized to determine the most frequently cited articles published after 1956 containing \"cartilage regeneration\" in the \"topic\" or \"title.\" The 50 most cited articles were included. The number of citations, year of publication, country of article origin, article institution, journal of publication, publication format, and authorship were then calculated for each article. The span of citations ranged from 1287 to 203 citations, with a mean of 361.02 citations per article in question. The articles originated from 11 countries, with the United States contributing 34 articles, followed by Japan with 5 articles. The articles were distributed across 34 high-impact journals. Biomaterials was the journal with the highest number of publications (seven articles) followed by the Journal of Orthopaedic Research (three articles). Of the 50 articles, 2 were clinical observational studies, 47 concerned basic science, and 1 was review article. The most cited articles involving cartilage regeneration are detected in both experimental and clinical research fields. The high ratio of basic science to clinical articles reflects the infancy of this relatively new specialty and that further clinical research is required in this area.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35192796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model. 组织工程肌腱用于大鼠肌腱套模型的末端再生。

BioResearch Open Access Pub Date : 2017-06-01 eCollection Date: 2017-01-01 DOI: 10.1089/biores.2016.0042

Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin

{"title":"Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model.","authors":"Michael J Smietana, Pablo Moncada-Larrotiz, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin","doi":"10.1089/biores.2016.0042","DOIUrl":"https://doi.org/10.1089/biores.2016.0042","url":null,"abstract":"Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue. Engineered tendons were fabricated from bone marrow-derived mesenchymal stem cells utilizing our well-described fabrication technology. Forty-three rats underwent unilateral detachment of the supraspinatus tendon followed by acute (immediate) or chronic (4 weeks retracted) repair by using either our engineered tendon or a trans-osseous suture technique. Animals were sacrificed at 8 weeks. Biomechanical and histological analyses of the regenerated enthesis and tendon were performed. Statistical analysis was performed by using a one-way analysis of variance with significance set at p < 0.05. Acute repairs using engineered tendon had improved enthesis structure and lower biomechanical failures compared with suture repairs. Chronic repairs with engineered tendon had a more native-like enthesis with increased fibrocartilage formation, reduced scar formation, and lower biomechanical failure compared with suture repair. Thus, the utilization of our tissue-engineered tendon showed improve enthesis regeneration and improved function in chronic RC repairs compared with suture repair. Clinical Significance: Our engineered tendon construct shows promise as a clinically relevant method for repair of RC injuries.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2016.0042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35192795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26