骨科植入物对二氧化钛的局部细胞反应。

Q2 Biochemistry, Genetics and Molecular Biology

BioResearch Open Access Pub Date : 2017-07-01 eCollection Date: 2017-01-01 DOI:10.1089/biores.2017.0017

Jie J Yao, Eric A Lewallen, William H Trousdale, Wei Xu, Roman Thaler, Christopher G Salib, Nicolas Reina, Matthew P Abdel, David G Lewallen, Andre J van Wijnen

{"title":"骨科植入物对二氧化钛的局部细胞反应。","authors":"Jie J Yao, Eric A Lewallen, William H Trousdale, Wei Xu, Roman Thaler, Christopher G Salib, Nicolas Reina, Matthew P Abdel, David G Lewallen, Andre J van Wijnen","doi":"10.1089/biores.2017.0017","DOIUrl":null,"url":null,"abstract":"We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO2 particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.","PeriodicalId":9100,"journal":{"name":"BioResearch Open Access","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/biores.2017.0017","citationCount":"31","resultStr":"{\"title\":\"Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.\",\"authors\":\"Jie J Yao, Eric A Lewallen, William H Trousdale, Wei Xu, Roman Thaler, Christopher G Salib, Nicolas Reina, Matthew P Abdel, David G Lewallen, Andre J van Wijnen\",\"doi\":\"10.1089/biores.2017.0017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO2 particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.\",\"PeriodicalId\":9100,\"journal\":{\"name\":\"BioResearch Open Access\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1089/biores.2017.0017\",\"citationCount\":\"31\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioResearch Open Access\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/biores.2017.0017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioResearch Open Access","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/biores.2017.0017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 31

摘要

我们评估了最近发表的有关二氧化钛(TiO2)颗粒对正常骨稳态、修复和种植体骨整合所需的局部内源性细胞的生物学效应的文章。二氧化钛颗粒的结构特征、大小、稳定性和团聚改变了多种骨相关细胞类型的活力和行为。由此引起的骨稳态的改变可能会增加骨吸收，并导致骨溶解、植入物松动和关节疼痛的临床事件。TiO2颗粒进入细胞(通过内吞作用或特洛伊木马机制)可能进一步破坏植入物的保留。我们认为，细胞对钛基纳米颗粒的反应有助于钛基金属植入物无菌性松动的病理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.

查看原文本刊更多论文

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.

We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO₂) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO₂ particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO₂ particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

BioResearch Open Access Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

自引率

0.00%

发文量

期刊介绍： BioResearch Open Access is a high-quality open access journal providing peer-reviewed research on a broad range of scientific topics, including molecular and cellular biology, tissue engineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, virology, and neuroscience. The Journal publishes basic science and translational research in the form of original research articles, comprehensive review articles, mini-reviews, rapid communications, brief reports, technology reports, hypothesis articles, perspectives, and letters to the editor.