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Editorial: Metabolism and Target Organ Damage 社论:代谢和靶器官损伤

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/MTOD.2021.01

A. Lonardo

引用次数: 3

Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review 男性性腺功能减退与糖尿病前期相互作用:关联还是因果关系?系统回顾

Metabolism and target organ damage Pub Date : 2021-01-01 DOI: 10.20517/mtod.2021.14

C. Greco, R. Corleto, Riccardo Ebert, M. Simoni, V. Rochira, D. Santi

{"title":"Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review","authors":"C. Greco, R. Corleto, Riccardo Ebert, M. Simoni, V. Rochira, D. Santi","doi":"10.20517/mtod.2021.14","DOIUrl":"https://doi.org/10.20517/mtod.2021.14","url":null,"abstract":"Aim: The association between type 2 diabetes mellitus (T2DM) and male hypogonadism has been largely demonstrated. Testosterone (T) serum levels are often lower in men with T2DM compared to the general population, and, conversely, men with higher T serum levels have shown lower risk of T2DM. On the contrary, the association between pre-diabetes and male hypogonadism has been less investigated thus far. Pre-diabetes is a common clinical condition preceding T2DM and has been recognized as a potential risk factor for other metabolic disorders and cardiovascular diseases. Therefore, the aims of this review are to investigate the association between pre-diabetes and male hypogonadism and to evaluate the potential effect of T treatment on glucose metabolism and anti-diabetic therapy on T serum levels. Methods: We conducted this systematic review developing different literature searches, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol. Page 2 of Greco et al. Metab Target Organ Damage 2022;2:11 https://dx.doi.org/10.20517/mtod.2021.14 18 Results: In our analysis, male hypogonadism has a prevalence of around 24%-35% in pre-diabetic men. Moreover, we observed improvement of metabolic parameters in pre-diabetes with T treatment. On the contrary, antidiabetic therapy seems to have no particular effects on T serum levels. Conclusion: Overall, we demonstrated that, although T administration could be considered in pre-diabetic men, pre-diabetes-related treatments should be confined to the control glucose metabolism, since no evidence for a positive effect on total T serum levels is available. Future research should be oriented to study the role of new antidiabetic drugs in the sex hormonal status in hypogonadal men.","PeriodicalId":91001,"journal":{"name":"Metabolism and target organ damage","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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