RNA & disease (Houston, Tex.)最新文献_第10页

Probing microRNA network with small molecules 用小分子探测microRNA网络

RNA & disease (Houston, Tex.) Pub Date : 2014-12-01 DOI: 10.14800/RD.450

Jinbo Li, Haixiao Huang, Tingting Xia, Yan Zhang, Chenyu Zhang

引用次数: 1

MicroRNA-135b as therapeutic target in cancers MicroRNA-135b作为癌症的治疗靶点

RNA & disease (Houston, Tex.) Pub Date : 2014-11-21 DOI: 10.14800/RD.410

Ching-Wen Lin, T. Hong, Pan‐Chyr Yang

引用次数: 4

Emerging role for PLCβ1 MiRNA and disease plc - β1 MiRNA在疾病中的新作用

RNA & disease (Houston, Tex.) Pub Date : 2014-10-27 DOI: 10.14800/RD.363

I. Faenza, L. Cocco

引用次数: 1

microRNAs control the function of telomeres in cancer microRNAs在癌症中控制端粒的功能

RNA & disease (Houston, Tex.) Pub Date : 2014-10-27 DOI: 10.14800/RD.282

Roberto Dinami, E. Petti, Rosanna Sestito, R. Benetti, Stefan Schoeftner

{"title":"microRNAs control the function of telomeres in cancer","authors":"Roberto Dinami, E. Petti, Rosanna Sestito, R. Benetti, Stefan Schoeftner","doi":"10.14800/RD.282","DOIUrl":"https://doi.org/10.14800/RD.282","url":null,"abstract":"Telomeres are located at the end of chromosomes and consist of DNA tandem repeats that recruit the specialized protein complex “shelterin”. Shelterin has a crucial role in controlling chromosome end protection, telomere recombination and telomere length. Telomeres shorten with every cell division, finally leading to telomere-dysfunction and the induction of senescence or apoptosis. Cancer formation is paralleled by a change in telomere regulation. Re-activation of telomerase ensures the maintenance of telomere function to facilitate unlimited proliferative potential. Importantly, aberrant function of the shelterin complex contributes to tumor formation and genomic instability in human cancer. miRNAs are important regulators of central cancer pathways and are of high clinical relevance. We recently showed that the onco-microRNA miR-155 controls the expression of TRF1 in human breast cancer to promote increased telomere fragility and genomic instability. Importantly, low TRF1 expression correlates with poor prognosis in estrogen receptor positive cancer patients, underlining the clinical relevance of miR-155 dependent regulation of TRF1 in human breast cancer. Our work suggests that multiple miRNAs exist that control telomere function in telomere related pathologies. Identification and functional validation of “telo-miRNAs” is expected to open new avenues in the understanding of telomere related maladies such as cancer and aging.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

MiR-92a - a key player in cardiovascular remodeling MiR-92a -心血管重塑的关键参与者

RNA & disease (Houston, Tex.) Pub Date : 2014-10-27 DOI: 10.14800/RD.371

J. Dutzmann, J. Daniel, J. Bauersachs, D. Sedding

引用次数: 1

Role of noncoding RNAs in diseases 非编码rna在疾病中的作用

RNA & disease (Houston, Tex.) Pub Date : 2014-10-21 DOI: 10.14800/RD.355

Beena Kadakkuzha

引用次数: 2

miR-126 and miR-223 as biomarkers of vascular damage in the course of Chronic Kidney Disease miR-126和miR-223作为慢性肾病过程中血管损伤的生物标志物

RNA & disease (Houston, Tex.) Pub Date : 2014-09-25 DOI: 10.14800/RD.347

V. L. Meuth, Z. Massy, L. Metzinger

{"title":"miR-126 and miR-223 as biomarkers of vascular damage in the course of Chronic Kidney Disease","authors":"V. L. Meuth, Z. Massy, L. Metzinger","doi":"10.14800/RD.347","DOIUrl":"https://doi.org/10.14800/RD.347","url":null,"abstract":"Development of disease is often due to deregulation of gene expression. The gene program is controlled at the post-transcriptional level by the action of small non-coding RNAs known as microRNAs (miRNAs), short, single-stranded molecules that control mRNA stability or translational repression via base pairing with regions in the 3' untranslated region of their target mRNAs. Over the last decade, considerable progress has been made to elucidate the roles of miRNAs in vascular pathogenesis and develop the use of miRNAs as innovative biomarkers in diagnostics, and as groundbreaking drugs in pharmacological treatments. It has been recently shown that several miRNAs are implicated in the course of chronic kidney disease (CKD) and are associated with vessel damage, such as vascular calcifications and atherosclerosis. The inflammatory miR-223 is increased in vitro in vascular smooth muscle cells subjected to uremic toxins and is also increased in vivo in more advanced stages of CKD. The endothelial-specific miR-126 is involved in vascular remodeling in response to laminar shear stress in HUVEC cells. Finally, miR-126 levels have been found to be deregulated in murine and human serum in the course of experimental CKD and in human diabetic patients. In conclusion, these miRNAs could play a role in CKD vascular remodeling and may therefore represent useful targets to prevent or treat complications of CKD.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Bone metastatic prostate cancer and resistance to tyrosine kinase inhibitors: an intimate relationship between loss of miR-203 and up-regulation of EGFR signaling 骨转移性前列腺癌与酪氨酸激酶抑制剂耐药:miR-203缺失与EGFR信号上调之间的密切关系

RNA & disease (Houston, Tex.) Pub Date : 2014-09-25 DOI: 10.14800/RD.345

W. Abou-Kheir, T. Mouhieddine, Muhieddine M. Itani, Yen-Nien Liu

{"title":"Bone metastatic prostate cancer and resistance to tyrosine kinase inhibitors: an intimate relationship between loss of miR-203 and up-regulation of EGFR signaling","authors":"W. Abou-Kheir, T. Mouhieddine, Muhieddine M. Itani, Yen-Nien Liu","doi":"10.14800/RD.345","DOIUrl":"https://doi.org/10.14800/RD.345","url":null,"abstract":"A tumor suppressor role for miR-203 in RAS-dependent prostate cancer metastasis has been described recently by our group. We have explored the regulatory mechanisms by which miR-203 is being regulated through EGFR signaling. We investigated the molecular mechanism of metastasis and identified novel roles of genes that interact with miR-203 downstream of activated Ras. We showed an amplifying regulatory loop involving the direct interaction of miR-203 with the EGFR ligands, AREG, EREG, and TGFA 3’UTR. Using clinical specimens and database analysis, our data suggested that decreasing miR-203 and increasing EGFR ligands, AREG, EREG, and TGFA expressions are correlated with prostate cancer progression. Since tyrosine kinase inhibitors (TKIs) have been shown to inhibit tyrosine phosphorylation of EGFR in a dose-dependent manner, we examined a role for miR-203 in TKIs-induced apoptosis in RAS-activated prostate cancer. We investigated the mechanisms by which miR-203 overexpression contributes to TKIs-resistant RAS-activated prostate cancer cells apoptosis. We have shown indications for candidate miR-203 targets that are either influenced by anti-apoptotic proteins (e.g. API5, BIRC2, and TRIAP1) or positively influenced by a novel NF-κB-inducible oncogenic molecule, TNFAIP8. These observations suggest that the latter category may be synergistically affected by the regulatory loop of miR-203 depletion and anti-apoptotic proteins overexpression. Our results provided evidence showing a role of miR-203 in regulating the expression of EGFR signaling genes in response to TKIs-resistance during prostate cancer progression.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Identification of microRNAs from Atlantic salmon macrophages upon Aeromonas salmonicida infection 大西洋鲑鱼巨噬细胞感染沙门氏气单胞菌的microrna鉴定

RNA & disease (Houston, Tex.) Pub Date : 2014-09-25 DOI: 10.14800/RD.303

V. I. HairulIslam, S. Saravanan, D. Sekar, K. Karikalan, P. Senthilkumar, Ravi Chandrika Chandrika, K. Thirugnanasambantham

引用次数: 3

Expression pattern of the microRNA miR-1 in ovarian cancer cell lines and tumor tissue samples implies a loss of miR-1's tumor suppressor properties microRNA miR-1在卵巢癌细胞系和肿瘤组织样本中的表达模式表明miR-1的肿瘤抑制特性的丧失

RNA & disease (Houston, Tex.) Pub Date : 2014-09-25 DOI: 10.14800/RD.348

M. Stope, S. Delogu, K. Diesing, Gerd Klinkmann, M. Evert, D. Koensgen, M. Zygmunt, M. Burchardt, A. Mustea

{"title":"Expression pattern of the microRNA miR-1 in ovarian cancer cell lines and tumor tissue samples implies a loss of miR-1's tumor suppressor properties","authors":"M. Stope, S. Delogu, K. Diesing, Gerd Klinkmann, M. Evert, D. Koensgen, M. Zygmunt, M. Burchardt, A. Mustea","doi":"10.14800/RD.348","DOIUrl":"https://doi.org/10.14800/RD.348","url":null,"abstract":"Despite ovarian cancer (OC) represents the leading cause of death in gynecology, however, current understanding of the molecular machinery governing initiation, development and recurrence of the tumor is still limited. Particularly, lack of specific biomarkers defining the complex states of OC limits effective diagnosis and prognosis and, subsequently, hinders appropriate therapy strategies for OC patients. MicroRNA (miR) are small non-coding, regulatory RNA molecules which have critical functions in tumor biology, and which have been functionally grouped into tumor suppressive and tumor promoting miR. miR-1 has been described operating as a tumor suppressor which attenuates proliferation and progression in divers solid cancer entities. Currently, there are no data available concerning miR-1 functionality in progression of OC, particularly, in regard to its potentialas a biomarker for OC diagnosis and treatment. Therefore, the present study examined miR-1 expression levels in established OC cell lines as well as in tissue samples from primary and relapsed OC patients to get a first understanding of putative miR-1 properties in OC progression. Notably, we found miR-1 in OC cell lines was linked to higher cell growth rates. Moreover, analysis of patient samples revealed miR-1 levels in relapsed tumors appeared being up-regulated compared to primary tumors. The findings of our preliminary study (1) may suggest a novel role of miR-1 in OC as a promotor of cancer progression or (2) exhibit a dysregulation of miR-1 functions by a so far unknown disruption of miR-1 regulatory cascades.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"123 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4