V. I. HairulIslam, S. Saravanan, D. Sekar, K. Karikalan, P. Senthilkumar, Ravi Chandrika Chandrika, K. Thirugnanasambantham
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Identification of microRNAs from Atlantic salmon macrophages upon Aeromonas salmonicida infection
Computational approach was used in to identify potent macrophage specific miRNAs involved in basic biological process of Salmo salar. Analysis of 1119 ESTs from macrophages of Atlantic salmon (Salmo salar) infected with Aeromonas salmonicida revealed expression of 3 miRNAs. Phylogenetic analysis of both the pre-miRNA sequence revealed its evolutionarily conserved nature among various species. Identified targets of the predicted miRNAs revealed the role of miRNA in pathogenesis, stress response and allosteric exchange of histones. Further detailed studies of these miRNAs will help in revealing its function in different biological process necessary for the action of macrophages upon pathogen infection.
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