Emerging role for PLCβ1 MiRNA and disease

Abstract

Nuclear inositides are independently regulated and their regulation is totally independent from the plasma membrane counterpart, suggesting that the nucleus constitutes a functionally distinct compartment of inositol lipids metabolism. This suggests that nuclear inositol lipids themselves can modulate nuclear processes as important as transcription and pre-mRNA splicing, growth, proliferation, cell cycle regulation and differentiation. Phospholipase C β1 (PLCβ1) is a key molecule for nuclear inositide signaling. Very recently it has been highlighted that the role of PLCβ1 during erythropoiesis is linked to that of miR-210. Moreover PLCβ1 signaling is linked to gene regulation and changes in microRNAs (miRNAs) occurs with PLCβ1 expression. Molecular targets of PLCβ1 have been found to be important during myogenesis and hematopoiesis. In addition, PLCβ1 signaling has been demonstrated to be impaired in diseases affecting both myogenic differentiation and affecting the hematopoietic system.