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Chinese Anti-Corruption Policy Choices in a Transitional Stage 转型期的中国反腐败政策选择
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-07-20 DOI: 10.14304/SURYA.JPR.V5N7.3
Zhaogang Qiao, Ying Zhang
{"title":"Chinese Anti-Corruption Policy Choices in a Transitional Stage","authors":"Zhaogang Qiao, Ying Zhang","doi":"10.14304/SURYA.JPR.V5N7.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N7.3","url":null,"abstract":"With rapid economic development, corruption has become more and more serious in China. This paper has set up an optimal utility model to analyze the factors leading to corruption in China. The model illustrates how higher salary, lower income from corruption, lower preparation costs, higher probability and degree of punishment can help to reduce corruption. Considering these findings, this paper provided some policy discussions in the end.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44211059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Does More Education Promote Civic Engagement 更多教育能促进公民参与吗
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-07-20 DOI: 10.14304/SURYA.JPR.V5N9.5
Zhaogang Qiao, Ying Zhang, Guodong Liang
{"title":"Does More Education Promote Civic Engagement","authors":"Zhaogang Qiao, Ying Zhang, Guodong Liang","doi":"10.14304/SURYA.JPR.V5N9.5","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N9.5","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45570746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Jadomycins: A Study of Their Synthesis and Biological Evaluation 雅多霉素的合成及生物学评价研究
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-25 DOI: 10.14304/SURYA.JPR.V5N5.3
Ehesan U. Sharif, G. O'Doherty
{"title":"Jadomycins: A Study of Their Synthesis and Biological Evaluation","authors":"Ehesan U. Sharif, G. O'Doherty","doi":"10.14304/SURYA.JPR.V5N5.3","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.3","url":null,"abstract":"Jadomycins are anticancer antibiotics isolated from Streptomyces venezuelae. The core of these natural products consists of a dihydro-phenanthridine ring-system. Another unique feature built to the core is a fused 1,3-oxazolidine-5-one ring. Recent synthetic reports suggest a structural revision of the fused oxazolidinone ring in jadomycin S and jadomycin T. This review will focus on the synthetic efforts leading to the structural revision, and the semisynthetic approaches to generate new jadomycin analogs and their biological activity.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45116973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The many roles of TET1 in the post-implantation mouse embryo TET1在小鼠胚胎植入后的多种作用
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-25 DOI: 10.14304/SURYA.JPR.V5N5.4
Rita Khoueiry
{"title":"The many roles of TET1 in the post-implantation mouse embryo","authors":"Rita Khoueiry","doi":"10.14304/SURYA.JPR.V5N5.4","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.4","url":null,"abstract":"","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45671287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose triglyceride lipolysis - adding fuel to the fire 脂肪甘油三酯脂解——火上浇油
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-25 DOI: 10.14304/SURYA.JPR.V5N5.5
V. Raje
{"title":"Adipose triglyceride lipolysis - adding fuel to the fire","authors":"V. Raje","doi":"10.14304/SURYA.JPR.V5N5.5","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.5","url":null,"abstract":"Recent studies have shown the presence of functional brown adipose tissue (BAT) in adult humans and it role in thermogenesis. This study by Blondin et al published in Cell Metabolism shows that similar to rodents; adult human brown adipose tissue uses lipids as its cellular fuel during thermogenesis. Inhibition of triglyceride lipolysis was associated with a shift in the skeletal muscle mediated shivering instead and a shift in fuel utilization from lipids to glucose. This study provides yet another confirmatory role of a functional brown fat in adult humans that is fueled by fatty acids.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46204391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing Antibiotics with “Selfish DNA” Plasmids 利用“自私DNA”质粒开发抗生素
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-25 DOI: 10.14304/SURYA.JPR.V5N5.1
A. Rao, Somdutta Saha
{"title":"Developing Antibiotics with “Selfish DNA” Plasmids","authors":"A. Rao, Somdutta Saha","doi":"10.14304/SURYA.JPR.V5N5.1","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.1","url":null,"abstract":"Plasmids are small circular double-stranded DNA molecules that are most commonly found in bacteria. They replicate independently of chromosomal DNA. Plasmids often encode genes that provide a survival advantage to the organisms(1). For instance, plasmids may carry genes that confer resistance to naturally occurring antibiotics, or may provide the organism the ability to selectively utilize particular nutrients that will aid in survival when food is scarce. However, the maintenance and replication of plasmids impose immense metabolic burden on the bacterial host, mainly in terms of reduced host growth and viability(2).","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44885606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-Sectional Study to Assess Mental Health Awareness among Adolescents 评估青少年心理健康意识的横断面研究
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-20 DOI: 10.14304/SURYA.JPR.V5N5.6
Anjali Kumar, M. Jadhav
{"title":"A Cross-Sectional Study to Assess Mental Health Awareness among Adolescents","authors":"Anjali Kumar, M. Jadhav","doi":"10.14304/SURYA.JPR.V5N5.6","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.6","url":null,"abstract":"Suicide is among the top three leading causes of death in adolescents, and the rate of suicide-related deaths is on the rise. A systematic approach to address this challenge is warranted. This study aimed to assess how many students had awareness of or have had mental health issues, or knew someone who struggled with mental health. A cross-sectional, web-based survey was conducted at Acton-Boxborough middle and high schools in Massachusetts, USA. An electronic, self-administered survey with a total of 13 questions, including closedand open-ended questions, was developed to collect feedback from students, teachers, counselors, and staff members. The survey was conducted between October 20 and November 13, 2016. The survey was posted on Facebook and was accessible to anyone with a Google email account linked to Acton-Boxborough schools. In this three–week survey, 623 completed responses were returned. The most frequent responders were middle school and younger students (n = 356; 57.1%), followed by high school students (n = 213; 34.2%), and college students (n = 39; 6.2%). A high number of participants (99%) considered mental health to be an important topic of discussion. A considerable number of the participants (n = 252; 40.4%) confirmed that they personally struggle with mental illness, most commonly anxiety (n = 324; 86.6%) and depression (n = 253; 67.6%) followed by bipolar disorder, drug/alcohol addiction and eating disorders. A large number (n = 570; 91.5%) responded that they know someone in their school suffering from mental illness. In conclusion, this web-based, cross-sectional questionnaire study revealed that there is an acute need to develop strategies to improve awareness of and education for mental illness among adolescents. There is also a need to plan, design, and execute early interventionbased studies in adolescents.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44663514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial plasmid addiction systems and their implications for antibiotic drug development. 细菌质粒成瘾系统及其对抗生素药物开发的影响。
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-01
Jennifer Tsang
{"title":"Bacterial plasmid addiction systems and their implications for antibiotic drug development.","authors":"Jennifer Tsang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bacteria frequently carry mobile genetic elements capable of being passed to other bacterial cells. An example of this is the transfer of plasmids (small, circular DNA molecules) that often contain antibiotic resistance genes from one bacterium to another. Plasmids have evolved mechanisms to ensure their survival through generations by employing plasmids segregation and replication machinery and plasmid addiction systems. Plasmid addiction systems utilize a post-segregational killing of cells that have not received a plasmid. In this review, the types of plasmid addiction systems are described as well as their prevalence in antibiotic resistant bacteria. Lastly, the possibility of targeting these plasmid addiction systems for the treatment of antibiotic resistant bacterial infections is explored.</p>","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"5 5","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542005/pdf/nihms879565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35295988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial plasmid addiction systems and their implications for antibiotic drug development. 细菌质粒成瘾系统及其对抗生素药物开发的影响。
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-05-01 DOI: 10.14304/SURYA.JPR.V5N5.2
J. Tsang
{"title":"Bacterial plasmid addiction systems and their implications for antibiotic drug development.","authors":"J. Tsang","doi":"10.14304/SURYA.JPR.V5N5.2","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N5.2","url":null,"abstract":"Bacteria frequently carry mobile genetic elements capable of being passed to other bacterial cells. An example of this is the transfer of plasmids (small, circular DNA molecules) that often contain antibiotic resistance genes from one bacterium to another. Plasmids have evolved mechanisms to ensure their survival through generations by employing plasmids segregation and replication machinery and plasmid addiction systems. Plasmid addiction systems utilize a post-segregational killing of cells that have not received a plasmid. In this review, the types of plasmid addiction systems are described as well as their prevalence in antibiotic resistant bacteria. Lastly, the possibility of targeting these plasmid addiction systems for the treatment of antibiotic resistant bacterial infections is explored.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":"396 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76436748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Regulatory function of membrane trafficking components in exosome secretion and cancer progression 膜运输成分在外泌体分泌和癌症进展中的调节功能
Postdoc journal : a journal of postdoctoral research and postdoctoral affairs Pub Date : 2017-03-20 DOI: 10.14304/SURYA.JPR.V5N3.5
A. Kulkarni
{"title":"Regulatory function of membrane trafficking components in exosome secretion and cancer progression","authors":"A. Kulkarni","doi":"10.14304/SURYA.JPR.V5N3.5","DOIUrl":"https://doi.org/10.14304/SURYA.JPR.V5N3.5","url":null,"abstract":"Cancer cell-derived exosomes have recently been implicated in contributing to metastasis. It is expectable that specific membrane trafficking factors would participate in the regulation of exosome formation, transport and release from cells. Recent investigations have revealed certain members belonging to the SNARE, sorting factor and Rab GTPase protein families as being crucial in governing the exosome life cycle. These trafficking components have therefore been primed as new targets potentially modulating cancer progression. This mini-review is focused on the involvement of membrane trafficking components in regulating exosome-related transport and signaling, and in turn influencing clinical outcomes in cancer.","PeriodicalId":90946,"journal":{"name":"Postdoc journal : a journal of postdoctoral research and postdoctoral affairs","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43776049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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